International Human Microbiome Coordination and Support Action

Livrables

Ethical and policy issues in microbiome research and symbiosis monitoring

D7.1 Ethical and policy issues in microbiome research and symbiosis monitoring (M24)Report on evidence-based tools for microbiome-oriented self-care and medical decisions aids based on international standards on metagenomics data production and validation, resulting in a Mutual learning protocol to empower early-stage researchers to explore and address ethical and policy issues in microbiome research. EUR

White paper and recommendations on the human microbiome addressing gaps, emerging fields and political priorities

D4.3 White paper and recommendations on the human microbiome addressing gaps, emerging fields and political priorities, UCC (M36)

Recommendations for responsible research and innovation rules in the field of microbiome

D7.3 Recommendations for responsible research and innovation rules in the field of microbiome EUR (M36)

Report proposing initiatives for unified repositories for processed data

D3.2 Report proposing initiatives for unified repositories for processed data, UNITN (M30)

Consensus opinion paper (submission) on new approaches for intervention studies

D5.3 Consensus opinion paper (submission) on new approaches for intervention studies. UP (M30).

Policies and regulations for self-management tools

D7.2 Policies and regulations for self-management tools. PRI (M36)1) Report on the different policies needed in order to ensure appropriate regulation and control of ethical issues surrounding self-management tools, and 2) Report on the adaptation of ICH and EMA guidelines on pharmacogenomic biomarkers to microbiome-specific aspects and recommendation to the EMA

Report on the Delphi consultation: Questionnaire & analysis of the. consultation answers

D5.1 Report on the Delphi consultation: Questionnaire & analysis of the. consultation answers

Consensus opinion paper (submission) on preclinical models for microbiome research with focus on causality

D5.2 Consensus opinion paper (submission) on preclinical models for microbiome research with focus on causality

Report on clinical endpoints metadata

D1.2 Report on clinical endpoints metadata, EF-CLIF (M36)

Sustainability plan including toolbox

D8.2 Sustainability plan including toolbox (EUFIC, M30)

Communication and dissemination plan

D81 Communication and dissemination plan EUFIC M6

Report on interoperability

D2.2 Report on interoperability, INRAE (M36)

Report on the highlights of communication and dissemination efforts with KPI indicators

D8.3 Report on the highlights of communication and dissemination efforts with KPI indicators (EUFIC, M36)

Report on human microbiome data

D2.1 Report on human microbiome data, UCPH (M24)

Report on recommendations for microbiome analysis standards

D3.1 Report on recommendations for microbiome analysis standards, UCPH (M30)

Roadmap proposal for a European Microbiome-Dedicated Surveillance Network

D7.4 Roadmap proposal for a European Microbiome-Dedicated Surveillance Network EUR (M36)

Position paper (submission) on biomarker identification, preanalytical & analytical validation

D6.2 Position paper (submission) on biomarker identification, preanalytical & analytical validation. LNS (M30)

Publications

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression.

Auteurs: Tyc O, Shi Y, Fan YC, Trebicka J, Xiang X
Publié dans: Frontiers in Immunology, Numéro 2023 Aug 15, 2023, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2023.1260749

Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS

Auteurs: Alexander Queck, Louise Schwierz, Wenyi Gu, Philip G. Ferstl, Christian Jansen, Frank E. Uschner, Michael Praktiknjo, Johannes Chang, Maximilian J. Brol, Filippo Schepis, Manuela Merli, Christian P. Strassburg, Jennifer Lehmann, Carsten Meyer, Jonel Trebicka
Publié dans: Hepatology, 2022, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.32676

"""Human-microbes symbiosis inhealth and disease, on earth andbeyond planetary boundaries"""

Auteurs: Dore J & Ortega-Ugalde S
Publié dans: Frontiers in Astronomy and Space Sciences, Numéro 2023 Sept, 2023, ISSN 2296-987X
Éditeur: Frontiers Media
DOI: 10.3389/fspas.2023.1180522

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Auteurs: Chandana B. Herath, Peter W. Angus, and Jonel Trebicka
Publié dans: Frontiers in Physiology, 2022, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery

Auteurs: Brol MJ, Drebber U, Yu X, Schierwagen R, Gu W, Plamper A, Klein S, Odenthal M, Uschner FE, Praktiknjo M, Trebicka J, Rheinwalt KP
Publié dans: Surgery for Obesity and Related Diseases, Numéro 2024, 2024, ISSN 1550-7289
Éditeur: Elsevier BV
DOI: 10.1016/j.soard.2024.02.006

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

Auteurs: Trebicka J, Hernaez R, Shawcross DL, Gerbes AL
Publié dans: Gut, Numéro 2024 Mar 25, 2024, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330584

Blood Endotoxin Levels as Biomarker of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Auteurs: Soppert, Josefin; Brandt, Elisa Fabiana; Heussen, Nicole Maria; Barzakova, Emona; Blank, Lars M.; Küpfer, Lars; Hornef, Mathias; Trebicka, Jonel; Jankowski, Joachim; Berres, Marie-Luise; Noels, Heidi
Publié dans: Clinical Gastroenterology and Hepatology, Numéro 7, 2023, Page(s) 2746-2758, ISSN 1542-3565
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2022.11.030

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

Auteurs: Schierwagen, Robert; Gu, Wenyi; Brieger, Angela; Brüne, Bernhard; Ciesek, Sandra; Đikić, Ivan; Dimmeler, Stefanie; Geisslinger, Gerd; Greten, Florian R.; Hermann, Eva; Hildt, Eberhard; Kempf, Volkhard A. J.; Klein, Sabine; Koch, Ina; Mühl, Heiko; Müller, Volker; Peiffer, Kai-Henrik; Kestner, Roxane-Isabelle; Piiper, Albrecht; Rohde, Gernot; Scholich, Klaus; Schulz, Marcel H.; Storf, Holger; T
Publié dans: American journal of physiology. Cell physiology, Numéro 8, 2023, ISSN 0363-6143
Éditeur: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial.

Auteurs: Kronborg TM, Schierwagen R, Trošt K, Gao Q, Moritz T, Bendtsen F, Gantzel RH, Andersen ML, Teisner AS, Grønbæk H, Hobolth L, Møller S, Trebicka J, Kimer N
Publié dans: Hepatology Communications, Numéro 2023 Dec 1, 2023, ISSN 2471-254x
Éditeur: Wolters Kluwer Health
DOI: 10.1097/hc9.0000000000000332

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure.

Auteurs: Mücke MM, El Bali N, Schwarzkopf KM, Uschner FE, Kraus N, Eberle L, Mücke VT, Bein J, Beyer S, Wild PJ, Schierwagen R, Klein S, Zeuzem S, Welsch C, Trebicka J, Brieger A
Publié dans: International Journal of Molecular Sciences, Numéro 2024 Jan 26, 2024, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031542

The rationale and study design of two phase II trials examining the effects of BI 685509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis

Auteurs: Reiberger, Thomas; Berzigotti, Annalisa; Trebicka, Jonel; Ertle, Judith; Gashaw, Isabella; Swallow, Ros; Tomisser, Andrea
Publié dans: Trials, Numéro 10, 2023, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.1186/s13063-023-07291-3

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges

Auteurs: Markus Kimmann; Jonel Trebicka
Publié dans: Journal of Personalized Medicine, Vol 13, Iss 7, p 1052 (2023), Numéro 11, 2023, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018).

Auteurs: Gu W, Zeleke Y, Hortlik H, Schaaf L, Uschner FE, Schulz M, Tischendorf M, Peiffer KH, Brol MJ, Kimmann M, Vogl T, Köhler M, Meyer C, Gerbes A, Rössle M, Laleman W, Zipprich A, Steib C, Praktiknjo M, Trebicka J; German TIPS Working Group.
Publié dans: Hepatology Communications, Numéro 2023 Sep 15, 2023, ISSN 2471-254x
Éditeur: Wolters Kluwer Health
DOI: 10.1097/hc9.0000000000000237

Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome

Auteurs: Lisa Derosa, Valerio Iebba, Carolina Alves Costa Silva, Gianmarco Piccinno, Guojun Wu, Leonardo Lordello, Bertrand Routy, Naisi Zhao, Cassandra Thelemaque, Marine Fidelle, Meriem Messaoudene, Andrew Maltez Thomas, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro-Sibilot, François Goldwasser, Arnaud Scherpereel, Hervé Pegliasco, François Ghiringhelli, Nicol
Publié dans: Cell, 2024, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2024.05.029

Gut Microbiota-Related Biomarkers in Immuno-oncology

Auteurs: Carolina Alves Costa Silva, Marine Fidelle, Andrew A. Almonte, Lisa Derosa, Laurence Zitvogel
Publié dans: Ann. Rev. Pharmacol, 2024, ISSN 0362-1642
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-061124-102218

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Auteurs: Sandra Torres; Cristina Ortiz; Nadine Bachtler; Wenyi Gu; Leon D. Grünewald; Nico Kraus; Robert Schierwagen; Christoph Hieber; Caroline Meier; Olaf Tyc; Maximilian Joseph Brol; Frank Erhard Uschner; Bart Nijmeijer; Christoph Welsch; Marie‐Luise Berres; Carmen Garcia‐Ruiz; Jose Carlos Fernandez‐Checa; Christian Trautwein; Thomas J. Vogl; Stefan Zeuzem; Jonel Trebicka; Sabine Klein
Publié dans: Hepatology, 2022, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Auteurs: Emmanuel Weiss; Carlos de la Peña-Ramirez; Ferran Aguilar; Juan-Jose Lozano; Cristina Sánchez-Garrido; Patricia Sierra; Pedro Izquierdo-Bueno Martin; Juan Manuel Diaz; François Fenaille; Florence A Castelli; Thierry Gustot; Wim Laleman; Agustín Albillos; Carlo Alessandria; Marco Domenicali; Paolo Caraceni; Salvatore Piano; Faouzi Saliba; Stefan Zeuzem; Alexander L Gerbes; Julia A Wendon; Chris
Publié dans: Gut, Numéro 6, 2023, Page(s) 1581-1591, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-328708

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018).

Auteurs: Gu W, Schaaf L, Hortlik H, Zeleke Y, Brol MJ, Schnitzbauer AA, Bechstein WO, Zeuzem S, Queck A, Peiffer KH, Tischendorf M, Pascher A, Laleman W, Praktiknjo M, Schulz MS, Uschner FE, Rennebaum F, Trebicka J
Publié dans: European Journal of Gastroenterology & Hepatology, Numéro 2023 Nov 1, 2023, Page(s) 1289-1297, ISSN 0954-691X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/meg.0000000000002640

“Love is a microbe too” : Microbiome dialectics

Auteurs: Hub Zwart
Publié dans: Endeavour, Numéro 46, 2022, Page(s) 100816, ISSN 0160-9327
Éditeur: Elsevier BV
DOI: 10.1016/j.endeavour.2022.100816

From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders

Auteurs: Kriaa A, Mariaule V, De Rudder C, Jablaoui A, Sokol H, Wilmes P, Maguin E, Rhimi M.
Publié dans: Gut Microbes, Numéro 2024 Jan-Dec;16(1):2333434, 2024, ISSN 1949-0984
Éditeur: Taylor and Francis
DOI: 10.1080/19490976.2024.2333434

Design of a proteolytic module for improved metabolic modeling of Bacteroides caccae.

Auteurs: Paulay A, Grimaud GM, Caballero R, Laroche B, Leclerc M, Labarthe S, Maguin E
Publié dans: mSystems, Numéro 2024 Apr 16;9(4):e0015324, 2024, ISSN 0021-9193
Éditeur: American Society for Microbiology
DOI: 10.1128/msystems.00153-24

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

Auteurs: Bachtler, Nadine; Torres, Sandra; Ortiz, Cristina; Schierwagen, Robert; Tyc, Olaf; Hieber, Christoph; Berres, Marie-Luise; Meier, Caroline; Kraus, Nico; Zeuzem, Stefan; Nijmeijer, Bart; Pronk, Sebas; Trebicka, Jonel; Klein, Sabine
Publié dans: PLoS ONE, Vol 18, Iss 1, p e0270288 (2023), Numéro 7, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0270288

Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases

Auteurs: Thiele M, Villesen IF, Niu L, Johansen S, Sulek K, Nishijima S, Van Espen L, Keller M, Israelsen M, Suvitaival T, de Zawadzki A, Juel HB, Brol MJ, Stinson SE, Huang Y, Alvarez Silva MC, Kuhn M, Anastasiadou E, Leeming DJ, Karsdal M, Matthijnssens J, Arumugam M, Dalgaard LT, Legido-Quigley C, Mann M, Trebicka J, Bork P, Jensen LJ, Hansen T, Krag A; MicrobLiver and GALAXY consortia; GALAXY consortiu
Publié dans: Journal of Hepatology, Numéro 2024 Mar 27, 2024, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2024.03.035

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?

Auteurs: Sauerbruch T, Hennenberg M, Trebicka J, Schierwagen R
Publié dans: Frontiers in Medicine, Numéro 2023 Jan 9, 2023, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2022.1100966

Genetic variation in<i>TERT</i>modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Auteurs: Buch, Stephan; Innes, Hamish; Lutz, Philipp Ludwig; Nischalke, Hans Dieter; Marquardt, Jens U; Fischer, Janett; Weiss, Karl Heinz; Rosendahl, Jonas; Marot, Astrid; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Eyer, Florian; Vogel, Arndt; Marhenke, Silke; von Felden, Johann; Sharma, Rohini; Atkinson, Stephen Rahul; McQuillin, Andrew; Nattermann, Jacob; Schafmayer, Clemens; Franke, Andre; Stras
Publié dans: Gut, Numéro 8, 2023, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327196

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial.

Auteurs: Torp N, Israelsen M, Coenraad M, Papp M, Shawcross D, Korenjak M, Angeli P, Laleman W, Juanola A, Gines P, Trebicka J, Krag A; MICROB-PREDICT Consortium.
Publié dans: BMJ Open, Numéro 2024 Feb 14, 2024, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-079309

Modeling microbiota-associated human diseases: from minimal models to complex systems

Auteurs: Doriane Aguanno, Amira Metwaly, Olivia I. Coleman, Dirk Haller
Publié dans: Microbiome Research Reports, 2022, ISSN 2771-5965
Éditeur: OAE Publishing Inc.
DOI: 10.20517/mrr.2022.01

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Auteurs: Kennedy KM, de Goffau MC, Perez-Muñoz ME, Arrieta M-C, Bäckhed F, Bork P, Braun T, Bushman FD, Dore J, de Vos WM, Earl AM, Eisen JA, Elovitz MA, Ganal-Vonarburg SC, Gänzle MG, Garrett WS, Hall LJ, Hornef MW, Huttenhower C, Konnikova L, Lebeer S, Macpherson AJ, Massey RC, McHardy AC, Koren O, Lawley TD, Ley RE, O’Mahony L, O’Toole PW, Pamer EG, Parkhill J, Raes J, Rattei T, Salonen A, Segal
Publié dans: Nature, Numéro 2023 Jan, 2023, Page(s) 639-649, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05546-8

Operating under pressure: Is there a place for preoperative TIPS?

Auteurs: Praktiknjo M, Trebicka J.
Publié dans: JHEP Reports, Numéro 2024 Feb 9, 2024, ISSN 2589-5559
Éditeur: Elsevier B.V.
DOI: 10.1016/j.jhepr.2024.101034

Myostatin is associated with the presence and development of acute-on-chronic liver failure.

Auteurs: Ruiz-Margáin A, Pohlmann A, Lanzerath S, Langheinrich M, Campos-Murguía A, Román-Calleja BM, Schierwagen R, Klein S, Uschner FE, Brol MJ, Torre-Delgadillo A, Flores-García NC, Praktiknjo M, Macías Rodríguez RU, Trebicka J
Publié dans: JHEP Reports, Numéro 2023 Apr 14, 2023, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/j.jhepr.2023.100761

Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders

Auteurs: Amira Metwaly, Sandra Reitmeier, Dirk Haller
Publié dans: Nature Reviews Gastroentrology & Hepatology, 2022, ISSN 1759-5045
Éditeur: Nature Publishing Group
DOI: 10.1038/s41575-022-00581-2

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