Descripción del proyecto
¿Cómo interactúan dinámicamente el medio ambiente y nuestro estilo de vida con nuestra salud?
El estilo de vida y los entornos en los que vivimos han cambiado. La exposición a factores medioambientales, como la contaminación acústica y ambiental, y el entorno urbanizado, así como el estilo de vida y la situación social y psicológica de los individuos, reacciona con factores genéticos que llevan a un riesgo más elevado de desarrollar enfermedades como la obesidad, la diabetes de tipo 2 y enfermedades cardiovasculares. El proyecto LONGITOOLS, financiado con fondos europeos, estudiará y medirá cómo la exposición a esos factores medioambientales contribuye al riesgo de desarrollar dichas enfermedades a lo largo de la vida de una persona. El proyecto planteará un enfoque «exposoma» o basado en la holística para determinar cuáles son los mejores momentos de la vida, con el objetivo de intervenir para reducir dichos riesgos, generar pruebas para la formulación de políticas, así como diseñar aplicaciones sanitarias innovadoras. LongITools es uno de los nueve proyectos de la European Human Exposome Network (Red Europea de Exposoma Humano).
Objetivo
Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. The extent to which these exposures may cause their attributed health effects (via molecular mediation) directly or indirectly as a result of associations to an individual’s psychosocial context is largely unknown. NCDs arise from a lifelong process influencing anthropometric, glycaemic, cardiac and lipid-related health trajectories. Risks may start as early as during the fetal period and are modified during sensitive periods in childhood, adolescence and adulthood. Despite this, research has not focused enough on the life-course characterisation of the exposome and the application of this to health and disease. In 5 years, LONGITOOLS, a partnership of 15 academic groups and 3 small companies will harness a catalogue of birth cohorts, longitudinal data, registers and biobanks. We will characterise coincident longitudinal trajectories of exposure and cardiometabolic health combining the study of longitudinal effects and internal responses. The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. LONGITOOLS will implement this longitudinal approach in 11 work packages designed to generate a catalogue of FAIR data and a novel analytical toolbox. Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. A key objective will be to generate evidence-based predictions which can ultimately translate into innovative healthcare applications (apps) and policy options. LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. LONGITOOLS is one of the nine projects composing the European Human Exposome Network.
Ámbito científico
- medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosis
- medical and health sciencesclinical medicineendocrinologydiabetes
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- natural sciencesbiological sciencesgeneticsRNA
- medical and health scienceshealth sciencesnutritionobesity
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2019-Single-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
90014 Oulu
Finlandia