Rezultaty
Guidelines for licensing and collaborating with industry.
Viral databaseTo include >2,500 qualified viral strains during the 4 years of the project following a yearly programme, in accordance with the following criteria: (i) ≥50% of QCS1 and QCS2 strains; <25% of QCS5 strains.
Protocols for inactivation of RG4 virusesValidated protocols for inactivation of RG4 viruses
SOPs for virus storageSOPs for sample stabilization under ambient temperatures and for long term storage Updates will be delivered at M36, M48.
Cell collectionTo include > 10 new bat / rodent / interferon deficient cell lines.
Yearly Progress Report on Transfer of knowledge ActivitiesYearly Progress Report on Transfer of knowledge Activities, including meetings proceedings and upcoming communication plan. Updates will be delivered at M24, M36, M48.
Protocols for viruses isolationTo propose standardised protocols allowing to increase the sensitivity of virus isolation Updates will be delivered at M24, M36, M48.
Report on ethical issues by EEABReport on ethical issues by EEAB. Updates will be delivered at M24, M36, M48.
List of protocols to rescue virusesTo produce a list of viruses and standardised protocol for rescuing replicative virus from inactivated samples. One update will be delivered at M48.
Specialized culture platformTo produce an automated culture platform operating in BSL3 environment for both mosquito and vertebrate cell lines.
Yearly communication and dissemination tools, including vulgarization materialYearly communication and dissemination tools, including vulgarization material. Updates will be delivered at M24, M36, M48.
WP5 Final ReportWP2 Final Results
Protocol for virus FTA cards production
Protocol for virus FTA cards made available through EVA Portal
FTA cards assays protocolsAvailability of assays through EVA
Cooperation agreementsImplementation of cooperation agreements with institutions from endemic areas to organize local staff training and material exchanges Updates will be delivered at M36, M48.
WP7 Final ResultsWP8 final Results
WP8 final Results.
Assessment of the genome-sequencing qualityProcedure for the post-sequencing genome analysis and quality control Updates will be delivered at M36, M48.
EVAg achievement related to the COVID-19 outbreakReport on achievement related to the COVID19 outbreak
Networking reportReport on the connections and formalized agreements between EVAg and other EU-funded projects and other Institutions for sharing viral strains and related products. Updates will be delivered at M36, M48
Inclusion of viruses in the EVAg DB arising from partnership with non-EVA European institutionsInclusion of viruses in the EVAg DB arising from partnership with non-EVA European institutions. Updates will be delivered at M36, M48.
List of available vertebrate and invertebrate in vivo systemsList of available vertebrate and invertebrate in vivo systems and corresponding offered facility accesses for using these systems among the partners Updates will be delivered at M24, M36, M48.
Procedures to back-up collection of materialBackup global securing system of the collection Updates will be delivered at M36, M48.
WP4 Final ResultsCatalogue of mouse models
Mouse model and GP model of SFTS and Oropuche virus.
Abstract of publication on nucleic acid extraction efficienciesPeer reviewed manuscript on the relative nucleic acid extraction efficiencies from different specimen matrices (using synthetic RNA)
WP6 Final ResultsWP6 Final Results.
Protocol for mosquito infectionEstablishment of a passage-model for mosquito-borne viruses. One update will be delivered at M48.
List of specific virusesCharacterization of the viruses defined in Milestones “List of newly, in the course of the project, isolated viruses which will be characterized in terms of their ability to use various invertebrate hosts as vectors” at M24 in terms of their ability to use various invertebrate hosts as vectors One update will be delivered at M48.
Cost-effective NGS sequencing protocolsProviding cost-effective NGS sequencing protocols that fulfil abovementioned quality criteria for RNA virus sequencing
New protocols on NGS techniquesNGS innovative technical tools for sequencing viruses of the collection Updates will be delivered at M24, M36, M48.
WP3 Final ResultsWP3 Final Results.
Procedures for viruses inactivation and viruses removal in biological samplesProducing procedures for (i) virus inactivation, (ii) virus removal, (iii) virus inactivation in fixed biological specimens, (iv) viral inactivation of clinical specimens, (v) gamma irradiation Updates will be delivered at M24, M36, M48.
Protocol for isolation of vector-borne virusesIsolation attempts performed for the viruses defined in Milestone “List of vector-borne viruses identified as candidates for isolation attempts using in vivo invertebrate models” One update will be delivered at M48.
According to Article 20.5 of the H2020 Annotated Grant Agreement, for grants above EUR 5 million with reporting periods beyond 18 months, the coordinator must inform the Commission by 31 December 2019 of the cumulative expenditure incurred by the beneficiaries from the starting date of the action and for each calendar year, even for years of activity included in the periods of less than 18 months.This information is required for the Commission’s accounting purposes and will not be used to calculate the final grant amount.
Signature of agreements with related national structures of non-EU partners to organize local financial supportSignature of agreements with related national structures of non-EU partners to organize local financial support. Updates will be delivered at M24, M36, M48.
PCR SOPs updated cataloguePCR SOPs and synthetic positive controls in catalogue. Day of outbreak + Week 3 max.
Database of epidemic virusesEpidemic viruses are characterised and available via EVAg database. Day of outbreak + Week 8
Documented updated catalogueSOPs with amended documentation and optional inhibition control in catalogue. Day of outbreak + Week 8
Antigens and protocols in EVAg catalogueAntigens and protocols in EVAg catalogue. Day of outbreak + Week 12
Signature of agreements with CDC and other international health organization to formalize links with EVAgSignature of agreements with CDC and other international health organization to formalize links with EVAg. Updates will be delivered at M24, M36, M48.
Final Release of the EVAg compatible Software for sample management.
EVAg PORTAL user's private area available onlineEVA PORTAL user's private area available online.
E Training materialE Training material. One update will be delivered at M48.
Updated version of the EVAg Website available onlineUpdated version of the EVAg Website available online.
Periodically updated database of genome sequences and alignments of selected virus families accessible through public WEB-site Updates will be delivered at M24, M36, M48.
Specialized platform for recombinant proteins productionOperational platforms for proteins and antibodies production
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Nature, Numer 585/7826, 2020, Strona(/y) 584-587, ISSN 0028-0836
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Eurosurveillance, Numer 25/27, 2020, ISSN 1560-7917
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ECDC
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Journal of Immunological Methods, Numer 489, 2021, Strona(/y) 112937, ISSN 0022-1759
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10.1016/j.jim.2020.112937
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Journal of Clinical Virology, Numer 129, 2020, Strona(/y) 104510, ISSN 1386-6532
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Eurosurveillance, Numer 24/50, 2019, ISSN 1560-7917
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ECDC
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Cell Death & Disease, Numer 11/8, 2020, ISSN 2041-4889
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The Journal of Infectious Diseases, Numer 217/6, 2017, Strona(/y) 926-932, ISSN 0022-1899
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Journal of Virology, Numer 91/6, 2017, Strona(/y) e02096-16, ISSN 0022-538X
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American Society for Microbiology
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Archives of Virology, Numer 162/5, 2017, Strona(/y) 1441-1446, ISSN 0304-8608
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Springer Verlag
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Archives of Virology, Numer 162/8, 2017, Strona(/y) 2505-2538, ISSN 0304-8608
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Springer Verlag
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Archives of Virology, 2018, ISSN 0304-8608
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Nature Reviews Microbiology, Numer 15/3, 2017, Strona(/y) 161-168, ISSN 1740-1526
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Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
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BioMed Central
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Eurosurveillance, Numer 22/11, 2017, ISSN 1025-496X
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PLOS ONE, Numer 10/9, 2015, Strona(/y) e0138703, ISSN 1932-6203
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Eurosurveillance, Numer 25/3, 2020, ISSN 1560-7917
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