Objetivo
The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the KNIME software.
Ámbito científico
Convocatoria de propuestas
FP7-HEALTH-2010-Alternative-Testing
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Régimen de financiación
CP-IP - Large-scale integrating projectCoordinador
L3 5UX Liverpool
Reino Unido
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Participantes (14)
1049 Bruxelles / Brussel
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20993 Silver Spring
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40191 Dusseldorf
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64293 DARMSTADT
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60550 Verneuil En Halatte
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1200 Bruxelles / Brussel
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43235 1623 Columbus Oh
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70563 Stuttgart
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8005 ZURICH
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90411 Nurnberg
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1113 Sofia
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1000 Ljubljana
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BD7 1DP Bradford
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36100 VICENZA
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