Enhancers Decoding the Mechanisms Underlying CAD Risk

Publications

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Auteurs: Redouane Aherrahrou, Liang Guo, V. Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F. Alencar, Arjan Boltjes, Sander W. van der Laan, Emily Farber, Daniela Fuller, Rita Anane-Wae, Ngozi Akingbesote, Ani W. Manichaikul, Lijiang Ma, Minna U. Kaikkonen, Johan L.M. Björkegren, Suna Önengüt-Gümüşcü, Gerard Pasterkamp, Clint L. Miller, Gary K. Owens, Alok
Publié dans: Circulation Research, Numéro 127/12, 2020, Page(s) 1552-1565, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317415

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Auteurs: Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

Technological advancements in functional interpretation of genome‐wide association studies (<scp>GWAS</scp>) findings: bridging the gap to clinical translation

Auteurs: Redouane Aherrahrou, Minna U Kaikkonen
Publié dans: FEBS Letters, Numéro Apr 29, 2024, ISSN 0014-5793
Éditeur: Elsevier BV
DOI: 10.1002/1873-3468.14884

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Auteurs: Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali
Publié dans: Nature Communications, Numéro 12, 2022, Page(s) 6486, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Auteurs: Austin C. Conklin, Hitoo Nishi, Florencia Schlamp, Tiit Örd, Kadri Õunap, Minna U. Kaikkonen, Edward A. Fisher, Casey E. Romanoski
Publié dans: Immunometabolism, 2021, ISSN 2633-0407
Éditeur: Hapres Limited
DOI: 10.20900/immunometab20210022

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Auteurs: Tiit Örd, Kadri Õunap, Lindsey K. Stolze, Redouane Aherrahrou, Valtteri Nurminen, Anu Toropainen, Ilakya Selvarajan, Tapio Lönnberg, Einari Aavik, Seppo Ylä-Herttuala, Mete Civelek, Casey E. Romanoski, Minna U. Kaikkonen
Publié dans: Circulation Research, Numéro 129/2, 2021, Page(s) 240-258, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318971

ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component

Auteurs: Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Mustafa Beter, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä-Herttuala, Johanna P Laakkonen
Publié dans: eLife, Numéro 12, 2023, Page(s) e82543, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.82543

Genetic variation drives differences in obesity-related gene regulation

Auteurs: Minna U. Kaikkonen
Publié dans: Trends in Genetics, Numéro 40, 2024, Page(s) 296-298, ISSN 0168-9525
Éditeur: Elsevier BV
DOI: 10.1016/j.tig.2024.02.009

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Auteurs: Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P
Publié dans: Circulation Research, Numéro 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316770

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Auteurs: Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D Nguyen, Sinem Karaman, Emilia A Korhonen, Ralf H Adams, Hellmut G Augustin, Katariina Öörni, Oliver Soehnlein, Minna U Kaikkonen, Kari Alitalo
Publié dans: Nature Cardiovascular Research, Numéro Mar 13;2(3), 2022, Page(s) 307-321, ISSN 2731-0590
Éditeur: Nature Portfolio
DOI: 10.1038/s44161-023-00224-y

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Auteurs: Seung Hyuk T. Lee, Kristina M. Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao, Marcus Alvarez, Amogha Koka, Nicholas Darci-Maher, Jihane N. Benhammou, David Z. Pan, Tiit Örd, Dorota Kaminska, Ville Männistö, Sini Heinonen, Martin Wabitsch, Markku Laakso, Vatche G. Agopian, Joseph R. Pisegna, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Minna U. Kaikkonen, Päivi Pajukanta
Publié dans: eBioMedicine, Numéro 106, 2024, Page(s) 105232, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105232

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Auteurs: Rédouane Aherrahrou, Dillon Lue, R Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan, Joon Yuhl Soh, Tiit Örd, Prosanta Singha, Qianyi Yang, Huda Gilani, Ernest Diez Benavente 4 , Doris Wong, Jameson Hinkle, Lijiang Ma, Gloria M Sheynkman, Hester M den Ruijter, Clint L Miller, Johan L M Björkegren, Minna U Kaikkonen, Mete Civelek
Publié dans: Circulation Research, Numéro Feb 3;132(3), 2023, Page(s) 323-338, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321586

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Auteurs: Maleeha Maria, Negar Pouyanfar, Tiit Örd, Minna U Kaikkonen
Publié dans: Genes, Numéro Mar 12;13(3), 2022, Page(s) 502, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13030502

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

Auteurs: Huang, Zhiqiang; Liang, Ning; Goñi, Saioa; Damdimopoulos, Anastasios; Wang, Cheng; Ballaire, Raphaelle; Jager, Jennifer; Niskanen, Henri; Han, HongYa; Jakobsson, Tomas; Bracken, Adrian,; Aouadi, Myriam; Venteclef, Nicolas; Kaikkonen, Minna,; Fan, Rongrong; Treuter, Eckardt
Publié dans: Molecular Cell, Numéro 81/5, 2021, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2020.12.040

Functional non-coding SNPs in human endothelial cells fine-map vascular trait associations

Auteurs: Anu Toropainen; Lindsey K. Stolze; Tiit Örd; Michael B. Whalen; Paula Martí Torrell; Verena M. Link; Minna U. Kaikkonen; Casey E. Romanoski
Publié dans: Crossref, Numéro Mar;32(3), 2022, Page(s) 409-424, ISSN 1088-9051
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2021.08.03.454513

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

Auteurs: Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Õunap, Maleeha Maria, Pierre R Moreau, Pashupati P Mishra, Senthil Palani, Jenni Virta, Heidi Liljenbäck, Einari Aavik, Anne Roivainen, Seppo Ylä-Herttuala, Johanna P Laakkonen, Terho Lehtimäki, Minna U Kaikkonen
Publié dans: American Journal of Human Genetics, Numéro May 4;110(5), 2023, Page(s) 722-740, ISSN 0002-9297
Éditeur: University of Chicago Press
DOI: 10.1016/j.ajhg.2023.03.013

Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types

Auteurs: Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Õunap, Tiit Örd, Heidi H. Pulkkinen, Petri Pölönen, Merja Heinäniemi, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 41/7, 2021, Page(s) 2149-2167, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.121.315579

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Auteurs: Ilakya Selvarajan, Anu Toropainen, Kristina M. Garske, Maykel López Rodríguez, Arthur Ko, Zong Miao, Dorota Kaminska, Kadri Õunap, Tiit Örd, Aarthi Ravindran, Oscar H. Liu, Pierre R. Moreau, Ashik Jawahar Deen, Ville Männistö, Calvin Pan, Anna-Liisa Levonen, Aldons J. Lusis, Sami Heikkinen, Casey E. Romanoski, Jussi Pihlajamäki, Päivi Pajukanta, Minna U. Kaikkonen
Publié dans: The American Journal of Human Genetics, Numéro 108/3, 2021, Page(s) 411-430, ISSN 0002-9297
Éditeur: University of Chicago Press
DOI: 10.1016/j.ajhg.2021.02.006

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Auteurs: Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam
Publié dans: Nucleic Acids Research, 2021, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab633

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

Auteurs: Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivelä, Juha Hartikainen, Mikko Hippeläinen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U Kaikkonen
Publié dans: Cardiovascular Research, Numéro Jul 19, 2020, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa219

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA

Auteurs: Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta
Publié dans: Hepatology Communications, Numéro 3/10, 2019, Page(s) 1356-1372, ISSN 2471-254X
Éditeur: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1413

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Auteurs: Lindsey K. Stolze, Austin C. Conklin, Michael B. Whalen, Maykel López Rodríguez, Kadri Õunap, Ilakya Selvarajan, Anu Toropainen, Tiit Örd, Jin Li, Anna Eshghi, Alice E. Solomon, Yun Fang, Minna U. Kaikkonen, Casey E. Romanoski
Publié dans: The American Journal of Human Genetics, Numéro 106/6, 2020, Page(s) 748-763, ISSN 0002-9297
Éditeur: University of Chicago Press
DOI: 10.1016/j.ajhg.2020.04.008

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Auteurs: Leena E. Viiri, Tommi Rantapero, Mostafa Kiamehr, Anna Alexanova, Mikko Oittinen, Keijo Viiri, Henri Niskanen, Matti Nykter, Minna U. Kaikkonen, Katriina Aalto-Setälä
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-39215-0

Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells

Auteurs: Isidore Mushimiyimana, Vanesa Tomas Bosch, Henri Niskanen, Nicholas L. Downes, Pierre R. Moreau, Kiley Hartigan, Seppo Ylä-Herttuala, Nihay Laham-Karam, Minna U. Kaikkonen
Publié dans: Molecular and Cellular Biology, Numéro 41/7, 2021, ISSN 0270-7306
Éditeur: American Society for Microbiology
DOI: 10.1128/mcb.00594-20

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Auteurs: Sanna Kettunen, Anna-Kaisa Ruotsalainen, Tiit Örd, Tuisku Suoranta, Janne Heikkilä, Minna U. Kaikkonen, Nihay Laham-Karam, Seppo Ylä-Herttuala
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 10, 2023, Page(s) Mar 6:10:1113890, ISSN 2297-055X
Éditeur: Frontiers in Cardiovascular Medicine
DOI: 10.3389/fcvm.2023.1113890

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

Auteurs: Suvi Linna-Kuosmanen, Eloi Schmauch, Kyriakitsa Galani, Johannes Ojanen, Carles A. Boix, Tiit Örd, Anu Toropainen, Prosanta K. Singha, Pierre R. Moreau, Kristiina Harju, Adriana Blazeski, Åsa Segerstolpe, Veikko Lahtinen, Lei Hou, Kai Kang, Elamaran Meibalan, Leandro Z. Agudelo, Hannu Kokki, Jari Halonen, Juho Jalkanen, Jarmo Gunn, Calum A. MacRae, Maija Hollmén, Juha E.K. Hartikainen, Minna U.
Publié dans: Cell Reports Medicine, Numéro 5, 2024, Page(s) 101556, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2024.101556

Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection

Auteurs: Z. Alireza, M. Maleeha, M. Kaikkonen, V. Fortino
Publié dans: Journal of Translational Medicine, Numéro 22, 2024, Page(s) 356, ISSN 1479-5876
Éditeur: BioMed Central
DOI: 10.1186/s12967-024-05090-1

Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro

Auteurs: Ilakya Selvarajan, Miika Kiema, Ru-Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna Kathryn Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Maximiliano Arce, Peetra U. Magnusson, Stephen White, Casey E. Romanoski, Merja Heinäniemi, Johanna P. Laakkonen, Yun Fang, Minna U. Kaikkonen
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 44, 2024, Page(s) 1330-1345, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.123.318964

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Auteurs: Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee, David Z Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N Benhammou, Martin Wabitsch, Joseph R Pisegna, Ville Männistö, Kirsi H Pietiläinen, Markku Laakso, Janet S Sinsheimer, Minna U Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Publié dans: EBioMedicine, Numéro Jun;92, 2023, Page(s) 104620, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104620

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Auteurs: Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ru
Publié dans: Circulation Research, Numéro 134, 2024, Page(s) 1405-1423, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.323184

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