Real-time analysis of ribosomal frameshifting and its impact on immunity and disease

Project Information

T-FRAME

Grant agreement ID: 948636

DOI 10.3030/948636

EC signature date 25 November 2020

Start date 1 February 2021

End date 31 July 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 852,00

EU contribution € 1 499 852,00

Coordinated by

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

Publications

Peer reviewed articles (9)

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Author(s): Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, Thomas Pietschmann
Published in: Microbiology Spectrum, 2023, ISSN 2165-0497
Publisher: ASM Journal
DOI: 10.1128/spectrum.01284-23

Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Author(s): Hill, C. H.; Pekarek, L.; Napthine, S.; Kibe, A.; Firth, A. E.; Graham, S. C.; Caliskan, N.; Brierley, I.
Published in: Nature Communications, Issue 20411723, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27400-7

Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

Author(s): Riegger, R. J.; Caliskan, N.
Published in: Frontiers in Molecular Biosciences, Issue 2296889X, 2022, ISSN 2296-889X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.84226

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Author(s): Zimmer, M. M.; Kibe, A.; Rand, U.; Pekarek, L.; Ye, L.; Buck, S.; Smyth, R. P.; Cicin-Sain, L.; Caliskan N.
Published in: Nature Communications, Issue 20411723, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27431-0

Insights from structural studies of the cardiovirus 2A protein

Author(s): Caliskan, N.; Hill, C. H.
Published in: Bioscience Reports, Issue 01448463, 2022, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/bsr20210406

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

Author(s): Chris H. Hill; Georgia M. Cook; Sawsan Napthine; Anuja Kibe; Katherine A. Brown; Neva Caliskan; Andrew E. Firth; Stephen C. Graham; Ian Brierley
Published in: Nucleic Acid Research, Issue 03051048, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1101/2020.08.11.245068

Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Author(s): Lukas Pekarek, Matthias M Zimmer, Anne-Sophie Gribling-Burrer, Stefan Buck, Redmond Smyth, Neva Caliskan
Published in: Nucleic Acids Research, 2023, Page(s) 728-743, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac1184

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Author(s): Pekarek, L.; Buck, S.; Caliskan, N.
Published in: Journal of Visualized Experiments, Issue 1940087X, 2022, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62589

POTATO: Automated pipeline for batch analysis of optical tweezers data

Author(s): Stefan Buck, Lukas Pekarek, Neva Caliskan
Published in: Biophysical Journal, 2022, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2022.06.030