Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise Safety

Informazioni relative al progetto

COSMOS

ID dell’accordo di sovvenzione: 266835

Progetto chiuso

Data di avvio 1 Gennaio 2011

Data di completamento 31 Dicembre 2015

Finanziato da

• Specific Programme "Cooperation": Health

Costo totale € 6 797 335,60

Contributo UE € 3 344 666,00

Coordinato da

LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom

Obiettivo

The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the KNIME software.

Campo scientifico

• natural sciences › computer and information sciences › software
• natural sciences › computer and information sciences › databases
• medical and health sciences › basic medicine › toxicology

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH.2010.4.2-9-4 - Computational modelling and estimation techniques. FP7-HEALTH-2010-Alternative-Testing-Strategies

Invito a presentare proposte

FP7-HEALTH-2010-Alternative-Testing
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

LIVERPOOL JOHN MOORES UNIVERSITY

• Contributo UE: € 577 496,00
• Indirizzo: RODNEY STREET 2 EGERTON COURT ; L3 5UX Liverpool ; Regno Unito
• Regione: North West (England) › Merseyside › Liverpool
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Mark Cronin (Prof.)
• Costo totale: Nessun dato

Partecipanti (14)

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgio

• Contributo UE: € 355 026,00
• Indirizzo: Rue de la Loi 200 ; 1049 Bruxelles / Brussel
• Regione: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Tipo di attività: Research Organisations
• Contatto amministrativo: Andrew Paul Worth (Dr.)
• Costo totale: Nessun dato

U.S. Food & Drug Administration

Stati Uniti

• Contributo UE: Nessun dato
• Indirizzo: New Hampshire Avenue 10903 ; 20993 Silver Spring
• Tipo di attività: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Contatto amministrativo: Mitchell Cheeseman (Dr.)
• Costo totale: Nessun dato

HENKEL KGaA

Germania

• Contributo UE: Nessun dato
• Indirizzo: HENKELSTRASSE 67 ; 40191 Dusseldorf
• Regione: Nordrhein-Westfalen › Düsseldorf › Düsseldorf, Kreisfreie Stadt
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Detlef Keller (Dr.)
• Costo totale: Nessun dato

Merck KGaA

Germania

• Contributo UE: € 15 000,00
• Indirizzo: FRANKFURTER STRASSE 250 ; 64293 DARMSTADT
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Soheila Anzali (Dr.)
• Costo totale: Nessun dato

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

Francia

• Contributo UE: € 365 000,00
• Indirizzo: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Regione: Hauts-de-France › Picardie › Oise
• Tipo di attività: Research Organisations
• Contatto amministrativo: Alexandre Pery (Dr.)
• Costo totale: Nessun dato

INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL

Belgio

• Contributo UE: € 117 500,00
• Indirizzo: Av. E. Mounier 83 ; 1200 Bruxelles / Brussel
• Regione: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Tipo di attività: Research Organisations
• Contatto amministrativo: Nico Van Belzen (Dr.)
• Costo totale: Nessun dato

ALTAMIRA LLC

Stati Uniti

• Contributo UE: € 237 500,00
• Indirizzo: CANDLEWOOD DRIVE 1455 ; 43235 1623 Columbus Oh
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Chihae Yang (Dr.)
• Costo totale: Nessun dato

INSILICO BIOTECHNOLOGY AG

Germania

• Contributo UE: € 195 000,00
• Indirizzo: MEITNERSTRASSE 9 ; 70563 Stuttgart
• Regione: Baden-Württemberg › Stuttgart › Stuttgart, Stadtkreis
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Klaus Mauch (Mr.)
• Costo totale: Nessun dato

KNIME.COM AG

Svizzera

• Contributo UE: € 250 000,00
• Indirizzo: TECHNOPARKSTRASSE 1 ; 8005 ZURICH
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Michael Berthold (Prof.)
• Costo totale: Nessun dato

MOLECULAR NETWORKS GMBH COMPUTERCHEMIE

Germania

• Contributo UE: € 435 200,00
• Indirizzo: NEUMEYERSTR 28-34 ; 90411 Nurnberg
• Regione: Bayern › Mittelfranken › Nürnberg, Kreisfreie Stadt
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Lothar Terfloth (Dr.)
• Costo totale: Nessun dato

INSTITUT PO BIOFIZIKA I BIOMEDITSINSKO INZHENERSTVO (INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING)

Bulgaria

• Contributo UE: € 240 000,00
• Indirizzo: Akad. G. Bonchev bl. 21 ; 1113 Sofia
• Tipo di attività: Research Organisations
• Contatto amministrativo: Ivanka Tsakovska (Dr.)
• Costo totale: Nessun dato

KEMIJSKI INSTITUT

Slovenia

• Contributo UE: € 45 000,00
• Indirizzo: HAJDRIHOVA 19 ; 1000 Ljubljana
• Regione: Slovenija › Zahodna Slovenija › Osrednjeslovenska
• Tipo di attività: Research Organisations
• Contatto amministrativo: Marjan Vracko (Dr.)
• Costo totale: Nessun dato

UNIVERSITY OF BRADFORD

Regno Unito

• Contributo UE: € 282 500,00
• Indirizzo: RICHMOND ROAD ; BD7 1DP Bradford
• Regione: Yorkshire and the Humber › West Yorkshire › Bradford
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Daniel Neagu (Dr.)
• Costo totale: Nessun dato

S-IN SOLUZIONI INFORMATICHE SRL

Italia

• Contributo UE: € 229 444,00
• Indirizzo: VIA G FERRARI 14 ; 36100 VICENZA
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Manuela Pavan (Dr.)
• Costo totale: Nessun dato