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Heat shock protein 60 as a novel therapeutic target for diabetes and rheumatoid arthritis (HSPFORTHERAPY)

Ziel

Heat shock proteins are antigens of immune responses in autoimmunity. In experimental models they suppress inflammation and in clinical trials in diabetes and arthritis hsp60 has a proven therapeutic potential. We propose to analyse the underlying mechanisms by monitoring immunity to hsp60 in the models, in patients and during hsp60 peptide trials, with respect to both the adaptive and the innate part of the immune system.

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UTRECHT UNIVERSITY
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