Novel Coding Factors in Heart Disease

Deliverables

Publications

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

Author(s): Bjoern Gaertner, Sebastiaan van Heesch, Valentin Schneider-Lunitz, Jana Felicitas Schulz, Franziska Witte, Susanne Blachut, Steven Nguyen, Regina Wong, Ileana Matta, Norbert Hübner, Maike Sander
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58659

Evolution and implications of de novo genes in humans.

Author(s): Broeils LA, Ruiz-Orera J, Snel B, Hubner N, van Heesch S.
Published in: Nat Ecol Evol, 2023, ISSN 2397-334X
Publisher: Springer Nature
DOI: 10.1038/s41559-023-02014-y

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

Author(s): Shovamayee Maharana, Stefanie Kretschmer, Susan Hunger, Xiao Yan, David Kuster, Sofia Traikov, Thomas Zillinger, Marc Gentzel, Nagaraja Chappidi, Nadja Lucas, Katharina Isabell Maser, Henrike Maatz, Alexander Rapp, Virginie Marchand, K. Venkatesan Iyer, Akshita Chhabra, Young-Tae Chang, Yuri Motorin, Norbert Hubner, Gunther Hartmann, Anthony Hyman, Simon Alberti, Min Ae Lee-Kirsch
Published in: Mol Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1101/2022.07.12.499661

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

Author(s): Valentin Schneider-Lunitz; Jorge Ruiz-Orera; Norbert Hubner; Sebastiaan van Heesch
Published in: Plos Computational Biology, Issue 1, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1009658

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.

Author(s): Ansari, S.A.; Dantoft, W.; Ruiz-Orera, J.; Syed, A.P.; Blachut, S.; van Heesch, S.; Hübner, N.; Uhlenhaut, N.H.
Published in: Comp. Struc. Biotech. J. 20, 5622-5638 (2022), Issue 3, 2022, Page(s) 5622-5638, ISSN 2001-0370
Publisher: Science Direct
DOI: 10.1016/j.csbj.2022.09.042

Amplification of autoimmune organ damage by NKp46-activated ILC1s

Author(s): Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A. Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W. Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric L. Lindberg, He
Published in: Nature, Issue 634, 2024, Page(s) 952-960, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07907-x

Standardized annotation of translated open reading frames.

Author(s): Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S
Published in: Nat Biotechnol., Issue Jul;40(7):994-999, 2022, Page(s) 994-999, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01369-0

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

Author(s): Ercu M, Mücke MB, Pallien T, Markó L, Sholokh A, Schächterle C, Aydin A, Kidd A, Walter S, Esmati Y, McMurray BJ, Lato DF, Yumi Sunaga-Franze D, Dierks PH, Flores BIM, Walker-Gray R, Gong M, Merticariu C, Zühlke K, Russwurm M, Liu T, Batolomaeus TUP, Pautz S, Schelenz S, Taube M, Napieczynska H, Heuser A, Eichhorst J, Lehmann M, Miller DC, Diecke S, Qadri F, Popova E, Langanki R, Movsesian MA,
Published in: Circulation, Issue Dec 6;146(23):1758-1778, 2022, Page(s) 1758-1778, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.060210

The Translational Landscape of the Human Heart

Author(s): Sebastiaan van Heesch, Franziska Witte, Valentin Schneider-Lunitz, Jana F. Schulz, Eleonora Adami, Allison B. Faber, Marieluise Kirchner, Henrike Maatz, Susanne Blachut, Clara-Louisa Sandmann, Masatoshi Kanda, Catherine L. Worth, Sebastian Schafer, Lorenzo Calviello, Rhys Merriott, Giannino Patone, Oliver Hummel, Emanuel Wyler, Benedikt Obermayer, Michael B. Mücke, Eric L. Lindberg, Franziska Trn
Published in: Cell, Issue 178/1, 2019, Page(s) 242-260.e29, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.05.010

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

Author(s): Damon A. Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R. Clauser, Alexandra L. Condurat, Jip T. van Dinter, Sem A.G. Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N. Zhou, Jayne Vogelzang, Keith L. Ligon, Timothy N. Phoenix, Jennifer A. Roth, David E. Root, Norbert Hubner, Todd R. Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R. Pren
Published in: Molecular Cell, Issue 84, 2024, Page(s) 261-276.e18, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.12.003

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Author(s): Witte, Franziska; Ruiz-Orera, Jorge; Mattioli, Camilla Ciolli; Blachut, Susanne; Adami, Eleonora; Schulz, Jana Felicitas; Schneider-Lunitz, Valentin; Hummel, Oliver; Patone, Giannino; Mücke, Michael Benedikt; Šilhavý, Jan; Heinig, Matthias; Bottolo, Leonardo; Sanchis, Daniel; Vingron, Martin; Chekulaeva, Marina; Pravenec, Michal; Hubner, Norbert; Van Heesch, Sebastiaan
Published in: Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021), Issue 3, 2021, ISSN 1474-760X
Publisher: biomedcentral
DOI: 10.17863/cam.71948

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

Author(s): C.L. Sandmann, J.F. Schulz, J. Ruiz-Orera, M. Kirchner, M. Ziehm, E. Adami, M. Marczenke, A. Christ, N. Liebe, J. Greiner, A. Schoenenberger, M.B. Mücke, N. Liang, R.L. Moritz, Z. Sun, E.W. Deutsch, M. Gotthardt, J.M. Mudge, J.R. Prensner, T.E. Willnow, P. Mertins, S. van Heesch, N. Hubner
Published in: Mol Cell, 2023, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.01.023

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Author(s): Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F,
Published in: Science, Issue Aug 5;377(6606):eabo1984., 2022, Page(s) 377, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abo1984

Cells of the adult human heart

Author(s): Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Jose
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2797-4

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