Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Project Information

ReCaP

Grant agreement ID: 788753

DOI 10.3030/788753

Project closed

EC signature date 20 June 2018

Start date 1 August 2018

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 999 410,00

EU contribution € 2 999 410,00

Coordinated by

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Publications

Peer reviewed articles (21)

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Author(s): Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J.
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031460

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Author(s): Brady, R.T.; O'Brien, F.J.; Hoey, D.A.
Published in: Bioengineering, 2022, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering9010035

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Author(s): Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Published in: Materials Today, 2021, ISSN 1369-7021
Publisher: Elsevier BV
DOI: 10.1016/j.mattod.2020.12.018

Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel

Author(s): Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Published in: Pharmaceutics, Issue 13/6, 2021, Page(s) 779, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13060779

Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence

Author(s): MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F.
Published in: International Urogynecology Journal, 2022, ISSN 1433-3023
Publisher: Springer
DOI: 10.1007/s00192-022-05160-2

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation

Author(s): Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J.
Published in: Bioengineering, 2022, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering9060232

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Author(s): Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Published in: Biochemical Society Transactions, Issue 48/4, 2020, Page(s) 1433-1445, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20190938

Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Author(s): Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Published in: Journal of Controlled Release, Issue 334, 2021, Page(s) 96-105, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.031

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Author(s): Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D.
Published in: APL Bioengineering, 2021, ISSN 1077-3118
Publisher: AIP Publishing
DOI: 10.1063/5.0068277

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Author(s): Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J.
Published in: Biomaterials and Biosystems, 2022, ISSN 2666-5344
Publisher: Elsevier
DOI: 10.1016/j.bbiosy.2022.100066

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Author(s): Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Published in: Pharmaceutics, Issue 12/12, 2020, Page(s) 1219, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Author(s): Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Published in: Acta Biomaterialia, Issue 109, 2020, Page(s) 267-279, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Author(s): William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Author(s): Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Published in: Advanced Healthcare Materials, Issue 9/10, 2020, Page(s) 1901827, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901827

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Author(s): Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Published in: Biomaterials, Issue 268, 2021, Page(s) 120540, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120540

A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition

Author(s): Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J.
Published in: Biomaterials Science, 2022, ISSN 2047-4849
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01417j

Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Author(s): Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K.
Published in: Materials Today Communications, 2021, ISSN 2352-4928
Publisher: Elsevier BV
DOI: 10.1016/j.mtcomm.2021.102933

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author(s): Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Published in: Science Advances, Issue 7/9, 2021, Page(s) eabb7921, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abb7921

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Author(s): O'Shea, D.G.; Curtin C.M.; O'Brien F.J.
Published in: Biomaterials Science, 2022, ISSN 2047-4849
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01540k

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Author(s): Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J.
Published in: Nature Reviews Rheumatology, 2021, ISSN 1759-4804
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-021-00724-w

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Author(s): Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien
Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202100878