Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Informazioni relative al progetto

ReCaP

ID dell’accordo di sovvenzione: 788753

DOI 10.3030/788753

Progetto chiuso

Data della firma CE 20 Giugno 2018

Data di avvio 1 Agosto 2018

Data di completamento 31 Luglio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 999 410,00

Contributo UE € 2 999 410,00

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Pubblicazioni

Peer reviewed articles (21)

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Autori: Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J.
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031460

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Autori: Brady, R.T.; O'Brien, F.J.; Hoey, D.A.
Pubblicato in: Bioengineering, 2022, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering9010035

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Autori: Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Pubblicato in: Materials Today, 2021, ISSN 1369-7021
Editore: Elsevier BV
DOI: 10.1016/j.mattod.2020.12.018

Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel

Autori: Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Pubblicato in: Pharmaceutics, Numero 13/6, 2021, Pagina/e 779, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13060779

Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence

Autori: MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F.
Pubblicato in: International Urogynecology Journal, 2022, ISSN 1433-3023
Editore: Springer
DOI: 10.1007/s00192-022-05160-2

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation

Autori: Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J.
Pubblicato in: Bioengineering, 2022, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering9060232

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Autori: Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Pubblicato in: Biochemical Society Transactions, Numero 48/4, 2020, Pagina/e 1433-1445, ISSN 0300-5127
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20190938

Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Autori: Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Pubblicato in: Journal of Controlled Release, Numero 334, 2021, Pagina/e 96-105, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.031

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Autori: Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D.
Pubblicato in: APL Bioengineering, 2021, ISSN 1077-3118
Editore: AIP Publishing
DOI: 10.1063/5.0068277

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Autori: Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J.
Pubblicato in: Biomaterials and Biosystems, 2022, ISSN 2666-5344
Editore: Elsevier
DOI: 10.1016/j.bbiosy.2022.100066

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Autori: Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Pubblicato in: Pharmaceutics, Numero 12/12, 2020, Pagina/e 1219, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Autori: Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Pubblicato in: Acta Biomaterialia, Numero 109, 2020, Pagina/e 267-279, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Autori: William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Autori: Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Pubblicato in: Advanced Healthcare Materials, Numero 9/10, 2020, Pagina/e 1901827, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901827

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Autori: Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Pubblicato in: Biomaterials, Numero 268, 2021, Pagina/e 120540, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120540

A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition

Autori: Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J.
Pubblicato in: Biomaterials Science, 2022, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm01417j

Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Autori: Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K.
Pubblicato in: Materials Today Communications, 2021, ISSN 2352-4928
Editore: Elsevier BV
DOI: 10.1016/j.mtcomm.2021.102933

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Autori: Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Pubblicato in: Science Advances, Numero 7/9, 2021, Pagina/e eabb7921, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abb7921

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Autori: O'Shea, D.G.; Curtin C.M.; O'Brien F.J.
Pubblicato in: Biomaterials Science, 2022, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm01540k

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Autori: Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J.
Pubblicato in: Nature Reviews Rheumatology, 2021, ISSN 1759-4804
Editore: Nature Publishing Group
DOI: 10.1038/s41584-021-00724-w

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Autori: Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202100878