Dynamic Complexes and Allosteric Regulation of Small Molecule Transporters

Project Information

EXCHANGE

Grant agreement ID: 820187

DOI 10.3030/820187

Project closed

EC signature date 28 January 2019

Start date 1 June 2019

End date 31 May 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 875,00

EU contribution € 1 999 875,00

Coordinated by

STOCKHOLMS UNIVERSITET
Sweden

Publications

Peer reviewed articles (5)

Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2

Author(s): Rei Matsuoka, Roman Fudim, Sukkyeong Jung, Chenou Zhang, Andre Bazzone, Yurie Chatzikyriakidou, Carol V. Robinson, Norimichi Nomura, So Iwata, Michael Landreh, Laura Orellana, Oliver Beckstein & David Drew
Published in: Nature Structural & Molecular Biology, Issue 29, 2022, Page(s) 108-120, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00738-2

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9

Author(s): Iven Winkelmann, Rei Matsuoka, Pascal F Meier, Denis Shutin, Chenou Zhang, Laura Orellana, Ricky Sexton, Michael Landreh, Carol V Robinson, Oliver Beckstein, David Drew
Published in: The EMBO Journal, Issue 39/24, 2020, Page(s) 4541-4559, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105908

Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger

Author(s): Yeo, H., Mehta, V., Gulati, A, Drew D.
Published in: Nature, 2023, Page(s) 193-201, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-023-06518-2

The GFP thermal shift assay for screening ligand and lipid interactions to solute carrier transporters

Author(s): Yurie Chatzikyriakidou, Do-Hwan Ahn, Emmanuel Nji, David Drew
Published in: Nature Protocols, 2021, Page(s) 5357–5376, ISSN 1750-2799
Publisher: Springer Nature
DOI: 10.1038/s41596-021-00619-w

Crystal structure of the Na+/H+ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing

Author(s): Winkelmann, Iven; Uzdavinys, Povilas; Kenney, Ian M; Brock, Joseph; Meier, Pascal F; Wagner, Lina-Marie; Gabriel, Florian; Jung, Sukkyeong; Matsuoka, Rei; von Ballmoos, Christoph; Beckstein, Oliver; Drew, David
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34120-z