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ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs

Livrables

Final list of publications, communications, press release and media coverage

Compilation of publications, communications, press release and media coverage Contributors: All

Implement ORTHOUNION project on the dedicated website and establish a secured collaborative platform

Collaborative plataform for ORTHOUNION project

Bone turnover markers as supplemental method to monitor healing of fracture non unions after cell therapy

Protocol and outcome analysis

Results and conclusions, ORTHOUNION clinical trial

Description and analysis of data according with the clinical protocol Contributors SERMAS 2 UULM 4 CHUT 7 IOR 8

Report on potency assay enabling the detection of highly osteogenic MSC preparation

Experimental protocols and results

Report on the results of the cost-effectiveness analysis and cost-utility analysis of BM MSC therapy in long bone union delay (both intra clinical trial length and extra clinical trial at longer time horizon)

Costeffectiveness and costutility outcome analysisContributors UULM 4 IOR 8 UAM 1

Intermediate list of publications, communications, press release and media coverage

Compilation of divulgation publications, communications, press release and media coverage

Report on a potential model for industrial production of BM-MSC for bone regeneration that would be adequate for wide access to patients in medical practice at an affordable cost.

Document suggesting a potential model for industrial production of BMMSC for bone regeneration that would be adequate for wide access to patients in medical practice at an affordable cost Contributors SERMAS 2 UULM 4 IOR 8 POLICLINICO 10UNIMORE 9

Report on the impact of MSCs on chemoattraction and differentiation of these cells by in vitro co-culture studies and by in vivo approaches in ectopic and orthotopic transplantation

Experimental protocols and results

Report on time course of biochemical markers of bone turnover in patients with long-bone non unions after treatment

Protocol and outcome analysis

Completed recruitment, ORTHOUNION clinical trial

Report including the real dates of patients recriutment per country Contributors SERMAS 2 UULM 4 CHUT 7 IOR 8

Report and publication of Consensus conference on non-unions treatment in Europe

Results of the consensus conference on nonunions treatment in Europe Contributors All

Publications

Frontiers in non-union research

Auteurs: Enrique Gómez-Barrena, Norma G. Padilla-Eguiluz, Philippe Rosset
Publié dans: EFORT Open Reviews, Numéro 5/10, 2020, Page(s) 574-583, ISSN 2396-7544
Éditeur: EFORT
DOI: 10.1302/2058-5241.5.190062

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors

Auteurs: Elisabetta Manuela Foppiani, Olivia Candini, Ilenia Mastrolia, Alba Murgia, Giulia Grisendi, Anna Valeria Samarelli, Giulia Boscaini, Lucrezia Pacchioni, Massimo Pinelli, Giorgio De Santis, Edwin M. Horwitz, Elena Veronesi, Massimo Dominici
Publié dans: Stem Cell Research & Therapy, Numéro 10/1, 2019, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-019-1200-6

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation

Auteurs: Meike Dahlhaus, Julian Roos, Daniel Engel, Daniel Tews, Daniel Halbgebauer, Jan-Bernd Funcke, Sophie Kiener, Patrick J. Schuler, Johannes Döscher, Thomas K. Hoffmann, Julia Zinngrebe, Markus Rojewski, Hubert Schrezenmeier, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
Publié dans: International Journal of Molecular Sciences, Numéro 21/21, 2020, Page(s) 7907, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21217907

Validation of a long bone fracture non-union healing score after treatment with mesenchymal stromal cells combined to biomaterials

Auteurs: Enrique Gómez-Barrena, Norma G. Padilla-Eguiluz, Eduardo García-Rey, Pablo Hernández-Esteban, José Cordero-Ampuero, Juan C. Rubio-Suárez
Publié dans: Injury, Numéro 51, 2020, Page(s) S55-S62, ISSN 0020-1383
Éditeur: Elsevier BV
DOI: 10.1016/j.injury.2020.02.030

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Auteurs: Luciano Vidal, Carina Kampleitner, Meadhbh Á. Brennan, Alain Hoornaert, Pierre Layrolle
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, ISSN 2296-4185
Éditeur: Creative Commons Attribution License
DOI: 10.3389/fbioe.2020.00061

Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds

Auteurs: Luciano Vidal, Carina Kampleitner, Stéphanie Krissian, Meadhbh Á Brennan, Oskar Hoffmann, Yago Raymond, Yassine Maazouz, Maria-Pau Ginebra, Philippe Rosset, Pierre Layrolle
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-63742-w

Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Auteurs: Paul Humbert, Meadhbh Á. Brennan, Julien De Lima, Régis Brion, Annie Adrait, Céline Charrier, Bénédicte Brulin, Valérie Trichet, Yohann Couté, Frédéric Blanchard, Pierre Layrolle
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-91258-4

Challenges of running a GMP facility for regenerative medicine in a public hospital

Auteurs: Mariele Viganò, Rosaria Giordano, Lorenza Lazzari
Publié dans: Regenerative Medicine, Numéro 12/7, 2017, Page(s) 803-813, ISSN 1746-0751
Éditeur: Future Medicine Ltd.
DOI: 10.2217/rme-2017-0051

A Multicentric, Open-Label, Randomized, Comparative Clinical Trial of Two Different Doses of Expanded hBM-MSCs Plus Biomaterial versus Iliac Crest Autograft, for Bone Healing in Nonunions after Long Bone Fractures: Study Protocol

Auteurs: Enrique Gómez-Barrena, Norma G. Padilla-Eguiluz, Cristina Avendaño-Solá, Concepción Payares-Herrera, Ana Velasco-Iglesias, Ferran Torres, Philippe Rosset, Florian Gebhard, Nicola Baldini, Juan C. Rubio-Suarez, Eduardo García-Rey, José Cordero-Ampuero, Javier Vaquero-Martin, Francisco Chana, Fernando Marco, Javier García-Coiradas, Pedro Caba-Dessoux, Pablo de la Cuadra, Philippe Hernigou, Ch
Publié dans: Stem Cells International, Numéro 2018, 2018, Page(s) 1-13, ISSN 1687-966X
Éditeur: Stem Cells International
DOI: 10.1155/2018/6025918

Bioactivity of Biphasic Calcium Phosphate Granules, the Control of a Needle-Like Apatite Layer Formation for Further Medical Device Developments

Auteurs: Cyril d’Arros, Thierry Rouillon, Joelle Veziers, Olivier Malard, Pascal Borget, Guy Daculsi
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 7, 2020, ISSN 2296-4185
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00462

Inflammatory response of mesenchymal stromal cells after in vivo exposure with selected trauma-related factors and polytrauma serum

Auteurs: Elisa Maria Amann, Alexander Groß, Markus Thomas Rojewski, Hans Armin Kestler, Miriam Kalbitz, Rolf Erwin Brenner, Markus Huber-Lang, Hubert Schrezenmeier
Publié dans: PLOS ONE, Numéro 14/5, 2019, Page(s) e0216862, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0216862

Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells: Concise Review

Auteurs: Ilenia Mastrolia, Elisabetta Manuela Foppiani, Alba Murgia, Olivia Candini, Anna Valeria Samarelli, Giulia Grisendi, Elena Veronesi, Edwin M. Horwitz, Massimo Dominici
Publié dans: STEM CELLS Translational Medicine, Numéro 8/11, 2019, Page(s) 1135-1148, ISSN 2157-6564
Éditeur: AlphaMed Press
DOI: 10.1002/sctm.19-0044

FOXP1 circular RNA sustains mesenchymal stem cell identity via microRNA inhibition

Auteurs: Alessandro Cherubini, Mario Barilani, Riccardo L Rossi, Murtadhah M K Jalal, Francesco Rusconi, Giuseppe Buono, Enrico Ragni, Giovanna Cantarella, Hamish A R W Simpson, Bruno Péault, Lorenza Lazzari
Publié dans: Nucleic Acids Research, Numéro Nucleic Acids Research, Volume 47, Numéro 10, 04 June 2019, 2019, Page(s) 5325–5340, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkz199

Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Auteurs: Paul Humbert, Meadhbh Á. Brennan, Noel Davison, Philippe Rosset, Valérie Trichet, Frédéric Blanchard, Pierre Layrolle
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.00663

Dissecting the Pharmacodynamics and Pharmacokinetics of MSCs to Overcome Limitations in Their Clinical Translation

Auteurs: Michela Salvadori, Nicola Cesari, Alba Murgia, Paola Puccini, Benedetta Riccardi, Massimo Dominici
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 14, 2019, Page(s) 1-15, ISSN 2329-0501
Éditeur: CellPress
DOI: 10.1016/j.omtm.2019.05.004

Tips and Tricks for Validation of Quality Control Analytical Methods in Good Manufacturing Practice Mesenchymal Stromal Cell Production

Auteurs: Mariele Viganò, Silvia Budelli, Cristiana Lavazza, Tiziana Montemurro, Elisa Montelatici, Stefania de Cesare, Lorenza Lazzari, Anna Rosa Orlandi, Giovanna Lunghi, Rosaria Giordano
Publié dans: Stem Cells International, Numéro 2018, 2018, Page(s) 1-16, ISSN 1687-966X
Éditeur: Hindawi
DOI: 10.1155/2018/3038565

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