Skip to main content
European Commission logo
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic: ORCHESTRA

Description du projet

Se préparer à réagir aux futures pandémies

Les effets de la pandémie de COVID-19 soulignent la nécessité de mieux se préparer aux menaces à venir. Le projet ORCHESTRA, financé par l’UE, propose une méthode innovante pour étudier la pandémie et proposer des recommandations pour de futures crises sanitaires. Plus spécifiquement, il compte établir une nouvelle cohorte à l’échelle de l’UE, basée sur des cohortes de population à grande échelle à la fois nouvelles et existantes dans l’UE et dans des pays non européens. ORCHESTRA entend analyser des données à travers une technique d’apprentissage fédéré, améliorée par des capacités de modélisation de pointe, afin d’intégrer des aspects épidémiologiques, cliniques, microbiologiques et génotypiques de cohortes basées sur des populations avec des éléments environnementaux et socio-économiques. Le projet rassemble des individus infectés et non infectés de tous âges et conditions, en mettant l’accent sur les populations à risque d’individus vulnérables et d’employés du secteur médical.

Objectif

The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 health crisis and derive recommendations for increasing preparedness for future outbreaks. The main outcome of the project is the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European and non-European countries. Data analysis through a federated learning technique supported by advanced modelling capabilities will allow the integration of epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environment and socio-economic features. The ORCHESTRA cohort will include SARS-CoV-2 infected and non-infected individuals of all ages and conditions and thereby enabling a retrospective evaluation of risk factors for the disease acquisition and progression of the disease and prospective follow-up aimed at exploring long term consequences and analysis of vaccination response. To better address these research questions, the ORCHESTRA-cohort will include adequately sampled representatives of general populations, COVID-19 patients and special ‘at risk’ populations of fragile individuals and health-care workers. The project aims also to evaluate how the acquisition of SARS-CoV-2 variants impacts on the severity of disease. ORCHESTRA will specifically assess the immunity function status in vaccinated and not vaccinated health care workers, including assessment in-between the first and the second dosages of any available vaccine and explore differences in level and durability of antibody immune responses and frequency of breakthrough infections (symptomatic and asymptomatic) in fragile population (e.g oncological, transplanted, hematological, HIV-infected and suffering from Parkison disease). The understanding of the evoked immune response by population, variants and type of vaccine are key to better understand how vaccines againstSARS-CoV-2 variants can prevent transmission and severe SARS-CoV-2 infections, why certain variants may be able to escape vaccines, and whether refresher boosters at regular intervals could change any of these outcomes. The participation of non-European and Low-Medium Income Countries and a Global COVID-19 Guidance group of major stakeholders and investigators from successful clinical trials addressing therapeutic approaches to COVID-19, ensures inclusion of all expertise needed and translation of recommendations to different social and economic settings. The project will significantly impact on the responsiveness to SARS-CoV-2 and can be used as a model for responsiveness for new public health threats.

Appel à propositions

H2020-SC1-PHE-CORONAVIRUS-2020-2

Voir d’autres projets de cet appel

Sous appel

H2020-SC1-PHE-CORONAVIRUS-2020-2-RTD

Coordinateur

UNIVERSITA DEGLI STUDI DI VERONA
Contribution nette de l'UE
€ 2 205 373,75
Adresse
VIA DELL ARTIGLIERE 8
37129 Verona
Italie

Voir sur la carte

Région
Nord-Est Veneto Verona
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 5 182 396,25

Participants (33)