Novel Coding Factors in Heart Disease

Risultati finali

Pubblicazioni

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

Autori: Bjoern Gaertner, Sebastiaan van Heesch, Valentin Schneider-Lunitz, Jana Felicitas Schulz, Franziska Witte, Susanne Blachut, Steven Nguyen, Regina Wong, Ileana Matta, Norbert Hübner, Maike Sander
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.58659

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

Autori: Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Pubblicato in: Nature Communications, Numero 13, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35306-1

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Autori: Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Hübner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 119, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2204174119

Evolution and implications of de novo genes in humans.

Autori: Broeils LA, Ruiz-Orera J, Snel B, Hubner N, van Heesch S.
Pubblicato in: Nat Ecol Evol, 2023, ISSN 2397-334X
Editore: Springer Nature
DOI: 10.1038/s41559-023-02014-y

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

Autori: Shovamayee Maharana, Stefanie Kretschmer, Susan Hunger, Xiao Yan, David Kuster, Sofia Traikov, Thomas Zillinger, Marc Gentzel, Nagaraja Chappidi, Nadja Lucas, Katharina Isabell Maser, Henrike Maatz, Alexander Rapp, Virginie Marchand, K. Venkatesan Iyer, Akshita Chhabra, Young-Tae Chang, Yuri Motorin, Norbert Hubner, Gunther Hartmann, Anthony Hyman, Simon Alberti, Min Ae Lee-Kirsch
Pubblicato in: Mol Cell, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1101/2022.07.12.499661

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

Autori: Valentin Schneider-Lunitz; Jorge Ruiz-Orera; Norbert Hubner; Sebastiaan van Heesch
Pubblicato in: Plos Computational Biology, Numero 1, 2021, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1009658

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.

Autori: Ansari, S.A.; Dantoft, W.; Ruiz-Orera, J.; Syed, A.P.; Blachut, S.; van Heesch, S.; Hübner, N.; Uhlenhaut, N.H.
Pubblicato in: Comp. Struc. Biotech. J. 20, 5622-5638 (2022), Numero 3, 2022, Pagina/e 5622-5638, ISSN 2001-0370
Editore: Science Direct
DOI: 10.1016/j.csbj.2022.09.042

Amplification of autoimmune organ damage by NKp46-activated ILC1s

Autori: Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A. Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W. Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric L. Lindberg, He
Pubblicato in: Nature, Numero 634, 2024, Pagina/e 952-960, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07907-x

Standardized annotation of translated open reading frames.

Autori: Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S
Pubblicato in: Nat Biotechnol., Numero Jul;40(7):994-999, 2022, Pagina/e 994-999, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-022-01369-0

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

Autori: Ercu M, Mücke MB, Pallien T, Markó L, Sholokh A, Schächterle C, Aydin A, Kidd A, Walter S, Esmati Y, McMurray BJ, Lato DF, Yumi Sunaga-Franze D, Dierks PH, Flores BIM, Walker-Gray R, Gong M, Merticariu C, Zühlke K, Russwurm M, Liu T, Batolomaeus TUP, Pautz S, Schelenz S, Taube M, Napieczynska H, Heuser A, Eichhorst J, Lehmann M, Miller DC, Diecke S, Qadri F, Popova E, Langanki R, Movsesian MA,
Pubblicato in: Circulation, Numero Dec 6;146(23):1758-1778, 2022, Pagina/e 1758-1778, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.060210

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts

Autori: Jorge Ruiz-Orera, Duncan C. Miller, Johannes Greiner, Carolin Genehr, Aliki Grammatikaki, Susanne Blachut, Jeanne Mbebi, Giannino Patone, Anna Myronova, Eleonora Adami, Nikita Dewani, Ning Liang, Oliver Hummel, Michael B. Muecke, Thomas B. Hildebrandt, Guido Fritsch, Lisa Schrade, Wolfram H. Zimmermann, Ivanela Kondova, Sebastian Diecke, Sebastiaan van Heesch, Norbert Hübner
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 1217-1235, ISSN 2731-0590
Editore: Springer Nature Limited
DOI: 10.1038/s44161-024-00544-7

The Translational Landscape of the Human Heart

Autori: Sebastiaan van Heesch, Franziska Witte, Valentin Schneider-Lunitz, Jana F. Schulz, Eleonora Adami, Allison B. Faber, Marieluise Kirchner, Henrike Maatz, Susanne Blachut, Clara-Louisa Sandmann, Masatoshi Kanda, Catherine L. Worth, Sebastian Schafer, Lorenzo Calviello, Rhys Merriott, Giannino Patone, Oliver Hummel, Emanuel Wyler, Benedikt Obermayer, Michael B. Mücke, Eric L. Lindberg, Franziska Trn
Pubblicato in: Cell, Numero 178/1, 2019, Pagina/e 242-260.e29, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.05.010

Spatially resolved multiomics of human cardiac niches

Autori: Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukas Mach, Monika Dabrowska, Nathan Richoz, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam N. Barnett, Shani Perera, Carlos Talavera-López, Ilaria
Pubblicato in: Nature, Numero 619, 2023, Pagina/e 801-810, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06311-1

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

Autori: Damon A. Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R. Clauser, Alexandra L. Condurat, Jip T. van Dinter, Sem A.G. Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N. Zhou, Jayne Vogelzang, Keith L. Ligon, Timothy N. Phoenix, Jennifer A. Roth, David E. Root, Norbert Hubner, Todd R. Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R. Pren
Pubblicato in: Molecular Cell, Numero 84, 2024, Pagina/e 261-276.e18, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2023.12.003

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Autori: Witte, Franziska; Ruiz-Orera, Jorge; Mattioli, Camilla Ciolli; Blachut, Susanne; Adami, Eleonora; Schulz, Jana Felicitas; Schneider-Lunitz, Valentin; Hummel, Oliver; Patone, Giannino; Mücke, Michael Benedikt; Šilhavý, Jan; Heinig, Matthias; Bottolo, Leonardo; Sanchis, Daniel; Vingron, Martin; Chekulaeva, Marina; Pravenec, Michal; Hubner, Norbert; Van Heesch, Sebastiaan
Pubblicato in: Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021), Numero 3, 2021, ISSN 1474-760X
Editore: biomedcentral
DOI: 10.17863/cam.71948

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

Autori: C.L. Sandmann, J.F. Schulz, J. Ruiz-Orera, M. Kirchner, M. Ziehm, E. Adami, M. Marczenke, A. Christ, N. Liebe, J. Greiner, A. Schoenenberger, M.B. Mücke, N. Liang, R.L. Moritz, Z. Sun, E.W. Deutsch, M. Gotthardt, J.M. Mudge, J.R. Prensner, T.E. Willnow, P. Mertins, S. van Heesch, N. Hubner
Pubblicato in: Mol Cell, 2023, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2023.01.023

Single-cell transcriptomics for the assessment of cardiac disease

Autori: Antonio M. A. Miranda, Vaibhao Janbandhu, Henrike Maatz, Kazumasa Kanemaru, James Cranley, Sarah A. Teichmann, Norbert Hübner, Michael D. Schneider, Richard P. Harvey, Michela Noseda
Pubblicato in: Nature Reviews Cardiology, Numero 20, 2024, Pagina/e 289-308, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-022-00805-7

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Autori: Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F,
Pubblicato in: Science, Numero Aug 5;377(6606):eabo1984., 2022, Pagina/e 377, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abo1984

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Autori: Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland, Roy Oelen, Hilde E. Groot, Jan Walter Benjamins, Sophia Brambs, Rainer Kaiser, Adrian Gottschlich, Gordon Victor Hoffmann, Luke Eivers, Alejandro Martinez-Navarro, Nils Bruns, Susanne Stiller, Sezer Akgöl, Keyang Yue, Vivien Polewka, Raphael Escaig, Markus Joppich, Aleksandar Janjic, Oliver Popp, Sebastian
Pubblicato in: Nature Medicine, Numero 30, 2024, Pagina/e 1696-1710, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-024-02953-4

Cells of the adult human heart

Autori: Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Jose
Pubblicato in: Nature, 2020, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2797-4

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Autori: Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling, Stu
Pubblicato in: Nature, Numero 632, 2024, Pagina/e 157-165, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07701-9

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart

Autori: Ivan Milenkovic, Helaine Graziele Santos Vieira, Morghan C Lucas, Jorge Ruiz-Orera, Giannino Patone, Scott Kesteven, Jianxin Wu, Michael Feneley, Guadalupe Espadas, Eduard Sabidó, Norbert Hubner, Sebastiaan van Heesch, Mirko Voelkers, Eva Maria Novoa
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.12.04.471171

A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq

Autori: Jonathan M. Mudge, Jorge Ruiz-Orera, John R. Prensner, Marie A. Brunet, Jose Manuel Gonzalez, Michele Magrane, Thomas Martinez, Jana Felicitas Schulz, Yucheng T. Yang, M. Mar Albà, Pavel V. Baranov, Ariel Bazzini, Elspeth Bruford, Maria Jesus Martin, Anne-Ruxandra Carvunis, Jin Chen, Juan Pablo Couso, Paul Flicek, Adam Frankish, Mark Gerstein, Norbert Hubner, Nicholas T. Ingolia, Gerben Menschaer
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.06.10.447896

Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

Autori: Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Joyce Wei Ting Goh, Jessie Tan, Chee Jian Pua, Radiance Lim, Brijesh K. Singh, Dasan Mary Cibi, Susanne Weber, Sze Yun Lim, Eleonora Adami, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Dominic J Withers, Norbert Hübner, Sebastian Schafer, Lena Ho, Jesus Gil, David Carling, Stuart A. Cook
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.07.09.548250

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