Risultati finali
Guidelines for licensing and collaborating with industry.
Viral databaseTo include >2,500 qualified viral strains during the 4 years of the project following a yearly programme, in accordance with the following criteria: (i) ≥50% of QCS1 and QCS2 strains; <25% of QCS5 strains.
Protocols for inactivation of RG4 virusesValidated protocols for inactivation of RG4 viruses
SOPs for virus storageSOPs for sample stabilization under ambient temperatures and for long term storage Updates will be delivered at M36, M48.
Cell collectionTo include > 10 new bat / rodent / interferon deficient cell lines.
Yearly Progress Report on Transfer of knowledge ActivitiesYearly Progress Report on Transfer of knowledge Activities, including meetings proceedings and upcoming communication plan. Updates will be delivered at M24, M36, M48.
Protocols for viruses isolationTo propose standardised protocols allowing to increase the sensitivity of virus isolation Updates will be delivered at M24, M36, M48.
Report on ethical issues by EEABReport on ethical issues by EEAB. Updates will be delivered at M24, M36, M48.
List of protocols to rescue virusesTo produce a list of viruses and standardised protocol for rescuing replicative virus from inactivated samples. One update will be delivered at M48.
Specialized culture platformTo produce an automated culture platform operating in BSL3 environment for both mosquito and vertebrate cell lines.
Yearly communication and dissemination tools, including vulgarization materialYearly communication and dissemination tools, including vulgarization material. Updates will be delivered at M24, M36, M48.
WP5 Final ReportWP2 Final Results
Protocol for virus FTA cards production
Protocol for virus FTA cards made available through EVA Portal
FTA cards assays protocolsAvailability of assays through EVA
Cooperation agreementsImplementation of cooperation agreements with institutions from endemic areas to organize local staff training and material exchanges Updates will be delivered at M36, M48.
WP7 Final ResultsWP8 final Results
WP8 final Results.
Assessment of the genome-sequencing qualityProcedure for the post-sequencing genome analysis and quality control Updates will be delivered at M36, M48.
EVAg achievement related to the COVID-19 outbreakReport on achievement related to the COVID19 outbreak
Networking reportReport on the connections and formalized agreements between EVAg and other EU-funded projects and other Institutions for sharing viral strains and related products. Updates will be delivered at M36, M48
Inclusion of viruses in the EVAg DB arising from partnership with non-EVA European institutionsInclusion of viruses in the EVAg DB arising from partnership with non-EVA European institutions. Updates will be delivered at M36, M48.
List of available vertebrate and invertebrate in vivo systemsList of available vertebrate and invertebrate in vivo systems and corresponding offered facility accesses for using these systems among the partners Updates will be delivered at M24, M36, M48.
Procedures to back-up collection of materialBackup global securing system of the collection Updates will be delivered at M36, M48.
WP4 Final ResultsCatalogue of mouse models
Mouse model and GP model of SFTS and Oropuche virus.
Abstract of publication on nucleic acid extraction efficienciesPeer reviewed manuscript on the relative nucleic acid extraction efficiencies from different specimen matrices (using synthetic RNA)
WP6 Final ResultsWP6 Final Results.
Protocol for mosquito infectionEstablishment of a passage-model for mosquito-borne viruses. One update will be delivered at M48.
List of specific virusesCharacterization of the viruses defined in Milestones “List of newly, in the course of the project, isolated viruses which will be characterized in terms of their ability to use various invertebrate hosts as vectors” at M24 in terms of their ability to use various invertebrate hosts as vectors One update will be delivered at M48.
Cost-effective NGS sequencing protocolsProviding cost-effective NGS sequencing protocols that fulfil abovementioned quality criteria for RNA virus sequencing
New protocols on NGS techniquesNGS innovative technical tools for sequencing viruses of the collection Updates will be delivered at M24, M36, M48.
WP3 Final ResultsWP3 Final Results.
Procedures for viruses inactivation and viruses removal in biological samplesProducing procedures for (i) virus inactivation, (ii) virus removal, (iii) virus inactivation in fixed biological specimens, (iv) viral inactivation of clinical specimens, (v) gamma irradiation Updates will be delivered at M24, M36, M48.
Protocol for isolation of vector-borne virusesIsolation attempts performed for the viruses defined in Milestone “List of vector-borne viruses identified as candidates for isolation attempts using in vivo invertebrate models” One update will be delivered at M48.
According to Article 20.5 of the H2020 Annotated Grant Agreement, for grants above EUR 5 million with reporting periods beyond 18 months, the coordinator must inform the Commission by 31 December 2019 of the cumulative expenditure incurred by the beneficiaries from the starting date of the action and for each calendar year, even for years of activity included in the periods of less than 18 months.This information is required for the Commission’s accounting purposes and will not be used to calculate the final grant amount.
Signature of agreements with related national structures of non-EU partners to organize local financial supportSignature of agreements with related national structures of non-EU partners to organize local financial support. Updates will be delivered at M24, M36, M48.
PCR SOPs updated cataloguePCR SOPs and synthetic positive controls in catalogue. Day of outbreak + Week 3 max.
Database of epidemic virusesEpidemic viruses are characterised and available via EVAg database. Day of outbreak + Week 8
Documented updated catalogueSOPs with amended documentation and optional inhibition control in catalogue. Day of outbreak + Week 8
Antigens and protocols in EVAg catalogueAntigens and protocols in EVAg catalogue. Day of outbreak + Week 12
Signature of agreements with CDC and other international health organization to formalize links with EVAgSignature of agreements with CDC and other international health organization to formalize links with EVAg. Updates will be delivered at M24, M36, M48.
Final Release of the EVAg compatible Software for sample management.
EVAg PORTAL user's private area available onlineEVA PORTAL user's private area available online.
E Training materialE Training material. One update will be delivered at M48.
Updated version of the EVAg Website available onlineUpdated version of the EVAg Website available online.
Periodically updated database of genome sequences and alignments of selected virus families accessible through public WEB-site Updates will be delivered at M24, M36, M48.
Specialized platform for recombinant proteins productionOperational platforms for proteins and antibodies production
Pubblicazioni
Autori:
Ellen G Murphy, Nicola J Williams, Malcolm Bennett, Daisy Jennings, Julian Chantrey, Lorraine M McElhinney
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Veterinary Record, Numero 184/17, 2019, Pagina/e 525-525, ISSN 0042-4900
Editore:
British Veterinary Association
DOI:
10.1136/vr.105249
Autori:
Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavi
Pubblicato in:
Nature, Numero 585/7826, 2020, Pagina/e 584-587, ISSN 0028-0836
Editore:
Nature Publishing Group
DOI:
10.1038/s41586-020-2558-4
Autori:
Veerle Matheeussen, Victor M Corman, Oliver Donoso Mantke, Elaine McCulloch, Christine Lammens, Herman Goossens, Daniela Niemeyer, Paul S Wallace, Paul Klapper, Hubert GM Niesters, Christian Drosten, Margareta Ieven
Pubblicato in:
Eurosurveillance, Numero 25/27, 2020, ISSN 1560-7917
Editore:
ECDC
DOI:
10.2807/1560-7917.es.2020.25.27.2001223
Autori:
Livia Mazzini, Donata Martinuzzi, Inesa Hyseni, Linda Benincasa, Eleonora Molesti, Elisa Casa, Giulia Lapini, Pietro Piu, Claudia Maria Trombetta, Serena Marchi, Ilaria Razzano, Alessandro Manenti, Emanuele Montomoli
Pubblicato in:
Journal of Immunological Methods, Numero 489, 2021, Pagina/e 112937, ISSN 0022-1759
Editore:
Elsevier BV
DOI:
10.1016/j.jim.2020.112937
Autori:
Zsófia Iglói, Margareta leven, Zain Abdel-Karem Abou-Nouar, Babette Weller, Veerle Matheeussen, Jasmine Coppens, Marion Koopmans, Richard Molenkamp
Pubblicato in:
Journal of Clinical Virology, Numero 129, 2020, Pagina/e 104510, ISSN 1386-6532
Editore:
Elsevier BV
DOI:
10.1016/j.jcv.2020.104510
Autori:
Lorraine McElhinney, Denise Marston, Emma Wise, Conrad Freuling, Hervé Bourhy, Reto Zanoni, Torfinn Moldal, Engbert Kooi, Antonie Neubauer-Juric, Tiina Nokireki, Thomas Müller, Anthony Fooks
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International Journal of Molecular Sciences, Numero 19/1, 2018, Pagina/e 156, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms19010156
Autori:
Chantal Reusken, Cecile Baronti, Ramona Mögling, Anna Papa, Katrin Leitmeyer, Remi N Charrel
Pubblicato in:
Eurosurveillance, Numero 24/50, 2019, ISSN 1560-7917
Editore:
ECDC
DOI:
10.2807/1560-7917.es.2019.24.50.1900051
Autori:
Allan Sauvat, Fabiola Ciccosanti, Francesca Colavita, Martina Di Rienzo, Concetta Castilletti, Maria Rosaria Capobianchi, Oliver Kepp, Laurence Zitvogel, Gian Maria Fimia, Mauro Piacentini, Guido Kroemer
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Cell Death & Disease, Numero 11/8, 2020, ISSN 2041-4889
Editore:
Nature Publishing Group
DOI:
10.1038/s41419-020-02842-x
Autori:
Katarina Resman Rus, Miša Korva, Petra Bogovič, Emil Pal, Franc Strle, Tatjana Avšič-Županc
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The Journal of Infectious Diseases, Numero 217/6, 2017, Pagina/e 926-932, ISSN 0022-1899
Editore:
University of Chicago Press
DOI:
10.1093/infdis/jix650
Autori:
Anastasia Gulyaeva, Magdalena Dunowska, Erik Hoogendoorn, Julia Giles, Dmitry Samborskiy, Alexander E. Gorbalenya
Pubblicato in:
Journal of Virology, Numero 91/6, 2017, Pagina/e e02096-16, ISSN 0022-538X
Editore:
American Society for Microbiology
DOI:
10.1128/JVI.02096-16
Autori:
Michael J. Adams, Elliot J. Lefkowitz, Andrew M. Q. King, Balázs Harrach, Robert L. Harrison, Nick J. Knowles, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Arcady R. Mushegian, Max L. Nibert, Sead Sabanadzovic, Hélène Sanfaçon, Stuart G. Siddell, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Richard J. Orton, Donald B. Smith, Alexander E. Gorbalenya, Andrew J. Davison
Pubblicato in:
Archives of Virology, Numero 162/5, 2017, Pagina/e 1441-1446, ISSN 0304-8608
Editore:
Springer Verlag
DOI:
10.1007/s00705-016-3215-y
Autori:
Michael J. Adams, Elliot J. Lefkowitz, Andrew M. Q. King, Balázs Harrach, Robert L. Harrison, Nick J. Knowles, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Arcady R. Mushegian, Max Nibert, Sead Sabanadzovic, Hélène Sanfaçon, Stuart G. Siddell, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Alexander E. Gorbalenya, Andrew J. Davison
Pubblicato in:
Archives of Virology, Numero 162/8, 2017, Pagina/e 2505-2538, ISSN 0304-8608
Editore:
Springer Verlag
DOI:
10.1007/s00705-017-3358-5
Autori:
Andrew M. Q. King, Elliot J. Lefkowitz, Arcady R. Mushegian, Michael J. Adams, Bas E. Dutilh, Alexander E. Gorbalenya, Balázs Harrach, Robert L. Harrison, Sandra Junglen, Nick J. Knowles, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Max L. Nibert, Luisa Rubino, Sead Sabanadzovic, Hélène Sanfaçon, Stuart G. Siddell, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Andrew J. Daviso
Pubblicato in:
Archives of Virology, 2018, ISSN 0304-8608
Editore:
Springer Verlag
DOI:
10.1007/s00705-018-3847-1
Autori:
Peter Simmonds, Mike J. Adams, Mária Benkő, Mya Breitbart, J. Rodney Brister, Eric B. Carstens, Andrew J. Davison, Eric Delwart, Alexander E. Gorbalenya, Balázs Harrach, Roger Hull, Andrew M.Q. King, Eugene V. Koonin, Mart Krupovic, Jens H. Kuhn, Elliot J. Lefkowitz, Max L. Nibert, Richard Orton, Marilyn J. Roossinck, Sead Sabanadzovic, Matthew B. Sullivan, Curtis A. Suttle, Robert B. Tesh, Ren
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Nature Reviews Microbiology, Numero 15/3, 2017, Pagina/e 161-168, ISSN 1740-1526
Editore:
Nature Publishing Group
DOI:
10.1038/nrmicro.2016.177
Autori:
Eleonora Cimini, Concetta Castilletti, Alessandra Sacchi, Rita Casetti, Veronica Bordoni, Antonella Romanelli, Federica Turchi, Federico Martini, Nicola Tumino, Emanuele Nicastri, Angela Corpolongo, Antonino Di Caro, Gary Kobinger, Alimuddin Zumla, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chiara Agrati
Pubblicato in:
Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-017-06536-x
Autori:
Nazli Ayhan, Bulent Alten, Vladimir Ivovic, Vit Dvořák, Franjo Martinkovic, Jasmin Omeragic, Jovana Stefanovska, Dusan Petric, Slavica Vaselek, Devrim Baymak, Ozge E. Kasap, Petr Volf, Remi N. Charrel
Pubblicato in:
Parasites & Vectors, Numero 10/1, 2017, ISSN 1756-3305
Editore:
BioMed Central
DOI:
10.1186/s13071-017-2334-y
Autori:
Marjan Wouthuyzen-Bakker, Marjolein Knoester, Aad P van den Berg, Corine H GeurtsvanKessel, Marion PG Koopmans, Coretta Van Leer-Buter, Bob Oude Velthuis, Suzan D Pas, Wilhelmina LM Ruijs, Jonas Schmidt-Chanasit, Stephen GS Vreden, Tjip S van der Werf, Chantal BEM Reusken, Wouter FW Bierman
Pubblicato in:
Eurosurveillance, Numero 22/11, 2017, ISSN 1025-496X
Editore:
Centre Europeen pour la Surveillance Epidemiologique du SIDA
DOI:
10.2807/1560-7917.ES.2017.22.11.30488
Autori:
Thérèse Atieh, Antoine Nougairède, Raphaëlle Klitting, Fabien Aubry, Anna-Bella Failloux, Xavier de Lamballerie, Stéphane Priet
Pubblicato in:
Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-017-14522-6
Autori:
Fabien Aubry, Antoine Nougairède, Lauriane de Fabritus, Géraldine Piorkowski, Ernest A. Gould, Xavier de Lamballerie
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PLOS ONE, Numero 10/9, 2015, Pagina/e e0138703, ISSN 1932-6203
Editore:
Public Library of Science
DOI:
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BMC Veterinary Research, Numero 13/1, 2017, ISSN 1746-6148
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BioMed Central
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Peter T. Witkowski, Jan F. Drexler, René Kallies, Martina Ličková, Silvia Bokorová, Gael D. Mananga, Tomáš Szemes, Eric M. Leroy, Detlev H. Krüger, Christian Drosten, Boris Klempa
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Editore:
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DOI:
10.1016/j.meegid.2016.03.036
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Laurence Bichaud, Morgan Seston, Xavier De Lamballerie, Cigdem Alkan, Sonia Sakhria, Rémi N. Charrel, Wasfi Fares, Géraldine Piorkowski, Sulaf Alwassouf, Elyes Zhioua, Khalil Dachraoui, Mohamed Mensi
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Editore:
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Bulletin of the World Health Organization, Numero 94/8, 2016, Pagina/e 574-584D, ISSN 0042-9686
Editore:
World Health Organization
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Victor M. Corman, Andrea Rasche, Cecile Baronti, Souhaib Aldabbagh, Daniel Cadar, Chantal B.E.M. Reusken, Suzan D. Pas, Abraham Goorhuis, Janke Schinkel, Richard Molenkamp, Beate M. Kuemmerer, Tobias Bleicker, Sebastian Brünink, Monika Eschbach-Bludau, Anna M. Eis-Hübinger, Marion P. Koopmans, Jonas Schmidt-Chanasit, Martin P. Grobusch, Xavier de Lamballerie, Christian Drosten, Jan Felix Drexler
Pubblicato in:
Bulletin of the World Health Organization, 2016, ISSN 0042-9686
Editore:
World Health Organization
DOI:
10.2471/BLT.16.175950
Autori:
Sulaf Alwassouf, Carla Maia, Nazli Ayhan, Monica Coimbra, Jose Manuel Cristovao, Herve Richet, Laurence Bichaud, Lenea Campino, Remi N. Charrel
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Journal of General Virology, Numero 97/11, 2016, Pagina/e 2816-2823, ISSN 0022-1317
Editore:
Society for General Microbiology
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Autori:
Martina Rueca, Barbara Bartolini, Cesare Ernesto Maria Gruber, Antonio Piralla, Fausto Baldanti, Emanuela Giombini, Francesco Messina, Luisa Marchioni, Giuseppe Ippolito, Antonino Di Caro, Maria Rosaria Capobianchi
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Editore:
MDPI
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10.3390/microorganisms8091302
Autori:
Victor M Corman, Olfert Landt, Marco Kaiser, Richard Molenkamp, Adam Meijer, Daniel KW Chu, Tobias Bleicker, Sebastian Brünink, Julia Schneider, Marie Luisa Schmidt, Daphne GJC Mulders, Bart L Haagmans, Bas van der Veer, Sharon van den Brink, Lisa Wijsman, Gabriel Goderski, Jean-Louis Romette, Joanna Ellis, Maria Zambon, Malik Peiris, Herman Goossens, Chantal Reusken, Marion PG Koopmans, Christia
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Eurosurveillance, Numero 25/3, 2020, ISSN 1560-7917
Editore:
ECDC
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10.2807/1560-7917.es.2020.25.3.2000045
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Arran J Folly, Becki Lawson, Fabian ZX Lean, Fiona McCracken, Simon Spiro, Shinto K John, Joseph P Heaver, Katharina Seilern-Moy, Nic Masters, Luis M Hernández-Triana, L Paul Phipps, Alejandro Nuñez, Anthony R Fooks, Andrew A Cunningham, Nicholas Johnson, Lorraine M McElhinney
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Eurosurveillance, Numero 25/41, 2020, ISSN 1560-7917
Editore:
ECDC
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John Wiley and Sons Ltd
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Editore:
BioRxiv
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Autori:
Denise A Marston, Daniel L Horton, Javier Nunez, Richard J Ellis, Richard J Orton, Nicholas Johnson, Ashley C Banyard, Lorraine M McElhinney, Conrad M Freuling, Müge Fırat, Nil Ünal, Thomas Müller, Xavier de Lamballerie, Anthony R Fooks
Pubblicato in:
Virus Evolution, Numero 3/2, 2017, ISSN 2057-1577
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europe pmc
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Heinz Ellerbrok, Sonja Jacobsen, Pranav Patel, Toni Rieger, Markus Eickmann, Stephan Becker, Stephan Günther, Dhamari Naidoo, Livia Schrick, Kathrin Keeren, Angelina Targosz, Anette Teichmann, Pierre Formenty, Matthias Niedrig
Pubblicato in:
PLOS Neglected Tropical Diseases, Numero 11/5, 2017, Pagina/e e0005570, ISSN 1935-2735
Editore:
PLOS
DOI:
10.1371/journal.pntd.0005570
Autori:
Martina Moriconi, Gianluca Rugna, Mattia Calzolari, Romeo Bellini, Alessandro Albieri, Paola Angelini, Roberto Cagarelli, Maria P. Landini, Remi N. Charrel, Stefania Varani
Pubblicato in:
PLOS Neglected Tropical Diseases, Numero 11/8, 2017, Pagina/e e0005660, ISSN 1935-2735
Editore:
europe pmc
DOI:
10.1371/journal.pntd.0005660
Autori:
Denise A. Marston, Jemma Watson, Emma L. Wise, Richard J. Ellis, Eric Bedin, Girma Ayalew, Muktar Abute, Xavier de Lamballerie, Anthony R. Fooks, Claudio Sillero-Zubiri, Ashley C. Banyard
Pubblicato in:
Genome Announcements, Numero 5/29, 2017, Pagina/e e00621-17, ISSN 2169-8287
Editore:
europe pmc
DOI:
10.1128/genomeA.00621-17
Autori:
Fabrizio Carletti, Patrizia Marsella, Francesca Colavita, Silvia Meschi, Eleonora Lalle, Licia Bordi, Domenico Di Lallo, Vincenzo Panella, Antonino Di Caro, Emanuele Nicastri, Paola Scognamiglio, Simone Lanini, Francesco Vairo, Maria R. Capobianchi, Giuseppe Ippolito, Concetta Castilletti
Pubblicato in:
Genome Announcements, Numero 5/49, 2017, Pagina/e e01306-17, ISSN 2169-8287
Editore:
Europe PMC
DOI:
10.1128/genomeA.01306-17
Autori:
Cigdem Alkan, Vahideh Moin Vaziri, Nazli Ayhan, Mehdi Badakhshan, Laurence Bichaud, Nourina Rahbarian, Ezat-Aldin Javadian, Bulent Alten, Xavier de Lamballerie, Remi N. Charrel
Pubblicato in:
PLOS Neglected Tropical Diseases, Numero 11/12, 2017, Pagina/e e0005978, ISSN 1935-2735
Editore:
europe pmc
DOI:
10.1371/journal.pntd.0005978
Autori:
Claude Sabeta, Baby Phahladira, Denise A. Marston, Emma L. Wise, Richard J. Ellis, Anthony R. Fooks
Pubblicato in:
Genome Announcements, Numero 3/5, 2015, Pagina/e e01085-15, ISSN 2169-8287
Editore:
Genome Announcements
DOI:
10.1128/genomeA.01085-15
Autori:
Cécile Baronti, Géraldine Piorkowski, Franck Touret, Rémi Charrel, Xavier de Lamballerie, Antoine Nougairede
Pubblicato in:
Genome Announcements, Numero 5/17, 2017, Pagina/e e00209-17, ISSN 2169-8287
Editore:
Genome Announcements
DOI:
10.1128/genomeA.00209-17
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