Hanover experimental lung research project

The role of vasculature and angiogenesis in respiratory diseases

Author(s): Maximilian Ackermann, Christopher Werlein, Edith Plucinski, Sophie Leypold, Mark P. Kühnel, Stijn E. Verleden, Hassan A. Khalil, Florian Länger, Tobias Welte, Steven J. Mentzer, Danny D. Jonigk
Published in: Angiogenesis, Issue 27, 2024, Page(s) 293-310, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09910-2

Non-invasive screening for subclinical liver graft injury in adults via donor-specific anti-HLA antibodies

Author(s): Anne Höfer, Danny Jonigk, Björn Hartleben, Murielle Verboom, Michael Hallensleben, Michael P. Manns, Elmar Jaeckel, Richard Taubert
Published in: Scientific Reports, Issue 10, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-70938-7

Cigarette smoke alters inflammatory genes and the extracellular matrix — investigations on viable sections of peripheral human lungs

Author(s): Helena Obernolte, Monika Niehof, Peter Braubach, Hans-Gerd Fieguth, Danny Jonigk, Olaf Pfennig, Thomas Tschernig, Gregor Warnecke, Armin Braun, Katherina Sewald
Published in: Cell and Tissue Research, Issue 387, 2023, Page(s) 249-260, ISSN 0302-766X
Publisher: Springer Verlag
DOI: 10.1007/s00441-021-03553-1

Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics

Author(s): Stevan D. Stojanović, Maximilian Fuchs, Chunguang Liang, Kevin Schmidt, Ke Xiao, Annette Just, Angelika Pfanne, Andreas Pich, Gregor Warnecke, Peter Braubach, Christina Petzold, Danny Jonigk, Jörg H. W. Distler, Jan Fiedler, Thomas Thum, Meik Kunz
Published in: Scientific Reports, Issue 11, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-89531-7

COVID-19: Auswirkungen auf Lunge und Herz

Author(s): Maximilian Ackermann, Christopher Werlein, Florian Länger, Mark P. Kühnel, Danny D. Jonigk
Published in: Der Pathologe, Issue 42, 2021, Page(s) 164-171, ISSN 0172-8113
Publisher: Springer Verlag
DOI: 10.1007/s00292-021-00918-9

Comprehensive three‐dimensional morphology of neoangiogenesis in pulmonary veno‐occlusive disease and pulmonary capillary hemangiomatosis

Author(s): Lavinia Neubert, Paul Borchert, Hoen‐Oh Shin, Friedemann Linz, Willi L Wagner, Gregor Warnecke, Florian Laenger, Axel Haverich, Helge Stark, Marius M Hoeper, Mark Kuehnel, Maximilian Ackermann, Danny Jonigk
Published in: The Journal of Pathology: Clinical Research, Issue 5, 2023, Page(s) 108-114, ISSN 2056-4538
Publisher: Wiley
DOI: 10.1002/cjp2.125

Multilamellated Basement Membranes in the Capillary Network of Alveolar Capillary Dysplasia

Author(s): Jan C. Kamp, Lavinia Neubert, Jonas C. Schupp, Peter Braubach, Christoph Wrede, Florian Laenger, Tim Salditt, Jakob Reichmann, Tobias Welte, Arjang Ruhparwar, Fabio Ius, Nicolaus Schwerk, Anke K. Bergmann, Sandra von Hardenberg, Matthias Griese, Christina Rapp, Karen M. Olsson, Jan Fuge, Da-Hee Park, Marius M. Hoeper, Danny D. Jonigk, Lars Knudsen, Mark P. Kuehnel
Published in: The American Journal of Pathology, Issue 194, 2024, Page(s) 180-194, ISSN 0002-9440
Publisher: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2023.10.012

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Author(s): Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Published in: Nature Communications, Issue 10, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10135-x

IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues

Author(s): Andrea J. Radtke, Colin J. Chu, Ziv Yaniv, Li Yao, James Marr, Rebecca T. Beuschel, Hiroshi Ichise, Anita Gola, Juraj Kabat, Bradley Lowekamp, Emily Speranza, Joshua Croteau, Nishant Thakur, Danny Jonigk, Jeremy L. Davis, Jonathan M. Hernandez, Ronald N. Germain
Published in: Nature Protocols, Issue 17, 2024, Page(s) 378-401, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00644-9

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

Author(s): Maximilian Ackermann, Jan C. Kamp, Christopher Werlein, Claire L. Walsh, Helge Stark, Verena Prade, Rambabu Surabattula, Willi L. Wagner, Catherine Disney, Andrew J. Bodey, Thomas Illig, Diana J. Leeming, Morten A. Karsdal, Alexandar Tzankov, Peter Boor, Mark P. Kühnel, Florian P. Länger, Stijn E. Verleden, Hans M. Kvasnicka, Hans H. Kreipe, Axel Haverich, Stephen M. Black, Axel Walch, Paul Taff
Published in: eBioMedicine, Issue 85, 2022, Page(s) 104296, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104296

Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

Author(s): C. L. Walsh, P. Tafforeau, W. L. Wagner, D. J. Jafree, A. Bellier, C. Werlein, M. P. Kühnel, E. Boller, S. Walker-Samuel, J. L. Robertus, D. A. Long, J. Jacob, S. Marussi, E. Brown, N. Holroyd, D. D. Jonigk, M. Ackermann, P. D. Lee
Published in: Nature Methods, Issue 18, 2023, Page(s) 1532-1541, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01317-x

Microvascular placental alterations in maternal COVID-19

Author(s): Maximilian Ackermann, Danny D. Jonigk
Published in: American Journal of Obstetrics and Gynecology, Issue 226, 2022, Page(s) 135-136, ISSN 0002-9378
Publisher: Mosby Inc.
DOI: 10.1016/j.ajog.2021.06.098

Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells

Author(s): Jonas C. Schupp, Edward P. Manning, Maurizio Chioccioli, Jan C. Kamp, Leonard Christian, Changwan Ryu, Erica Herzog, Mark P. Kühnel, Antje Prasse, Naftali Kaminski, Danny D. Jonigk, Robert J. Homer, Lavinia Neubert, Fabio Ius, Aurélien stringJustet, Lida P. Hariri, Benjamin Seeliger, Tobias Welte, Rachel S. Knipe, Jens Gottlieb
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 208, 2023, Page(s) 819-822, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202303-0544le

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

Author(s): Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P. Gunesch, Martina Kasten, Francisco J. Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F. Rimmelzwaan, Anne Höfer, Mark P. Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Sch
Published in: PLOS ONE, Issue 16, 2023, Page(s) e0255335, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0255335

Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging

Author(s): Ellen M. Quardokus, Diane C. Saunders, Elizabeth McDonough, John W. Hickey, Christopher Werlein, Christine Surrette, Presha Rajbhandari, Anna Martinez Casals, Hua Tian, Lisa Lowery, Elizabeth K. Neumann, Frida Björklund, Taruna V. Neelakantan, Josh Croteau, Anne E. Wiblin, Jeremy Fisher, April J. Livengood, Karen G. Dowell, Jonathan C. Silverstein, Jeffrey M. Spraggins, Gloria S. Pryhuber, Gail D
Published in: Nature Methods, Issue 20, 2023, Page(s) 1174-1178, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-01846-7

Author(s): Jan C. Kamp, Naomi N. Kappe, Carlos Fernández Moro, Jan Fuge, Mark P. Kuehnel, Sabine Wrenger, Tobias Welte, Bart van Hoek, Danny D. Jonigk, Padmini P. S. J. Khedoe, Pavel Strnad, Mikael Björnstedt, Jan Stolk, Sabina Janciauskiene, Antal Nemeth
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 2485, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032485

Molecular approach to the classification of chronic fibrosing lung disease—there and back again

Author(s): Stijn E. Verleden, Peter Braubach, Mark Kuehnel, Nicolas Dickgreber, Emily Brouwer, Pauline Tittmann, Florian Laenger, Danny Jonigk
Published in: Virchows Archiv, Issue 478, 2022, Page(s) 89-99, ISSN 0945-6317
Publisher: Springer Verlag
DOI: 10.1007/s00428-020-02964-9

When tissue is the issue: A histological review of chronic lung allograft dysfunction

Author(s): Stijn E. Verleden, Jan Von der Thüsen, Antoine Roux, Emily S. Brouwers, Peter Braubach, Mark Kuehnel, Florian Laenger, Danny Jonigk
Published in: American Journal of Transplantation, Issue 20, 2023, Page(s) 2644-2651, ISSN 1600-6135
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ajt.15864

Novel Insight into Pulmonary Fibrosis and Long COVID

Author(s): Jan C. Kamp, Christopher Werlein, Edith K. J. Plucinski, Lavinia Neubert, Tobias Welte, Peter D. Lee, Paul Tafforeau, Claire Walsh, Mark P. Kuehnel, Detlef Schuppan, Marius M. Hoeper, Danny D. Jonigk, Maximilian Ackermann
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 207, 2023, Page(s) 1105-1107, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202212-2314le

The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution

Author(s): Laura P M H de Rooij, Lisa M Becker, Laure-Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sébastien J Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amélie Dendooven, Anh-Co K Truong, Jan Gunst, Pierre Van Mol, Jasmin D Haslbauer, Katerina Rohlenova, Thomas Menter, Robb
Published in: Cardiovascular Research, Issue 119, 2023, Page(s) 520-535, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac139

Quantitative analysis of airway obstruction in lymphangioleiomyomatosis

Author(s): Stijn E. Verleden, Arno Vanstapel, Laurens De Sadeleer, Birgit Weynand, Matthieu Boone, Erik Verbeken, Davide Piloni, Dirk Van Raemdonck, Maximilian Ackermann, Danny D. Jonigk, Johny Verschakelen, Wim A. Wuyts
Published in: European Respiratory Journal, Issue 56, 2024, Page(s) 1901965, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.01965-2019

From Macroscopy to Ultrastructure: An Integrative Approach to Pulmonary Pathology

Author(s): Stijn E. Verleden, Peter Braubach, Christopher Werlein, Edith Plucinski, Mark P. Kuhnel, Annemiek Snoeckx, Haroun El Addouli, Tobias Welte, Axel Haverich, Florian P. Laenger, Sabine Dettmer, Patrick Pauwels, Veronique Verplancke, Paul E. Van Schil, Therese Lapperre, Johanna M. Kwakkel-Van-Erp, Maximilian Ackermann, Jeroen M. H. Hendriks, Danny Jonigk
Published in: Frontiers in Medicine, Issue 9, 2022, ISSN 2296-858X
Publisher: Frontiers
DOI: 10.3389/fmed.2022.859337

The Bronchial Circulation in COVID-19 Pneumonia

Author(s): Maximilian Ackermann, Paul Tafforeau, Willi L. Wagner, Claire L. Walsh, Christopher Werlein, Mark P. Kühnel, Florian P. Länger, Catherine Disney, Andrew J. Bodey, Alexandre Bellier, Stijn E. Verleden, Peter D. Lee, Steven J. Mentzer, Danny D. Jonigk
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 205, 2022, Page(s) 121-125, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202103-0594im

Fibrotischer Lungenparenchymumbau nach Lungen- und Stammzelltransplantation

Author(s): Christopher Werlein, Max Ackermann, Thia Leandra Hoffmann, Florian Laenger, Danny Jonigk
Published in: Der Pathologe, Issue 42, 2021, Page(s) 17-24, ISSN 0172-8113
Publisher: Springer Verlag
DOI: 10.1007/s00292-020-00898-2

Morphological and molecular motifs of fibrosing pulmonary injury patterns

Author(s): Danny Jonigk, Helge Stark, Peter Braubach, Lavinia Neubert, Hoen‐oh Shin, Nicole Izykowski, Tobias Welte, Sabina Janciauskiene, Gregor Warnecke, Axel Haverich, Mark Kuehnel, Florian Laenger
Published in: The Journal of Pathology: Clinical Research, Issue 5/4, 2019, Page(s) 256-271, ISSN 2056-4538
Publisher: Wiley Online Library
DOI: 10.1002/cjp2.141

Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases

Author(s): Maximilian Ackermann, Helge Stark, Lavinia Neubert, Stephanie Schubert, Paul Borchert, Friedemann Linz, Willi L. Wagner, Wolfram Stiller, Mark Wielpütz, Anne Hoefer, Axel Haverich, Steven J. Mentzer, Harshit R. Shah, Tobias Welte, Mark Kuehnel, Danny Jonigk
Published in: European Respiratory Journal, 2019, Page(s) 1900933, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.00933-2019

Schädigungsmuster interstitieller Lungenerkrankungen

Author(s): F. Länger, H. Stark, P. Braubach, M. Ackermann, K. Hussein, K. Teiken, L. Maegel, M. Kuehnel, D. Jonigk
Published in: Der Pathologe, Issue 39/S2, 2018, Page(s) 262-271, ISSN 0172-8113
Publisher: Springer Verlag
DOI: 10.1007/s00292-018-0503-1

Lungentransplantation

Author(s): J. Wohlschlaeger, F. Laenger, J. Gottlieb, T. Hager, A. Seidel, D. Jonigk
Published in: Der Pathologe, Issue 40/3, 2019, Page(s) 281-291, ISSN 0172-8113
Publisher: Springer Verlag
DOI: 10.1007/s00292-019-0598-z

Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo

Author(s): Petra Khan, Kleanthis Fytianos, Sabrina Blumer, Julien Roux, Amiq Gazdhar, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Sofia Mykoniati, Michael Tamm, Thomas Geiser, Katrin E. Hostettler
Published in: Frontiers in Bioengineering and Biotechnology, Issue 10, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.844119

Inflammation and vascular remodeling in COVID-19 hearts

Author(s): Christopher Werlein, Maximilian Ackermann, Helge Stark, Harshit R. Shah, Alexandar Tzankov, Jasmin Dinonne Haslbauer, Saskia von Stillfried, Roman David Bülow, Ali El-Armouche, Stephan Kuenzel, Jan Lukas Robertus, Marius Reichardt, Axel Haverich, Anne Höfer, Lavinia Neubert, Edith Plucinski, Peter Braubach, Stijn Verleden, Tim Salditt, Nikolaus Marx, Tobias Welte, Johann Bauersachs, Hans-Heinric
Published in: Angiogenesis, Issue 26, 2023, Page(s) 233-248, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-022-09860-7

FDA-Approved Inhibitors of RTK/Raf Signaling Potently Impair Multiple Steps of In Vitro and Ex Vivo Influenza A Virus Infections

Author(s): Robert Meineke, Sonja Stelz, Maximilian Busch, Christopher Werlein, Mark Kühnel, Danny Jonigk, Guus F. Rimmelzwaan, Husni Elbahesh
Published in: Viruses, Issue 14, 2024, Page(s) 2058, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14092058

Die aktualisierte S2k-Leitlinie zur Diagnostik der idiopathischen Lungenfibrose

Author(s): Ludger Fink, Danny Jonigk
Published in: Der Pathologe, Issue 42, 2021, Page(s) 40-47, ISSN 0172-8113
Publisher: Springer Verlag
DOI: 10.1007/s00292-020-00894-6

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

Author(s): Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev, Maria Sorokina, Olga Kudryashova, Mark Meerson, Margarita Polyakova, Ilia Galkin, Viktor Svekolkin, Sergey Isaev, Daniil Wiebe, Anna Sharun, Alexander Sarachakov, Grigory Perelman, Yaroslav Lozinsky, Ziv Yaniv, Bradley C. Lowekamp, Emily Speranza, Li Yao, Stefania Pittaluga, Arthur L. Shaffer, Danny Jonigk, James D. Phelan
Published in: Cancer Cell, Issue 42, 2024, Page(s) 444-463.e10, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2024.02.001

Role of the COX2-PGE2 axis in S. pneumoniae-induced exacerbation of experimental fibrosis

Author(s): Tina Bormann, Regina Maus, Jennifer Stolper, Danny Jonigk, Tobias Welte, Jack Gauldie, Martin Kolb, Ulrich A. Maus
Published in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Issue 320, 2021, Page(s) L377-L392, ISSN 1040-0605
Publisher: American Physiological Society
DOI: 10.1152/ajplung.00024.2020

Amyloid precursor protein as a fibrosis marker in infants with biliary atresia

Author(s): Jan C. Kamp, Omid Madadi-Sanjani, Marie Uecker, Christopher Werlein, Lavinia Neubert, Joachim F. Kübler, Mikal Obed, Norman Junge, Tobias Welte, Jannik Ruwisch, Danny D. Jonigk, Jan Stolk, Gertrud Vieten, Sabina Janciauskiene
Published in: Pediatric Research, 2024, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-024-03582-w

3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography

Author(s): Marina Eckermann, Jasper Frohn, Marius Reichardt, Markus Osterhoff, Michael Sprung, Fabian Westermeier, Alexandar Tzankov, Christopher Werlein, Mark Kühnel, Danny Jonigk, Tim Salditt
Published in: eLife, Issue 9, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60408

Comparative Analysis of Gene Expression in Fibroblastic Foci in Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis

Author(s): Jan C. Kamp, Lavinia Neubert, Helge Stark, Jan B. Hinrichs, Caja Boekhoff, Allison D. Seidel, Fabio Ius, Axel Haverich, Jens Gottlieb, Tobias Welte, Peter Braubach, Florian Laenger, Marius M. Hoeper, Mark P. Kuehnel, Danny D. Jonigk
Published in: Cells, Issue 11, 2024, Page(s) 664, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11040664

Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro

Author(s): Monika Szepes, Anna Melchert, Julia Dahlmann, Jan Hegermann, Christopher Werlein, Danny Jonigk, Axel Haverich, Ulrich Martin, Ruth Olmer, Ina Gruh
Published in: International Journal of Molecular Sciences, Issue 21, 2024, Page(s) 8947, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238947

Pulmonary Fibroelastotic Remodelling Revisited

Author(s): Peter Braubach, Christopher Werlein, Stijn E. Verleden, Isabell Maerzke, Jens Gottlieb, Gregor Warnecke, Sabine Dettmer, Florian Laenger, Danny Jonigk
Published in: Cells, Issue 10, 2024, Page(s) 1362, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10061362

FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants

Author(s): Robert Meineke, Sonja Stelz, Maximilian Busch, Christopher Werlein, Mark Kühnel, Danny Jonigk, Guus F. Rimmelzwaan, Husni Elbahesh
Published in: iScience, Issue 26, 2024, Page(s) 106309, ISSN 2589-0042
Publisher: MDPI
DOI: 10.1016/j.isci.2023.106309

Reply to Bush et al. and to Persson

Author(s): Maximilian Ackermann, Steven J. Mentzer, Danny D. Jonigk
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 206, 2022, Page(s) 229-230, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202201-0122le

A Morphomolecular Approach to Alveolar Capillary Dysplasia

Author(s): Jan C. Kamp, Lavinia Neubert, Maximilian Ackermann, Helge Stark, Edith Plucinski, Harshit R. Shah, Sabina Janciauskiene, Anke K. Bergmann, Gunnar Schmidt, Tobias Welte, Axel Haverich, Christopher Werlein, Peter Braubach, Florian Laenger, Nicolaus Schwerk, Karen M. Olsson, Jan Fuge, Da-Hee Park, Jonas C. Schupp, Marius M. Hoeper, Mark P. Kuehnel, Danny D. Jonigk
Published in: The American Journal of Pathology, Issue 192, 2022, Page(s) 1110-1121, ISSN 0002-9440
Publisher: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2022.05.004

Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties

Author(s): Tim Hempel, Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H. Shrimp, Olga Danov, Danny Jonigk, Armin Braun, Min Shen, Matthew D. Hall, Stefan Pöhlmann, Markus Hoffmann, Frank Noé
Published in: Chemical Science, Issue 12, 2024, Page(s) 12600-12609, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc01494c

<scp>Interleukin‐17A</scp> and interleukin‐22 production by conventional and non‐conventional lymphocytes in three different end‐stage lung diseases

Author(s): Melanie Albrecht, Olga Halle, Svenja Gaedcke, Sophia T Pallenberg, Julia Camargo Neumann, Marius Witt, Johanna Roediger, Marina Schumacher, Adan Chari Jirmo, Gregor Warnecke, Danny Jonigk, Peter Braubach, David DeLuca, Gesine Hansen, Anna‐Maria Dittrich
Published in: Clinical & Translational Immunology, Issue 11, 2023, ISSN 2050-0068
Publisher: Wiley
DOI: 10.1002/cti2.1398

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients

Author(s): Dickson W. L. Wong, Barbara M. Klinkhammer, Sonja Djudjaj, Sophia Villwock, M. Cherelle Timm, Eva M. Buhl, Sophie Wucherpfennig, Claudio Cacchi, Till Braunschweig, Ruth Knüchel-Clarke, Danny Jonigk, Christopher Werlein, Roman D. Bülow, Edgar Dahl, Saskia von Stillfried, Peter Boor
Published in: Cells, Issue 10, 2024, Page(s) 1900, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10081900

COVID-19: what the clinician should know about post-mortem findings

Author(s): Danny Jonigk, Bruno Märkl, Julie Helms
Published in: Intensive Care Medicine, Issue 47, 2021, Page(s) 86-89, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-020-06302-0

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Author(s): Maximilian Ackermann, Stijn E. Verleden, Mark Kuehnel, Axel Haverich, Tobias Welte, Florian Laenger, Arno Vanstapel, Christopher Werlein, Helge Stark, Alexandar Tzankov, William W. Li, Vincent W. Li, Steven J. Mentzer, Danny Jonigk
Published in: New England Journal of Medicine, Issue 383, 2020, Page(s) 120-128, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2015432

IBEX: An open and extensible method for high content multiplex imaging of diverse tissues

Author(s): Radtke, Andrea J.; Chu, Colin J.; Yaniv, Ziv; Yao, Li; Marr, James; Beuschel, Rebecca T.; Ichise, Hiroshi; Gola, Anita; Kabat, Juraj; Lowekamp, Bradley; Speranza, Emily; Croteau, Joshua; Thakur, Nishant; Jonigk, Danny; Davis, Jeremy; Hernandez, Jonathan M.; Germain, Ronald N.
Published in: Issue 2, 2021
Publisher: Cornell University
DOI: 10.48550/arxiv.2107.11364

A multiscale X-ray phase-contrast tomography dataset of whole human left lung

Author(s): R. Patrick Xian, Claire L. Walsh, Stijn E. Verleden, Willi L. Wagner, Alexandre Bellier, Sebastian Marussi, Maximilian Ackermann, Danny D. Jonigk, Joseph Jacob, Peter D. Lee, Paul Tafforeau
Published in: 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.11.20.469361

3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography

Author(s): Marius Reichardt, Patrick Møller Jensen, Vedrana Andersen Dahl, Anders Bjorholm Dahl, Maximilian Ackermann, Harshit Shah, Florian Länger, Christopher Werlein, Mark Kühnel, Danny Jonigk, Tim Salditt
Published in: 2022
Publisher: Cold Spring Harbour
DOI: 10.1101/2021.09.16.460594

Deep Learning for 3D Vascular Segmentation in Phase Contrast Tomography

Author(s): Ekin Yagis, Shahab Aslani, Yashvardhan Jain, Yang Zhou, Shahrokh Rahmani, Joseph Brunet, Alexandre Bellier, Christopher Werlein, Maximilian Ackermann, Danny Jonigk, Paul Tafforeau, Claire Walsh, Peter D Lee
Published in: 2024
Publisher: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-4613439/v1

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

Author(s): C. Walsh, P. Tafforeau, Willi L. Wagner, D. J. Jafree, A. Bellier, C. Werlein, M. P. Kühnel, E. Boller, S. Walker-Samuel, J. L. Robertus, D. A. Long, J. Jacob, S. Marussi, E. Brown, N. Holroyd, D. D. Jonigk, M. Ackermann, P. D. Lee
Published in: bioRxiv, 2024
Publisher: bioRxiv
DOI: 10.1101/2021.02.03.429481

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Published in: 03.03 - Mechanisms of lung injury and repair, 2024, Page(s) 433
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DOI: 10.1183/13993003.congress-2022.433

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