Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions

Risultati finali

Report on the monitoring strategy adopted
Report on SOPs and templates

Pubblicazioni

Plasma proteins elevated in severe asthma despite oral steroiduse and unrelated to Type-2 inflammation

Autori: Maria Sparreman Mikus, Johan Kolmert, Lars I. Andersson, Jörgen Östling, Richard G. Knowles, Cristina Gómez, Magnus Ericsson, John-Olof Thörngren, Payam Emami Khoonsari, Barbro Dahlén, Maciej Kupczyk, Bertrand De Meulder, Charles Auffray, Per S. Bakke, Bianca Beghe, Elisabeth H. Bel, Massimo Caruso, Pascal Chanez, Bo Chawes, Stephen J. Fowler, Mina Gaga, Thomas Geiser, Mark Gjomarkaj, Ildikó
Pubblicato in: European Respiratory journal, Numero 13993003, 2022, ISSN 1399-3003
Editore: European Respiratory Society
DOI: 10.1183/13993003.00142-2021

Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Autori: Khaleva, Ekaterina; Rattu, Anna; Brightling, Chris; Bush, Andrew; Bossios, Apostolos; Bourdin, Arnaud; Chung, Kian Fan; Chaudhuri, Rekha; Coleman, Courtney; Dahlén, Sven Erik; Djukanovic, Ratko; Deschildre, Antoine; Fleming, Louise; Fowler, Stephen J.; Gupta, Atul; Hamelmann, Eckard; Hashimoto, Simone; Hedlin, Gunilla; Koppelman, Gerard H.; Melén, Erik; Murray, Clare S.; Pilette, Charles; Porsbj
Pubblicato in: EUROPEAN RESPIRATORY JOURNAL, Numero 5, 2023, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.00606-2022

Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus

Autori: Julius Lindblom, Daniel Toro-Domínguez, Elena Carnero-Montoro, Lorenzo Beretta, Maria Orietta Borghi, Jessica Castillo, Yvonne Enman, PRECISESADS Clinical Consortium, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Ioannis Parodis
Pubblicato in: Journal of Autoimmunity Volume 136, April 2023, 103025, 2023, ISSN 1095-9157
Editore: Elsevier
DOI: 10.1016/j.jaut.2023.103025

Core outcome sets, developed collaboratively with patients, can improve the relevance and comparability of clinical trials

Autori: Alexander G. Mathioudakis, Ekaterina Khaleva, Markus Fally, Paula R. Williamson, Jens-Ulrik Jensen, Tim W. Felton, Chris Brightling, Andrew Bush, Tonya Winders, John Linnell, Valeria Ramiconi, Courtney Coleman, Tobias Welte, Graham Roberts, Jørgen Vestbo
Pubblicato in: ERS Journal, 2023, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.02107-2022

Transcription Factor Activity Inference in Systemic Lupus Erythematosus

Autori: Raúl López-Domínguez, Daniel Toro-Domínguez, Jordi Martorell-Marugan, Adrian García-Moreno, Christian H. Holland, Julio Saez-Rodriguez, Daniel Goldman, Michelle Petri, Marta E. Alarcón-Riquelme and Pedro Carmona-Sáez
Pubblicato in: Life, Numero 20751729, 2021, ISSN 2075-1729
Editore: MDPI
DOI: 10.3390/life11040299

Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Autori: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero 203/1, 2021, Pagina/e 37-53, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.201909-1869oc

Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohort

Autori: Ioannis Parodis, Julius Lindblom, Guillermo Barturen, Rafaela Ortega-Castro, Ricard Cervera, Jacques-Olivier Pers, Fernanda Genre, Falk Hiepe, Maria Gerosa, László Kovács, Ellen De Langhe, Silvia Piantoni , Georg Stummvoll, Carlos Vasconcelos, Barbara Vigone, Torsten Witte; PRECISESADS Clinical Consortium; Marta E Alarcón-Riquelme, Lorenzo Beretta
Pubblicato in: Annals of the Rheumatic Diseases, 2024, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-224795

Definitions of non-response and response to biological therapy for severe asthma: a systematic review

Autori: Ekaterina Khaleva; Anna Rattu; Chris Brightling; Andrew Bush; Arnaud Bourdin; Apostolos Bossios; Kian Fan Chung; Rekha Chaudhuri; Courtney Coleman; Ratko Djukanovic; Sven-Erik Dahlén; Andrew Exley; Louise Fleming; Stephen J. Fowler; Atul Gupta; Eckard Hamelmann; Gerard H. Koppelman; Erik Melén; Vera Mahler; Paul Seddon; Florian Singer; Celeste Porsbjerg; Valeria Ramiconi; Franca Rusconi; Valenty
Pubblicato in: "ERJ Open Research, 2023, 9 (3), pp.00444-2022. ⟨10.1183/23120541.00444-2022⟩", Numero 3, 2023, ISSN 2312-0541
Editore: European Respiratory Society
DOI: 10.1183/23120541.00444-2022

Serum profiling identifies CCL8, CXCL13, and IL-1RA as markers of active disease in patients with systemic lupus erythematosus

Autori: Julius Lindblom, Lorenzo Beretta, Maria Orietta Borghi, and PRECISESADS Clinical Consortium, Marta E. Alarcón-Riquelme, Ioannis Parodis
Pubblicato in: Front Immunol, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1257085

Risankizumab in severe asthma: A Phase IIa, placebo-controlled study

Autori: Christopher E. Brightling, Parameswaran Nair, Renaud Louis, Dave Singh
Pubblicato in: The New England Journal of Medicine, 2021, ISSN 1533-4406
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmoa2030880

Convert-Pheno: A software toolkit for the interconversion of standard data models for phenotypic data

Autori: Manuel Rueda, Ivo C Leist, Ivo G Gut
Pubblicato in: J Biomed Inform, 2024, ISSN 1532-0480
Editore: Elsevier
DOI: 10.1016/j.jbi.2023.104558

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

Autori: Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner, Anna Henning, Lina Welz, Nassim Kakavand, Maren Falk-Paulsen, Simon Imm, Finn Hinrichsen, Matthias Zilbauer, Stefan Schreiber, Arthur Kaser, Ri
Pubblicato in: Gastroenterology, Numero 159/4, 2020, Pagina/e 1357-1374.e10, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.088

Current Insights on Biomarkers in Lupus Nephritis: A Systematic Review of the Literature

Autori: Leonardo Palazzo, Julius Lindblom, Chandra Mohan, Ioannis Parodis
Pubblicato in: J. Clin. Med., 2022, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11195759

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Autori: Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra & Philip Rosenstiel
Pubblicato in: Nature communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33844-2

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma

Autori: Lars H. Nordenmark, Ph.D., Åsa Hellqvist, M.Sc., Claire Emson, Ph.D., Sarah Diver, M.D., Celeste Porsbjerg, M.D., Ph.D., Janet M. Griffiths, Ph.D., John D. Newell, Jr, M.D., +5, and Christopher E. Brightling, F.Med.Sci.
Pubblicato in: NEJM Evidence, 2023, ISSN 2766-5526
Editore: NEJM group
DOI: 10.1056/evidoa2300135

Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential

Autori: Ana Cvetko, Domagoj Kifer, Olga Gornik, Lucija Klarić, Elizabeth Visser, Gordan Lauc, James F. Wilson, Tamara Štambuk
Pubblicato in: Biomedicines, Numero 8/10, 2020, Pagina/e 410, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines8100410

Immune-Related Urine Biomarkers for the Diagnosis of Lupus Nephritis

Autori: Morell M., Pérez-Cózar F, Marañón C.
Pubblicato in: International Journal of Molecular Science, Numero 14220067, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137143

Stabilization of Human Whole Blood Samples for Multicenter and Retrospective Immunophenotyping Studies

Autori: Paulina Rybakowska, Catalina Burbano, Sofie Van Gassen, Nieves Varela, Rocío Aguilar‐Quesada, Yvan Saeys, Marta E. Alarcón‐Riquelme, Concepción Marañón
Pubblicato in: Cytometry Part A, 2020, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24241

PeacoQC: Peak-based selection of high quality cytometry data

Autori: Annelies Emmaneel, Katrien Quintelier, Dorine Sichien, Paulina Rybakowska, Concepción Marañón, Marta E. Alarcón-Riquelme, Gert Van Isterdael, Sofie Van Gassen, Yvan Saeys
Pubblicato in: Cytometry Part A, Numero 15524930, 2021, Pagina/e 325-338, ISSN 1552-4930
Editore: International Society for Advancement of Cytometry
DOI: 10.1002/cyto.a.24501

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

Autori: Olivia Castellini-Pérez, Elena Povedano, Guillermo Barturen, Manuel Martínez-Bueno, Andrii Iakovliev, Martin Kerick, Raúl López-Domínguez, Concepción Marañón, Javier Martín, Esteban Ballestar, PRECISEADS Clinical Consortium, PRECISEADS Flow Cytometry Study Group, María Orietta Borghi, Weiliang Qiu, Cheng Zhu, Srinivas Shankara, Athina Spiliopoulou, Emanuele de Rinaldis, Elena Carnero-Mon
Pubblicato in: npj Genomic Medicine, Numero 9, 38, 2024, ISSN 2056-7944
Editore: Springer Nature
DOI: 10.1038/s41525-024-00420-0

HLA-DRB1 and HLA-DQA1 associated with immunogenicity to adalimumab therapy in patients with rheumatoid arthritis

Autori: Chuan Fu Yap, Nisha Nair, Annick de Vries, Floris C Loeff, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme L Hyrich, Anne Barton, Darren Plant
Pubblicato in: Ann Rheum Dis., 2024, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-223955

Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease

Autori: Neha Mishra, Konrad Aden, Johanna I. Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B. Sørensen, Silja H. Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A. Lyons, Joachim L. Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T. Dermitzakis, Stefan Schreiber & Philip Ros
Pubblicato in: Genome Medicine, 2022, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-022-01112-z

Rare Variants in Systemic Lupus Erythematosus: From Monogenic to Polygenic Disease

Autori: Ruth D. Rodríguez, Marta E. Alarcón-Riquelme
Pubblicato in: Medical Research Archives, 2023, ISSN 2375-1916
Editore: European Society of Medicine
DOI: 10.18103/mra.v11i10.4363

Scoring personalized molecular portraits identify Systemic Lupus Erythematosus subtypes and predict individualized drug responses, symptomatology and disease progression

Autori: Daniel Toro-Domínguez, Jordi Martorell-Marugán, Manuel Martinez-Bueno, Raúl López-Domínguez, Elena Carnero-Montoro, Guillermo Barturen, Daniel Goldman, Michelle Petri, Pedro Carmona-Sáez, Marta E Alarcón-Riquelme
Pubblicato in: Briefings in Bioinformatics, Numero 14774054, 2022, ISSN 1477-4054
Editore: Oxford University Press
DOI: 10.1093/bib/bbac332

Narrative review to capture patients’ perceptions and opinions about non-response and response to biological therapy for severe asthma

Autori: Courtney Coleman; Ekaterina Khaleva; Anna Rattu; Betty Frankemölle; Hanna Nielsen; Graham Roberts; Clare Williams
Pubblicato in: Crossref, Numero 6, 2023, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.00837-2022

Data processing workflow for large-scale immune monitoring studies by mass cytometry

Autori: Paulina Rybakowska, Sofie Van Gassen, Katrien Quintelier, Yvan Saeys, Marta E. Alarcón-Riquelme, Concepción Marañón
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 19, 2021, Pagina/e 3160-3175, ISSN 2001-0370
Editore: Elsevier
DOI: 10.1016/j.csbj.2021.05.032

The Potential of Computational Modeling to Predict Disease Course and Treatment Response in Patients with Relapsing Multiple Sclerosis

Autori: Francesco Pappalardo, Giulia Russo, Marzio Pennisi, Giuseppe Alessandro Parasiliti Palumbo, Giuseppe Sgroi, Santo Motta, Davide Maimone
Pubblicato in: Cells, Numero 9/3, 2020, Pagina/e 586, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9030586

Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A systematic review and meta-analysis

Autori: David Charles, Jemma Shanley, Sasha-Nicole Temple, Anna Rattu, Ekaterina Khaleva, Graham Roberts
Pubblicato in: Clinical & Experimental Allergy, Numero 13652222, 2022, Pagina/e 616-627, ISSN 1365-2222
Editore: Britisch Society for Allergy & Clinical Immunology
DOI: 10.1111/cea.14112

Identifying and appraising outcome measures for severe asthma: a systematic review

Autori: Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlén, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melén, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts on behalf of the 3TR Conso
Pubblicato in: ERS Journal, 2023, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.01231-2022

Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives

Autori: Florian Tran, Jan Henrik Schirmer, Ilka Ratjen, Wolfgang Lieb, Philip Helliwell, Johan Burisch, Juliane Schulz, Florian Schrinner, Charlot Jaeckel, Ulf Müller-Ladner, Stefan Schreiber, Bimba F. Hoyer
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2021.614653

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Autori: Joana P Bernardes 1, Neha Mishra 1, Florian Tran 2, Thomas Bahmer 3, Lena Best 4, Johanna I Blase 1, Dora Bordoni 1, Jeanette Franzenburg 5, Ulf Geisen 6, Jonathan Josephs-Spaulding 4, Philipp Köhler 7, Axel Künstner 8, Elisa Rosati 1, Anna C Aschenbrenner 9, Petra Bacher 10, Nathan Baran 1, Teide Boysen 1, Burkhard Brandt 11, Niklas Bruse 12, Jonathan Dörr 6, Andreas Dräger 13, Gunnar Elke 14
Pubblicato in: Immunity, Numero 10747613, 2020, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2020.11.017

Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Autori: Florian Tran, Christine Klein, Alexander Arlt, Simon Imm, Evelyn Knappe, Alison Simmons, Philip Rosenstiel, Philip Seibler
Pubblicato in: Frontiers in Immunology, Numero 16643224, 2020, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2020.573562

Tryptophan degradation as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases

Autori: Danielle M M Harris, Silke Szymczak, Sven Schuchardt, Johannes Labrenz, Florian Tran, Lina Welz, Hanna Graßhoff, Henner Zirpel, Melike Sümbül, Mhmd Oumari, Nils Engelbogen, Ralf Junker, Claudio Conrad, Diamant Thaçi, Norbert Frey, Andre Franke, Stephan Weidinger, Bimba Hoyer, Philip Rosenstiel, Silvio Waschina, Stefan Schreiber, Konrad Aden
Pubblicato in: EBio Medicine, 2024, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105056

3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD.

Autori: Celeste Porsbjerg; Anke H. Maitland-van der Zee; Guy Brusselle; Giorgio Walter Canonica; Alvar Agusti; Rosa Faner; Claus Vogelmeier; Martijn C. Nawijn; Maarten van den Berge; Franca Rusconi; Charles Pilette; Valeria Ramiconi; Courtney Coleman; Rekha Chaudhuri; Kian Fan Chung; Jadwiga A. Wedzicha; Sejla Saglani; Marc P. van der Schee; Liam G Heaney; Arnaud Bourdin; Graham Roberts; Graham Roberts; G
Pubblicato in: European Respiratory Journal, 58(4):2102168. EUROPEAN RESPIRATORY SOC JOURNALS LTD, Numero 7, 2021, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.02168-2021

Risankizumab in severe asthma: A Phase IIa, placebo-controlled study

Autori: Brightling, Christopher E.; Nair, Parameswaran; Louis, Renaud; Singh, Dave
Pubblicato in: Airway pharmacology and treatment, Numero 1, 2020
Editore: European Respiratory Society
DOI: 10.1183/13993003.congress-2020.3699

Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design

Autori: Smith SJ, Gillespie L, Heaney LG, Brightling CE , McConnachie A¬, Siddiqui S, Mistry V4, Brown V , Jackson DJ, Lee NW, Fowler SJ, Mansur AH, Burhan H, Saralaya D, Kurukulaaratchy R, Nasser S, Pfeffer P, Brown T, Lordan J, Pavord ID, Chaudhuri R.
Pubblicato in: European Respiratory Journal, 2021, ISSN 1399-3003
Editore: European Respiratory Society
DOI: 10.1183/13993003.congress-2021.pa1108

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