Project description
Preparing to respond to future pandemics
The effects of the COVID-19 pandemic signal the need to build better preparedness for future threats. The EU-funded ORCHESTRA project provides an innovative method to study the pandemic and deliver recommendations for future health crises. Specifically, it will establish a new EU-wide cohort based on existing and new large-scale population cohorts in the EU and non-European countries. ORCHESTRA will perform data analysis through a federated learning technique enhanced by pioneering modelling capabilities to integrate epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environmental and socioeconomic elements. The project includes infected and non-infected individuals of all ages and conditions, focusing on at-risk populations of vulnerable individuals and healthcare workers.
Objective
The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 health crisis and derive recommendations for increasing preparedness for future outbreaks. The main outcome of the project is the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European and non-European countries. Data analysis through a federated learning technique supported by advanced modelling capabilities will allow the integration of epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environment and socio-economic features. The ORCHESTRA cohort will include SARS-CoV-2 infected and non-infected individuals of all ages and conditions and thereby enabling a retrospective evaluation of risk factors for the disease acquisition and progression of the disease and prospective follow-up aimed at exploring long term consequences and analysis of vaccination response. To better address these research questions, the ORCHESTRA-cohort will include adequately sampled representatives of general populations, COVID-19 patients and special ‘at risk’ populations of fragile individuals and health-care workers. The project aims also to evaluate how the acquisition of SARS-CoV-2 variants impacts on the severity of disease. ORCHESTRA will specifically assess the immunity function status in vaccinated and not vaccinated health care workers, including assessment in-between the first and the second dosages of any available vaccine and explore differences in level and durability of antibody immune responses and frequency of breakthrough infections (symptomatic and asymptomatic) in fragile population (e.g oncological, transplanted, hematological, HIV-infected and suffering from Parkison disease). The understanding of the evoked immune response by population, variants and type of vaccine are key to better understand how vaccines againstSARS-CoV-2 variants can prevent transmission and severe SARS-CoV-2 infections, why certain variants may be able to escape vaccines, and whether refresher boosters at regular intervals could change any of these outcomes. The participation of non-European and Low-Medium Income Countries and a Global COVID-19 Guidance group of major stakeholders and investigators from successful clinical trials addressing therapeutic approaches to COVID-19, ensures inclusion of all expertise needed and translation of recommendations to different social and economic settings. The project will significantly impact on the responsiveness to SARS-CoV-2 and can be used as a model for responsiveness for new public health threats.
Fields of science
Not validated
Not validated
- medical and health scienceshealth sciencespublic healthepidemiologyepidemics prevention
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
Keywords
Programme(s)
Call for proposal
H2020-SC1-PHE-CORONAVIRUS-2020-2
See other projects for this callSub call
H2020-SC1-PHE-CORONAVIRUS-2020-2-RTD
Funding Scheme
RIA - Research and Innovation actionCoordinator
37129 Verona
Italy
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Participants (33)
Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020.
121001 Faridabad
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Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020.
04021001 Sao Paulo
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
37126 Verona
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Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020.
560034 Koramangala
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40126 Bologna
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
40124 Bologna
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
40138 Bologna
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75654 Paris
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41071 Sevilla
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40033 Casalecchio Di Reno Bo
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1445 Strassen
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75012 Paris
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40127 Bologna
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
42100 Reggio Emilia
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08036 Barcelona
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80539 MUNCHEN
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2000 Antwerpen
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85764 Neuherberg
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50937 Koeln
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35127 Padova
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70174 Stuttgart
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118 Lambaréné
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975 56 Banska Bystrica
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10117 Berlin
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9713 GZ Groningen
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34097 Montpellier
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33003 OVIEDO
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1053 Buenos Aires
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050463 Bucuresti
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69120 Heidelberg
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30123 Venezia
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
35131 Padova
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Brazzaville
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