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Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Descrizione del progetto

L’impatto dello stress infantile in età avanzata

Lo stress infantile (Early Life Stress, ELS) è un principale fattore di rischio per la depressione e due delle sue principali comorbilità fisiche: malattia coronarica e diabete. Alcune ricerche suggeriscono che la depressione si sviluppi a partire da un’interazione complessa tra processi biologici e fisiologici. Il progetto EarlyCause, finanziato dall’UE, identificherà i contributi biologici da quattro ambiti chiave interconnessi: epigenetica, infiammazione, sistema neuroendocrino e microbioma. Esso prenderà in considerazione gli effetti di fattori quali sesso/genere, socioeconomia, stile di vita e comportamento. Il progetto combinerà ricerca di base, preclinica e clinica, tra cui metodi di inferenza causali, modelli animali di stress potenziale e postnatale, modelli cellulari in vari tessuti, bioinformatica integrativa e metodi di apprendimento automatico. Gli esiti approfondiranno la nostra comprensione di biomarcatori e risultati di innovazione in relazione a nuove percorsi di assistenza integrati.

Obiettivo

EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals.

To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity.

Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.

Invito a presentare proposte

H2020-SC1-BHC-2018-2020

Vedi altri progetti per questo bando

Bando secondario

H2020-SC1-2019-Two-Stage-RTD

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERSITAT DE BARCELONA
Contribution nette de l'UE
€ 887 156,25
Indirizzo
GRAN VIA DE LES CORTS CATALANES 585
08007 Barcelona
Spagna

Mostra sulla mappa

Regione
Este Cataluña Barcelona
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 887 156,25

Partecipanti (14)