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Contenido archivado el 2024-05-24

Synthesis and mechanism of action of novel classes of retinoids and rexinoids with antineoplastic activities

Objetivo

In vitro studies, clinical trials and the cure of acute promyelocytic leukemiahave unequivocally demonstrated the cancer therapeutic and cancer preventive action of retinues and resinous. We will generate novel types of legends that activate only a specific function and/or receptor isotope and define itscoregulator interaction pattern. We will identify anti-cancer drugs which exploit the
(1) link between retinues and selective-selective TRAIL death signalling,
(2) autonomous reined signalling that controls cell differentiation and apoptosis,
(3) activation by HDAC or methylamine inhibitors of growth regulation in retinoidnon-responsive cells,
(4) crosswalk with other signalling pathways that can prevent chemical carcinogen sis, and
(5) anti-viral action. The present consortium combines experts of different disciplines to chemically synthesize, screen and characterize novel ret (x) inroads and investigate the molecular basis of their anticancer action.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSITY OF VIGO
Aportación de la UE
Sin datos
Dirección

36200 VIGO
España

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Coste total
Sin datos

Participantes (6)