VIral and BacteRial Adhesin Network Training

Informazioni relative al progetto

ViBrANT

ID dell’accordo di sovvenzione: 765042

DOI 10.3030/765042

Progetto chiuso

Data della firma CE 31 Agosto 2017

Data di avvio 1 Gennaio 2018

Data di completamento 30 Giugno 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 3 925 220,40

Contributo UE € 3 925 220,40

Coordinato da

UNIVERSITY OF LEEDS
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Release of the modelling protocol for adhesin structure determination as software
Report with updated exploitation strategy
Report on exploitation strategy
Outreach plan

Plan for communications and outreach

White paper on best practices in the ETN
Data management plan

Websites, patent fillings, videos etc. (4)

>10 review articles published/in press
Developed materials and methods for capture/enrichment of multiple pathogens based on adhesin-ligand binding

Developed materials and methods for captureenrichment of multiple pathogens based on adhesinligand binding

Initial website

Initial public website goes live

30 publications in high-quality open-access journals

30 publications in highquality openaccess journals

Other (2)

Recruitment of all ESRs
Supervisory Board of network

Compulsory Deliverable

Demonstrators, pilots, prototypes (1)

Mapping of Interfaces between viral adhesins and receptors

Pubblicazioni

Peer reviewed articles (31)

Novel Biorecognition Elements against Pathogens in the Design of State-of-the Art Diagnostics

Autori: Sande M.G, Rodrigues J.L, Ferreira D, Silva C.J, Rodrigues L. R.
Pubblicato in: Biosensors, 2021, ISSN 2079-6374
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios11110418

Complete Genome Sequence of Bartonella alsatica Strain IBS 382 (CIP 105477)

Autori: Arno Thibau, Tilman G. Schultze, Wibke Ballhorn, Volkhard A. J. Kempf
Pubblicato in: Microbiology Resource Announcements, Numero Volume 9 Numero 34, 2020, ISSN 2576-098X
Editore: American Society for Microbiology
DOI: 10.1128/mra.00769-20

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens

Autori: Alex van Belkum, Carina Almeida, Benjamin Bardiaux, Sarah V. Barrass, Sarah J. Butcher, Tuğçe Çaykara, Sounak Chowdhury, Rucha Datar, Ian Eastwood, Adrian Goldman, Manisha Goyal, Lotta Happonen, Nadia Izadi-Pruneyre, Theis Jacobsen, Pirjo H. Johnson, Volkhard A. J. Kempf, Andreas Kiessling, Juan Leva Bueno, Anchal Malik, Johan Malmström, Ina Meuskens, Paul A. Milner, Michael Nilges, Nicole Pam
Pubblicato in: Diagnostics, Numero 11/7, 2021, Pagina/e 1259, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics11071259

Secondary structure and 1H, 15N & 13C resonance assignments of the periplasmic domain of OutG, Major pseudodopilin from Dickeya dadantii type II secretion system

Autori: Jacobsen T, Dazzoni R, Renault M.G, Bardiaux B, Nilges M, Shevchik V, Izadi-Pruneyre N.
Pubblicato in: Biomol NMR Assign, 2022, ISSN 1874-2718
Editore: Springer Verlag
DOI: 10.1007/s12104-022-10085-4

Type V Secretion Systems: An Overview of Passenger Domain Functions

Autori: Ina Meuskens, Athanasios Saragliadis, Jack C. Leo, Dirk Linke
Pubblicato in: Frontiers in Microbiology, Numero 10, 2019, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2019.01163

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels

Autori: Pablo Rodriguez-Mateos, Bongkot Ngamsom, Charlotte E. Dyer, Alexander Iles, Nicole Pamme
Pubblicato in: Electrophoresis, Numero 42, 2021, Pagina/e 2246-2255, ISSN 0173-0835
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/elps.202100083

Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

Autori: Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21863-4

Molecular Organisation of Tick-Borne Encephalitis Virus

Autori: Pulkkinen L.I.A, Barrass S. V, Domanska A, Överby A.K, Anastasina M, Butcher S. J.
Pubblicato in: Viruses, 2022, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14040792

Long-Read Sequencing Reveals Genetic Adaptation of Bartonella Adhesin A Among Different Bartonella henselae Isolates

Autori: Arno Thibau, Katharina Hipp, Diana J. Vaca, Sounak Chowdhury, Johan Malmström, Athanasios Saragliadis, Wibke Ballhorn, Dirk Linke, Volkhard A. J. Kempf
Pubblicato in: Frontiers in Microbiology, Numero Volume 13, Article 838267, 2022, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2022.838267

The C-terminal head domain of Burkholderia pseudomallei BpaC has a striking hydrophilic core with an extensive solvente network

Autori: Kiessling A. R, Harris S. A, Weimer K. M, Wells G, Goldman A.
Pubblicato in: Mol Microbiology, 2022, ISSN 1365-2958
Editore: Wiley
DOI: 10.1111/mmi.14953

Different SARS-CoV-2 haplotypes associate with geographic origin and case fatality rates of COVID-19 patients

Autori: Goyal M, De Bruyne K, van Belkum A, West B
Pubblicato in: Infection Genetics and Evolution, Numero 90, 2021, ISSN 1567-1348
Editore: Elsevier BV
DOI: 10.1016/j.meegid.2021.104730

Automated antimicrobial susceptibility testing of slow-growing Pseudomonas aeruginosa strains in the presence of tetrazolium salt WST-1

Autori: Datar R, Perrin G, Chalansonnet V, Perry A, Perry JD, van Belkum A, Orenga S
Pubblicato in: Journal of Microbiological Methods, Numero 186, 2021, ISSN 0167-7012
Editore: Elsevier BV
DOI: 10.1016/j.mimet.2021.106252

The Trimeric Autotransporter Adhesin YadA of Yersina enterocolitica Serotype O:9 Binds Glycan Moieties

Autori: Meuskens I, Leva-Bueno J, Millner P, Schutz M, Peyman SA, Linke D.
Pubblicato in: Front Microbiology, Numero Volume 22, 2022, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2021.738818

Interaction of Bartonella henselae with fibronectin represents the molecular basis for adhesion to host cells

Autori: Diana J. Vaca, Arno Thibau, Matthias S. Leisegang, Johan Malmström, Dirk Linke, Johannes A. Eble, Wibke Ballhorn, Martin Schaller, Lotta Happonen, Volkhard A. J. Kempf
Pubblicato in: Microbiology Spectrum, 2022, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.00598-22

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings

Autori: Pablo Rodriguez-Mateos, Bongkot Ngamsom, Cheryl Walter, Charlotte E.Dyer, Jesse Gitaka Alexander Iles, Nicole Pamme
Pubblicato in: Analytica Chimica Acta, Numero Volume 1177, 8 September 2021, 2021, Pagina/e 338758, ISSN 0003-2670
Editore: Elsevier BV
DOI: 10.1016/j.aca.2021.338758

Distinct serotypes of streptococcal M proteins mediate fibrinogen-dependent platelet activation and pro-inflammatory effects

Autori: Palm F, Chowdhury S, Wettemark S, Malmström J, Happonen L, Shannon O
Pubblicato in: Infect Immunology, 2022, ISSN 2379-5077
Editore: ASM Journals
DOI: 10.1128/iai.00462-21

Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma, Bartonella, Coxiella, Orientia and Rickettsia

Autori: Diana J. Vaca, Gerhard Dobler, Silke F. Fischer, Christian Keller, Maik Konrad, Friederike D. von Loewenich, Sylvain Orenga, Siddhesh U. Sapre, Alex van Belkum, Volkhard A. J. Kempf
Pubblicato in: FEMS Microbiology Reviews, Numero fuac013, 2022, ISSN 0168-6445
Editore: Blackwell
DOI: 10.1093/femsre/fuac013

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Autori: Arno Thibau, Alexander A. Dichter, Diana J. Vaca, Dirk Linke, Adrian Goldman, Volkhard A. J. Kempf
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00649-y

Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria

Autori: Diana J. Vaca, Arno Thibau, Monika Schütz, Peter Kraiczy, Lotta Happonen, Johan Malmström, Volkhard A. J. Kempf
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00644-3

Recent advances in the understanding of trimeric autotransporter adhesions

Autori: Andreas R. Kiessling, Anchal Malik, Adrian Goldman
Pubblicato in: Medical Microbiology and Immunology (2019), 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00652-3

Brexit in the channel: Europe cut off: a young German scientist's perspective

Autori: Andreas R. Kiessling
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00646-1

Human adenovirus binding to host cell receptors: a structural view

Autori: Aleksandra Cecylia Stasiak, Thilo Stehle
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00645-2

FISH and chips: a review of microfluidic platforms for FISH analysis

Autori: Pablo Rodriguez-Mateos, Nuno Filipe Azevedo, Carina Almeida, Nicole Pamme
Pubblicato in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00654-1

Advances in high-throughput methods for the identification of virus receptors

Autori: Sarah V. Barrass, Sarah J. Butcher
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00653-2

Innovative training networks: a new way of collaboration-propped PhD training

Autori: Ina Meuskens, Seamus Higson, Dirk Linke
Pubblicato in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-019-00647-0

New solutions to capture and enrich bacteria from complex samples

Autori: Maria G. Sande, Tugçe Çaykara, Carla Joana Silva, Ligia R. Rodrigues
Pubblicato in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-020-00659-1

Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria–human protein interactions

Autori: Sounak Chowdhury, Lotta Happonen, Hamed Khakzad, Lars Malmström, Johan Malmström
Pubblicato in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editore: Springer Verlag
DOI: 10.1007/s00430-020-00663-5

Phenotypic and Genomic Variability of Serial Peri-Lung Transplantation Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Autori: Datar R, Coello Pelegrin A, Orenga S, Chalansonnet V, Mirande C, Dombrecht J, Perry JD, Perry A, Goossens H, van Belkum A
Pubblicato in: Frontiers in Microbiology, Numero Volume 12, 2021, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2021.604555

Recent Advances in Rapid Antimicrobial Susceptibility Testing

Autori: Datar R, Orenge S, Pogorelcnik R, Rochas O, Simner PJ, van Belkum A
Pubblicato in: Clinical Chemistry, Numero Volume 68, Numero 1, 2021, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab207

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes

Autori: Chowdhury S, Khakzad H, Bergdahl GE, Lood R, Ekström S, Linke D, Malmström L, Happonen L, Malmström J.
Pubblicato in: mSystems, 2021, ISSN 2379-5077
Editore: ASM Journals
DOI: 10.1128/msystems.00271-21

Retrospective Definition of Clostridioides difficile PCR Ribotypes on the Basis of Whole Genome Polymorphisms: A Proof of Principle Study

Autori: Goyal M, Hauben L, Pouseele H, Jaillard M, De Bruyne K, van Belkum A, Goering R
Pubblicato in: Diagnostics, Numero 10(12), 2020, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics10121078

Non-peer reviewed articles (1)

Proteome-wide cross-linking mass spectrometry to identify specific virus capsid-host interactions between tick-borne encephalitis virus and neuroblastoma cells

Autori: Barrass S. V, Pulkkinen L.I.A, Vapalahti O, Kuivanen S. H, Anastasina M, Happonen L, Butcher S. J.
Pubblicato in: bioRxiv, 2021, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.29.464531