Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Livrables

Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Dissemination, communication & outreach strategy
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Data harmonisation process for public use
Project website and communication materials
Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Data Coordination Centre
System for dataset incorporation into DCC

Data Management Plan version 1

Publications

DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication

Auteurs: Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil, Henning Tiemeier
Publié dans: Epigenetics, Numéro 18, 2023, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2023.2207253

Epigenetic Inheritance: Impact for Biology and Society

Auteurs: Arzate-Mejia, R. G and Mansuy, I.M.
Publié dans: Environmental Epigenetics, 2022, ISSN 2470-0991
Éditeur: Oxford University Press
DOI: 10.1093/eep/dvac021

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Auteurs: Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Publié dans: Journal of the American Heart Association, Numéro 13, 2024, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Auteurs: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Publié dans: International Journal of Epidemiology, 2021, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyaa267

Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population‐based study

Auteurs: Anna Suleri, Anna‐Sophie Rommel, Alexander Neumann, Mannan Luo, Manon Hillegers, Lotje de Witte, Veerle Bergink, Charlotte A. M. Cecil
Publié dans: Journal of Child Psychology and Psychiatry, Numéro 65, 2024, Page(s) 874-886, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13923

The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability

Auteurs: Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. Morris, Gary Donohoe
Publié dans: Genes, Brain and Behavior, Numéro 22, 2023, ISSN 1601-1848
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/gbb.12850

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

Auteurs: Rodrigo G. Arzate-Mejia, Nancy V.N. Carullo, Isabelle M. Mansuy
Publié dans: Current Opinion in Neurobiology, Numéro 84, 2024, Page(s) 102832, ISSN 0959-4388
Éditeur: Elsevier BV
DOI: 10.1016/j.conb.2023.102832

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Auteurs: Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Publié dans: Molecular Psychiatry, 2023, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Auteurs: Isabel K. Schuurmans, Sander Lamballais, Runyu Zou, Ryan L. Muetzel, Manon H.J. Hillegers, Charlotte A.M. Cecil, Annemarie I. Luik
Publié dans: Journal of Psychiatric Research, Numéro 158, 2023, Page(s) 126-133, ISSN 0022-3956
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2022.12.018

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Auteurs: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Publié dans: Diabetes Care, 2022, ISSN 1939-327X
Éditeur: American Diabetes Association
DOI: 10.2337/dc21-1701

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Auteurs: Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Mar
Publié dans: Molecular Psychiatry, Numéro 29, 2024, Page(s) 348-358, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Auteurs: Boscardin C., Manuella, F. and Mansuy, I.M.
Publié dans: Environmental Epigenetics, 2022, ISSN 2470-0991
Éditeur: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Auteurs: Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Publié dans: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Childhood abuse <i>v.</i> neglect and risk for major psychiatric disorders

Auteurs: Anne Alkema, Mattia Marchi, Jeroen A. J. van der Zaag, Daniëlle van der Sluis, Varun Warrier, null null, Roel A. Ophoff, René S. Kahn, Wiepke Cahn, Jacqueline G. F. M. Hovens, Harriëtte Riese, Floortje Scheepers, Brenda W. J. H. Penninx, Charlotte Cecil, Albertine J. Oldehinkel, Christiaan H. Vinkers, Marco P. M. Boks
Publié dans: Psychological Medicine, Numéro 54, 2024, Page(s) 1598-1609, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291723003471

Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

Auteurs: Nathan J. Cohen, Serena Defina, Sheryl L. Rifas-Shiman, Sabrina Faleschini, Russell S. Kirby, Henian Chen, Ronee Wilson, Kimberly Fryer, Hanan El Marroun, Charlotte A.M. Cecil, Marie-France Hivert, Emily Oken, Henning Tiemeier, Amy C. Alman
Publié dans: BMC Pediatrics, Numéro 23, 2023, ISSN 1471-2431
Éditeur: BioMed Central
DOI: 10.1186/s12887-023-04372-9

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Auteurs: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Publié dans: Clinical Epigenetics, Numéro 15, 2023, Page(s) 148, ISSN 1868-7083
Éditeur: BMC
DOI: 10.1186/s13148-023-01542-5

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Auteurs: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Publié dans: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Éditeur: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Auteurs: Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Publié dans: Frontiers in Genetics, 2022, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

An epigenome-wide association study of child appetitive traits and DNA methylation

Auteurs: Holly A. Harris, Chloe Friedman, Anne P. Starling, Dana Dabelea, Susan L. Johnson, Bernard F. Fuemmeler, Dereje Jima, Susan K. Murphy, Cathrine Hoyo, Pauline W. Jansen, Janine F. Felix, Rosa H. Mulder
Publié dans: Appetite, Numéro 191, 2023, Page(s) 107086, ISSN 0195-6663
Éditeur: Elsevier BV
DOI: 10.1016/j.appet.2023.107086

The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women

Auteurs: Isabel K. Schuurmans, Sanne J.W. Hoepel, Charlotte A.M. Cecil, Manon H.J. Hillegers, M. Arfan Ikram, Annemarie I. Luik
Publié dans: Journal of Alzheimer's Disease, Numéro 93, 2023, Page(s) 97-106, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-220923

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Auteurs: Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Publié dans: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Auteurs: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Publié dans: Preventive Medicine, Numéro 182, 2024, Page(s) 107926, ISSN 0091-7435
Éditeur: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Auteurs: Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Publié dans: Child Development, 2022, ISSN 0009-3920
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Auteurs: Christin S. Kaupper, Sophia M. Blaauwendraad, Charlotte A. M. Cecil, Rosa H. Mulder, Romy Gaillard, Romy Goncalves, Ingo Borggraefe, Berthold Koletzko, Vincent W. V. Jaddoe
Publié dans: Metabolites, Numéro 13, 2023, Page(s) 1140, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo13111140

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Auteurs: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Publié dans: Clinical Epigenetics, 2022, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Plasma neurofilament light chain in association to late‐life depression in the general population

Auteurs: Isabel K. Schuurmans, Mohsen Ghanbari, Charlotte A. M. Cecil, M. Arfan Ikram, Annemarie I. Luik
Publié dans: Psychiatry and Clinical Neurosciences, Numéro 78, 2024, Page(s) 97-103, ISSN 1323-1316
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pcn.13608

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity, and Their Comorbidity

Auteurs: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Carmine M. Pariante, Karim Lekadir, Vincent W.V. Jaddoe, Fadila Serdarevic, Henning Tiemeier, Esther Walton, Janine F. Felix, Charlotte A.M. Cecil
Publié dans: Journal of the American Academy of Child & Adolescent Psychiatry, Numéro 63, 2024, Page(s) 255-265, ISSN 0890-8567
Éditeur: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Fairness and bias correction in machine learning for depression prediction across four study populations

Auteurs: Vien Ngoc Dang, Anna Cascarano, Rosa H. Mulder, Charlotte Cecil, Maria A. Zuluaga, Jerónimo Hernández-González, Karim Lekadir
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-58427-7

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Auteurs: Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Auteurs: Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Publié dans: Epigenetics, Numéro 15/6-7, 2020, Page(s) 750-764, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Auteurs: Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Hüls, Nastassja Koen, Stephanie J. Londo
Publié dans: Molecular Psychiatry, Numéro 28, 2024, Page(s) 5090-5100, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Experiences of acquired brain injury survivors participating in online and hybrid performance arts programmes: an ethnographic study

Auteurs: Elizabeth Rose Taylor, Carolina Estevao, Lucinda Jarrett, Anthony Woods, Nikki Crane, Daisy Fancourt, Carmine Pariante, Fiona Jones
Publié dans: Arts & Health, Numéro 16, 2024, Page(s) 189-205, ISSN 1753-3015
Éditeur: Taylor and Francis Inc.
DOI: 10.1080/17533015.2023.2226697

The Gut Microbiome in Early Life Stress: A Systematic Review

Auteurs: Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Publié dans: Nutrients, Numéro 15, 2023, Page(s) 2566, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15112566

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Auteurs: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Publié dans: Molecular psychiatry, 2022, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Auteurs: Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 112, 2020, Page(s) 392-409, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Auteurs: Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Publié dans: Psychological Medicine, 2020, Page(s) 1-11, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Auteurs: Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Publié dans: Molecular Psychiatry, 2020, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Auteurs: Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Publié dans: PLOS ONE, Numéro 16/1, 2021, Page(s) e0245475, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0245475

Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

Auteurs: Ellen Verhoef, Andrea G. Allegrini, Philip R. Jansen, Katherine Lange, Carol A. Wang, Angela T. Morgan, Tarunveer S. Ahluwalia, Christos Symeonides, Ole A. Andreassen, Meike Bartels, Dorret Boomsma, Philip S. Dale, Erik Ehli, Dietmar Fernandez-Orth, Mònica Guxens, Christian Hakulinen, Kathleen Mullan Harris, Simon Haworth, Lucía de Hoyos, Vincent Jaddoe, Liisa Keltikangas-Järvinen, Terho Lehtim
Publié dans: Biological Psychiatry, Numéro 95, 2024, Page(s) 859-869, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2023.11.025

Life stress and adiposity in mothers: A 14‐year follow‐up in the general population

Auteurs: Sanne J. W. Hoepel, Isabel K. Schuurmans, Charlotte A. M. Cecil, Vincent W. V. Jaddoe, Annemarie I. Luik
Publié dans: Stress and Health, Numéro 40, 2024, ISSN 1532-2998
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/smi.3290

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Auteurs: Dylan E. Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M. Bazer, Casey E. Hopkinson, Kevin F. Dowling, Alysa E. Doyle, Erin C. Dunn, Hamdi Eryilmaz, Jodi M. Gilman, Daphne J. Holt, Eve M. Valera, Jordan W. Smoller, Charlotte A. M. Cecil, Henning Tiemeier, Phil H. Lee, Joshua L. Roffman
Publié dans: Nature Neuroscience, Numéro 26, 2023, Page(s) 959-969, ISSN 1097-6256
Éditeur: Nature Publishing Group
DOI: 10.1038/s41593-023-01321-8

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Auteurs: Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Publié dans: European Journal of Nutrition, 2021, ISSN 1436-6207
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Keeping It in the Family: Consanguinity Reveals <i>P4HTM</i> as a Novel Syndromic Obesity Gene

Auteurs: Janine F. Felix, Struan F.A. Grant
Publié dans: Diabetes, Numéro 72, 2023, Page(s) 1184-1186, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dbi23-0010

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Auteurs: Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Auteurs: Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Publié dans: Biological Psychiatry, 2022, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

Auteurs: Serena Defina, Carolina C.V. Silva, Charlotte A.M. Cecil, Henning Tiemeier, Janine F. Felix, Ryan L. Mutzel, Vincent W.V. Jaddoe
Publié dans: Hypertension, Numéro 81, 2024, Page(s) 162-171, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.21672

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Auteurs: Cecil C, Neumann A, Walton E
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Auteurs: Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Publié dans: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

What are Sertoli cells? Historical, methodological, and functional aspects

Auteurs: Kristina M. Thumfart, Isabelle M. Mansuy
Publié dans: Andrology, Numéro 11, 2023, Page(s) 849-859, ISSN 2047-2919
Éditeur: Wiley Periodicals LLC
DOI: 10.1111/andr.13386

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

Auteurs: Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H. Vinkers, Erik J. Giltay, Edith J. Liemburg, Brenda W. J. H. Penninx
Publié dans: Psychological Medicine, Numéro 54, 2024, Page(s) 1373-1381, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291723003264

Genome-wide DNA methylation patterns associated with general psychopathology in children

Auteurs: Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Publié dans: Journal of Psychiatric Research, Numéro 140, 2021, Page(s) 214-220, ISSN 0022-3956
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Auteurs: Cecil CAM & Nigg JT
Publié dans: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Éditeur: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Auteurs: Vilte Baltramonaityte, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Priyanka Choudhary, Marjo-Riitta Järvelin, Brenda W. J. H. Penninx, Janine Felix, Sylvain Sebert, Yuri Milaneschi, Esther Walton, null null
Publié dans: PLOS Genetics, Numéro 19, 2023, Page(s) e1010508, ISSN 1553-7404
Éditeur: PLOS Genetics
DOI: 10.1371/journal.pgen.1010508

Single-cell multiomics techniques: from conception to applications.

Auteurs: Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Publié dans: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Éditeur: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Auteurs: Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Publié dans: JAMA Network Open., 2022, ISSN 2574-3805
Éditeur: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Auteurs: Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Publié dans: Nucleic Acids Research, Numéro 49/D1, 2020, Page(s) D82-D85, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Auteurs: Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Publié dans: Microbiology Resource Announcements, Numéro 10/4, 2021, ISSN 2576-098X
Éditeur: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Auteurs: Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Publié dans: Child Abuse & Neglect, 2022, ISSN 0145-2134
Éditeur: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Auteurs: Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Publié dans: JCPP Advances, 2022, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Remembering through the genome: the role of chromatin states in brain functions and diseases

Auteurs: Rodrigo G. Arzate-Mejia, Isabelle M. Mansuy
Publié dans: Translational Psychiatry, Numéro 13, 2023, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-023-02415-4

<scp>DNA</scp> methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study

Auteurs: Mannan Luo, Esther Walton, Alexander Neumann, Chris H. L. Thio, Janine F. Felix, Marinus H. van IJzendoorn, Irene Pappa, Charlotte A. M. Cecil
Publié dans: Journal of Child Psychology and Psychiatry, Numéro 65, 2023, Page(s) 77-90, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13866

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Auteurs: Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Publié dans: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Éditeur: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Auteurs: McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Publié dans: Molecular Psychiatry, 2022, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Auteurs: Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Publié dans: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023)

Auteurs: Charlotte A. M. Cecil, Isabel K. Schuurmans
Publié dans: Research on Child and Adolescent Psychopathology, Numéro 51, 2023, Page(s) 1805-1808, ISSN 2730-7166
Éditeur: Springer
DOI: 10.1007/s10802-023-01103-7

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Auteurs: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Publié dans: Human Molecular Genetics, Numéro 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Auteurs: Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Publié dans: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Auteurs: Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Publié dans: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numéro 186/4, 2021, Page(s) 228-241, ISSN 1552-4841
Éditeur: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Auteurs: Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Publié dans: Frontiers in Genetics, Numéro 11, 2020, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Auteurs: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Pen
Publié dans: BMC Medicine, Numéro 21, 2023, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Auteurs: Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Publié dans: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Éditeur: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Auteurs: Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Publié dans: Brain, Behavior, and Immunity, Numéro 118, 2024, Page(s) 117-127, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2024.02.024

EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests

Auteurs: Victor Ibañez, Laurens Bohlen, Francesca Manuella, Isabelle Mansuy, Fritjof Helmchen, Anna-Sophia Wahl
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-31094-w

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Auteurs: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Publié dans: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Auteurs: Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Publié dans: The Lancet Psychiatry, Numéro 8/5, 2021, Page(s) 373-386, ISSN 2215-0366
Éditeur: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Auteurs: Esther Walton, Vilte Baltramonaityte, Vince Calhoun, Bastiaan T. Heijmans, Paul M. Thompson, Charlotte A. M. Cecil
Publié dans: Molecular Psychiatry, Numéro 28, 2023, Page(s) 2839-2847, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02067-2

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Auteurs: Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Publié dans: Translational Psychiatry, Numéro 10/1, 2020, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Auteurs: Mansuy, I.M., Gurret, J.M. Lelief, A.
Publié dans: 2020
Éditeur: Berlin Verlag

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