Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Resultado final

Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Dissemination, communication & outreach strategy
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Data harmonisation process for public use
Project website and communication materials
Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Data Coordination Centre
System for dataset incorporation into DCC

Data Management Plan version 1

Publicaciones

DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication

Autores: Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil, Henning Tiemeier
Publicado en: Epigenetics, Edición 18, 2023, ISSN 1559-2294
Editor: Landes Bioscience
DOI: 10.1080/15592294.2023.2207253

Epigenetic Inheritance: Impact for Biology and Society

Autores: Arzate-Mejia, R. G and Mansuy, I.M.
Publicado en: Environmental Epigenetics, 2022, ISSN 2470-0991
Editor: Oxford University Press
DOI: 10.1093/eep/dvac021

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Autores: Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Publicado en: Journal of the American Heart Association, Edición 13, 2024, ISSN 2047-9980
Editor: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Autores: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Publicado en: International Journal of Epidemiology, 2021, ISSN 0300-5771
Editor: Oxford University Press
DOI: 10.1093/ije/dyaa267

Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population‐based study

Autores: Anna Suleri, Anna‐Sophie Rommel, Alexander Neumann, Mannan Luo, Manon Hillegers, Lotje de Witte, Veerle Bergink, Charlotte A. M. Cecil
Publicado en: Journal of Child Psychology and Psychiatry, Edición 65, 2024, Página(s) 874-886, ISSN 0021-9630
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13923

The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability

Autores: Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. Morris, Gary Donohoe
Publicado en: Genes, Brain and Behavior, Edición 22, 2023, ISSN 1601-1848
Editor: Blackwell Publishing Inc.
DOI: 10.1111/gbb.12850

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

Autores: Rodrigo G. Arzate-Mejia, Nancy V.N. Carullo, Isabelle M. Mansuy
Publicado en: Current Opinion in Neurobiology, Edición 84, 2024, Página(s) 102832, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2023.102832

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Autores: Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Publicado en: Molecular Psychiatry, 2023, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Autores: Isabel K. Schuurmans, Sander Lamballais, Runyu Zou, Ryan L. Muetzel, Manon H.J. Hillegers, Charlotte A.M. Cecil, Annemarie I. Luik
Publicado en: Journal of Psychiatric Research, Edición 158, 2023, Página(s) 126-133, ISSN 0022-3956
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2022.12.018

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Autores: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Publicado en: Diabetes Care, 2022, ISSN 1939-327X
Editor: American Diabetes Association
DOI: 10.2337/dc21-1701

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Autores: Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Mar
Publicado en: Molecular Psychiatry, Edición 29, 2024, Página(s) 348-358, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Autores: Boscardin C., Manuella, F. and Mansuy, I.M.
Publicado en: Environmental Epigenetics, 2022, ISSN 2470-0991
Editor: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Autores: Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Publicado en: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Childhood abuse <i>v.</i> neglect and risk for major psychiatric disorders

Autores: Anne Alkema, Mattia Marchi, Jeroen A. J. van der Zaag, Daniëlle van der Sluis, Varun Warrier, null null, Roel A. Ophoff, René S. Kahn, Wiepke Cahn, Jacqueline G. F. M. Hovens, Harriëtte Riese, Floortje Scheepers, Brenda W. J. H. Penninx, Charlotte Cecil, Albertine J. Oldehinkel, Christiaan H. Vinkers, Marco P. M. Boks
Publicado en: Psychological Medicine, Edición 54, 2024, Página(s) 1598-1609, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291723003471

Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

Autores: Nathan J. Cohen, Serena Defina, Sheryl L. Rifas-Shiman, Sabrina Faleschini, Russell S. Kirby, Henian Chen, Ronee Wilson, Kimberly Fryer, Hanan El Marroun, Charlotte A.M. Cecil, Marie-France Hivert, Emily Oken, Henning Tiemeier, Amy C. Alman
Publicado en: BMC Pediatrics, Edición 23, 2023, ISSN 1471-2431
Editor: BioMed Central
DOI: 10.1186/s12887-023-04372-9

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autores: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Publicado en: Clinical Epigenetics, Edición 15, 2023, Página(s) 148, ISSN 1868-7083
Editor: BMC
DOI: 10.1186/s13148-023-01542-5

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Autores: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Publicado en: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Editor: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Autores: Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Publicado en: Frontiers in Genetics, 2022, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

An epigenome-wide association study of child appetitive traits and DNA methylation

Autores: Holly A. Harris, Chloe Friedman, Anne P. Starling, Dana Dabelea, Susan L. Johnson, Bernard F. Fuemmeler, Dereje Jima, Susan K. Murphy, Cathrine Hoyo, Pauline W. Jansen, Janine F. Felix, Rosa H. Mulder
Publicado en: Appetite, Edición 191, 2023, Página(s) 107086, ISSN 0195-6663
Editor: Elsevier BV
DOI: 10.1016/j.appet.2023.107086

The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women

Autores: Isabel K. Schuurmans, Sanne J.W. Hoepel, Charlotte A.M. Cecil, Manon H.J. Hillegers, M. Arfan Ikram, Annemarie I. Luik
Publicado en: Journal of Alzheimer's Disease, Edición 93, 2023, Página(s) 97-106, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-220923

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Autores: Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Publicado en: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Autores: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Publicado en: Preventive Medicine, Edición 182, 2024, Página(s) 107926, ISSN 0091-7435
Editor: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Autores: Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Publicado en: Child Development, 2022, ISSN 0009-3920
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Autores: Christin S. Kaupper, Sophia M. Blaauwendraad, Charlotte A. M. Cecil, Rosa H. Mulder, Romy Gaillard, Romy Goncalves, Ingo Borggraefe, Berthold Koletzko, Vincent W. V. Jaddoe
Publicado en: Metabolites, Edición 13, 2023, Página(s) 1140, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo13111140

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Autores: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Publicado en: Clinical Epigenetics, 2022, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Plasma neurofilament light chain in association to late‐life depression in the general population

Autores: Isabel K. Schuurmans, Mohsen Ghanbari, Charlotte A. M. Cecil, M. Arfan Ikram, Annemarie I. Luik
Publicado en: Psychiatry and Clinical Neurosciences, Edición 78, 2024, Página(s) 97-103, ISSN 1323-1316
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pcn.13608

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity, and Their Comorbidity

Autores: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Carmine M. Pariante, Karim Lekadir, Vincent W.V. Jaddoe, Fadila Serdarevic, Henning Tiemeier, Esther Walton, Janine F. Felix, Charlotte A.M. Cecil
Publicado en: Journal of the American Academy of Child & Adolescent Psychiatry, Edición 63, 2024, Página(s) 255-265, ISSN 0890-8567
Editor: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Fairness and bias correction in machine learning for depression prediction across four study populations

Autores: Vien Ngoc Dang, Anna Cascarano, Rosa H. Mulder, Charlotte Cecil, Maria A. Zuluaga, Jerónimo Hernández-González, Karim Lekadir
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-58427-7

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Autores: Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Publicado en: JCPP Advances, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Autores: Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Publicado en: Epigenetics, Edición 15/6-7, 2020, Página(s) 750-764, ISSN 1559-2294
Editor: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Autores: Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Hüls, Nastassja Koen, Stephanie J. Londo
Publicado en: Molecular Psychiatry, Edición 28, 2024, Página(s) 5090-5100, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Experiences of acquired brain injury survivors participating in online and hybrid performance arts programmes: an ethnographic study

Autores: Elizabeth Rose Taylor, Carolina Estevao, Lucinda Jarrett, Anthony Woods, Nikki Crane, Daisy Fancourt, Carmine Pariante, Fiona Jones
Publicado en: Arts & Health, Edición 16, 2024, Página(s) 189-205, ISSN 1753-3015
Editor: Taylor and Francis Inc.
DOI: 10.1080/17533015.2023.2226697

The Gut Microbiome in Early Life Stress: A Systematic Review

Autores: Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Publicado en: Nutrients, Edición 15, 2023, Página(s) 2566, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15112566

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Autores: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Publicado en: Molecular psychiatry, 2022, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Autores: Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Publicado en: Neuroscience & Biobehavioral Reviews, Edición 112, 2020, Página(s) 392-409, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Autores: Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Publicado en: Psychological Medicine, 2020, Página(s) 1-11, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Autores: Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Publicado en: Molecular Psychiatry, 2020, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Autores: Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Publicado en: PLOS ONE, Edición 16/1, 2021, Página(s) e0245475, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0245475

Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

Autores: Ellen Verhoef, Andrea G. Allegrini, Philip R. Jansen, Katherine Lange, Carol A. Wang, Angela T. Morgan, Tarunveer S. Ahluwalia, Christos Symeonides, Ole A. Andreassen, Meike Bartels, Dorret Boomsma, Philip S. Dale, Erik Ehli, Dietmar Fernandez-Orth, Mònica Guxens, Christian Hakulinen, Kathleen Mullan Harris, Simon Haworth, Lucía de Hoyos, Vincent Jaddoe, Liisa Keltikangas-Järvinen, Terho Lehtim
Publicado en: Biological Psychiatry, Edición 95, 2024, Página(s) 859-869, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2023.11.025

Life stress and adiposity in mothers: A 14‐year follow‐up in the general population

Autores: Sanne J. W. Hoepel, Isabel K. Schuurmans, Charlotte A. M. Cecil, Vincent W. V. Jaddoe, Annemarie I. Luik
Publicado en: Stress and Health, Edición 40, 2024, ISSN 1532-2998
Editor: John Wiley & Sons Inc.
DOI: 10.1002/smi.3290

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Autores: Dylan E. Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M. Bazer, Casey E. Hopkinson, Kevin F. Dowling, Alysa E. Doyle, Erin C. Dunn, Hamdi Eryilmaz, Jodi M. Gilman, Daphne J. Holt, Eve M. Valera, Jordan W. Smoller, Charlotte A. M. Cecil, Henning Tiemeier, Phil H. Lee, Joshua L. Roffman
Publicado en: Nature Neuroscience, Edición 26, 2023, Página(s) 959-969, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-023-01321-8

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Autores: Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Publicado en: European Journal of Nutrition, 2021, ISSN 1436-6207
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Keeping It in the Family: Consanguinity Reveals <i>P4HTM</i> as a Novel Syndromic Obesity Gene

Autores: Janine F. Felix, Struan F.A. Grant
Publicado en: Diabetes, Edición 72, 2023, Página(s) 1184-1186, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/dbi23-0010

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Autores: Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Publicado en: JCPP Advances, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Autores: Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Publicado en: Biological Psychiatry, 2022, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

Autores: Serena Defina, Carolina C.V. Silva, Charlotte A.M. Cecil, Henning Tiemeier, Janine F. Felix, Ryan L. Mutzel, Vincent W.V. Jaddoe
Publicado en: Hypertension, Edición 81, 2024, Página(s) 162-171, ISSN 0194-911X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.21672

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Autores: Cecil C, Neumann A, Walton E
Publicado en: JCPP Advances, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Autores: Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Publicado en: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

What are Sertoli cells? Historical, methodological, and functional aspects

Autores: Kristina M. Thumfart, Isabelle M. Mansuy
Publicado en: Andrology, Edición 11, 2023, Página(s) 849-859, ISSN 2047-2919
Editor: Wiley Periodicals LLC
DOI: 10.1111/andr.13386

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

Autores: Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H. Vinkers, Erik J. Giltay, Edith J. Liemburg, Brenda W. J. H. Penninx
Publicado en: Psychological Medicine, Edición 54, 2024, Página(s) 1373-1381, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291723003264

Genome-wide DNA methylation patterns associated with general psychopathology in children

Autores: Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Publicado en: Journal of Psychiatric Research, Edición 140, 2021, Página(s) 214-220, ISSN 0022-3956
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Autores: Cecil CAM & Nigg JT
Publicado en: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Editor: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Autores: Vilte Baltramonaityte, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Priyanka Choudhary, Marjo-Riitta Järvelin, Brenda W. J. H. Penninx, Janine Felix, Sylvain Sebert, Yuri Milaneschi, Esther Walton, null null
Publicado en: PLOS Genetics, Edición 19, 2023, Página(s) e1010508, ISSN 1553-7404
Editor: PLOS Genetics
DOI: 10.1371/journal.pgen.1010508

Single-cell multiomics techniques: from conception to applications.

Autores: Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Publicado en: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Autores: Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Publicado en: JAMA Network Open., 2022, ISSN 2574-3805
Editor: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Autores: Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Publicado en: Nucleic Acids Research, Edición 49/D1, 2020, Página(s) D82-D85, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Autores: Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Publicado en: Microbiology Resource Announcements, Edición 10/4, 2021, ISSN 2576-098X
Editor: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Autores: Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Publicado en: Child Abuse & Neglect, 2022, ISSN 0145-2134
Editor: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Autores: Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Publicado en: JCPP Advances, 2022, ISSN 0021-9630
Editor: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Remembering through the genome: the role of chromatin states in brain functions and diseases

Autores: Rodrigo G. Arzate-Mejia, Isabelle M. Mansuy
Publicado en: Translational Psychiatry, Edición 13, 2023, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-023-02415-4

<scp>DNA</scp> methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study

Autores: Mannan Luo, Esther Walton, Alexander Neumann, Chris H. L. Thio, Janine F. Felix, Marinus H. van IJzendoorn, Irene Pappa, Charlotte A. M. Cecil
Publicado en: Journal of Child Psychology and Psychiatry, Edición 65, 2023, Página(s) 77-90, ISSN 0021-9630
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13866

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Autores: Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Publicado en: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Editor: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Autores: McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Publicado en: Molecular Psychiatry, 2022, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Autores: Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Publicado en: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023)

Autores: Charlotte A. M. Cecil, Isabel K. Schuurmans
Publicado en: Research on Child and Adolescent Psychopathology, Edición 51, 2023, Página(s) 1805-1808, ISSN 2730-7166
Editor: Springer
DOI: 10.1007/s10802-023-01103-7

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Autores: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Publicado en: Human Molecular Genetics, Edición 30/1, 2021, Página(s) 119-134, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Autores: Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Publicado en: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Autores: Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Publicado en: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Edición 186/4, 2021, Página(s) 228-241, ISSN 1552-4841
Editor: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Autores: Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Publicado en: Frontiers in Genetics, Edición 11, 2020, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Autores: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Pen
Publicado en: BMC Medicine, Edición 21, 2023, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Autores: Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Publicado en: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Editor: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Autores: Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Publicado en: Brain, Behavior, and Immunity, Edición 118, 2024, Página(s) 117-127, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2024.02.024

EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests

Autores: Victor Ibañez, Laurens Bohlen, Francesca Manuella, Isabelle Mansuy, Fritjof Helmchen, Anna-Sophia Wahl
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-31094-w

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Autores: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Publicado en: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Autores: Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Publicado en: The Lancet Psychiatry, Edición 8/5, 2021, Página(s) 373-386, ISSN 2215-0366
Editor: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Autores: Esther Walton, Vilte Baltramonaityte, Vince Calhoun, Bastiaan T. Heijmans, Paul M. Thompson, Charlotte A. M. Cecil
Publicado en: Molecular Psychiatry, Edición 28, 2023, Página(s) 2839-2847, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-023-02067-2

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Autores: Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Publicado en: Translational Psychiatry, Edición 10/1, 2020, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Autores: Mansuy, I.M., Gurret, J.M. Lelief, A.
Publicado en: 2020
Editor: Berlin Verlag

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