Descrizione del progetto
Bersagliare le proteine del sensore di stress nel cancro e nelle malattie neurodegenerative
L’obiettivo generale del progetto INSPIRED, finanziato dal programma di azioni Marie Skłodowska-Curie, è dare vita a una rete interdisciplinare di esperti per promuovere la ricerca e l’innovazione nell’ambito dello stress cellulare e dello sviluppo di farmaci oncologici e per le malattie neurodegenerative. Un sensore di stress e trasduttore di segnale noto come IRE1 (inositol-requiring enzyme 1) viene attivato dall’accumulo di proteine non ripiegate correttamente nel reticolo endoplasmatico. Il consorzio INSPIRED concentrerà l’attenzione sui meccanismi di segnalazione di IRE1 nella risposta allo stress. La ricerca svilupperà nuovi modulatori di IRE1 con dati preclinici a sostegno del bersagliamento di tale trasduttore nel cancro e nelle malattie neurodegenerative. I partecipanti al progetto avranno inoltre l’opportunità di sviluppare nuove competenze e tecnologie, che aumenteranno le loro opportunità di carriera.
Obiettivo
The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives.
IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.
Campo scientifico
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
Parole chiave
Programma(i)
Meccanismo di finanziamento
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinatore
H91 Galway
Irlanda