Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

Livrables

Entry of AOP network into AOP-Wiki and submission for OECD review

Report describing the final AOP network

Report on in silico bioavailability triggers applied to TDCs

Status report on the on in silico bioavailability triggers applied to TDCs

Publications

The metabolome of pink-footed goose: Heavy metals and lipid metabolism

Auteurs: Mette Jensen; Rikke Poulsen; Rikke Langebæk; Bjørn Munro Jenssen; Johanna Moe; Tomasz M. Ciesielski; Rune Dietz; Christian Sonne; Jesper Madsen; Martin Hansen
Publié dans: Environmental Research, Numéro 231, 116043, 2023, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2023.116043

Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

Auteurs: Barbara Kubickova, Carmel Ramwell, Klara Hilscherova, Miriam Naomi Jacobs
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, Page(s) 20, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00428-0

Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Auteurs: Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G.
Publié dans: Integrated Environmental Assessment and Management, 2022, ISSN 1551-3793
Éditeur: Society of Environmental Toxicology and Chemistry (SETAC)
DOI: 10.1002/ieam.4632

Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen.

Auteurs: Flamant, F., Zekri, Y. and Guyot, R.
Publié dans: Endocrinology, Numéro 163 (8), 2022, ISSN 0013-7227
Éditeur: The Endocrine Society
DOI: 10.1210/endocr/bqac084

AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure

Auteurs: Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L.
Publié dans: Environmental Toxicology and Chemistry, Numéro Vol 41. Numéro 8, 2022, ISSN 1552-8618
Éditeur: Wiley
DOI: 10.1002/etc.5452

Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish.

Auteurs: Van Dingenen, I., Vergauwen, L., Haigis, A., Blackwell, B. R., Stacy, E., Villeneuve, D. L., & Knapen, D.
Publié dans: Aquatic Toxicology, Numéro 261, 106632, 2023, ISSN 0166-445X
Éditeur: Elsevier BV
DOI: 10.1016/j.aquatox.2023.106632

Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain

Auteurs: Quentin Hamdaoui; Yanis Zekri; Sabine Richard; Denise Aubert; Romain Guyot; Suzy Markossian; Karine Gauthier; François Gaie-Levrel; Anna Bencsik; Frédéric Flamant
Publié dans: Chemosphere, Numéro 287 Part 3, 2022, Page(s) 132253, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2021.132253

An Atlas of Thyroid Hormone Receptors’ Target Genes in Mouse Tissues

Auteurs: Yanis Zekri; Romain Guyot; Frédéric Flamant
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2022.08.16.504127

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish.

Auteurs: Horie, Y., Nomura, M., Okamoto, K., Takahashi, C., Sato, T., Miyagawa, S., Okamura, H., & Iguchi, T.
Publié dans: Journal of Applied Toxicology, Numéro 42(8), 2022, Page(s) 1385–1395, ISSN 1099-1263
Éditeur: Wiley
DOI: 10.1002/jat.4302

Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.

Auteurs: Haigis, A., Vergauwen, L., LaLone, C. A., Villeneuve, D. L., O’Brien, J. M., & Knapen, D.
Publié dans: Toxicological Sciences, 2023, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfad063

Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro

Auteurs: Barbara Kubickova, Sarka Martinkova, Dasa Bohaciakova, Marketa Nezvedova, Runze Liu, Ondrej Brozman, Zdeněk Spáčil, Klara Hilscherova
Publié dans: Toxicology, Numéro 487, 2023, Page(s) 153461, ISSN 0300-483X
Éditeur: Elsevier BV
DOI: 10.1016/j.tox.2023.153461

Reversibility of thyroid hormone system‐disrupting effects on eye and thyroid follicle development in zebrafish (Danio rerio) embryos.

Auteurs: Pannetier, P., Poulsen, R., Gölz, L., Coordes, S., Stegeman, H., Koegst, J., Reger, L., Braunbeck, T., Hansen, M. R. H., & Baumann, L.
Publié dans: Environmental Toxicology and Chemistry, Numéro 42(6), 1276–1292, 2023, ISSN 1552-8618
Éditeur: Wiley
DOI: 10.1002/etc.5608

Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities

Auteurs: Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O.
Publié dans: Frontiers in Toxicology, Numéro Volume 3, Article 787017, 2021, ISSN 2673-3080
Éditeur: Frontiers Media
DOI: 10.3389/ftox.2021.787017

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation.

Auteurs: Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M.
Publié dans: Toxicological Sciences, Numéro Volume 184 Numéro 2, 2021, Page(s) Pages 183–190, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin of Rana [Lithobates] catesbeiana tadpoles and frogs during metamorphosis

Auteurs: Poulsen, Rikke; Jackman, Shireen H.; Hansen, Martin; Helbing, Caren C.
Publié dans: Frontiers in Endocrinology, Numéro 13: 1103051, 2023, ISSN 1664-2392
Éditeur: Frontiers Media
DOI: 10.3389/fendo.2022.1103051

Thyroid hormone as a temporal switch in mouse development

Auteurs: Flamant, F. and Ren, J.
Publié dans: European Thyroid Journal, Numéro 12(2), 2023, ISSN 2235-0802
Éditeur: Bioscientifica
DOI: 10.1530/etj-22-0225

Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes.

Auteurs: Maximilian Kraft; Lisa Gölz; Maximilian Rinderknecht; Johannes Koegst; Thomas Braunbeck; Lisa Baumann
Publié dans: Environmental Science and Pollution Research, Numéro 30, 2023, Page(s) 33711–33724, ISSN 1614-7499
Éditeur: Springer Science + Business Media
DOI: 10.1007/s11356-022-24531-2

Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome

Auteurs: Rikke Poulsen, Yanis Zekri, Romain Guyot, Frédéric Flamant, Martin Hansen
Publié dans: Environmental Pollution, Numéro 340, 2023, Page(s) 122783, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122783

Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study

Auteurs: Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L.
Publié dans: Journal of Hazardous Materials, Numéro vol. 424, 2022, Page(s) 127705, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.127705

A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka

Auteurs: Elise Pesce, Marion Garde, Muriel Rigolet, Andrew J. Tindall, Gregory F. Lemkine, Lisa A. Baumann, Laurent M. Sachs, David Du Pasquier
Publié dans: Environmental Science & Technology, Numéro 58, 2024, Page(s) 99-109, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.3c05515

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.

Auteurs: Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J.
Publié dans: Science signaling, Numéro 15 (738), eabj4583, 2022, ISSN 1945-0877
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abj4583

Endocrine disruption in teleosts and amphibians is mediated by anthropogenic and natural environmental factors: implications for risk assessment

Auteurs: Werner Kloas, Matthias Stöck, Ilka Lutz, Andrea Ziková-Kloas
Publié dans: Philosophical Transactions of the Royal Society B: Biological Sciences, Numéro 379, 2024, ISSN 0962-8436
Éditeur: Royal Society of London
DOI: 10.1098/rstb.2022.0505

Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Auteurs: Zekri, Y., Flamant, F., & Gauthier, K.
Publié dans: Cells, Numéro 10(6):1, 2021, Page(s) 1327-1330, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10061327

In silico bioavailability triggers applied to direct and indirect thyroid hormone disruptors

Auteurs: Ralph Kühne, Klára Hilscherová, Marie Smutna, Friederike Leßmöllmann, Gerrit Schüürmann
Publié dans: Chemosphere, Numéro 348, 2024, Page(s) 140611, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2023.140611

Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges.

Auteurs: Katyeny Manuela Da Silva; Elias Iturrospe; Chloé Bars; Dries Knapen; Steven Van Cruchten; Adrian Covaci; Alexander L.N. van Nuijs
Publié dans: Metabolites, Numéro 2, 2021, ISSN 2218-1989
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11090635

Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

Auteurs: Yanis Zekri; Romain Guyot; Inés Garteizgogeascoa Suñer; Laurence Canaple; Amandine Gautier-Stein; Justine Vily-Petit; Denise Aubert; Sabine Richard; Frédéric Flamant; Karine Gauthier
Publié dans: Elife 11: e81996, Numéro 4, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.81996

A candidate sex determination locus in amphibians which evolved by structural variation between X- and Y-chromosomes

Auteurs: Heiner Kuhl, Wen Hui Tan, Christophe Klopp, Wibke Kleiner, Baturalp Koyun, Mitica Ciorpac, Romain Feron, Martin Knytl, Werner Kloas, Manfred Schartl, Christoph Winkler, Matthias Stöck
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-49025-2

The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?

Auteurs: Teresa Fagundes, Pauline Pannetier, Lisa Gölz, Laura Behnstedt, Jane Morthorst, Lucia Vergauwen, Dries Knapen, Henrik Holbech, Thomas Braunbeck, Lisa Baumann
Publié dans: Aquatic Toxicology, Numéro 272, 2024, Page(s) 106969, ISSN 0166-445X
Éditeur: Elsevier BV
DOI: 10.1016/j.aquatox.2024.106969

Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the ‘extended speciation continuum'

Auteurs: Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K.
Publié dans: Philosophical Transactions of the Royal Society B: Biological Sciences, Numéro vol. 376, no. 1833, 2021, Page(s) p. 20200103, ISSN 0962-8436
Éditeur: Royal Society of London
DOI: 10.1098/rstb.2020.0103

PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes

Auteurs: Nichlas Davidsen; Louise Ramhøj; Claus Asger Lykkebo; Indusha Kugathas; Rikke Poulsen; Anna Kjerstine Rosenmai; Bertrand Evrard; Thomas A. Darde; Marta Axelstad; Martin Iain Bahl; Martin Hansen; Frederic Chalmel; Tine Rask Licht; Terje Svingen
Publié dans: Davidsen , N , Ramhøj , L , Lykkebo , C A , Kugathas , I , Poulsen , R , Rosenmai , A K , Evrard , B , Darde , T A , Axelstad , M , Bahl , M I , Hansen , M , Chalmel , F , Licht , T R & Svingen , T 2022 , ' PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes ' , Environmental Pollution , vol. 305 , 119340 . https://doi.org/10.1016/j.envpol.202, Numéro 2, 2022, Page(s) 119340, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2022.119340

In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods

Auteurs: Runze Liu, Jiří Novák, Klára Hilscherová
Publié dans: Archives of Toxicology, Numéro 98, 2024, Page(s) 2631-2645, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-024-03766-7

Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima)

Auteurs: Even Fjære; Rikke Poulsen; Arne Duinker; Bjørn Liaset; Martin Hansen; Lise Madsen; Lene Secher Myrmel
Publié dans: Foods, Numéro 11: 24, 2022, ISSN 2304-8158
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/foods11243943

Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution

Auteurs: Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N.
Publié dans: Philosophical Transactions of the Royal Society B: Biological Sciences, Numéro vol. 376, no. 1833, 2021, Page(s) p. 20200097, ISSN 0962-8436
Éditeur: Royal Society of London
DOI: 10.1098/rstb.2020.0097

Bisphenol A alters retinal morphology, visually guided behavior, and thyroid hormone levels in zebrafish larvae

Auteurs: Sina N. Volz, Rikke Poulsen, Martin Hansen, Henrik Holbech
Publié dans: Chemosphere, Numéro 348, 2024, Page(s) 140776, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2023.140776

Polyquaternium polymers cause inflammatory response and alterations of the lipidome in Danio rerio larvae

Auteurs: Anna Magdalene Brun Hansen, Rikke Poulsen, Louise von Gersdorff Jørgensen, Martin Hansen
Publié dans: Journal of Hazardous Materials Letters, Numéro 5, 2024, Page(s) 100095, ISSN 2666-9110
Éditeur: Elsevier
DOI: 10.1016/j.hazl.2023.100095

Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system.

Auteurs: Tribondeau, A., Sachs, L.M. and Buisine, N.
Publié dans: Frontiers in Genetics 13:996826, 2022, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2022.996826

Overlapping action of T3 and T4 during Xenopus laevis development

Auteurs: Alicia Tribondeau, David Du Pasquier, Médine Benchouaia, Corinne Blugeon, Nicolas Buisine, Laurent M. Sachs
Publié dans: Frontiers in Endocrinology, Numéro 15, 2024, Page(s) 1360188, ISSN 1664-2392
Éditeur: Frontiers
DOI: 10.3389/fendo.2024.1360188

Iopanoic acid alters thyroid hormone-related gene expression, thyroid hormone levels, swim bladder inflation, and swimming performance in Japanese medaka

Auteurs: Yoshifumi Horie, Ayaka Sawada, Uaciquete Dorcas, Babu Rajendran Ramaswamy, Taisen Iguchi
Publié dans: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Numéro 281, 2024, Page(s) 109930, ISSN 1532-0456
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpc.2024.109930

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Auteurs: Karine Rousseau, Sylvie Dufour, Laurent M. Sachs
Publié dans: Frontiers in Ecology and Evolution, Numéro 9, 2021, ISSN 2296-701X
Éditeur: Frontiers
DOI: 10.3389/fevo.2021.735487

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

Auteurs: Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant
Publié dans: iScience, Numéro 23/3, 2020, Page(s) 100899, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2020.100899

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Auteurs: Henrik Holbech, Peter Matthiessen, Martin Hansen, Gerrit Schüürmann, Dries Knapen, Marieke Reuver, Frédéric Flamant, Laurent Sachs, Werner Kloas, Klara Hilscherova, Marc Leonard, Jürgen Arning, Volker Strauss, Taisen Iguchi, Lisa Baumann
Publié dans: International Journal of Molecular Sciences, Numéro 21/8, 2020, Page(s) 2954, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082954

Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

Auteurs: Evelyn Stinckens, Lucia Vergauwen, Brett R. Blackwell, Gerald T. Ankley, Daniel L. Villeneuve, Dries Knapen
Publié dans: Environmental Science & Technology, Numéro 54/10, 2020, Page(s) 6213-6223, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.9b07204

Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

Auteurs: Dries Knapen, Evelyn Stinckens, Jenna E. Cavallin, Gerald T. Ankley, Henrik Holbech, Daniel L. Villeneuve, Lucia Vergauwen
Publié dans: Environmental Science & Technology, 2020, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.9b07205

In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

Auteurs: Yanis Zekri, Laure Dall Agnol, Frédéric Flamant, Romain Guyot
Publié dans: iScience, Numéro 24/9, 2021, Page(s) 102957, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2021.102957

Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?

Auteurs: Ramhøj, L., Guyot, R., Svingen, T., Kortenkamp, A., Flamant, F. and Axelstad, M.
Publié dans: Regulatory Toxicology and Pharmacology, Numéro 142, 105445, 2023, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2023.105445

Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).

Auteurs: Horie, Y., Yamagishi, T., Yamamoto, J., Suzuki, M., Onishi, Y., Chiba, T., Miyagawa, S., Lange, A., Tyler, C. R., Okamura, H., & Iguchi, T.
Publié dans: Comparative Biochemistry and Physiology C-toxicology & Pharmacology, Numéro 263, 109502, 2023, ISSN 1532-0456
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpc.2022.109502

Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis

Auteurs: Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M.
Publié dans: Cells 11, no. 10, 2022, Page(s) 1595, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11101595

Detailed review paper (DRP) on the thyroid hormone system in fish and identification of potential thyroid hormone system related endpoints for inclusion in existing OECD fish Test Guidelines

Auteurs: OECD
Publié dans: OECD Series on Testing and Assessment, Numéro No. 381, 2023
Éditeur: OECD Publishing

Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Auteurs: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Publié dans: OECD Series on Adverse Outcome Pathways, Numéro No. 24, 2022
Éditeur: OECD Publishing
DOI: 10.1787/9cb525e9-en.

Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation”,

Auteurs: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Publié dans: OECD Series on Adverse Outcome Pathways, Numéro No. 25, 2022
Éditeur: OECD Publishing
DOI: 10.1787/9f651c16-en

Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Auteurs: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Publié dans: OECD Series on Adverse Outcome Pathways, Numéro No. 22, 2022
Éditeur: OECD Publishing
DOI: 10.1787/dc406014-en.

Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation

Auteurs: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Publié dans: OECD Series on Adverse Outcome Pathways, Numéro No. 23, 2022
Éditeur: OECD Publishing
DOI: 10.1787/b1bf0bea-en.

Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation

Auteurs: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Publié dans: OECD Series on Adverse Outcome Pathways, Numéro No.26, 2022
Éditeur: OECD Publishing
DOI: 10.1787/447c5cba-en

Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway.

Auteurs: Anna Melina Steinbach
Publié dans: 2021
Éditeur: University of Milan and BASF SE

"Sex chromosomes in so-called ""asexual"" hybrid vertebrates: along the ‘extended speciation continuum’"

Auteurs: Matthias Stöck , Dmitrij Dedukh , Radka Reifová , Dunja K. Lamatsch , Zuzana Starostová, Karel Janko
Publié dans: """ESEB Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne """, 2021
Éditeur: European Society of Evolutionary Biology

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