Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Informazioni relative al progetto

ReCaP

ID dell’accordo di sovvenzione: 788753

DOI 10.3030/788753

Progetto chiuso

Data della firma CE 20 Giugno 2018

Data di avvio 1 Agosto 2018

Data di completamento 31 Luglio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 999 410,00

Contributo UE € 2 999 410,00

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (30)

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Autori: Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J.
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031460

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Autori: Brady, R.T.; O'Brien, F.J.; Hoey, D.A.
Pubblicato in: Bioengineering, 2022, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering9010035

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Autori: Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Pubblicato in: Materials Today, 2021, ISSN 1369-7021
Editore: Elsevier BV
DOI: 10.1016/j.mattod.2020.12.018

Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel

Autori: Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Pubblicato in: Pharmaceutics, Numero 13/6, 2021, Pagina/e 779, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13060779

Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence

Autori: MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F.
Pubblicato in: International Urogynecology Journal, 2022, ISSN 1433-3023
Editore: Springer
DOI: 10.1007/s00192-022-05160-2

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation

Autori: Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J.
Pubblicato in: Bioengineering, 2022, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering9060232

Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms

Autori: Joanna M. Sadowska, Monika Ziminska, Cole Ferreira, Austyn Matheson, Auden Balouch, Jasmine Bogle, Samantha Wojda, John Redmond, Ahmed Elkashif, Nicholas Dunne, Helen O. McCarthy, Seth Donahue, Fergal J. O'Brien
Pubblicato in: Biomaterials, Numero 303, 2024, Pagina/e 122398, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122398

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Autori: Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Pubblicato in: Biochemical Society Transactions, Numero 48/4, 2020, Pagina/e 1433-1445, ISSN 0300-5127
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20190938

Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects

Autori: M Joyce, T Hodgkinson, C Intini, JE Dixon, DJ Kelly, FJ O'Brien
Pubblicato in: European Cells and Materials, Numero 47, 2024, Pagina/e 91-108, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a07

An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects

Autori: Donagh G O’Shea, Tom Hodgkinson, Caroline M Curtin, Fergal J O’Brien
Pubblicato in: Biofabrication, Numero 16, 2023, Pagina/e 015007, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ad047a

Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Autori: Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Pubblicato in: Journal of Controlled Release, Numero 334, 2021, Pagina/e 96-105, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.031

An Innovative miR‐Activated Scaffold for the Delivery of a miR‐221 Inhibitor to Enhance Cartilage Defect Repair

Autori: Claudio Intini, Lia Blokpoel Ferreras, Sarah Casey, James E. Dixon, John P. Gleeson, Fergal J. O'Brien
Pubblicato in: Advanced Therapeutics, Numero 6, 2023, ISSN 2366-3987
Editore: Wiley
DOI: 10.1002/adtp.202200329

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Autori: Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D.
Pubblicato in: APL Bioengineering, 2021, ISSN 1077-3118
Editore: AIP Publishing
DOI: 10.1063/5.0068277

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Autori: Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J.
Pubblicato in: Biomaterials and Biosystems, 2022, ISSN 2666-5344
Editore: Elsevier
DOI: 10.1016/j.bbiosy.2022.100066

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Autori: Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Pubblicato in: Pharmaceutics, Numero 12/12, 2020, Pagina/e 1219, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Autori: Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Pubblicato in: Acta Biomaterialia, Numero 109, 2020, Pagina/e 267-279, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Autori: William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Autori: Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Pubblicato in: Advanced Healthcare Materials, Numero 9/10, 2020, Pagina/e 1901827, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901827

Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects

Autori: M Joyce, T Hodgkinson, M Lemoine, A González-Vázquez, DJ Kelly, FJ O’Brien
Pubblicato in: European Cells and Materials, Numero 45, 2023, Pagina/e 158-172, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a11

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Autori: Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Pubblicato in: Biomaterials, Numero 268, 2021, Pagina/e 120540, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120540

Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing

Autori: Yang Liu, Manoj Puthia, Eamon J. Sheehy, Ines Ambite, Jitka Petrlova, Sujeethkumar Prithviraj, Maria Wimer Oxborg, Sujeesh Sebastian, Corina Vater, Stefan Zwingenberger, André Struglics, Paul E. Bourgine, Fergal J. O'Brien, Deepak Bushan Raina
Pubblicato in: Acta Biomaterialia, Numero 162, 2023, Pagina/e 164-181, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2023.03.028

Interleukin-1 receptor antagonist enhances the therapeutic efficacy of a low dose of rhBMP-2 in a weight-bearing rat femoral defect model

Autori: William A. Lackington, Dominic Gehweiler, Ensi Zhao, Ivan Zderic, Dirk Nehrbass, Stephan Zeiter, Arlyng González-Vázquez, Fergal J. O'Brien, Martin J. Stoddart, Keith Thompson
Pubblicato in: Acta Biomaterialia, Numero 149, 2024, Pagina/e 189-197, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2022.07.012

A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition

Autori: Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J.
Pubblicato in: Biomaterials Science, 2022, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm01417j

Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Autori: Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K.
Pubblicato in: Materials Today Communications, 2021, ISSN 2352-4928
Editore: Elsevier BV
DOI: 10.1016/j.mtcomm.2021.102933

A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles

Autori: Joanna M. Sadowska, Rachael. N. Power, Katelyn J. Genoud, Austyn Matheson, Arlyng González‐Vázquez, Lara Costard, Kian Eichholz, Pierluca Pitacco, Tanguy Hallegouet, Gang Chen, Caroline M. Curtin, Ciara M. Murphy, Brenton Cavanagh, Huijun Zhang, Daniel J. Kelly, Aldo R. Boccaccini, Fergal J. O'Brien
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202307639

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications

Autori: Katie McCormick, Jorge Moreno Herrero, Heinrich Haas, Sarinj Fattah, Andreas Heise, Fergal J. O’Brien, Sally-Ann Cryan
Pubblicato in: Molecular Pharmaceutics, Numero 21, 2024, Pagina/e 1662-1676, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00898

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Autori: Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Pubblicato in: Science Advances, Numero 7/9, 2021, Pagina/e eabb7921, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abb7921

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Autori: O'Shea, D.G.; Curtin C.M.; O'Brien F.J.
Pubblicato in: Biomaterials Science, 2022, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm01540k

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Autori: Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J.
Pubblicato in: Nature Reviews Rheumatology, 2021, ISSN 1759-4804
Editore: Nature Publishing Group
DOI: 10.1038/s41584-021-00724-w

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Autori: Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202100878