Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Risultati finali

End-of-project conference, to be organised with EDC testing cluster, to present advances in EDC testing (strategies) resulting from the SC1-BHC-27-2018 call, including FREIA’s outcomes, to relevant stakeholders and disseminate FREIA test strategy and test methodologies.

Public Website online

FREIA public WEB portal with description of the project, challenges and goals, project members and updates on current activities (including news/conferences/workshops).

Collaborative website (intranet) ready to use

Platform for secured internal information exchange and project documents archive.

Health promotion Strategy

Health Promotion Strategy based on collated information gathered and generated on EDCs and effects on female reproductive health, to be used for promotion of female reproductive health.

FREIA stakeholder database (updated continuously)

Database of relevant actors and stakeholder groups for dissemination, communication and exploitation purposes.

Pubblicazioni

The mammalian ovary: Concerns about the evaluation of prenatal environmental exposures

Autori: Laetitia L. Lecante; Pauline Lelandais; Séverine Mazaud-Guittot; Paul A. Fowler
Pubblicato in: Current Opinion in Endocrine and Metabolic Research, Numero 18, 2021, Pagina/e 171–177, ISSN 2451-9650
Editore: Elsevier Ltd.
DOI: 10.1016/j.coemr.2021.03.012

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound

Autori: Asimaki, K; Vazakidou, P; van Tol, H T A; Oei, C H Y; Modder, E A; van Duursen, M B M; Gadella, B M; dES/dFAH FR; FAH klinische reproductie; Veterinaire biochemie; dB&C FR-RMSC FR
Pubblicato in: Frontiers in Toxicology, Numero 2, 4, 2022, ISSN 2673-3080
Editore: Frontiers
DOI: 10.3389/ftox.2022.811285

Six Decades of Research on Human Fetal Gonadal Steroids

Autori: Stéphane Connan-Perrot, Thibaut Léger, Pauline Lelandais, Christèle Desdoits-Lethimonier, Arthur David, Paul A. Fowler, Séverine Mazaud-Guittot
Pubblicato in: International Journal of Molecular Sciences, Numero 22/13, 2021, Pagina/e 6681, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136681

The profile of steroid hormones in human fetal and adult ovaries.

Autori: Vazakidou P, Evangelista S, Li T, et al. . Published 2024 May 22.
Pubblicato in: Reprod Biol Endocrinol., Numero 22(1), 2024, Pagina/e 60, ISSN 1477-7827
Editore: BioMed Central
DOI: 10.1186/s12958-024-01233-7

Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment.Epub 2023 Jul 22.

Autori: Hallberg I, Björvang RD, Hadziosmanovic N, Koekkoekk J, Pikki A, van Duursen M, Lenters V, Sjunnesson Y, Holte J, Berglund L, Persson S, Olovsson M, Damdimopoulou P.
Pubblicato in: J Expo Sci Environ Epidemiol., Numero Sep;33(5), 2023, Pagina/e 699-709, ISSN 1559-0631
Editore: Nature Publishing Group
DOI: 10.1038/s41370-023-00579-1

AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles.

Autori: Panagiotou EM, Draskau MK, Li T, Hirschberg A, Svingen T, Damdimopoulou P. :. doi: 10.1016/j.reprotox.2022.07.004. Epub 2022 Jul 19. PMID: 35868514.
Pubblicato in: Reproductive Toxicology, Numero Sep;112, 2022, Pagina/e 136-147, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2022.07.004

Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries.

Autori: Boberg J, Johansson HKL, Franssen D, et al.
Pubblicato in: Toxicol Lett., Numero 373, 2023, Pagina/e 114-122, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2022.11.010

Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro

Autori: Tianyi Li, Richelle D. Björvang, Jie Hao, Valentina Di Nisio, Anastasios Damdimopoulos, Cecilia Lindskog, Kiriaki Papaikonomou, Pauliina Damdimopoulou
Pubblicato in: Environment International, Numero 187, 2024, Pagina/e 108710, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108710

Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies

Autori: Eva Bongaerts, Laetitia L Lecante, Hannelore Bové, Maarten B J Roeffaers, Marcel Ameloot, Paul A Fowler, Tim S Nawrot
Pubblicato in: The Lancet Planetary Health, Numero 6, 2024, Pagina/e e804-e811, ISSN 2542-5196
Editore: Elsevier
DOI: 10.1016/s2542-5196(22)00200-5

Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models

Autori: Tianyi Li 1, Paraskevi Vazakidou 2, Pim E G Leonards 3, Anastasios Damdimopoulos 4, Eleftheria Maria Panagiotou 5, Catarina Arnelo 6, Kerstin Jansson 7, Karin Pettersson 8, Kiriaki Papaikonomou 9, Majorie van Duursen 10, Pauliina Damdimopoulou 11
Pubblicato in: Toxicology, Numero 485, 2023, Pagina/e 153425, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/j.tox.2023.153425

High throughput LC-MS/MS method for steroid hormone analysis in rat liver and plasma - unraveling methodological challenges.

Autori: Evangelista S, Vazakidou P, Koekkoek J, Heinzelmann MT, Lichtensteiger W, Schlumpf M, Tresguerres JAF, Linillos-Pradillo B, van Duursen MBM, Lamoree MH, Leonards PEG
Pubblicato in: Talanta, Numero Jul 24, 2023, Pagina/e 266(Pt 1):124981, ISSN 0039-9140
Editore: Elsevier BV
DOI: 10.1016/j.talanta.2023.124981

In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity.

Autori: Rooda, I., Hassan, J., Hao, J. et al.
Pubblicato in: Nat Commun, Numero 15, 6989, 2024, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1038/s41467-024-51185-0

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Autori: Richelle D. Björvang; Ida Hallberg; Anne Pikki; Lars Berglund; Matteo Pedrelli; Hannu Kiviranta; Panu Rantakokko; Päivi Ruokojärvi; Christian H. Lindh; Matts Olovsson; Sara Persson; Jan Holte; Ylva Sjunnesson; Pauliina Damdimopoulou
Pubblicato in: Environmental Research, Numero 208, 2021, Pagina/e 112626, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2021.112626

Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats

Autori: Tianyi Li, Julie Boberg, Hanna K L Johansson, Valentina Di Nisio, Sofie Christiansen, Terje Svingen, Pauliina Damdimopoulou
Pubblicato in: Reproductive Toxicology, Numero Aug;119, 2023, Pagina/e 108416, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2023.108416

Effects of chemical in vitro activation versus fragmentation on human ovarian tissue and follicle growth in culture.

Autori: Hao J, Li T, Heinzelmann M, et al.
Pubblicato in: Hum Reprod Open., Numero (3), 2024, Pagina/e hoae028 Published 2024 May 22, ISSN 2399-3529
Editore: Oxford University Press
DOI: 10.1093/hropen/hoae028

The insulin-like growth factor system: A target for endocrine disruptors?

Autori: Chiara Talia, Lisa Connolly, Paul A. Fowler
Pubblicato in: Environment International, Numero Volume 147, February 2021, 106311, 2021, Pagina/e 106311, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106311

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures.

Autori: Caporale N, Leemans M, Birgersson L, et al.
Pubblicato in: Science, Numero 375(6582), 2022, Pagina/e eabe8244, ISSN 1095-9203
Editore: Washington, D.C.
DOI: 10.1126/science.abe8244

Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia

Autori: Andrea Bellavia 1, Runyu Zou 2, Richelle D Björvang 3, Kristine Roos 4, Ylva Sjunnesson 5, Ida Hallberg 5, Jan Holte 6, Anne Pikki 6, Virissa Lenters 7, Lützen Portengen 8, Jacco Koekkoek 9, Marja Lamoree 9, Majorie Van Duursen 9, Roel Vermeulen 2, Andres Salumets 10, Agne Velthut-Meikas 11, Pauliina Damdimopoulou 3
Pubblicato in: Environ Res, Numero 216(Pt 1), 2023, Pagina/e 114447, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2022.114447

A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals

Autori: Delphine Franssen, Terje Svingen, David Lopez Rodriguez, Majorie Van Duursen, Julie Boberg, Anne-Simone Parent
Pubblicato in: Neuroendocrinology, 2021, ISSN 0028-3835
Editore: S. Karger AG
DOI: 10.1159/000515478

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Autori: Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14936-3

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

Autori: Richelle D. Björvang, Pauliina Damdimopoulou
Pubblicato in: Upsala Journal of Medical Sciences, Numero 125/2, 2020, Pagina/e 85-94, ISSN 0300-9734
Editore: Taylor & Francis
DOI: 10.1080/03009734.2020.1727073

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Autori: Majorie B. M. van Duursen, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler, Bart M. Gadella, Jan Holte, Kersti Jääger, Hanna K. L. Johansson, Tianyi Li, Séverine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling Xie, Martin van den Berg
Pubblicato in: International Journal of Molecular Sciences, Numero 21/9, 2020, Pagina/e 3215, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093215

Dynamics of the transcriptional landscape during human fetal testis and ovary development

Autori: Estelle Lecluze, Antoine D Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoué, Paul A Fowler, Séverine Mazaud-Guittot, Bernard Jégou, Frédéric Chalmel
Pubblicato in: Human Reproduction, Numero 35/5, 2020, Pagina/e 1099-1119, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/deaa041

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Autori: Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Pubblicato in: Human Reproduction, 2020, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/deaa091

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Autori: Hanna Katarina Lilith Johansson, Terje Svingen, Julie Boberg, Paul A. Fowler, David Stead, Anne Marie Vinggaard, Panagiotis Filis
Pubblicato in: Archives of Toxicology, Numero 94/4, 2020, Pagina/e 1241-1250, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02697-3

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Autori: Hanna K. L. Johansson, Pauliina Damdimopoulou, Majorie B. M. van Duursen, Julie Boberg, Delphine Franssen, Marijke de Cock, Kersti Jääger, Magdalena Wagner, Agne Velthut-Meikas, Yuling Xie, Lisa Connolly, Pauline Lelandais, Severine Mazaud-Guittot, Andres Salumets, Monica Kam Draskau, Panagiotis Filis, Paul A. Fowler, Sofie Christiansen, Anne-Simone Parent, Terje Svingen
Pubblicato in: Archives of Toxicology, 2020, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02834-y

Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole

Autori: Hanna K.L. Johansson, Sofie Christiansen, Monica Kam Draskau, Terje Svingen, Julie Boberg
Pubblicato in: Reproductive Toxicology, Numero 101, 2021, Pagina/e 9-17, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.003

Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.

Autori: Lecante LL, Leverrier-Penna S, Gicquel T, et al.
Pubblicato in: J Clin Endocrinol Metab., Numero 107(6), 2022, Pagina/e 1647-1661, ISSN 1945-7197
Editore: Oxford University Press
DOI: 10.1210/clinem/dgac080

Comparison of female rat reproductive effects of pubertal versus adult exposure to known endocrine disruptors.

Autori: Julie Boberg1 Tianyi Li2,3 Sofie Christiansen1 Monica K. Draskau1 Pauliina Damdimopoulou2,3 Terje Svingen1 Hanna K. L. Johansson1*
Pubblicato in: Frontiers in Endocrinology, Numero 14, 2023, ISSN 1124-1292
Editore: Frontiers Media
DOI: 10.3389/fendo.2023.1126485

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation

Autori: Terje Svingen, Daniel L Villeneuve, Dries Knapen, Eleftheria Maria Panagiotou, Monica Kam Draskau, Pauliina Damdimopoulou, Jason M O’Brien
Pubblicato in: Toxicological Sciences, Numero 184, 2021, Pagina/e 183-190, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.

Autori: Franssen D, Johansson HKL, Lopez-Rodriguez D, Lavergne A, Terwagne Q, Boberg J, Christiansen S, Svingen T, Parent A-S
Pubblicato in: Front Endocrinol, Numero Apr 3;14, 2023, Pagina/e 1140886, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2023.1140886

A method for in vitro data and structure curation to optimize for QSAR modelling of minimum absolute potency levels and a comparative use case.

Autori: Nikolov NG, Nissen ACVE, Wedebye EB.
Pubblicato in: Environ Toxicol Pharmacol., Numero Mar;98, 2023, Pagina/e 104069, ISSN 1382-6689
Editore: Elsevier BV
DOI: 10.1016/j.etap.2023.104069

Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole

Autori: Indusha Kugathas; Hanna K. L. Johansson; Edith Chan Sock Peng; Maryne Toupin; Bertrand Evrard; Thomas A. Darde; Julie Boberg; Monica K. Draskau; Antoine D. Rolland; Séverine Mazaud-Guittot; Frédéric Chalmel; Terje Svingen
Pubblicato in: Crossref, Numero 5, 2023, Pagina/e 849–863, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03442-2

Ketoconazole blocks progesterone production without affecting other parameters of cumulus-oocyte complex maturation

Autori: K. Asimaki, P. Vazakidou, H.T.A. van Tol, M.B.M. van Duursen, B.M. Gadella
Pubblicato in: Reproductive Toxicology, Numero 128, 2024, Pagina/e 108637, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2024.108637

Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.

Autori: Matouskova K, Szabo GK, Daum J, Fenton SE, Christiansen S, Soto AM, Kay JE, Cardona B, Vandenberg LN.
Pubblicato in: Reproductive Toxicology, Numero Sep;112, 2022, Pagina/e 51-67, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2022.06.011

Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies

Autori: Zafeiri A, Raja EA, Mitchell RT, Hay DC, Bhattacharya S, Fowler PA.
Pubblicato in: BMJ Open, Numero 2022 May 3, 2022, Pagina/e 12(5):e048092, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-048092

Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities

Autori: Kay JE, Cardona B, Rudel RA, Vandenberg LN, Soto AM, Christiansen S, Birnbaum LS, Fenton SE.
Pubblicato in: Curr Environ Health Rep, Numero Dec;9(4), 2022, Pagina/e 535-562, ISSN 2196-5412
Editore: Springer International Publishing AG
DOI: 10.1007/s40572-022-00376-2

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