Descrizione del progetto
In che modo l’ambiente e il nostro stile di vita interagiscono dinamicamente con la nostra salute?
Lo stile di vita e l’ambiente in cui si vive sono cambiati. Le esposizioni all’ambiente, come l’inquinamento atmosferico e acustico e l’ambiente edificato, e lo stile di vita, la situazione psicologica e sociale di un individuo, reagiscono con fattori genetici che portano ad un aumento del rischio di sviluppare malattie come l’obesità, il diabete di tipo 2 e le malattie cardiovascolari. Il progetto LONGITOOLS, finanziato dall’UE, studierà e misurerà in che modo l’esposizione a questi fattori ambientali contribuisce al rischio di sviluppare tali malattie attraverso la vita di una persona. Il progetto adotterà un approccio basato sull’«esposoma» o olistico per determinare i punti migliori della vita per intervenire al fine di ridurre questi rischi, generando prove per la politica e progettando applicazioni sanitarie innovative. LongITools è uno dei nove progetti della rete europea sull’esposoma umano (European Human Exposome Network).
Obiettivo
Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. The extent to which these exposures may cause their attributed health effects (via molecular mediation) directly or indirectly as a result of associations to an individual’s psychosocial context is largely unknown. NCDs arise from a lifelong process influencing anthropometric, glycaemic, cardiac and lipid-related health trajectories. Risks may start as early as during the fetal period and are modified during sensitive periods in childhood, adolescence and adulthood. Despite this, research has not focused enough on the life-course characterisation of the exposome and the application of this to health and disease. In 5 years, LONGITOOLS, a partnership of 15 academic groups and 3 small companies will harness a catalogue of birth cohorts, longitudinal data, registers and biobanks. We will characterise coincident longitudinal trajectories of exposure and cardiometabolic health combining the study of longitudinal effects and internal responses. The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. LONGITOOLS will implement this longitudinal approach in 11 work packages designed to generate a catalogue of FAIR data and a novel analytical toolbox. Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. A key objective will be to generate evidence-based predictions which can ultimately translate into innovative healthcare applications (apps) and policy options. LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. LONGITOOLS is one of the nine projects composing the European Human Exposome Network.
Campo scientifico
- medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosis
- medical and health sciencesclinical medicineendocrinologydiabetes
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- natural sciencesbiological sciencesgeneticsRNA
- medical and health scienceshealth sciencesnutritionobesity
Parole chiave
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SC1-2019-Single-Stage-RTD
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
90014 Oulu
Finlandia