Dynamic Complexes and Allosteric Regulation of Small Molecule Transporters

Información del proyecto

EXCHANGE

Identificador del acuerdo de subvención: 820187

DOI 10.3030/820187

Proyecto cerrado

Fecha de la firma de la CE 28 Enero 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 31 Mayo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 999 875,00

Aportación de la UE € 1 999 875,00

Coordinado por

STOCKHOLMS UNIVERSITET
Sweden

Publicaciones

Peer reviewed articles (6)

Structure and mechanism of the K+/H+ exchanger KefC

Autores: Gulati A, Kokane S, Perez-Boerema A, Alleva C, Meier P.F, Matsuoka R, Drew D.
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-49082-7

Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2

Autores: Rei Matsuoka, Roman Fudim, Sukkyeong Jung, Chenou Zhang, Andre Bazzone, Yurie Chatzikyriakidou, Carol V. Robinson, Norimichi Nomura, So Iwata, Michael Landreh, Laura Orellana, Oliver Beckstein & David Drew
Publicado en: Nature Structural & Molecular Biology, Edición 29, 2022, Página(s) 108-120, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-022-00738-2

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9

Autores: Iven Winkelmann, Rei Matsuoka, Pascal F Meier, Denis Shutin, Chenou Zhang, Laura Orellana, Ricky Sexton, Michael Landreh, Carol V Robinson, Oliver Beckstein, David Drew
Publicado en: The EMBO Journal, Edición 39/24, 2020, Página(s) 4541-4559, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020105908

Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger

Autores: Yeo, H., Mehta, V., Gulati, A, Drew D.
Publicado en: Nature, 2023, Página(s) 193-201, ISSN 1476-4687
Editor: Springer Nature
DOI: 10.1038/s41586-023-06518-2

The GFP thermal shift assay for screening ligand and lipid interactions to solute carrier transporters

Autores: Yurie Chatzikyriakidou, Do-Hwan Ahn, Emmanuel Nji, David Drew
Publicado en: Nature Protocols, 2021, Página(s) 5357–5376, ISSN 1750-2799
Editor: Springer Nature
DOI: 10.1038/s41596-021-00619-w

Crystal structure of the Na+/H+ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing

Autores: Winkelmann, Iven; Uzdavinys, Povilas; Kenney, Ian M; Brock, Joseph; Meier, Pascal F; Wagner, Lina-Marie; Gabriel, Florian; Jung, Sukkyeong; Matsuoka, Rei; von Ballmoos, Christoph; Beckstein, Oliver; Drew, David
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34120-z