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BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle

Descrizione del progetto

Applicazione della genomica nella produzione di bestiame

È risaputo che le modifiche epigenetiche sono implicate nella regolazione dell’espressione genica, ma le associazioni tra queste modifiche e i fenotipi complessi sono poco comprese. Il progetto BovReg, finanziato dall’UE, è interessato a capire in che modo la variazione epigenetica nel bestiame si traduce in fenotipi importanti sotto il profilo commerciale. Il progetto riunisce ricercatori da diverse parti del mondo per generare dati di genomica funzionale relativi a robustezza, salute ed efficienza biologica nei bovini. Gli strumenti di previsione forniranno l’opportunità di selezionare le popolazioni di bestiame, mantenere il benessere degli animali e supportare l’allevamento di precisione per una produzione efficiente.

Obiettivo

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.

Invito a presentare proposte

H2020-SFS-2018-2020

Vedi altri progetti per questo bando

Bando secondario

H2020-SFS-2018-2

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

FORSCHUNGSINSTITUT FUR NUTZTIERBIOLOGIE
Contribution nette de l'UE
€ 999 837,50
Indirizzo
WILHELM-STAHL-ALLEE 2
18196 Dummerstorf
Germania

Mostra sulla mappa

Regione
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Landkreis Rostock
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 1 039 837,50

Partecipanti (20)