New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Resultado final

ACCEL will create a communication portfolio of updated VANGUARD print visual and media information and documentation including factsheets brochures and posters and visual content will be developed to offer information about the project in a condensed form that can be handed out during various events and downloaded from the project website

VANGUARD Stakeholder Engagement and Dissemination Assessment Reports

To asses the implementation and impact of the stakeholder engagement and dissemination activities, ACCEL will monitor and document (D9.4, M48) the implemented measures to assess the individual activities and adapt any activities where required to facilitate outreach and impact M24 and 48)

ELSA Training Manual

Training of VANGUARD researchers in M6, in particular newly recruited staff, on the ethical implications and safety requirements involved in regenerative medicine in general and the therapy developed during the VANGUARD project. The existing literature will be reviewed, experts in bioethics consulted, and together with partners we will develop a training manual.

Project website

To support aforementioned dissemination and communication activities throughout the duration of the project, ACCEL will set up and maintain the project website, which will notably function as the main source of information and resources related to the project, partners, latest developments, publications and public deliverables for all stakeholders.

Publicaciones

Vascularized endocrine pancreas for type 1 diabetes

Autores: Bellofatto, Kevin; Lebreton, Fanny; Fonseca, Laura Mar; Hanna, Reine; Bignard, Juliette; Galvan, Victor; Peloso, Andrea; Berney, Thierry; Compagnon, Philippe; VANGUARD Consortium; Berishvili, Ekaterine
Publicado en: Transplantation, Edición 107, 2023, Página(s) 58
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994052.77218.10

Ethics of Early Clinical Trials of Bio-Artificial Organs

Autores: Bunnik, E.M., de Jongh, D. and Massey, E.
Publicado en: Transplant International, Edición 35, 2022, Página(s) 10621, ISSN 0934-0874
Editor: Frontiers Publishing Partnerships
DOI: 10.3389/ti.2022.10621

Generation of Prevascularized Endocrine Constructs to Treat Type 1 Diabetes

Autores: Bellofatto K, Lebreton F, Wassmer CH Fonseca L, Hanna R, Berishvili E.
Publicado en: Transplantation, Edición 9, 2022
Editor: Lippincott Williams & Wilkins
DOI: 10.1097/01.tp.0000885936.38573.32

Hydrogel-based, prevascularized, retrievable endocrine construct to treat Type 1 Diabetes

Autores: Bellofatto K, Lebreton F, Hanna R, Fonseca L M, Bignard J, Galvan V, Peloso A, Berney TH, Compagnon PH, VANGUARD Consortium, Berishvili E.
Publicado en: Transplantation, Edición 107, 2023, Página(s) 57
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994048.59940.dd

Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells

Autores: Lebreton F, Hanna R, Wassmer CH, Bellofatto K, Perez L, Othenin-Girard V, de Tejada BM, Cohen M, Berishvili E.
Publicado en: Stem Cell Reviews and Reports, Edición 18, 2021, Página(s) 346-359, ISSN 1550-8943
Editor: Springer Verlag
DOI: 10.1007/s12015-021-10269-w

Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome

Autores: Honarpisheh M, Lei Y, Zhang Y, Pehl M, Kemter E, Lange A, Wolf E, Wolf-van Buerck L, VANGUARD consortium, Seissler S.
Publicado en: Transplant International, Edición 35, 2022, ISSN 1432-2277
Editor: Frontiers
DOI: 10.3389/ti.2022.10697

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

Autores: Alibashe-Ahmed M., Berney T., Giovannoni L., Berishvili E.
Publicado en: CellR4, Edición 8, 2020, ISSN 2329-7042
Editor: Verduci International
DOI: 10.32113/cellr4_20205_2850

Regulatory Challenges at the Intersection of Cellular and Medical Device Therapies in Europe: The Case of the Bioartificial Pancreas

Autores: Cronin AJ, Thom RL.
Publicado en: Law, Technology and Human, Edición 5(2), 2023, ISSN 2652-4074
Editor: QUT
DOI: 10.5204/lthj.3118

Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Autores: Charles-Henri Wassmer, Ekaterine Berishvili
Publicado en: Current Diabetes Reports, Edición 20/8, 2020, Página(s) 31, ISSN 1534-4827
Editor: Current Science Inc.
DOI: 10.1007/s11892-020-01316-w

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

Autores: Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Publicado en: Transplant International, Edición 33/12, 2020, Página(s) 1577-1588, ISSN 0934-0874
Editor: Blackwell Publishing Inc.
DOI: 10.1111/tri.13721

Organoids: a systematic review of ethical issues

Autores: Dide de Jongh, Emma K. Massey , the VANGUARD consortium*, Eline M. Bunnik
Publicado en: Stem Cell Research & Therapy, Edición 13, 2022, Página(s) 337, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-022-02950-9

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy

Autores: Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Publicado en: Stem Cell Reviews and Reports, Edición 17/1, 2021, Página(s) 63-70, ISSN 2629-3277
Editor: Springer
DOI: 10.1007/s12015-020-10004-x

Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues

Autores: de Jongh, D., Massey, E. K., Cronin, A. J., Schermer, M. H. N., Bunnik, E. M. and the VANGUARD Consortium
Publicado en: Transplant International, Edición 14322277, 2022, ISSN 1432-2277
Editor: Frontiers Publishing Partnership
DOI: 10.3389/ti.2022.10751

Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study

Autores: Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili, Fanny Lebreton
Publicado en: Cell Transplantation, Edición 29, 2020, Página(s) 096368972093729, ISSN 0963-6897
Editor: Cognizant Communication Corp.
DOI: 10.1177/0963689720937292

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Autores: Olgasi, C., Borsotti, C., Merlin, S., Bergmann, T., Bittorf, P., Adewoye, A. B., Wragg, N., Patterson, K., Calabria, A., Benedicenti, F., Cucci, A., Borchiellini, A., Pollio, B., Montini, E., Mazzuca, D. M., Zierau, M., Stolzing, A., Toleikis, P., Braspenning, J., & Follenzi, A.
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 23, 2021, Página(s) 551-566, ISSN 2329-0501
Editor: Cell Press
DOI: 10.1016/j.omtm.2021.10.015

Legal and Regulatory Challenges for Emerging Regenerative Medicine Solutions for Diabetes

Autores: Thom RL, Cronin AJ; VANGUARD Consortium.
Publicado en: Transplantation, Edición 9, 2023, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004797

Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations

Autores: de Jongh D, Thom RL, Cronin AJ, Bunnik EM, Massey EK.
Publicado en: Transplant international, 2023, ISSN 1432-2277
Editor: Frontiers
DOI: 10.3389/ti.2023.11705

From islet of Langerhans transplantation to the bioartificial pancreas

Autores: Thierry Berney; Charles H. Wassmer; Fanny Lebreton; Kevin Bellofatto; Laura Mar Fonseca; Juliette Bignard; Reine Hanna; Andrea Peloso; Ekaterine Berishvili
Publicado en: La Presse Médicale, Edición 9, 2022, ISSN 0755-4982
Editor: Elsevier Masson
DOI: 10.1016/j.lpm.2022.104139

Therapeutic potential of fetal liver cell transplantation in hemophilia A mice

Autores: Simone, Merlin; Saicharan, Akula; Alessia, Cottonaro; Tamara, Garcia-Leal; Luis Javier, Serrano; Ester, Borroni; Vakhtang, Kalandadze; Rocio, Galiano; Chiara, Borsotti; Antonio, Liras; María José, Sanchez; Antonia, Follenzi
Publicado en: Haematologica, Edición 6, 2023, Página(s) 1544-1554, ISSN 1592-8721
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282001

Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives

Autores: Pires, Salomé; Bollini, Sveva; Botelho, Maria Filomena; Lang-Olip, Ingrid; Ponsaerts, Peter; Balbi, Carolina; Lange-Consiglio, Anna; Fénelon, Mathilde; Mojsilović, Slavko; Cremonesi, Fausto; Bugarski, Diana; Berishvili, Ekaterine; Gazouli, Maria; Gellhaus, Alexandra; Kerdjoudj, Halima; Schoeberlein, Andreina
Publicado en: Methods and Protocols, 2023, ISSN 2409-9279
Editor: MDPI
DOI: 10.3390/mps6030045

Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells

Autores: Pignatelli C, Campo F, Neroni A, Piemonti L and Citro A
Publicado en: Transplant International, Edición 14322277, 2022, ISSN 1432-2277
Editor: Frontiers
DOI: 10.3389/ti.2022.10555

Advances and challenges of endocrine pancreas bioengineering

Autores: Hanna, R., & Berishvili, E.
Publicado en: Current Opinion in Endocrine and Metabolic Research, Edición 23, 100320, 2022, ISSN 2451-9650
Editor: Elsevier Ltd.
DOI: 10.1016/j.coemr.2022.100320

I’ve got you under my skin

Autores: Thierry Berney, Ekaterine Berishvili
Publicado en: Nature Metabolism, Edición 2/10, 2020, Página(s) 993-994, ISSN 2522-5812
Editor: Nature Research
DOI: 10.1038/s42255-020-0268-8

Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes

Autores: Wassmer, C.H., Lebreton, F., Bellofatto, K., Perez, L., Cottet-Dumoulin, D., Andres, A., Bosco, D., Berney, T., Othenin-Girard, V., Martinez De Tejada, B., Cohen, M., Follenzi, A., Berishvili, E., and the VANGUARD Consortium
Publicado en: Transplant International, Edición 35, 2022, ISSN 1432-2277
Editor: Frontiers
DOI: 10.3389/ti.2021.10214

Organoïdes sécréteurs d’insuline

Autores: Fanny Lebreton, Charles-Henri Wassmer, Kevin Belofatto, Thierry Berney, Ekaterine Berishvili
Publicado en: médecine/sciences, Edición 36/10, 2020, Página(s) 879-885, ISSN 0767-0974
Editor: Editions E D K
DOI: 10.1051/medsci/2020129

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