Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases

Project Information

NABBA

Grant agreement ID: 642028

DOI 10.3030/642028

Project closed

EC signature date 5 December 2014

Start date 1 January 2015

End date 28 February 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 2 851 274,54

EU contribution € 2 851 274,54

Coordinated by

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

Deliverables

Websites, patent fillings, videos etc. (1)

Website

Network Website operative.

Other (1)

ESRs representative

ESRs representative nominated.

Publications

Peer reviewed articles (17)

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

Author(s): Gianpiero Lazzari, Valérie Nicolas, Michiya Matsusaki, Mitsuru Akashi, Patrick Couvreur, Simona Mura
Published in: Acta Biomaterialia, Issue 78, 2018, Page(s) 296-307, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.08.008

Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery

Author(s): Hanzey Yasar, Duy-Khiet Ho, Chiara De Rossi, Jennifer Herrmann, Sarah Gordon, Brigitta Loretz, Claus-Michael Lehr
Published in: Polymers, Issue 10/3, 2018, Page(s) 252, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym10030252

A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy

Author(s): Daniele Vinciguerra, Stéphanie Denis, Julie Mougin, Merel Jacobs, Yohann Guillaneuf, Simona Mura, Patrick Couvreur, Julien Nicolas
Published in: Journal of Controlled Release, Issue 286, 2018, Page(s) 425-438, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.08.013

Advances on the formulation of proteins using nanotechnologies

Author(s): Irene Santalices, Andrea Gonella, Dolores Torres, María José Alonso
Published in: Journal of Drug Delivery Science and Technology, Issue 42, 2017, Page(s) 155-180, ISSN 1773-2247
Publisher: Editions de Sante
DOI: 10.1016/j.jddst.2017.06.018

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake

Author(s): Duy-Khiet Ho, Ana Costa, Chiara De Rossi, Cristiane de Souza Carvalho-Wodarz, Brigitta Loretz, Claus-Michael Lehr
Published in: Molecular Pharmaceutics, Issue 15/3, 2018, Page(s) 1081-1096, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00967

Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Author(s): Anshuman Dasgupta, Mengjiao Liu, Tarun Ojha, Gert Storm, Fabian Kiessling, Twan Lammers
Published in: Drug Discovery Today: Technologies, Issue 20, 2016, Page(s) 41-48, ISSN 1740-6749
Publisher: Elsevier BV
DOI: 10.1016/j.ddtec.2016.07.007

Telechelic polymers from reversible-deactivation radical polymerization for biomedical applications

Author(s): Daniele Vinciguerra, Johanna Tran, Julien Nicolas
Published in: Chemical Communications, Issue 54/3, 2018, Page(s) 228-240, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc08544c

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

Author(s): Alysia Cox, Patrizia Andreozzi, Roberta Dal Magro, Fabio Fiordaliso, Alessandro Corbelli, Laura Talamini, Clizia Chinello, Francesca Raimondo, Fulvio Magni, Maria Tringali, Silke Krol, Paulo Jacob Silva, Francesco Stellacci, Massimo Masserini, Francesca Re
Published in: ACS Nano, Issue 12/7, 2018, Page(s) 7292-7300, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b03500

Phage-displayed peptides targeting specific tissues and organs

Author(s): Josu Andrieu, Francesca Re, Laura Russo, Francesco Nicotra
Published in: Journal of Drug Targeting, 2018, Page(s) 1-11, ISSN 1061-186X
Publisher: Taylor & Francis
DOI: 10.1080/1061186x.2018.1531419

Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus–Particle Interactions

Author(s): Duy-Khiet Ho, Sarah Frisch, Alexander Biehl, Emmanuel Terriac, Chiara De Rossi, Konrad Schwarzkopf, Franziska Lautenschläger, Brigitta Loretz, Xabier Murgia, Claus-Michael Lehr
Published in: Biomacromolecules, Issue 19/8, 2018, Page(s) 3489-3501, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00795

Sonoporation enhances liposome accumulation and penetration in tumors with low EPR

Author(s): Benjamin Theek, Maike Baues, Tarun Ojha, Diana Möckel, Seena Koyadan Veettil, Julia Steitz, Louis van Bloois, Gert Storm, Fabian Kiessling, Twan Lammers
Published in: Journal of Controlled Release, Issue 231, 2016, Page(s) 77-85, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2016.02.021

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Author(s): Miriam Colombo, Luisa Fiandra, Giulia Alessio, Serena Mazzucchelli, Manuela Nebuloni, Clara De Palma, Karsten Kantner, Beatriz Pelaz, Rany Rotem, Fabio Corsi, Wolfgang J. Parak, Davide Prosperi
Published in: Nature Communications, Issue 7, 2016, Page(s) 13818, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13818

Targeting cellular and microenvironmental multidrug resistance

Author(s): Okan Tezcan, Tarun Ojha, Gert Storm, Fabian Kiessling, Twan Lammers
Published in: Expert Opinion on Drug Delivery, Issue 13/9, 2016, Page(s) 1199-1202, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2016.1214570

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

Author(s): Gianpiero Lazzari, Patrick Couvreur, Simona Mura
Published in: Polym. Chem., Issue 8/34, 2017, Page(s) 4947-4969, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7py00559h

Synthetic nanocarriers for the delivery of polynucleotides to the eye

Author(s): Sofia M. Saraiva, Vanessa Castro-López, Covadonga Pañeda, María José Alonso
Published in: European Journal of Pharmaceutical Sciences, Issue 103, 2017, Page(s) 5-18, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.03.001

Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors

Author(s): Tarun Ojha, Vertika Pathak, Yang Shi, Wim E. Hennink, Chrit T.W. Moonen, Gert Storm, Fabian Kiessling, Twan Lammers
Published in: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2017.07.007

Enhancing Tumor Penetration of Nanomedicines

Author(s): Qingxue Sun, Tarun Ojha, Fabian Kiessling, Twan Lammers, Yang Shi
Published in: Biomacromolecules, Issue 18/5, 2017, Page(s) 1449-1459, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.7b00068

Intellectual Property Rights

Patent (1)

AMINOGLYCOSIDE DERIVATIVES AND NANO-ASSEMBLIES THEREOF, INCLUDING THOSE WITH QUORUM SENSING INHIBITORY FUNCTION

Application/Publication number: EP 17179011
Date: 2017-06-30
Applicant(s): HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH