Novel immunotherapies for type 1 diabetes

Informations projet

NAIMIT

N° de convention de subvention: 241447

Projet clôturé

Date de début 1 Novembre 2009

Date de fin 30 Avril 2015

Financé au titre de

• Specific Programme "Cooperation": Health

Coût total € 14 247 400,00

Contribution de l’UE € 10 920 800,00

Coordonné par

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Objectif

This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two key players of the immune system in beta-cell destruction will be targeted: the dendritic cell (WP1: Re-educating antigen-presenting cells) and the T-lymphocyte (WP2: Restoring the T-cell balance). In both cell types, interventions using steroid hormones (vitamin D and glucocorticoids) will be used to induce tolerance. Moreover, novel interventions using soluble T-cell receptors to target immune cells and beta-cells in an antigen-specific way (WP3: TCR-mediated immunotherapy) will be introduced. Novel mucosal interventions using probiotics and recombinant L. lactis as a carrier for specific peptides in combination with cytokines (WP4: Mucosal intervention for tolerance restoration) will be studied for their immune modulating potential. A full work package (WP5: Beta-cell protection and restoration – the dialogue with the immune system) is dedicated to the beta-cell and its role in driving and amplifying the immune attack through communication between beta-cells and the immune system. The last scientific work package (WP6: Pharmacogenetics) will identify genetic profiles within patients that predict responsiveness to the steroid interventions proposed. WP7 and 8 are dedicated to training and management of the consortium. For this purpose, a multidisciplinary consortium of leading European diabetologists and immunologists from 11 academic research institutions, in co-operation with 3 SMEs developing novel technologies allowing translation of basic research results towards clinical applications, has been established.

Champ scientifique

• natural sciences › biological sciences › biochemistry › biomolecules
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › immunology › immunotherapy

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Thème(s)

• HEALTH-2009-2.4.3-2 - Novel immunotherapies for type 1 diabetes

Appel à propositions

FP7-HEALTH-2009-single-stage
Voir d’autres projets de cet appel

Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

KATHOLIEKE UNIVERSITEIT LEUVEN

• Contribution de l’UE: € 1 636 200,80
• Adresse: OUDE MARKT 13 ; 3000 Leuven ; Belgique
• Région: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Myriam Witvrouw (Dr.)
• Coût total: Aucune donnée

Participants (14)

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Allemagne

• Contribution de l’UE: € 650 100,00
• Adresse: THEODOR W ADORNO PLATZ 1 ; 60323 Frankfurt Am Main
• Région: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Rolf Draeger (Mr.)
• Coût total: Aucune donnée

UNIVERSITY OF BRISTOL

Royaume-Uni

• Contribution de l’UE: € 709 845,60
• Adresse: BEACON HOUSE QUEENS ROAD ; BS8 1QU Bristol
• Région: South West (England) › Gloucestershire, Wiltshire and Bristol/Bath area › Bristol, City of
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Vince Boyle (Mr.)
• Coût total: Aucune donnée

FUNDACAO CALOUSTE GULBENKIAN

Portugal

• Contribution de l’UE: € 597 300,00
• Adresse: AVENIDA BERNA 45A ; 1067-001 LISBOA
• Région: Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa
• Type d’activité: Research Organisations
• Contact administratif: Jose Mario Leite (Mr.)
• Coût total: Aucune donnée

UNIVERSITA DEGLI STUDI DI SIENA

Italie

• Contribution de l’UE: € 596 100,00
• Adresse: VIA BANCHI DI SOTTO 55 ; 53100 Siena
• Région: Centro (IT) › Toscana › Siena
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Silvano Focardi (Prof.)
• Coût total: Aucune donnée

UNIVERSITE LIBRE DE BRUXELLES

Belgique

• Contribution de l’UE: € 699 300,00
• Adresse: AVENUE FRANKLIN ROOSEVELT 50 ; 1050 Bruxelles / Brussel
• Région: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Patrick Goblet (Mr.)
• Coût total: Aucune donnée

MEDIZINISCHE HOCHSCHULE HANNOVER

Allemagne

• Contribution de l’UE: € 928 500,00
• Adresse: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Région: Niedersachsen › Hannover › Region Hannover
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Angela Steinhusen (Ms.)
• Coût total: Aucune donnée

UNIVERSITA DI PISA

Italie

• Contribution de l’UE: € 494 100,00
• Adresse: LUNGARNO PACINOTTI 43/44 ; 56126 Pisa
• Région: Centro (IT) › Toscana › Pisa
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Enio Martino (Prof.)
• Coût total: Aucune donnée

KING'S COLLEGE LONDON

Royaume-Uni

• Contribution de l’UE: € 805 299,60
• Adresse: STRAND ; WC2R 2LS London
• Région: London › Inner London — West › Westminster
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Paul Labbett (Mr.)
• Coût total: Aucune donnée

ACADEMISCH ZIEKENHUIS LEIDEN

Pays-Bas

• Contribution de l’UE: € 1 074 962,40
• Adresse: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Région: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Sonja Croes De Bruin (Ms.)
• Coût total: Aucune donnée

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Royaume-Uni

• Contribution de l’UE: € 670 500,00
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Région: East of England › East Anglia › Cambridgeshire CC
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Keith Cann (Mr.)
• Coût total: Aucune donnée

ActoGeniX NV

Belgique

• Contribution de l’UE: € 652 500,00
• Adresse: Technologiepark 4 ; 9052 Zwijnaarde
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Magda Van Hijfte (Ms.)
• Coût total: Aucune donnée

DanDrit Biotech A/S

Participation terminée

Danemark

• Contribution de l’UE: € 62 437,20
• Adresse: Fruebjergvej 3 ; 2100 Copenhagen
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Mai-Britt Zocca (Dr.)
• Coût total: Aucune donnée

Immunocore Limited

Royaume-Uni

• Contribution de l’UE: € 832 500,00
• Adresse: Milton Park 57c ; OX14 4RX Abingdon
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Stephen Megit (Dr.)
• Coût total: Aucune donnée

CARDIFF UNIVERSITY

Royaume-Uni

• Contribution de l’UE: € 511 154,40
• Adresse: NEWPORT ROAD 30 36 ; CF24 0DE Cardiff
• Région: Wales › East Wales › Cardiff and Vale of Glamorgan
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Nick Bodycombe (Mr.)
• Coût total: Aucune donnée