Descripción del proyecto
Imágenes mamarias altamente específicas con un enfoque multimodal
Los programas de cribado del cáncer de mama basados en la mamografía han permitido mejorar la capacidad de detección, los resultados clínicos y los niveles de supervivencia de las pacientes. Por desgracia, estas mamografías suelen ser propensas a arrojar falsos positivos, lo que puede dar lugar a procedimientos invasivos innecesarios. Para hacer frente a estos inconvenientes, el equipo del proyecto SOLUS, financiado con fondos europeos, reúne a diversos expertos de la comunidad científica e investigadora, clínico e industrial con el fin de desarrollar un innovador sistema obtención de imágenes para el diagnóstico preciso del cáncer de mama. En la iniciativa se elaborarán conceptos y componentes fotónicos avanzados para crear un sistema de obtención de imágenes (tanto ópticas como ultrasónicas) multimodal, atraumático y asequible con una especificidad sin precedentes. Este avanzado sistema permitirá la caracterización exhaustiva del tejido mamario, lo que mejorará el diagnóstico del cáncer de mama para beneficio de las mujeres de toda Europa.
Objetivo
SOLUS is a trans-disciplinary 54-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in their fields, to develop an innovative non-invasive, point-of-care, low-cost, easy-to-operate, multi-modal imaging system (diffuse optics and ultrasounds/shear wave elastography) for high-specificity diagnosis of breast cancer, the most common female cancer in Europe. Mammographic screening is effective in reducing mortality, however the 10-year cumulative false-positive risk is 50-60%, leading to needless additional invasive procedures (e.g. biopsy). The project addresses the unmet clinical need for higher specificity in breast cancer imaging following screening by fully combining photonics with non-photonics techniques, developing and clinically validating innovative and previously unthinkable photonics concepts and components: time-domain small source-detector distance optical tomography, miniaturized picosecond pulsed laser sources, high-dynamic-range time-gated single-photons detectors to achieve unprecedented sensitivity and depth penetration. For the first time, this allows a comprehensive quantitative characterization of breast tissue including composition (water, lipids, collagen), functional blood parameters, morphologic information and mechanical parameters (stiffness). This innovative multi-parametric characterization will significantly improve the specificity of breast screening, with great impact on the quality of life of millions of European women every year, and huge savings for the healthcare systems. The strong involvement of leading industrial players at all levels in the value chain will push the European innovation process and make a significant contribution to ensuring Europe’s industrial leadership in the biophotonics healthcare market, while addressing one of the largest societal challenges in health and well-being.
Ámbito científico
Not validated
Not validated
- natural sciencescomputer and information sciencessoftwaresoftware applicationssystem software
- medical and health sciencesclinical medicineoncologybreast cancer
- natural sciencesphysical sciencesopticslaser physicspulsed lasers
- engineering and technologymedical engineeringdiagnostic imaging
- natural sciencesphysical sciencesacousticsultrasound
Palabras clave
Programa(s)
Tema(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-ICT-2016-1
Régimen de financiación
RIA - Research and Innovation actionCoordinador
20133 Milano
Italia