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Holistic solution to improve animal food production through deconstructing the biomolecular interactions between feed, gut microorganisms and animals in relation to performance parameters

Description du projet

Optimiser les animaux pour la production humaine

Des habitants des campagnes élevant des poulets de basse-cour aux éleveurs à la tête d’un cheptel de milliers de bovins, la santé animale est la priorité absolue. Le projet HoloFood, financé par l’UE, utilisera une nouvelle approche hologénomique pour étudier la santé des animaux en tenant compte de leur paysage biochimique et de leur microbiome. Le projet s’intéressera au saumon et au poulet, deux systèmes d’élevage qui revêtent une importance capitale. Il caractérisera non seulement les génomes, les transcriptomes et les métabolomes des micro-organismes associés, mais aussi l’interaction entre le microbiome et les génomes et les transcriptomes des animaux dans le nouveau cadre holo-omique, en rapport avec les indices clés de performance et les questions de bien-être animal. Ces informations permettront d’optimiser les additifs alimentaires en les adaptant au contexte génétique et au stade de développement des animaux.

Objectif

Optimising food production is not only of commercial interest for companies, but with the planet’s population approaching the nine billion mark, also of critical importance for humanity. Animal food production can be optimised by modulating animal-associated microbiomes through the use of feed additives such as prebiotics and probiotics. Previously developed feed additives have not acknowledged the specific means of action of the additives on the microbiome and host organisms, and consequently i) their performance is inconsistent across animals with different genetic background and when grown under different environments, ii) improvement of feed additives is inefficient and costly, and iii) optimal solutions are unlikely to be found without taking a more holistic approach. HoloFood showcases a holistic approach that will improve the efficiency of food production systems by deciphering the molecular and physiological processes triggered by feed additives across animals with different genetic background and grown under different environments. We will use two critically important farmed animal systems as our models -salmon and chicken- and characterise not only their associated microorganisms’ genomes, transcriptomes and metabolomes but also how the microbiome interacts with animals' genomes and transcriptomes within the new holo-omic framework in relation to key performance indices and animal welfare issues. The knowledge generated will be used to optimise feed additive administration strategies of already implemented products by tailoring them to the genetic background and developmental stage of the animals as well as production environment, to improve the quantity, quality and safety of the produced food, as well as sustainability of food production and animal welfare. HoloFood will also serve to raise awareness about the importance of microbiomes in food production, and to establish bridges between companies and academia to foster science-based strategies.

Appel à propositions

H2020-SFS-2018-2020

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Sous appel

H2020-SFS-2018-1

Régime de financement

IA - Innovation action

Coordinateur

KOBENHAVNS UNIVERSITET
Contribution nette de l'UE
€ 3 797 766,00
Adresse
NORREGADE 10
1165 Kobenhavn
Danemark

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Région
Danmark Hovedstaden Byen København
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 3 858 827,50

Participants (10)