Novel immunotherapies for type 1 diabetes

Informazioni relative al progetto

NAIMIT

ID dell’accordo di sovvenzione: 241447

Progetto chiuso

Data di avvio 1 Novembre 2009

Data di completamento 30 Aprile 2015

Finanziato da

• Specific Programme "Cooperation": Health

Costo totale € 14 247 400,00

Contributo UE € 10 920 800,00

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Obiettivo

This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two key players of the immune system in beta-cell destruction will be targeted: the dendritic cell (WP1: Re-educating antigen-presenting cells) and the T-lymphocyte (WP2: Restoring the T-cell balance). In both cell types, interventions using steroid hormones (vitamin D and glucocorticoids) will be used to induce tolerance. Moreover, novel interventions using soluble T-cell receptors to target immune cells and beta-cells in an antigen-specific way (WP3: TCR-mediated immunotherapy) will be introduced. Novel mucosal interventions using probiotics and recombinant L. lactis as a carrier for specific peptides in combination with cytokines (WP4: Mucosal intervention for tolerance restoration) will be studied for their immune modulating potential. A full work package (WP5: Beta-cell protection and restoration – the dialogue with the immune system) is dedicated to the beta-cell and its role in driving and amplifying the immune attack through communication between beta-cells and the immune system. The last scientific work package (WP6: Pharmacogenetics) will identify genetic profiles within patients that predict responsiveness to the steroid interventions proposed. WP7 and 8 are dedicated to training and management of the consortium. For this purpose, a multidisciplinary consortium of leading European diabetologists and immunologists from 11 academic research institutions, in co-operation with 3 SMEs developing novel technologies allowing translation of basic research results towards clinical applications, has been established.

Campo scientifico

• natural sciences › biological sciences › biochemistry › biomolecules
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › immunology › immunotherapy

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH-2009-2.4.3-2 - Novel immunotherapies for type 1 diabetes

Invito a presentare proposte

FP7-HEALTH-2009-single-stage
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

KATHOLIEKE UNIVERSITEIT LEUVEN

• Contributo UE: € 1 636 200,80
• Indirizzo: OUDE MARKT 13 ; 3000 Leuven ; Belgio
• Regione: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Myriam Witvrouw (Dr.)
• Costo totale: Nessun dato

Partecipanti (14)

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Germania

• Contributo UE: € 650 100,00
• Indirizzo: THEODOR W ADORNO PLATZ 1 ; 60323 Frankfurt Am Main
• Regione: Nordrhein-Westfalen › Arnsberg › Siegen-Wittgenstein
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Rolf Draeger (Mr.)
• Costo totale: Nessun dato

UNIVERSITY OF BRISTOL

Regno Unito

• Contributo UE: € 709 845,60
• Indirizzo: BEACON HOUSE QUEENS ROAD ; BS8 1QU Bristol
• Regione: South West (England) › Gloucestershire, Wiltshire and Bristol/Bath area › Bristol, City of
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Vince Boyle (Mr.)
• Costo totale: Nessun dato

FUNDACAO CALOUSTE GULBENKIAN

Portogallo

• Contributo UE: € 597 300,00
• Indirizzo: AVENIDA BERNA 45A ; 1067-001 LISBOA
• Regione: Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa
• Tipo di attività: Research Organisations
• Contatto amministrativo: Jose Mario Leite (Mr.)
• Costo totale: Nessun dato

UNIVERSITA DEGLI STUDI DI SIENA

Italia

• Contributo UE: € 596 100,00
• Indirizzo: VIA BANCHI DI SOTTO 55 ; 53100 Siena
• Regione: Centro (IT) › Toscana › Siena
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Silvano Focardi (Prof.)
• Costo totale: Nessun dato

UNIVERSITE LIBRE DE BRUXELLES

Belgio

• Contributo UE: € 699 300,00
• Indirizzo: AVENUE FRANKLIN ROOSEVELT 50 ; 1050 Bruxelles / Brussel
• Regione: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Patrick Goblet (Mr.)
• Costo totale: Nessun dato

MEDIZINISCHE HOCHSCHULE HANNOVER

Germania

• Contributo UE: € 928 500,00
• Indirizzo: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Regione: Niedersachsen › Hannover › Region Hannover
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Angela Steinhusen (Ms.)
• Costo totale: Nessun dato

UNIVERSITA DI PISA

Italia

• Contributo UE: € 494 100,00
• Indirizzo: LUNGARNO PACINOTTI 43/44 ; 56126 Pisa
• Regione: Centro (IT) › Toscana › Pisa
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Enio Martino (Prof.)
• Costo totale: Nessun dato

KING'S COLLEGE LONDON

Regno Unito

• Contributo UE: € 805 299,60
• Indirizzo: STRAND ; WC2R 2LS London
• Regione: London › Inner London — West › Westminster
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Paul Labbett (Mr.)
• Costo totale: Nessun dato

ACADEMISCH ZIEKENHUIS LEIDEN

Paesi Bassi

• Contributo UE: € 1 074 962,40
• Indirizzo: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Regione: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Sonja Croes De Bruin (Ms.)
• Costo totale: Nessun dato

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Regno Unito

• Contributo UE: € 670 500,00
• Indirizzo: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Regione: East of England › East Anglia › Cambridgeshire CC
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Keith Cann (Mr.)
• Costo totale: Nessun dato

ActoGeniX NV

Belgio

• Contributo UE: € 652 500,00
• Indirizzo: Technologiepark 4 ; 9052 Zwijnaarde
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Magda Van Hijfte (Ms.)
• Costo totale: Nessun dato

DanDrit Biotech A/S

Partecipazione conclusa

Danimarca

• Contributo UE: € 62 437,20
• Indirizzo: Fruebjergvej 3 ; 2100 Copenhagen
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Mai-Britt Zocca (Dr.)
• Costo totale: Nessun dato

Immunocore Limited

Regno Unito

• Contributo UE: € 832 500,00
• Indirizzo: Milton Park 57c ; OX14 4RX Abingdon
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Stephen Megit (Dr.)
• Costo totale: Nessun dato

CARDIFF UNIVERSITY

Regno Unito

• Contributo UE: € 511 154,40
• Indirizzo: NEWPORT ROAD 30 36 ; CF24 0DE Cardiff
• Regione: Wales › East Wales › Cardiff and Vale of Glamorgan
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Nick Bodycombe (Mr.)
• Costo totale: Nessun dato