Description du projet
Cibler les protéines des capteurs de stress dans le cancer et les maladies neurodégénératives
Financé par le programme Actions Marie Skłodowska-Curie, l’objectif global du projet INSPIRED est de créer un réseau interdisciplinaire d’experts afin de promouvoir la recherche et l’innovation dans le domaine du stress cellulaire et du développement de médicaments contre le cancer et les maladies neurodégénératives. Un capteur de stress et un transducteur de signaux connu sous le nom d’enzyme requérant l’inositol 1 (IRE1) est activé par l’accumulation de protéines mal repliées dans le réticulum endoplasmique. Le consortium INSPIRED se concentrera sur les mécanismes de signalisation de l’IRE1 dans la réponse au stress. La recherche développera de nouveaux modulateurs de l’IRE1 avec des données précliniques pour soutenir le ciblage de l’IRE1 dans le cancer et les maladies neurodégénératives. En outre, les participants au projet auront la possibilité d’acquérir de nouvelles compétences et technologies, ce qui leur ouvrira de nouvelles perspectives de carrière.
Objectif
The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives.
IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.
Champ scientifique
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
Mots‑clés
Programme(s)
Régime de financement
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinateur
H91 Galway
Irlande