Chromatin-localized central metabolism regulating gene expression and cell identity

Project Information

CHROMABOLISM

Grant agreement ID: 772437

DOI 10.3030/772437

Project closed

EC signature date 6 April 2018

Start date 1 May 2018

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 980 916,00

EU contribution € 1 980 916,00

Coordinated by

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria

Publications

Peer reviewed articles (11)

Metabolic modulation of transcription: The role of one-carbon metabolism

Author(s): Jung-Ming G Lin, Savvas Kourtis, Ritobrata Ghose, Natalia Pardo Lorente, Stefan Kubicek, Sara Sdelci
Published in: Cell Chem Biol., Issue S2451, 2022, Page(s) 9456(22)00415-9, ISSN 2451-9448
Publisher: Cell Press
DOI: 10.1016/j.chembiol.2022.11.009

Acute BAF perturbation causes immediate changes in chromatin accessibility

Author(s): Sandra Schick, Sarah Grosche, Katharina Eva Kohl, Danica Drpic, Martin G. Jaeger, Nara C. Marella, Hana Imrichova, Jung-Ming G. Lin, Gerald Hofstätter, Michael Schuster, André F. Rendeiro, Anna Koren, Mark Petronczki, Christoph Bock, André C. Müller, Georg E. Winter, Stefan Kubicek
Published in: Nature Genetics, Issue 53/3, 2021, Page(s) 269-278, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00777-3

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Author(s): Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek
Published in: Genome Biology, Issue 21(1), 2020, Page(s) 106, ISSN 1474-760X
Publisher: Biomed Central
DOI: 10.1186/s13059-020-02006-2

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Author(s): Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Published in: Nature Metabolism, Issue 3/5, 2021, Page(s) 651-664, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-021-00386-8

Therapeutic targeting of chromatin: Status and opportunities

Author(s): Marton Siklos, Stefan Kubicek
Published in: The FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15966

SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression

Author(s): Tamara Casteels; Simon Bajew; Jiří Reiniš; Lennart Enders; Michael Schuster; Frédéric Fontaine; André C. Müller; Bridget K. Wagner; Christoph Bock; Stefan Kubicek
Published in: Cell Reports, Issue 1, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111288

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Author(s): Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans M
Published in: Nature Genetics, Issue 51/6, 2019, Page(s) 990-998, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0413-z

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Author(s): Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, Anna Ringler, Bernd Boidol, Melanie Hinkel, Peter Májek, Loan Vulliard, Thomas Penz, Katja Parapatics, Christian Schmidl, Jörg Menche, Guido Boehmelt, Mark Petronczki, André C. Müller, Christoph Bock, Stefan Kubicek
Published in: Nature Genetics, Issue 51/9, 2019, Page(s) 1399-1410, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0477-9

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Author(s): Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Published in: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 469-478, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0483-3

PlateFlo – A software-controllable plate-scale perfusion system for culture of adherent cells

Author(s): Robert Pazdzior; Stefan Kubicek
Published in: HardwareX, Issue e00222, 2021, ISSN 2468-0672
Publisher: Elsevier
DOI: 10.1016/j.ohx.2021.e00222

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

Author(s): Andreas Reicher, Anna Koren, Stefan Kubicek
Published in: Genome Research, Issue 30, 2020, Page(s) 1846-1855, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.261503.120