Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Project Information

ReCaP

Grant agreement ID: 788753

DOI 10.3030/788753

Project closed

EC signature date 20 June 2018

Start date 1 August 2018

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 999 410,00

EU contribution € 2 999 410,00

Coordinated by

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Author(s): Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J.
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031460

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Author(s): Brady, R.T.; O'Brien, F.J.; Hoey, D.A.
Published in: Bioengineering, 2022, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering9010035

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Author(s): Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Published in: Materials Today, 2021, ISSN 1369-7021
Publisher: Elsevier BV
DOI: 10.1016/j.mattod.2020.12.018

Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel

Author(s): Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Published in: Pharmaceutics, Issue 13/6, 2021, Page(s) 779, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13060779

Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence

Author(s): MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F.
Published in: International Urogynecology Journal, 2022, ISSN 1433-3023
Publisher: Springer
DOI: 10.1007/s00192-022-05160-2

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation

Author(s): Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J.
Published in: Bioengineering, 2022, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering9060232

Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms

Author(s): Joanna M. Sadowska, Monika Ziminska, Cole Ferreira, Austyn Matheson, Auden Balouch, Jasmine Bogle, Samantha Wojda, John Redmond, Ahmed Elkashif, Nicholas Dunne, Helen O. McCarthy, Seth Donahue, Fergal J. O'Brien
Published in: Biomaterials, Issue 303, 2024, Page(s) 122398, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122398

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Author(s): Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Published in: Biochemical Society Transactions, Issue 48/4, 2020, Page(s) 1433-1445, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20190938

Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects

Author(s): M Joyce, T Hodgkinson, C Intini, JE Dixon, DJ Kelly, FJ O'Brien
Published in: European Cells and Materials, Issue 47, 2024, Page(s) 91-108, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a07

An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects

Author(s): Donagh G O’Shea, Tom Hodgkinson, Caroline M Curtin, Fergal J O’Brien
Published in: Biofabrication, Issue 16, 2023, Page(s) 015007, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ad047a

Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Author(s): Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Published in: Journal of Controlled Release, Issue 334, 2021, Page(s) 96-105, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.031

An Innovative miR‐Activated Scaffold for the Delivery of a miR‐221 Inhibitor to Enhance Cartilage Defect Repair

Author(s): Claudio Intini, Lia Blokpoel Ferreras, Sarah Casey, James E. Dixon, John P. Gleeson, Fergal J. O'Brien
Published in: Advanced Therapeutics, Issue 6, 2023, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202200329

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Author(s): Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D.
Published in: APL Bioengineering, 2021, ISSN 1077-3118
Publisher: AIP Publishing
DOI: 10.1063/5.0068277

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Author(s): Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J.
Published in: Biomaterials and Biosystems, 2022, ISSN 2666-5344
Publisher: Elsevier
DOI: 10.1016/j.bbiosy.2022.100066

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Author(s): Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Published in: Pharmaceutics, Issue 12/12, 2020, Page(s) 1219, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Author(s): Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Published in: Acta Biomaterialia, Issue 109, 2020, Page(s) 267-279, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Author(s): William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Author(s): Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Published in: Advanced Healthcare Materials, Issue 9/10, 2020, Page(s) 1901827, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901827

Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects

Author(s): M Joyce, T Hodgkinson, M Lemoine, A González-Vázquez, DJ Kelly, FJ O’Brien
Published in: European Cells and Materials, Issue 45, 2023, Page(s) 158-172, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a11

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Author(s): Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Published in: Biomaterials, Issue 268, 2021, Page(s) 120540, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120540

Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing

Author(s): Yang Liu, Manoj Puthia, Eamon J. Sheehy, Ines Ambite, Jitka Petrlova, Sujeethkumar Prithviraj, Maria Wimer Oxborg, Sujeesh Sebastian, Corina Vater, Stefan Zwingenberger, André Struglics, Paul E. Bourgine, Fergal J. O'Brien, Deepak Bushan Raina
Published in: Acta Biomaterialia, Issue 162, 2023, Page(s) 164-181, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2023.03.028

Interleukin-1 receptor antagonist enhances the therapeutic efficacy of a low dose of rhBMP-2 in a weight-bearing rat femoral defect model

Author(s): William A. Lackington, Dominic Gehweiler, Ensi Zhao, Ivan Zderic, Dirk Nehrbass, Stephan Zeiter, Arlyng González-Vázquez, Fergal J. O'Brien, Martin J. Stoddart, Keith Thompson
Published in: Acta Biomaterialia, Issue 149, 2024, Page(s) 189-197, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.07.012

A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition

Author(s): Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J.
Published in: Biomaterials Science, 2022, ISSN 2047-4849
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01417j

Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Author(s): Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K.
Published in: Materials Today Communications, 2021, ISSN 2352-4928
Publisher: Elsevier BV
DOI: 10.1016/j.mtcomm.2021.102933

A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles

Author(s): Joanna M. Sadowska, Rachael. N. Power, Katelyn J. Genoud, Austyn Matheson, Arlyng González‐Vázquez, Lara Costard, Kian Eichholz, Pierluca Pitacco, Tanguy Hallegouet, Gang Chen, Caroline M. Curtin, Ciara M. Murphy, Brenton Cavanagh, Huijun Zhang, Daniel J. Kelly, Aldo R. Boccaccini, Fergal J. O'Brien
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202307639

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications

Author(s): Katie McCormick, Jorge Moreno Herrero, Heinrich Haas, Sarinj Fattah, Andreas Heise, Fergal J. O’Brien, Sally-Ann Cryan
Published in: Molecular Pharmaceutics, Issue 21, 2024, Page(s) 1662-1676, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00898

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author(s): Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Published in: Science Advances, Issue 7/9, 2021, Page(s) eabb7921, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abb7921

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Author(s): O'Shea, D.G.; Curtin C.M.; O'Brien F.J.
Published in: Biomaterials Science, 2022, ISSN 2047-4849
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01540k

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Author(s): Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J.
Published in: Nature Reviews Rheumatology, 2021, ISSN 1759-4804
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-021-00724-w

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Author(s): Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien
Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202100878