Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Rezultaty

End-of-project conference, to be organised with EDC testing cluster, to present advances in EDC testing (strategies) resulting from the SC1-BHC-27-2018 call, including FREIA’s outcomes, to relevant stakeholders and disseminate FREIA test strategy and test methodologies.

Public Website online

FREIA public WEB portal with description of the project, challenges and goals, project members and updates on current activities (including news/conferences/workshops).

Collaborative website (intranet) ready to use

Platform for secured internal information exchange and project documents archive.

Health promotion Strategy

Health Promotion Strategy based on collated information gathered and generated on EDCs and effects on female reproductive health, to be used for promotion of female reproductive health.

FREIA stakeholder database (updated continuously)

Database of relevant actors and stakeholder groups for dissemination, communication and exploitation purposes.

Publikacje

The mammalian ovary: Concerns about the evaluation of prenatal environmental exposures

Autorzy: Laetitia L. Lecante; Pauline Lelandais; Séverine Mazaud-Guittot; Paul A. Fowler
Opublikowane w: Current Opinion in Endocrine and Metabolic Research, Numer 18, 2021, Strona(/y) 171–177, ISSN 2451-9650
Wydawca: Elsevier Ltd.
DOI: 10.1016/j.coemr.2021.03.012

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound

Autorzy: Asimaki, K; Vazakidou, P; van Tol, H T A; Oei, C H Y; Modder, E A; van Duursen, M B M; Gadella, B M; dES/dFAH FR; FAH klinische reproductie; Veterinaire biochemie; dB&C FR-RMSC FR
Opublikowane w: Frontiers in Toxicology, Numer 2, 4, 2022, ISSN 2673-3080
Wydawca: Frontiers
DOI: 10.3389/ftox.2022.811285

Six Decades of Research on Human Fetal Gonadal Steroids

Autorzy: Stéphane Connan-Perrot, Thibaut Léger, Pauline Lelandais, Christèle Desdoits-Lethimonier, Arthur David, Paul A. Fowler, Séverine Mazaud-Guittot
Opublikowane w: International Journal of Molecular Sciences, Numer 22/13, 2021, Strona(/y) 6681, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136681

The profile of steroid hormones in human fetal and adult ovaries.

Autorzy: Vazakidou P, Evangelista S, Li T, et al. . Published 2024 May 22.
Opublikowane w: Reprod Biol Endocrinol., Numer 22(1), 2024, Strona(/y) 60, ISSN 1477-7827
Wydawca: BioMed Central
DOI: 10.1186/s12958-024-01233-7

Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment.Epub 2023 Jul 22.

Autorzy: Hallberg I, Björvang RD, Hadziosmanovic N, Koekkoekk J, Pikki A, van Duursen M, Lenters V, Sjunnesson Y, Holte J, Berglund L, Persson S, Olovsson M, Damdimopoulou P.
Opublikowane w: J Expo Sci Environ Epidemiol., Numer Sep;33(5), 2023, Strona(/y) 699-709, ISSN 1559-0631
Wydawca: Nature Publishing Group
DOI: 10.1038/s41370-023-00579-1

AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles.

Autorzy: Panagiotou EM, Draskau MK, Li T, Hirschberg A, Svingen T, Damdimopoulou P. :. doi: 10.1016/j.reprotox.2022.07.004. Epub 2022 Jul 19. PMID: 35868514.
Opublikowane w: Reproductive Toxicology, Numer Sep;112, 2022, Strona(/y) 136-147, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1016/j.reprotox.2022.07.004

Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries.

Autorzy: Boberg J, Johansson HKL, Franssen D, et al.
Opublikowane w: Toxicol Lett., Numer 373, 2023, Strona(/y) 114-122, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2022.11.010

Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro

Autorzy: Tianyi Li, Richelle D. Björvang, Jie Hao, Valentina Di Nisio, Anastasios Damdimopoulos, Cecilia Lindskog, Kiriaki Papaikonomou, Pauliina Damdimopoulou
Opublikowane w: Environment International, Numer 187, 2024, Strona(/y) 108710, ISSN 0160-4120
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108710

Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies

Autorzy: Eva Bongaerts, Laetitia L Lecante, Hannelore Bové, Maarten B J Roeffaers, Marcel Ameloot, Paul A Fowler, Tim S Nawrot
Opublikowane w: The Lancet Planetary Health, Numer 6, 2024, Strona(/y) e804-e811, ISSN 2542-5196
Wydawca: Elsevier
DOI: 10.1016/s2542-5196(22)00200-5

Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models

Autorzy: Tianyi Li 1, Paraskevi Vazakidou 2, Pim E G Leonards 3, Anastasios Damdimopoulos 4, Eleftheria Maria Panagiotou 5, Catarina Arnelo 6, Kerstin Jansson 7, Karin Pettersson 8, Kiriaki Papaikonomou 9, Majorie van Duursen 10, Pauliina Damdimopoulou 11
Opublikowane w: Toxicology, Numer 485, 2023, Strona(/y) 153425, ISSN 0300-483X
Wydawca: Elsevier BV
DOI: 10.1016/j.tox.2023.153425

High throughput LC-MS/MS method for steroid hormone analysis in rat liver and plasma - unraveling methodological challenges.

Autorzy: Evangelista S, Vazakidou P, Koekkoek J, Heinzelmann MT, Lichtensteiger W, Schlumpf M, Tresguerres JAF, Linillos-Pradillo B, van Duursen MBM, Lamoree MH, Leonards PEG
Opublikowane w: Talanta, Numer Jul 24, 2023, Strona(/y) 266(Pt 1):124981, ISSN 0039-9140
Wydawca: Elsevier BV
DOI: 10.1016/j.talanta.2023.124981

In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity.

Autorzy: Rooda, I., Hassan, J., Hao, J. et al.
Opublikowane w: Nat Commun, Numer 15, 6989, 2024, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1038/s41467-024-51185-0

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Autorzy: Richelle D. Björvang; Ida Hallberg; Anne Pikki; Lars Berglund; Matteo Pedrelli; Hannu Kiviranta; Panu Rantakokko; Päivi Ruokojärvi; Christian H. Lindh; Matts Olovsson; Sara Persson; Jan Holte; Ylva Sjunnesson; Pauliina Damdimopoulou
Opublikowane w: Environmental Research, Numer 208, 2021, Strona(/y) 112626, ISSN 0013-9351
Wydawca: Academic Press
DOI: 10.1016/j.envres.2021.112626

Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats

Autorzy: Tianyi Li, Julie Boberg, Hanna K L Johansson, Valentina Di Nisio, Sofie Christiansen, Terje Svingen, Pauliina Damdimopoulou
Opublikowane w: Reproductive Toxicology, Numer Aug;119, 2023, Strona(/y) 108416, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1016/j.reprotox.2023.108416

Effects of chemical in vitro activation versus fragmentation on human ovarian tissue and follicle growth in culture.

Autorzy: Hao J, Li T, Heinzelmann M, et al.
Opublikowane w: Hum Reprod Open., Numer (3), 2024, Strona(/y) hoae028 Published 2024 May 22, ISSN 2399-3529
Wydawca: Oxford University Press
DOI: 10.1093/hropen/hoae028

The insulin-like growth factor system: A target for endocrine disruptors?

Autorzy: Chiara Talia, Lisa Connolly, Paul A. Fowler
Opublikowane w: Environment International, Numer Volume 147, February 2021, 106311, 2021, Strona(/y) 106311, ISSN 0160-4120
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106311

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures.

Autorzy: Caporale N, Leemans M, Birgersson L, et al.
Opublikowane w: Science, Numer 375(6582), 2022, Strona(/y) eabe8244, ISSN 1095-9203
Wydawca: Washington, D.C.
DOI: 10.1126/science.abe8244

Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia

Autorzy: Andrea Bellavia 1, Runyu Zou 2, Richelle D Björvang 3, Kristine Roos 4, Ylva Sjunnesson 5, Ida Hallberg 5, Jan Holte 6, Anne Pikki 6, Virissa Lenters 7, Lützen Portengen 8, Jacco Koekkoek 9, Marja Lamoree 9, Majorie Van Duursen 9, Roel Vermeulen 2, Andres Salumets 10, Agne Velthut-Meikas 11, Pauliina Damdimopoulou 3
Opublikowane w: Environ Res, Numer 216(Pt 1), 2023, Strona(/y) 114447, ISSN 0013-9351
Wydawca: Academic Press
DOI: 10.1016/j.envres.2022.114447

A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals

Autorzy: Delphine Franssen, Terje Svingen, David Lopez Rodriguez, Majorie Van Duursen, Julie Boberg, Anne-Simone Parent
Opublikowane w: Neuroendocrinology, 2021, ISSN 0028-3835
Wydawca: S. Karger AG
DOI: 10.1159/000515478

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Autorzy: Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-14936-3

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

Autorzy: Richelle D. Björvang, Pauliina Damdimopoulou
Opublikowane w: Upsala Journal of Medical Sciences, Numer 125/2, 2020, Strona(/y) 85-94, ISSN 0300-9734
Wydawca: Taylor & Francis
DOI: 10.1080/03009734.2020.1727073

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Autorzy: Majorie B. M. van Duursen, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler, Bart M. Gadella, Jan Holte, Kersti Jääger, Hanna K. L. Johansson, Tianyi Li, Séverine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling Xie, Martin van den Berg
Opublikowane w: International Journal of Molecular Sciences, Numer 21/9, 2020, Strona(/y) 3215, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093215

Dynamics of the transcriptional landscape during human fetal testis and ovary development

Autorzy: Estelle Lecluze, Antoine D Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoué, Paul A Fowler, Séverine Mazaud-Guittot, Bernard Jégou, Frédéric Chalmel
Opublikowane w: Human Reproduction, Numer 35/5, 2020, Strona(/y) 1099-1119, ISSN 0268-1161
Wydawca: Oxford University Press
DOI: 10.1093/humrep/deaa041

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Autorzy: Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Opublikowane w: Human Reproduction, 2020, ISSN 0268-1161
Wydawca: Oxford University Press
DOI: 10.1093/humrep/deaa091

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Autorzy: Hanna Katarina Lilith Johansson, Terje Svingen, Julie Boberg, Paul A. Fowler, David Stead, Anne Marie Vinggaard, Panagiotis Filis
Opublikowane w: Archives of Toxicology, Numer 94/4, 2020, Strona(/y) 1241-1250, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-020-02697-3

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Autorzy: Hanna K. L. Johansson, Pauliina Damdimopoulou, Majorie B. M. van Duursen, Julie Boberg, Delphine Franssen, Marijke de Cock, Kersti Jääger, Magdalena Wagner, Agne Velthut-Meikas, Yuling Xie, Lisa Connolly, Pauline Lelandais, Severine Mazaud-Guittot, Andres Salumets, Monica Kam Draskau, Panagiotis Filis, Paul A. Fowler, Sofie Christiansen, Anne-Simone Parent, Terje Svingen
Opublikowane w: Archives of Toxicology, 2020, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-020-02834-y

Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole

Autorzy: Hanna K.L. Johansson, Sofie Christiansen, Monica Kam Draskau, Terje Svingen, Julie Boberg
Opublikowane w: Reproductive Toxicology, Numer 101, 2021, Strona(/y) 9-17, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.003

Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.

Autorzy: Lecante LL, Leverrier-Penna S, Gicquel T, et al.
Opublikowane w: J Clin Endocrinol Metab., Numer 107(6), 2022, Strona(/y) 1647-1661, ISSN 1945-7197
Wydawca: Oxford University Press
DOI: 10.1210/clinem/dgac080

Comparison of female rat reproductive effects of pubertal versus adult exposure to known endocrine disruptors.

Autorzy: Julie Boberg1 Tianyi Li2,3 Sofie Christiansen1 Monica K. Draskau1 Pauliina Damdimopoulou2,3 Terje Svingen1 Hanna K. L. Johansson1*
Opublikowane w: Frontiers in Endocrinology, Numer 14, 2023, ISSN 1124-1292
Wydawca: Frontiers Media
DOI: 10.3389/fendo.2023.1126485

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation

Autorzy: Terje Svingen, Daniel L Villeneuve, Dries Knapen, Eleftheria Maria Panagiotou, Monica Kam Draskau, Pauliina Damdimopoulou, Jason M O’Brien
Opublikowane w: Toxicological Sciences, Numer 184, 2021, Strona(/y) 183-190, ISSN 1096-6080
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.

Autorzy: Franssen D, Johansson HKL, Lopez-Rodriguez D, Lavergne A, Terwagne Q, Boberg J, Christiansen S, Svingen T, Parent A-S
Opublikowane w: Front Endocrinol, Numer Apr 3;14, 2023, Strona(/y) 1140886, ISSN 1664-2392
Wydawca: Frontiers Media SA
DOI: 10.3389/fendo.2023.1140886

A method for in vitro data and structure curation to optimize for QSAR modelling of minimum absolute potency levels and a comparative use case.

Autorzy: Nikolov NG, Nissen ACVE, Wedebye EB.
Opublikowane w: Environ Toxicol Pharmacol., Numer Mar;98, 2023, Strona(/y) 104069, ISSN 1382-6689
Wydawca: Elsevier BV
DOI: 10.1016/j.etap.2023.104069

Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole

Autorzy: Indusha Kugathas; Hanna K. L. Johansson; Edith Chan Sock Peng; Maryne Toupin; Bertrand Evrard; Thomas A. Darde; Julie Boberg; Monica K. Draskau; Antoine D. Rolland; Séverine Mazaud-Guittot; Frédéric Chalmel; Terje Svingen
Opublikowane w: Crossref, Numer 5, 2023, Strona(/y) 849–863, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03442-2

Ketoconazole blocks progesterone production without affecting other parameters of cumulus-oocyte complex maturation

Autorzy: K. Asimaki, P. Vazakidou, H.T.A. van Tol, M.B.M. van Duursen, B.M. Gadella
Opublikowane w: Reproductive Toxicology, Numer 128, 2024, Strona(/y) 108637, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1016/j.reprotox.2024.108637

Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.

Autorzy: Matouskova K, Szabo GK, Daum J, Fenton SE, Christiansen S, Soto AM, Kay JE, Cardona B, Vandenberg LN.
Opublikowane w: Reproductive Toxicology, Numer Sep;112, 2022, Strona(/y) 51-67, ISSN 0890-6238
Wydawca: Elsevier BV
DOI: 10.1016/j.reprotox.2022.06.011

Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies

Autorzy: Zafeiri A, Raja EA, Mitchell RT, Hay DC, Bhattacharya S, Fowler PA.
Opublikowane w: BMJ Open, Numer 2022 May 3, 2022, Strona(/y) 12(5):e048092, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-048092

Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities

Autorzy: Kay JE, Cardona B, Rudel RA, Vandenberg LN, Soto AM, Christiansen S, Birnbaum LS, Fenton SE.
Opublikowane w: Curr Environ Health Rep, Numer Dec;9(4), 2022, Strona(/y) 535-562, ISSN 2196-5412
Wydawca: Springer International Publishing AG
DOI: 10.1007/s40572-022-00376-2

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