Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic: ORCHESTRA

Deliverables

Report on feasibility of enrolling vaccinated HCWs in phase 4 vaccine trials

Results of the feasibility study will be conducted to assess whether the pooled cohort of vaccinated HCWs can be used as population for phase-4 (post-marketing) COVID-19 vaccine trials. This deliverable will be under the responsibility of UNIBO and INSP.

Project Management Guidelines

Guidelines elaborated ad hoc for the ORCHESTRA project with information relating to both scientific and administrative management of the project

Systematic review of the literature on determinants of COVID-19 manifestation/ progression
Report on assessment of intra-host viral dynamics and immunity half-life
First report on serology in fragile populations

A report of serology results will be provided for at least 2,000 patients in the fragile population cohorts in the prospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Algorithms for guiding therapeutic decisions for COVID-19 patients

The algorithms will include evidence from retrospective and prospective cohorts and systematic review for guiding therapeutic decisions for COVID-19 patients

First interim risk analysis of breakthrough infection

First interim risk analysis of breakthrough infection, with regard to vaccination manufacturer, post-vaccination titer, last 3 monthly titer, viral strain

Communication and dissemination strategy plan and website online
Quality and kinetic of long-term immune response to COVID-19 vaccination in fragile patients (interim report)

Assessment of humoral and cellular immune response at 6 and 12 months after vaccination

First report on immunity analysis from prospective cohorts (COVID-19, vaccinated and not vaccinated)

A first report of immunity results will be provided for at least 2,500 individuals in the prospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Quality and kinetic of early immune response to COVID-19 vaccination in fragile patients

Assessment of humoral and cellular immune response in-between vaccination doses and at 3 months after vaccination

Identification of break-through infections in population-based cohorts
Report on viral loads, viral genome sequences on prospective cohorts (preliminary report)

A final report of the viral loads and viral genome sequences will be provided for a total of 10,000 patients combining retrospective and prospective analyses. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR

Report on viral genome sequences and serology in case of breakthrough infections

In case of breakthrough infections after vaccination, samples collected from these patients will be analysed using serology and viral genome sequencing. Results will be reported as soon as they become available. Routinely updated. The publication of the deliverable for personal individual data will follow the relevant laws and regulation andnotably the GDPR.

Report on estimates of intervention effects using compartment model
Final report of 6-month follow up by clinical, immunological and virological features
Results of analysis of determinants of COVID-19 and their longitudinal changes among HCWs

Summary of determinants of diseases and their change based on the epidemiological scenario

Report on the serological immune responses of non-vaccinated infected, vaccinated, and breakthrough infected individuals
Preliminary report on seroprevalence in EU countries
Final analysis of serology results after vaccination

Results of serological immune function of HCWs after vaccination by type of vaccination. Final deliverable version at M12 (3-6 months after vaccination). This deliverable will be under the responsibility of UNIBO and LMU.

Interim analysis of serology results after vaccination

Preliminary results of serological immune function of HCWs after vaccination by type of vaccination. First deliverable version at M7 (2-6 weeks after vaccination). This deliverable will be under the responsibility of UNIBO and LMU.

Report on risk associated with socio-economic factors
Report on serology analysis of retrospective COVID-19 cohorts

A report of the serology results will be provided for the 1,500 patients in the retrospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Final risk analysis of breakthrough infection

Final risk analysis of breakthrough infection, with regard to vaccination manufacturer, post-vaccination titer, last 3 monthly titer, viral strain

Immunological response in vaccinated and not vaccinated HCWs (temporal trend) final

Final results of serological immune function of HCWs after vaccination by type of vaccination. This deliverable will be under the responsibility of UNIBO and UNIVR.

Report on cytokine chemokine analysis in COVID-19 patients from retrospective cohorts

A report of the cytokine/chemokine results will be provided for the 1,500 patients in the retrospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Report on serology analysis including long-term sequelae and natural immunity (WP2)

A report of serology results will be provided for at least 2,000 patients focusing on long-term sequelae in the prospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Final report on cellular immunity analysis for prospective cohorts (COVID-19, vaccinated and not vaccinated)

A second and final report of cellular immunity results will be provided for a total of 5,000 individuals (including the ones reported for D6.8) in the prospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Incidence of breakthrough infections

Incidence of breakthrough infections in the HCWs cohorts

Report on impact of pandemic on socio-economic indicators
Report on estimates of intervention effects using individual-based models
Report on dataset of genome-wide methylation patterns

The final results of the genome-wide methylation analysis of a total of 1,500 patients will be completed. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Final report of 12-month follow up by clinical, immunological and virological features
Report on cytokine chemokine analysis in COVID-19 patients (including long-term sequelae)

A report of cytokine chemokine results will be provided for COVID-19 patients focused on long-term sequelae in the prospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Report on viral loads, viral genome sequences of retrospective cohorts

A report of the results of the viral (variant) genome sequencing and viral loads will be provided for the 1,500 patients in the retrospective study. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Cohort Builder and Dashboard online
Social media accounts created and accredited
First regular graphics visualized

Anonymous dataset for the public published

This deliverable will include an explicit confirmation that the data used in the project is publicly available can be freely used for the purpose of the project.

Call for first science challenge based on anonymized project dataset
Automated emails service for stakeholders
Dataset of human genome sequencing of patients with COVID-19 from retrospective cohorts

The sequencing of the human genome for 500 patients in the retrospective study will be completed. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Dataset of 16S rRNA sequencing of retrospective cohorts

16S rRNA gene sequencing data from patients with varying degrees of COVID-19 will be completed for a maximum number of 1,500 patients. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

Dataset of human genomic sequencing outcome of patients from prospective COVID-19 cohorts

The sequencing of the human genome for 1,000 patients in the prospective study will be completed. The publication of the deliverable for personal individual data will follow the relevant laws and regulation and notably the GDPR.

In silico model of vaccination strategies

Publications

Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021–22: a status-based multi-variant model

Author(s): Thomas Haschka, Elisabeta Vergu, Benjamin Roche, Chiara Poletto, Lulla Opatowski
Published in: BMC Infectious Diseases, Issue 22, 2022, Page(s) 815, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-022-07821-5

Vaccination Confidence among Healthcare Workers: Results from Two Anamnestic Questionnaires Adopted in the COVID-19 and Influenza Campaign

Author(s): Mansour I, Collatuzzo G, De Pasquale V, Mirra I, Ciocan C, Godono A, Pira E, Boffetta P
Published in: Vaccines, Issue 10(11), 2022, Page(s) 1835, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111835

SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

Author(s): Stefano Porru; Maria Grazia Lourdes Monaco; Gianluca Spiteri; Angela Carta; Maria Diletta Pezzani; Giuseppe Lippi; Davide Gibellini; Evelina Tacconelli; Ilaria Dalla Vecchia; Emma Sala; Emanuele Sansone; Giuseppe De Palma; Carlo Bonfanti; Massimo Lombardo; Luigina Terlenghi; Enrico Pira; Ihab Mansour; Maurizio Coggiola; Catalina Ciocan; Alessandro Godono; Adonina Tardon; Marta-Maria Rodriguez-Suar
Published in: Vaccines, Issue 10(8), 2022, Page(s) 1193, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10081193

Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison

Author(s): Inge Kroidl, Simon Winter, Raquel Rubio-Acero, Abhishek Bakuli, Christof Geldmacher, Tabea M. Eser, Flora Déak, Sacha Horn, Anna Zielke, Mohamed I. M. Ahmed, Paulina Diepers, Jessica Guggenbühl, Jonathan Frese, Jan Bruger, Kerstin Puchinger, Jakob Reich, Philine Falk, Alisa Markgraf, Heike Fensterseifer, Ivana Paunovic, Angelika Thomschke, Michael Pritsch, Friedrich Riess, Elmar Saathoff, KoCo19
Published in: Virology Journal, Issue September 2023, 200, 2023, ISSN 1743-422X
Publisher: BioMed Central
DOI: 10.1186/s12985-023-02167-z

Effectiveness of prevention of SARS-CoV-2 transmission among unvaccinated Italian healthcareworkers

Author(s): Collatuzzo G, Mansour I, Ciocan C, Ditano G, Godono A, Rossello P, Coggiola M, Pira E, Boffetta P, Working Group On Sars-Cov-Prevention
Published in: La Medicina del Lavoro, Issue 113(6), 2022, ISSN 0025-7818
Publisher: Mattioli 1885 SpA
DOI: 10.23749/mdl.v113i6.13577

ISO/TS 21564:2019- based Evaluation of a Semantic Map between Variables in the ISARIC Freestanding Follow Up Survey and ORCHESTRA Studies

Author(s): Eugenia Rinaldi, Sylvia Thun, Caroline Stellmach
Published in: Journal of Medical Systems, Issue 47(115), 2023, ISSN 0148-5598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10916-023-02012-4

Evaluation of the kinetics of antibody response to COVID-19 vaccine in solid organ transplant recipients: the prospective, multicentre ORCHESTRA cohort

Author(s): Giannella M, Righi E, Pascale R, Rinaldi M, Caroccia N, Gamberini C, Palacios-Baena ZR, Caponcello G, Morelli MC, Tamè M, Busutti M, Comai G, Potena L, Salvaterra E, Feltrin G, Cillo U, Gerosa G, Cananzi M, Piano S, Benetti E, Burra P, Loy M, Furian L, Zaza G, Onorati F, Carraro A, Gastaldon F, Nordio M, Kumar-Singh S, Abedini M, Boffetta P, Rodríguez-Baño J, Lazzarotto T, Viale P, Tacconelli E
Published in: Microorganisms, Issue 10(5), 2022, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms10051021

Diagnostic Accuracy of a Rapid SARS-CoV-2 Antigen Test Among People Experiencing Homelessness: A Prospective Cohort and Implementation Study

Author(s): Pasquale De Nardo; Maela Tebon; Alessia Savoldi; Nicola Soriolo; Elisa Danese; Denise Peserico; Matteo Morra; Elisa Gentilotti; Gulser Caliskan; Pierpaolo Marchetti; Riccardo Cecchetto; Annarita Mazzariol; Giuseppe Verlato; Davide Gibellini; Evelina Tacconelli
Published in: Infectious Diseases and Therapy, Issue 12, 2023, Page(s) 1073-1082, ISSN 2193-8229
Publisher: OMICS International
DOI: 10.1007/s40121-023-00787-0

High sera levels of SARS-CoV-2 N antigen are associated with death in hospitalized COVID-19 patients

Author(s): Houssem Redha Chenane, Guillaume Lingas, Reyene Menidjel, Cédric Laouenan, Sarah Tubiana, Diane Descamps, Quentin Le Hingrat, Laurent Abel, Jérémie Guedj, Surbhi Malhotra, Samir Kumar-Singh, Benoit Visseaux, Jade Ghosn, Charlotte Charpentier, Samuel Lebourgeois, the French COVID Cohort Study Group
Published in: Journal of Medical Virology, Issue 95(11), 2023, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29247

A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of Coronavirus Disease 2019 (COVID-19) Prognostic Scores

Author(s): Katharina S. Appel, Ramsia Geisler, Daniel Maier, Olga Miljukov, Sina M. Hopff, J. Janne Vehreschild
Published in: Clinical Infectious Diseases, Issue ciad618, 2023, ISSN 1537-6591
Publisher: Oxford University Press
DOI: 10.1093/cid/ciad618

Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study

Author(s): Visci G, Zunarelli C, Mansour I, Porru S, De Palma G, Duval X, Monaco MGL, Spiteri G, Carta A, Lippi G, Verlato G, Sansone E, Sala E, Lombardo M, Abedini M, Violante F, Boffetta P.
Published in: La Medicina del Lavoro, Issue 113(2), 2022, ISSN 0025-7818
Publisher: Mattioli 1885 SpA
DOI: 10.23749/mdl.v113i2.13017

Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA project

Author(s): Giulia Collatuzzo, Giovanni Visci, Francesco S. Violante, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Fillon, Corrado Negro, Christian Janke, Noemi Castelletti, Giuseppe De Palma, Emanuele Sansone, Dana Mates, Silvia Teodorescu, Eleonóra Fabiánová, Jana Bérešová, Luigi Vimercati, Silvio Tafuri, Mahsa Abedini, Giorgia Ditano, Shuffield S. Asafo, Paolo Boffe
Published in: Frontiers in Immunology, Issue September 2022, Volume 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.986085

The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers

Author(s): Christina Reinkemeyer; Yeganeh Khazaei; Maximilian Weigert; Marlene Hannes; Ronan Le Gleut; Michael Plank; Simon Winter; Ivan Noreña; Theresa Meier; Lisa Xu; Raquel Rubio-Acero; Simon Wiegrebe; Thu Giang Le Thi; Christiane Fuchs; Katja Radon; Ivana Paunovic; Christian Janke; Andreas Wieser; Helmut Küchenhoff; Michael Hoelscher; Noemi Castelletti
Published in: Viruses, Issue 15(7), 2023, Page(s) 1574, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15071574

Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

Author(s): Mohamed Ibraheem Mahmoud Ahmed; Paulina Diepers; Christian Janke; Michael Plank; Tabea M. Eser; Raquel Rubio-Acero; Anna Fuchs; Olga Baranov; Noemi Castelletti; Inge Kroidl; Laura Olbrich; Bernadette Bauer; Danni Wang; Martina Prelog; Johannes G. Liese; Christina Reinkemeyer; Michael Hoelscher; Philipp Steininger; Klaus Überla; Andreas Wieser; Christof Geldmacher
Published in: Frontiers in Immunology, Issue December 2022, 13:13:1026473, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.1026473

SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes

Author(s): Luigi De Maria; Stefania Sponselli; Antonio Caputi; Pasquale Stefanizzi; Antonella Pipoli; Gianmarco Giannelli; Giuseppe Delvecchio; Silvio Tafuri; Francesco Inchingolo; Giovanni Migliore; Francesco Paolo Bianchi; Paolo Boffetta; Luigi Vimercati
Published in: Journal of Clinical Medicine; Volume 12; Issue 2; Pages: 628, Issue 12(2), 2023, Page(s) 628, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12020628

Integrative modelling of reported case numbers and seroprevalence reveals time-dependent test efficiency and infection rates

Author(s): Lorenzo Contento; Noemi Castelletti; Elba Raimúndez; Elba Raimúndez; Le Gleut R; Yannik Schaelte; Paul Stapor; Hinske Lc; Michael Hoelscher; Andreas Wieser; Katja Radon; Christiane Fuchs; Jan Hasenauer; Jan Hasenauer
Published in: Volume 43, June 2023, 100681, Issue 34, 2023, ISSN 1755-4365
Publisher: Elsevier BV
DOI: 10.1016/j.epidem.2023.100681

SARS-CoV-2 mRNA Vaccine Response in People Living with HIV According to CD4 Count and CD4/CD8 Ratio

Author(s): Vergori A, Tavelli A, Matusali G, Azzini AM, Augello M, Mazzotta V, Pellicanò GF, Costantini A, Cascio A, De Vito A, Marconi L, Righi E, Sartor A, Pinnetti C, Maggi F, Bai F, Lanini S, Piconi S, Levy Hara G, Marchetti G, Giannella M, Tacconelli E, d'Arminio Monforte A, Antinori A, Cozzi-Lepri A, On Behalf Of The Vax-Icona-Orchestra Study
Published in: Vaccines, Issue 11(11), 2023, Page(s) 1664, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111664

Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: a systematic review and meta-analysis

Author(s): Elena Carrara, Elisa Razzaboni, Anna Maria Azzini, Maria Elena De Rui, Mariana Nunes Pinho Guedes, Anna Gorska, Maddalena Giannella, Linda Bussini, Michele Bartoletti, Federica Arbizzani, Zaira R. Palacios-Baena, Giulia Caponcello, Natalia Maldonado, Jesús Rodríguez-Baño, Carlo Visco, Mauro Krampera, Evelina Tacconelli
Published in: Hematological Oncology, Issue 41(1), 2022, Page(s) 16-25, ISSN 0278-0232
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hon.3084

Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay

Author(s): Isabel Brand, Leonard Gilberg, Jan Bruger, Mercè Garí, Andreas Wieser, Tabea M. Eser, Jonathan Frese, Mohamed I. M. Ahmed, Raquel Rubio-Acero, Jessica M. Guggenbuehl Noller, Noemi Castelletti, Jana Diekmannshemke, Sophie Thiesbrummel, Duc Huynh, Simon Winter, Inge Kroidl, Christiane Fuchs, Michael Hoelscher, Julia Roider, Sebastian Kobold, Michael Pritsch, Christof Geldmacher on behalf of the Ko
Published in: Frontiers in Immunology, Issue May 2021, Volume 12, 2021, Page(s) Frontiers, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.688436

ORCHESTRA project in Romania - a prospective occupational cohort to study the impact of COVID-19 pandemic on health care workers

Author(s): Dana Mateș, Violeta Claudia Calotă, Cătălin Alexandru Staicu, Lavinia Călugăreanu, Mădălina Ipate, Michaela Mărgineanu, Marina Ruxandra Oțelea, Ovidiu Persecă, Felicia Steliana Popescu, Agripina Rașcu, Silvia Teodorescu, Georgeta Botin, Angelica Voinoiu, Andra Neamțu
Published in: Romanian Journal of Occupational Medicine, Issue vol 72 (1) dec 2021, 2021, Page(s) 54-58, ISSN 2601-0828
Publisher: De Gruyter Poland
DOI: 10.2478/rjom-2021-0008

Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

Author(s): Akshita Gupta; Angelina Konnova; Mathias Smet; Matilda Berkell; Alessia Savoldi; Matteo Morra; Vincent Van averbeke; Fien H.R. De Winter; Denise Peserico; Elisa Danese; An Hotterbeekx; Elda Righi; Pasquale De Nardo; Evelina Tacconelli; Surbhi Malhotra-Kumar; Samir Kumar-Singh
Published in: The journal of clinical investigation, Issue 133(6), 2023, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci166032

Clinical efficacy of different monoclonal antibody regimens among non-hospitalised patients with mild to 1moderate COVID-19at high risk for disease progression: a prospective cohort study

Author(s): Alessia Savoldi, Matteo Morra, Pasquale De Nardo, Anna Maria Cattelan, Massimo Mirandola, Vinicio Manfrin, Piergiorgio Scotton, Maria Teresa Giordani, Lucio Brollo, Sandro Panese, Massimiliano Lanzafame, Giovanna Scroccaro, Matilda Berkell, Giuseppe Lippi, Angelina Konnova, Mathias Smet, Surbhi Malhotra-Kumar, Samir Kumar-Singh, Evelina Tacconelli, and the mAb Working Group
Published in: European Journal of Clinical Microbiology & Infectious Diseases, 2022, ISSN 0934-9723
Publisher: Springer Verlag
DOI: 10.1007/s10096-022-04464-x

SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers

Author(s): De Maria L, Delvecchio G, Sponselli S, Cafaro F, Caputi A, Giannelli G, Stefanizzi P, Bianchi FP, Stufano A, Tafuri S, Lovreglio P, Boffetta P, Vimercati L.
Published in: Journal of Clinical Medicine, Issue 12(21), 2023, Page(s) 6800, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12216800

Usefulness and Limitations of Anti-S IgG Assay in Detecting Previous SARS-CoV-2 Breakthrough Infection in Fully Vaccinated Healthcare Workers

Author(s): Gianluca Spiteri, Maria Grazia Lourdes Monaco, Gulser Caliskan, Angela Carta, Maria Diletta Pezzani, Giuseppe Lippi,Davide Gibellini, Giuseppe Verlato, Stefano Porru
Published in: Diagnostics, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/diagnostics12092152

Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study

Author(s): Elda Righi, Massimo Mirandola, Fulvia Mazzaferri, Giuditta Dossi, Elisa Razzaboni, Amina Zaffagnini, Federico Ivaldi, Alessandro Visentin, Lorenza Lambertenghi, Cinzia Arena, Claudio Micheletto, Davide Gibellini, Evelina Tacconelli
Published in: Journal of Infection, Issue 84 (4), 2022, Page(s) 566-572, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.02.003

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Author(s): Gatti M, Rinaldi M, Bussini L, Bonazzetti C, Pascale R, Pasquini Z, Faní F, Pinho Guedes MN, Azzini AM, Carrara E, Palacios-Baena ZR, Caponcello G, Reyna-Villasmil E, Tacconelli E, Rodríguez-Baño J, Viale P, Giannella M; ORCHESTRA study group
Published in: Clinical Microbiology and Infection, 2022, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.02.039

The impact of SARS-CoV-2 on healthcare workers of a large University Hospital in the Veneto Region: risk of infection and clinical presentation in relation to different pandemic phases and some relevant determinants

Author(s): Filippo Liviero, Anna Volpin, Patrizia Furlan, Monica Battistella, Alessia Broggio, Laura Fabris, Francesco Favretto, Paola Mason, Silvia Cocchio, Claudia Cozzolino, Vincenzo Baldo, Angelo Moretto, Maria Luisa Scapellato
Published in: Frontiers in Public Health, Issue 11, 2023, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1250911

Labor market participation and depression during the COVID-19 pandemic among young adults (18 to 30 years): A nationally representative study in France

Author(s): Maria Melchior; Aline-Marie Florence; Camille Davisse-Paturet; Bruno Falissard; Cédric Galéra; Jean-Baptiste Hazo; Cécile Vuillermoz; Josiane Warszawski; Fallou Dione; Alexandra Rouquette
Published in: Frontiers in Public Health, Issue 10, 2022, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/fpubh.2022.904665

Stronger and durable SARS-CoV-2 immune response to mRNA vaccines in 5–11 years old children with prior COVID-19

Author(s): Costanza Di Chiara, Anna Cantarutti, Maria Raffaella Petrara, Francesco Bonfante, Elisa Benetti, Riccardo Boracchini, Luca Bosa, Francesco Carmona, Chiara Cosma, Nicola Cotugno, Marthe Le Prevost, Giorgia Martini, Alessandra Meneghel, Matteo Pagliari, Paolo Palma, Elena Ruffoni, Annachiara Zin, Anita De Rossi, Carlo Giaquinto, Daniele Donà, Andrea Padoan
Published in: Vaccine, Issue 41(2), 2024, Page(s) 263-270, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2023.12.006

Protective SARS-CoV-2 Antibody Response in Children With Inflammatory Bowel Disease

Author(s): Luca Bosa, Costanza Di Chiara, Paola Gaio, Chiara Cosma, Andrea Padoan, Sandra Cozzani, Giorgio Perilongo, Mario Plebani, Carlo Giaquinto, Daniele Donà and Mara Cananzi
Published in: Frontiers in Pediatrics, Issue 10, 2022, ISSN 2296-2360
Publisher: Frontiers
DOI: 10.3389/fped.2022.815857

Higher risk, higher protection: COVID-19 risk among immigrants in France—results from the population-based EpiCov survey

Author(s): Anne Gosselin, Josiane Warszawski, Nathalie Bajos, for the EpiCov Study Group
Published in: European Journal of Public Health, Issue 32(4), 2022, ISSN 1101-1262
Publisher: Oxford University Press
DOI: 10.1093/eurpub/ckac046

Predictive model for BNT162b2 vaccine response in cancer patients based on cytokines and growth factors

Author(s): Angelina Konnova; Fien HR De Winter; Akshita Gupta; Lise Verbruggen; An Hotterbeekx; Matilda Berkell; Laure-Anne Teuwen; Greetje Vanhoutte; Bart Peeters; Silke Raats; Isolde Van der Massen; Sven De Keersmaecker; Yana Debie; Manon Huizing; Pieter Pannus; Kristof Y Neven; Kevin K Ariën; Geert A. Martens; Marc Van Den Bulcke; Ella Roelant; Isabelle Desombere; Sébastien Anguille; Zwi Berneman; Maria
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.1062136

Use of health care services among people with Covid-19 symptoms in the first pandemic peak in France

Author(s): Jeanna-Eve, Pousson; Léna, Silberzan; Florence, Jusot; Laurence, Meyer; Josiane, Warszawski; Nathalie, Bajos
Published in: PLOS ONE, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0279538

Using machine learning to predict antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients: the multicentre ORCHESTRA cohort

Author(s): Giannella, Maddalena; Huth, Manuel; Righi, Elda; Hasenauer, Jan; Marconi, Lorenzo; Konnova, Angelina; Gupta, Akshita; Hotterbeekx, An; Berkell, Matilda; Palacios-Baena, Zaira R; Morelli, Maria Cristina; Tamè, Mariarosa; Busutti, Marco; Potena, Luciano; Salvaterra, Elena; Feltrin, Giuseppe; Gerosa, Gino; Furian, Lucrezia; Burra, Patrizia; Piano, Salvatore; Cillo, Umberto; Cananzi, Mara; Loy, Monic
Published in: Clinical Microbiology and Infection, Issue 38, 2023, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2023.04.027

Prevalence of post-acute COVID-19 symptoms twelve months after hospitalisation in participants retained in follow-up: analyses stratified by gender from a large prospective cohort

Author(s): Jade Ghosn,Delphine Bachelet,Marine Livrozet,Minerva Cervantes-Gonzalez,Julien Poissy,François Goehringer,Charlotte Salmon Gandonniere,Mylène Maillet,Firouzé Bani-Sadr,Guillaume Martin-Blondel,Pierre Tattevin,Odile Launay,Laure Surgers et al.
Published in: Clinical Microbiology and Infection, Issue Volume 29, Issue 2, 2023, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.08.028

Trends in social exposure to SARS-Cov-2 in France. Evidence from the national socio-epidemiological cohort – EPICOV

Author(s): Josiane Warszawski,Laurence Meyer,Jeanna-Eve Franck,Delphine Rahib,Nathalie Lydié,Anne Gosselin,Emilie Counil,Robin Kreling,Sophie Novelli,Remy Slama,Philippe Raynaud,Guillaume Bagein,Vianney Costemalle,Patrick Sillard,Toscane Fourie,Xavier de Lamballerie,Nathalie Bajos,Epicov Team
Published in: PLoS ONE, Issue 17(5), 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0267725

SARS-CoV-2 vaccination in solid-organ transplant recipients: What the clinician needs to know

Author(s): Maddalena Giannella, Lígia C. Pierrotti, Ilkka Helanterä, Oriol Manuel
Published in: Transplant International, Issue 34(10), 2021, Page(s) 1776-1788, ISSN 0934-0874
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tri.14029

Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers

Author(s): Francesco Bonfante, DVM; Paola Costenaro, MD, DTM&H; Anna Cantarutti, PhD; Costanza Di Chiara, MD; Alessio Bortolami, DVM, PhD; Maria Raffaella Petrara, PhD; Francesco Carmona, BSc; Matteo Pagliari, PhD; Chiara Cosma, MD; Sandra Cozzani, MD; Eva Mazzetto, DVM; Giovanni Di Salvo, MD; Liviana Da Dalt, MD; Paolo Palma, MD; Luisa Barzon, MD; Giovanni Corrao; Calogero Terregino, MD; Andrea Padoan, MD;
Published in: Pediatrics, 2021, ISSN 0031-4005
Publisher: American Academy of Pediatrics
DOI: 10.1542/peds.2021-052173

SARS-CoV-2 Reinfections in Health-Care Workers, 1 March 2020–31 January 2023

Author(s): Luca Cegolon, Greta Magnano, Corrado Negro, Francesca Larese Filon, ORCHESTRA Working Group
Published in: Viruses, Issue 15(7), 2023, Page(s) 1551, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15071551

Challenges of data sharing in European Covid-19 projects: A learning opportunity for advancing pandemic preparedness and response

Author(s): Evelina Tacconelli, Anna Gorska, Elena Carrara, Ruth Joanna Davis, Marc Bonten, Alex W.Friedrich, Corinna Glasner, Herman Goossens, Jan Hasenauer, Josep Maria Haro Abad, José L. Peñalvo, Albert Sanchez-Niubo, Anastassja Sialm, Gabriella Scipione, Gloria Soriano, Yazdan Yazdanpanah, Ellen Vorstenbosch, Thomas Jaenisch
Published in: The Lancet Regional Health - Europe, Issue Volume 21, October 2022, 2022, ISSN 2666-7762
Publisher: Elsevier BV
DOI: 10.1016/j.lanepe.2022.100467

Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Author(s): Stefano Porru, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Gulser Caliskan, Concepción Violán, Pere Torán-Monserrat, Luigi Vimercati, Silvio Tafuri, Paolo Boffetta, Francesco Saverio Violante, Emma Sala, Emanuele Sansone, Fabriziomaria Gobba, Loretta Casolari, Andreas Wieser, Christian Janke, Adonina Tardon, Marta Maria Rodriguez-Suarez, Filippo Liviero, Maria Luisa Scapellato,
Published in: Journal of Epidemiology and Global Health, Issue 13, 2023, Page(s) 577-588, ISSN 2210-6006
Publisher: Elsevier BV
DOI: 10.1007/s44197-023-00139-8

Comparison of Depression and Anxiety Following Self-reported COVID-19–Like Symptoms vs SARS-CoV-2 Seropositivity in France

Author(s): Alexandra Rouquette, Arthur Descarpentry, Fallou Dione, Bruno Falissard, Stéphane Legleye, Cécile Vuillermoz, Anne Pastorello, Laurence Meyer, Josiane Warszawski, Camille Davisse-Paturet, Maria Melchior
Published in: JAMA Network Open, Issue 6(5), 2023, ISSN 2574-3805
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2023.12892

Determinants of Anti-S Immune Response at 9 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

Author(s): Giulia Collatuzzo, Vittorio Lodi, Daniela Feola, Giuseppe De Palma, Emanuele Sansone, Emma Sala, Christian Janke, Noemi Castelletti, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Filon, Corrado Negro, Luca Cegolon, Jana Beresova, Eleonora Fabianove, Lucia A. Carrasco-Ribelles, Pere Toran-Monserrat, Marta Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Shuffiel
Published in: Viruses, Issue November 2022, 14(2), 2657, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14122657

Factors Associated with SARS-CoV-2 Infection before Vaccination among European Health Care Workers

Author(s): Ihab Mansour, Alessandro Godono, Emanuele Sansone, Giovanni Visci, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Dana Mates, Agripina Rascu, Xavier Duval, Enrico Pira, Catalina Ciocan, Francesco Violante, Vittorio Lodi, Giuseppe De Palma, Emma Sala, Marco Dell’Omo, Corrado Negro, Loretta Casolari, Mahsa Abedini, Giorgia Ditano, Shuffield Asafo, Paolo Boffetta, and Orchestra WP5 Working Group
Published in: La Medicina del Lavoro, Issue Volume 114, issue 3, 2023, Page(s) 1-14, ISSN 0025-7818
Publisher: Mattioli 1885 SpA
DOI: 10.23749/mdl.v114i3.14422

Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: An individual-level analysis within 13 months in the ORCHESTRA cohort

Author(s): Giulia Collatuzzo, Giuseppe De Palma, Francesco S Violante, Stefano Porru, Francesca Larese Filon, Eleonora Fabianova, Concepción Violán, Luigi Vimercati, Mihaela Leustean, Marta Maria Rodriguez-Suarez, Emanuele Sansone, Emma Sala, Carlotta Zunarelli, Vittorio Lodi, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Corrado Negro, Jana Beresova, LucÌa A Carrasco-Ribelles, Silvio Tafuri, Shuffield S
Published in: Frontiers Immunology, Issue Volume 13 - 2022, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.1079884

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author(s): Gentilotti E, Górska A, Tami A, Gusinow R, Mirandola M, Rodríguez Baño J, Palacios Baena ZR, Rossi E, Hasenauer J, Lopes-Rafegas I, Righi E, Caroccia N, Cataudella S, Pasquini Z, Osmo T, Del Piccolo L, Savoldi A, Kumar-Singh S, Mazzaferri F, Caponcello MG, de Boer G, Hara GL; ORCHESTRA Study Group; De Nardo P, Malhotra S, Canziani LM, Ghosn J, Florence AM, Lafhej N, van der Gun BTF, Giannella M
Published in: eClinicalMedicine, Issue 21:62:102107, 2023, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2023.102107

Primary SARS-CoV-2 Infections, Re-infections and Vaccine Effectiveness during the Omicron Transmission Period in Healthcare Workers of Trieste and Gorizia (Northeast Italy), 1 December 2021–31 May 2022

Author(s): Cegolon, Luca; Negro, Corrado; Mastrangelo, Giuseppe; Larese Filon, Francesca; ORCHESTRA working group
Published in: Viruses, Issue Volume 14; Issue 12;, 2022, Page(s) 2688, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14122688

The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant

Author(s): Ronan Le Gleut, Michael Plank, Peter Pütz, Katja Radon, Abishek Bakuli, Raquel Rubio-Acero, Ivana Paunovic, Friedrich Rieß, Simon Winter, Christina Reinkemeyer, Yannik Schälte, Laura Olbrich, Marlene Hannes, Inge Kroidl, Ivan Noreña, Christian Janke, Andreas Wieser, Michael Hoelscher, Christiane Fuchs, Noemi Castelletti
Published in: BMC Infectious Diseases, Issue July 2023, 466 (2023), 2023, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-023-08435-1

Seroepidemiology and model-based prediction of SARS-CoV-2 in Ethiopia: longitudinal cohort study among front-line hospital workers and communities

Author(s): Esayas Kebede Gudina, Solomon Ali, Eyob Girma, Addisu Gize, Birhanemeskel Tegene, Gadissa Bedada Hundie, Wondewosen Tsegaye Sime, Rozina Ambachew, Alganesh Gebreyohanns, Mahteme Bekele, Abhishek Bakuli, Kira Elsbernd, Simon Merkt, Lorenzo Contento, Michael Hoelscher, Jan Hasenauer, Andreas Wieser, Arne Kroidl
Published in: The Lancet Global Health, Issue 9(11), 2021, Page(s) e1517-e1527, ISSN 2214-109X
Publisher: Elsevier BV
DOI: 10.1016/s2214-109x(21)00386-7

European HPC cloud infrastructure for managing SARS-CoV-2 data in compliance with GDPR

Author(s): Chiara Dellacasa; M Ortali; E Rossi; M D'Antonio; T Osmo; F Prasser; M Puskaric; E Rinaldi; G Scipione; Orchestra Working Group
Published in: European Journal of Public Health, Issue Volume 32, Issue Supplement_3, 2022, Page(s) 173-174, ISSN 1101-1262
Publisher: Oxford University Press
DOI: 10.1093/eurpub/ckac129.427

Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection

Author(s): Costanza Di Chiara; Anna Cantarutti; Paola Costenaro; Daniele Donà; Francesco Bonfante; Chiara Cosma; Martina Ferrarese; Sandra Cozzani; Maria Raffaella Petrara; Francesco Carmona; Cecilia Liberati; Paolo Palma; Giovanni Di Salvo; Anita De Rossi; Mario Plebani; Andrea Padoan; Carlo Giaquinto
Published in: JAMA Network Open, Issue 5(7), 2022, ISSN 2574-3805
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.21616

From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany)

Author(s): Katja Radon, Abhishek Bakuli, Peter Pütz, Ronan Le Gleut, Jessica Michelle Guggenbuehl Noller, Laura Olbrich, Elmar Saathoff, Mercè Garí, Yannik Schälte, Turid Frahnow, Roman Wölfel, Michael Pritsch, Camilla Rothe, Michel Pletschette, Raquel Rubio-Acero, Jessica Beyerl, Dafni Metaxa, Felix Forster, Verena Thiel, Noemi Castelletti, Friedrich Rieß, Maximilian N. Diefenbach, Günter Fröschl, J
Published in: BMC Infectious Diseases, Issue 21, 2021, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-021-06589-4

Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children

Author(s): Di Chiara Costanza, Carraro Silvia, Zanconato, Stefania, Cozzani Sandra, Baraldi Eugenio. Giaquinto Carlo, Ferraro Valentina Agnese, Donà Daniele
Published in: Children, 2022, ISSN 2227-9067
Publisher: MDPI
DOI: 10.3390/children9070952

Impact of Omicron Variant Infection on Assessment of Spike-Specific Immune Responses Using the EUROIMMUN Quan-T-Cell SARS-CoV-2 Assay and Roche Elecsys Anti-SARS-CoV-2-S

Author(s): Mohamed I. M. Ahmed, Michael Plank, Noemi Castelletti, Paulina Diepers, Tabea M. Eser, Raquel Rubio-Acero, Ivan Noreña, Christina Reinkemeyer, Dorinja Zapf, Michael Hoelscher, Christian Janke, Andreas Wieser, Christof Geldmacher, and on behalf of the KoCo19/ORCHESTRA Study Group
Published in: Diagnostics, Issue March 2023, Volume 13, ISSUE 6, 2023, ISSN 2075-4418
Publisher: Basel MDPI
DOI: 10.3390/diagnostics13061024

Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern

Author(s): Eveline Santos da Silva, Jean-Yves Servais, Michel Kohnen, Vic Arendt, Therese Staub, the CON-VINCE Consortium, the CoVaLux Consortium, Rejko Krüger, Guy Fagherazzi, Paul Wilmes, Judith M. Hübschen, Markus Ollert, Danielle Perez-Bercoff, and Carole Seguin-Devaux
Published in: International Journal of Molecular Sciences, Issue 24(19), 2023, Page(s) 14965, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241914965

From intentions to practices: what drove people to get the COVID-19 vaccine? Findings from the French longitudinal socioepidemiological cohort survey

Author(s): Alexis Spire, Antoine Sireyjol, Nathalie Bajos; EpiCoV study group; EpiCov study group
Published in: BMJ Open, Issue 13, 2023, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-073465

Enabling Open Science in Medicine Through Data Sharing: An Overview and Assessment of Common Approaches from the European Perspective

Author(s): Hammam Abu Attieh,Anna Haber, Felix Nikolaus Wirth, Benedikt Buchner, Fabian Prasser
Published in: Journal of Open Access to Law, Issue 11(2), 2023, ISSN 2372-7152
Publisher: Ithaca NY

Left ventricular longitudinal strain alterations in asymptomatic or mildly symptomatic paediatric patients with SARS-CoV-2 infection

Author(s): Domenico Sirico, Costanza Di Chiara, Paola Costenaro, Francesco Bonfante, Sandra Cozzani, Mario Plebani, Elena Reffo, Biagio Castaldi, Daniele Donà, Liviana Da Dalt, Carlo Giaquinto, Giovanni Di Salvo
Published in: European Heart Journal - Cardiovascular Imaging, 2021, ISSN 2047-2404
Publisher: Oxford University Press
DOI: 10.1093/ehjci/jeab127

Chest Computed Tomography Characteristics of Critically Ill COVID-19 Patients with Auto-antibodies Against Type I Interferons

Author(s): Baptiste Lafont Rapnouil, Youssef Zaarour, Romain Arrestier, Paul Bastard, Bastien Peiffer, Elsa Moncomble, Mélodie Parfait, Raphaël Bellaïche, Jean-Laurent Casanova, Armand Mekontso Dessap, Sébastien Mule & Nicolas de Prost
Published in: Journal of Clinical Immunology, Issue 44, 2024, ISSN 0271-9142
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-023-01606-4

SARS-CoV-2 and Its Variants in Thrice-Infected Health Workers: A Case Series from an Italian University Hospital

Author(s): Maria Grazia Lourdes Monaco; Gianluca Spiteri; Gulser Caliskan; Virginia Lotti; Angela Carta; Davide Gibellini; Giuseppe Verlato; Stefano Porru
Published in: Viruses, Issue 14(11), 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14112536

Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers—Orchestra Project

Author(s): Concepción Violán, Lucía A. Carrasco-Ribelles, Giulia Collatuzzo, Giorgia Ditano, Mahsa Abedini, Christian Janke, Christina Reinkemeyer, Le Thi Thu Giang, Filippo Liviero, Maria Luisa Scapellato, Marcella Mauro, Francesca Rui, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Angela Carta, Marina Otelea, Agripina Rascu, Eleonóra Fabiánová, Zuzana Klöslová, Paolo Boffetta, Pere
Published in: Vaccines, Issue August 2023, 11(8), 1340, 2023, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11081340

The Effect of the Immunization Schedule and Antibody Levels (Anti-S) on the Risk of SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers in Northern Italy

Author(s): Sansone E, Collatuzzo G, Renzetti S, Ditano G, Bonfanti C, Sala E, Terlenghi L, Matteelli A, Abedini M, Asafo SS, Boffetta P, De Palma G.
Published in: Vaccines, Issue 11(4), 2023, Page(s) 746, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040746

A Multi-Center Study Investigating Long COVID-19 in Healthcare Workers from North-Eastern Italy: Prevalence, Risk Factors and the Impact of Pre-Existing Humoral Immunity—ORCHESTRA Project

Author(s): Luca Cegolon, Marcella Mauro, Donatella Sansone, Alice Tassinari, Fabrizio Maria Gobba, Alberto Modenese, Loretta Casolari, Filippo Liviero, Sofia Pavanello, Maria Luisa Scapellato, Francesco Taus, Angela Carta, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Stefano Porru; Francesca Larese Filon
Published in: Vaccines, Issue Volume 11, Issue 12, 2023, Page(s) 1-33, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11121769

Differences by immigration status on Covid-19 acute outcomes in the Emilia-Romagna ORCHESTRA cohort

Author(s): A Corsaro, F Banchelli, R Buttazzi, C Gagliotti, E Ricchizzi, M L Moro, E Berti, N Caranci
Published in: European Journal of Public Health, Issue Volume 33, Issue Supplement_2, 2023, ISSN 1101-1262
Publisher: Oxford University Press
DOI: 10.1093/eurpub/ckad160.1273

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Author(s): Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Peng Zhang, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Pe
Published in: Genome Medicine, Issue 15, 2023, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-023-01173-8

Development, validation, and accuracy of ORCHESTRA emotional exhaustion screening questionnaire among healthcare workers during COVID-19 Pandemic

Author(s): Rick Kye Gan, Pedro Arcos González, Guillermo Fernandez-Tardon, Alexandre Zerbo, Violeta Claudia Calota, Zuzana Klöslová, Marina Ruxandra Otelea, Eleonóra Fabiánová, Marta-Maria Rodriguez-Suarez, Adonina Tardon
Published in: British Journal of Health Psychology, 2023, ISSN 1359-107X
Publisher: Wiley-Blackwell
DOI: 10.1111/bjhp.12706

Risk factors for community and intra-household transmission of SARS-Cov-2: a modelling study in the French national population-based EpiCov cohort

Author(s): Sophie Novelli, Lulla Opatowski, Carmelite Manto, Delphine Rahib, Xavier de Lamballerie, Josiane Warszawski, Laurence Meyer the EpiCov study group
Published in: American Journal of Epidemiology, 2023, ISSN 0002-9262
Publisher: Oxford University Press
DOI: 10.1093/aje/kwad174

Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

Author(s): Reyna-Villasmil, Eduardo; Caponcello, Maria Giulia; Maldonado, Natalia; Olivares, Paula; Caroccia, Natascia; Bonazzetti, Cecilia; Tazza, Beatrice; Carrara, Elena; Giannella, Maddalena; Tacconelli, Evelina; Rodríguez-Baño, Jesús; Palacios-Baena, Zaira R; ORCHESTRA Study
Published in: Biomedicines, Issue 10(10), 2022, Page(s) 2437, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10102437

Harmonization and standardization of data for a pan-European cohort on SARS- CoV-2 pandemic

Author(s): Eugenia Rinaldi, Caroline Stellmach, Naveen Moses Raj Rajkumar, Natascia Caroccia, Chiara Dellacasa, Maddalena Giannella, Mariana Guedes, Massimo Mirandola, Gabriella Scipione, Evelina Tacconelli & Sylvia Thun
Published in: npj Digital Medicine, Issue 5, 2022, Page(s) 75, ISSN 2398-6352
Publisher: Springer Nature
DOI: 10.1038/s41746-022-00620-x

Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19

Author(s): Costanza Di Chiara, Elisa Barbieri, Yu Xi Chen, Elisa Visonà, Sara Cavagnis, Giulia Sturniolo, Agnese Parca, Cecilia Liberati, Luigi Cantarutti, Angela Lupattelli, Marthe Le Prevost, Giovanni Corrao, Carlo Giaquinto, Daniele Donà, Anna Cantarutti
Published in: Acta paediatrica, Issue Volume112, Issue12, 2023, Page(s) 2563-2571, ISSN 0803-5253
Publisher: Taylor & Francis
DOI: 10.1111/apa.16966

Exhaustion in Healthcare Workers after the First Three Waves of the COVID-19 Pandemic

Author(s): Marina Ruxandra Oțelea; Agripina Rașcu; Cătălin Staicu; Lavinia Călugăreanu; Mădălina Ipate; Silvia Teodorescu; Ovidiu Persecă; Angelica Voinoiu; Andra Neamțu; Violeta Calotă; Dana Mateș
Published in: International Journal of Environmental Research and Public Health, Issue Volume 19; Issue 14;, 2022, Page(s) 8871, ISSN 1660-4601
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/ijerph19148871

Relationship Between Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Development of Breakthrough Infection in Solid Organ Transplant Recipients: The CONTRAST Cohort

Author(s): Cecilia, Bonazzetti; Beatrice, Tazza; Dino, Gibertoni; Zeno, Pasquini; Natascia, Caroccia; Francesca, Fanì; Giacomo, Fornaro; Renato, Pascale; Matteo, Rinaldi; Beatrice, Miani; Chiara, Gamberini; Maria Cristina, Morelli; Mariarosa, Tamé; Marco, Busutti; Giorgia, Comai; Luciano, Potena; Laura, Borgese; Elena, Salvaterra; Tiziana, Lazzarotto; Luigia, Scudeller; Pierluigi, Viale; Maddalena, Giannel
Published in: Clinical Infectious Diseases, Issue Volume 76, Issue 10, 2023, Page(s) 1761–1767, ISSN 1537-6591
Publisher: Oxford University Press
DOI: 10.1093/cid/ciad016

When Lack of Trust in the Government and in Scientists Reinforces Social Inequalities in Vaccination Against COVID-19

Author(s): Nathalie Bajos, Alexis Spire, Léna Silberzan, Antoine Sireyjol, Florence Jusot, Laurence Meyer, Jeanna-Eve Franck, Josiane Warszawski, the EpiCov study group
Published in: Frontiers in Public Health, Issue 10, 2022, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/fpubh.2022.908152

Accessibility of covariance information creates vulnerability in Federated Learning frameworks

Author(s): Manuel Huth, Jonas Arruda, Roy Gusinow, Lorenzo Contento, Evelina Tacconelli, Jan Hasenauer
Published in: Bioinformatics, Issue 39(9), 2023, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btad531

How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Author(s): Anna Maria Azzini, Lorenzo Maria Canziani, Ruth Joanna Davis, Massimo Mirandola, Michael Hoelscher, Laurence Meyer, Cédric Laouénan, Maddalena Giannella, Jesús Rodríguez-Baño, Paolo Boffetta, Dana Mates, Surbhi Malhotra-Kumar, Gabriella Scipione, Caroline Stellmach, Eugenia Rinaldi, Jan Hasenauer, Evelina Tacconelli
Published in: Vaccines, Issue 11(8), 2023, Page(s) 1361, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11081361

Social Isolation Among Older Adults in the Time of COVID-19

Author(s): Léna Silberzan, Claude Martin, Nathalie Bajos and EpiCov Study Group
Published in: Frontiers in Public Health, Issue 10, 2022, ISSN 2296-2565
Publisher: Frontiers
DOI: 10.3389/fpubh.2022.840940

Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern

Author(s): Fulvia Mazzaferri, Massimo Mirandola, Alessia Savoldi, Pasquale De Nardo,Matteo Morra, Maela Tebon, Maddalena Armellini, Giulia De Luca, Lucrezia Calandrino, Lolita Sasset, Denise D'Elia, Emanuela Sozio, Elisa Danese, Davide Gibellini, Isabella Monne, Giovanna Scroccaro, Nicola Magrini, Annamaria Cattelan, Carlo Tascini, MANTICO Working Group, Evelina Tacconelli
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.79639

International Clinical Research Data Ecosystem: From Data Standardization to Federated Analysis

Author(s): Eugenia Rinaldi, Chiara Dellacasa, Miroslav Puskaric, Thomas Osmo, Anna Gorska, Caroline Stellmach
Published in: Studies in Health Technology and Informatics, Issue Volume 309, 2023, Page(s) 133-134, ISSN 1879-8365
Publisher: IOS Press
DOI: 10.3233/shti230757

Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in Congolese individuals

Author(s): Francine Ntoumi; Armel Landry Batchi-Bouyou; Jean Claude Djontu; Jeannhey Christevy Vouvoungui; Claujens Chastel Mapanguy Mfoutou; Line Lobaloba Ingoba; Jiré Séphora Mougany; Kamal Rauchelvy Boumpoutou; Steve Diafouka-kietela; Raoul Ampa
Published in: BMC Infectious Diseases, Issue 22, 2022, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-022-07593-y

Perceived Psychological Impact on Children and Parents of Experiencing COVID-19 Infection in One or More Family Members

Author(s): Paola Costenaro; Costanza Di Chiara; Valentina Boscolo; Alessia Barbieri; Alice Tomasello; Anna Cantarutti; Sandra Cozzani; Cecilia Liberati; Serenella Oletto; Carlo Giaquinto; Daniele Donà
Published in: Children, Issue 9(9), 2022, Page(s) 1370, ISSN 2227-9067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/children9091370

The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients

Author(s): Tami A, van der Gun BTF, Wold KI, Vincenti-González MF, Veloo ACM, Knoester M, Harmsma VPR, de Boer GC, Huckriede ALW, Pantano D, Gard L, Rodenhuis-Zybert IA, Upasani V, Smit J, Dijkstra AE, de Haan JJ, van Elst JM, van den Boogaard J, O' Boyle S, Nacul L, Niesters HGM, Friedrich AW.
Published in: PLOS ONE, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0273599

Global Association of COVID-19 Pandemic Measures with Cancer Treatment: A Systematic Review and Meta-Analysis

Author(s): Federica Teglia; Marco Angelini; Giulia Casolari; Laura Astolfi; Paolo Boffetta
Published in: Cancers, Issue 14(22), 2022, Page(s) 5490, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225490

Cross-sectional survey evaluating the psychological impact of the COVID-19 vaccination campaign in patients with cancer: The VACCINATE study

Author(s): Daniela Tregnago,Alice Avancini,Lorenzo Belluomini,Ilaria Trestini,Marco Sposito,Jessica Insolda,Federica Bianchi,Teodoro Sava,Chiara Gaiani,Lidia Del Piccolo,Valentina Guarnieri,Giuseppe Verlato,Ahmad Tfaily,Roberta Vesentini,Serena Zuliani,Sara Pilotto,Michele Milella
Published in: PLOS One, Issue 19(1), 2024, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0290792

The incidence and risk factors of selected drug prescriptions and outpatient care after SARS-CoV-2 infection in low-risk subjects: a multicenter population-based cohort study

Author(s): Carlo Gagliotti1, Federico Banchelli, Angela De Paoli, Rossella Buttazzi, Elena Narne, Enrico Ricchizzi, Elena Schievano, Stefania Bellio, Gisella Pitter, Michele Tonon, Lorenzo Maria Canziani, Maurizia Rolli, Evelina Tacconelli, Elena Berti,‡ Francesca Russo, Maria Luisa Moro
Published in: Frontiers in Public Health, Issue Volume 11, 2023, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1241401

Risk and severity of SARS-CoV-2 infection in breast cancer patients undergoing a structured infection screening program at the University and Hospital Trust of Verona

Author(s): S.Zanelli, E. Fiorio, I. Zampiva, F. Zacchi, G. Borghesan, E. Giontella1V. Parolin, P.Biondani, S. Zuliani, M. V. Dieci, E. Mioranza, M. Zorzi, M. Conti, D. Gibellini, G. Verlato, M. Milella
Published in: Annals of Oncology, Issue 33(6), 2022, Page(s) 661-663, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1016/j.annonc.2022.02.227

Mucosal response of inactivated and recombinant COVID-19 vaccines in Congolese individuals

Author(s): Freisnel H. Mouzinga, Constanze Heinzel, Abel Lissom, Andrea Kreidenweiss, Armel L. Batchi-Bouyou, Jacques D. Mbama Ntabi, Jean C. Djontu, Etienne Ngumbi, Peter G. Kremsner, Rolf Fendel, Francine Ntoumi
Published in: Immunity, Inflammation and Disease, Issue 11(12), 2023, ISSN 2050-4527
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/iid3.1116

Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study

Author(s): Alessia Savoldi, Matteo Morra, Alessandro Castelli, Massimo Mirandola, Matilda Berkell, Mathias Smet, Angelina Konnova, Elisa Rossi, Salvatore Cataudella, Pasquale De Nardo, Elisa Gentilotti, Akshita Gupta, Daniele Fasan, Enrico Gibbin, Filippo Cioli Puviani, Jan Hasenauer, Roy Gusinow, Adriana Tami, Samir Kumar-Singh, Surbhi Malhotra-Kumar, mAb Orchestra Working Group, Evelina Tacconelli
Published in: Biomedicines, Issue 10(9):2063, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10092063

Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project

Author(s): Ludovica Leomanni , Giulia Collatuzzo , Emanuele Sansone , Emma Sala , Giuseppe De Palma, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Daniela Basso, Sofia Pavanello, Maria Luisa Scapellato, Francesca Larese Filon, Luca Cegolon, Marcella Mauro, Vittorio Lodi, Tiziana Lazzarotto, Ivan Noreña , Christina Reinkemeyer, Le Thi Thu Giang, Eleonóra Fabiánová, Jozef Strhársky, Marco
Published in: Vaccines, Issue September 2023, 11(10), 1527, 2023, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11101527

Effect of a Fourth Dose of mRNA Vaccine and of Immunosuppression in Preventing SARS-CoV-2 Breakthrough Infections in Heart Transplant Patients

Author(s): Marco Masetti; Maria Francesca Scuppa; Alessio Aloisio; Laura Giovannini; Laura Borgese; Stefania Manno; Beatrice Tazza; Renato Pascale; Cecilia Bonazzetti; Natascia Caroccia; Mario Sabatino; Giosafat Spitaleri; Pierluigi Viale; Maddalena Giannella; Luciano Potena
Published in: Microorganisms, Issue 11(3), 2023, Page(s) 755, ISSN 2076-2607
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/microorganisms11030755

ORCHESTRA: Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2

Author(s): Gabriella Scipione, Chiara Dellacasa, Elisa Rossi
Published in: Cineca HPC Report 2021-2022, Issue annual, 2022, Page(s) 39-40, ISBN 9788886037440
Publisher: Grafiche Zanini

ORCHESTRA: Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic

Author(s): Mattia D’Antonio, Chiara Dellacasa, Maurizio Ortali, Elisa Rossi, Gabriella Scipione
Published in: Cineca HPC Report 2020, Issue annual, 2022, Page(s) 31, ISBN 9788886037426
Publisher: Grafiche Zanini

Projects in “-omics” science field

Author(s): Elisa Rossi, Silvia Gioiosa, Beatrice Chiavarini, Giuseppa Muscianisi
Published in: Cineca HPC Report 2022-2023, Issue annual, 2023, Page(s) 38, ISBN 9788886037464
Publisher: Grafiche Zanini

Immunological biomarkers of COVID-19: response to vaccination and monoclonal antibody treatments in immunocompromised patients

Author(s): Angelina Konnova
Published in: PhD dissertation, Issue 1, 2023, Page(s) 1-193
Publisher: University of Antwerp

Development, Validation, and Accuracy of ORCHESTRA Emotional Exhaustion Questionnaire

Author(s): R.K. Gan, P. Arcos González, M. Rodríguez‑Suárez, G. Fernández Tardón, A. Zerbo, D. Mates, E. Fabiánová, M. Otelea, A.Tardon
Published in: Gaceta Sanitaria, Issue 37(S1), 2023, Page(s) S187, ISSN 1578-1283
Publisher: Elsevier B.V.

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