Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation

Informations projet

VetBioNet

N° de convention de subvention: 731014

DOI 10.3030/731014

Projet clôturé

Date de signature de la CE 27 Mars 2017

Date de début 1 Mars 2017

Date de fin 28 Février 2023

Financé au titre de

• EXCELLENT SCIENCE - Research Infrastructures

Coût total € 10 017 890,51

Contribution de l’UE € 9 999 140,50

Coordonné par

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France

Livrables

Documents, reports (46)

Training material for specific critical positions in animal high containment facilities forwarded to WP5

NA

Quantity of access provided over the duration of the project to viruses and virus-related reagents

NA

Draft prototype of structure and mode of operation for the future of VetBioNet

NA

Quantity of access provided over the duration of the project to animal facility

NA

Quantity of access provided over the duration of the project to INRA infrastructures

NA

Quantity of access provided over the duration of the project to RI Containment laboratories

NA

Ethics Committee Best Practice Guidance

NA

Optimised pathogenesis and immunity models in genetic context for BSL3 pathogens

NA

ERG Agreement drafted for Partners willing to commit themselves after the end of the EU funding

NA

Guidance on implementation of the 3Rs and EU Animal Experimentation Directive

NA

Process guidelines for designing and upgrading BSL3/3+facilities for farmed animal species including design and assessment

NA

Quantity of access provided over the duration of the project to INIA-BSL3-CISA

NA

Development of alternative ELISAs for fish disease diagnostics and surveillance

NA

Quantity of access provided over the duration of the project to ANSES-Ploufragran Plouzané

NA

Quantity of access provided over the duration of the project to TPI-ISO10&11

NA

Guidelines of minimum requirements and criteria for training provision and competency assessment

NA

Novel avian/mammalian host models for airborne transmission and susceptibility

NA

Draft plan outlining strategies for VetBioNet sustainability

NA

Quantity of access provided over the duration of the project to APHA infrastructures

NA

Quantity of access provided over the duration of the project to BSL3 lab & animal facility

NA

Report on best practice for facility management, including emergency response and planning

NA

Viral population/quasispecies analysis by NGS and analysis pipelines

NA

Pulmonar microbiome effects related to porcine influenza infections

NA

Updated guidelines for best practice and procedure exchange of aquatic animal infection facilities

NA

Development of a differential serological assay to separate RHDV infection from RHDV2

NA

Quantity of access provided over the duration of the project to MRI

NA

Quantity of access provided over the duration of the project to BSL3/2 laboratories

NA

Quantity of access provided over the duration of the project to IZSVe

NA

Quantity of access provided over the duration of the project to Animal and BSL3 laboratories facilities

NA

Quantity of access provided over the duration of the project to CVI

NA

Position paper for policy makers on the biosafety of alkaline hydrolysis (biodigesters) as an alternative destruction technique to incineration based on the practical experience gained in the sector in Europe

NA

Quantity of access provided over the duration of the project to ANSES-Nancy

NA

Quantity of access provided over the duration of the project to AU-ANIS

NA

Quantity of access provided over the duration of the project to EMC

NA

Biorisk management programme for facilities handling large animals to achieve CWA 15793 standard

NA

Quantity of access provided over the duration of the project to high-end molecular typing and immunological technologies

NA

Novel reservoir host infection models for BSL3 zoonotic pathogens

NA

Application of newly developed high throughput transcriptomic analytical tools NanoString and Fluidigm to livestock to examine the response to BSL3 pathogens

NA

Quantity of access provided over the duration of the project to PIEWT-MFB

NA

Report on the ethics of high containment (BSL3/BSL3+) animal infectious disease research

NA

List of samples available from collections and procedure for the generation of samples on-demand published on the website

NA

Open science and Stakeholder Engagement Strategy Report

NA

Guidelines for best practice in Post-Mortem facilities

NA

List of Activities of Interest to be maintained after the EU funding period, inventory of potential external funding sources and identification of Partner legal requirements

NA

Improved fish model for relevant pathogens in aquiculture

NA

Quantity of access provided over the duration of the project to FLI3

NA

Demonstrators, pilots, prototypes (8)

Validation of integrated telemetry and behavioural monitoring

NA

Enhanced temporal and organ-specific readouts of infectious diseases models including more refined criteria for the application of humane end points in order to minimize animal welfare impact

NA

Effective decontamination of biological specimens infected with class 3 viruses for further study outside containment

NA

Utilisation of NGS based tools to explore the T and B cell repertoires in domestic livestock before and after infection with BSL3 pathogen

NA

Development and validation of molecular tags to study the interaction of class 3 viruses including organ and cell type tropism and host responses

NA

Prototype telemetry sensors and behavioural analysis software

NA

Use of nanoparticules for the location and the follow up of inflammatory cells through optical imaging (whole body) and in tissues (confocal microscopy)

NA

Development of high throughput class I MHC genotyping methods for sheep and cattle

NA

Other (9)

Creating ‘Safe Spaces' for research and animal ethics debate

NA

Three webinars available online

NA

Organisation of a 3Rs training event

NA

e-learning platform

NA

Animal infectious disease research, social impact and contributions to the EU bio-based economy

NA

Launch of the structure that will replace VetBioNet after current period of EU funding on the basis of the Sustainability Plan

NA

Adaptation of light sheet confocal microscopy to the imaging of living pathogens and host cells interactions (cell cultures and biopsies)

NA

Two short videos targeting veterinary laboratories and general public

NA

Event targeting Policy makers

NA

Websites, patent fillings, videos etc. (6)

Organization of 1 Summer Course at INRA premises

NA

Organization of 1 Summer Course at RI premises

NA

Creation of the Website and communication package

NA

Organization of the final conference and intermediary workshop

NA

Organization of 1 Summer Course at EAAP premises

NA

Organization of 1 Summer Course at IRTA premises

NA

Open Research Data Pilot (1)

Creation of the Data Management Plan (DMP)

NA

Publications

Peer reviewed articles (76)

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence.

Auteurs: Eloiflin, Roger-Junior; Grau-Roma, Llorenç; Python, Sylvie; Mehinagic, Kemal; Godel, Aurélie; Libeau, Geneviève; Summerfield, Artur; Bataille, Arnaud; García-Nicolás, Obdulio
Publié dans: Veterinary Resources, Numéro 6, 2022, ISSN 1297-9716
Éditeur: BMC
DOI: 10.48350/171216

Airway Administration of Flagellin Regulates the Inflammatory Response to Pseudomonas aeruginosa

Auteurs: Raquel López-Gálvez, Isabelle Fleurot, Pablo Chamero, Sascha Trapp, Michel Olivier, Claire Chevaleyre, Céline Barc, Mickael Riou, Christelle Rossignol, Antoine Guillon, Mustapha Si-Tahar, Tobias May, Pascal Barbry, Andrea Bähr, Nikolai Klymiuk, Jean-Claude Sirard, Ignacio Caballero
Publié dans: American Journal of Respiratory Cell and Molecular Biology, 2021, ISSN 1044-1549
Éditeur: American Lung Association
DOI: 10.1165/rcmb.2021-0125oc

Pathogenicity of Different Betanodavirus RGNNV/SJNNV Reassortant Strains in European Sea Bass

Auteurs: Lorena Biasini; Paola Berto; Miriam Abbadi; Alessandra Buratin; Marica Toson; Andrea Marsella; Anna Toffan; Francesco Pascoli
Publié dans: Pathogens, Numéro 20760817, 2022, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens11040458

Development and Evaluation of a Duplex Lateral Flow Assay for the Detection and Differentiation between Rabbit Haemorrhagic Disease Virus Lagovirus europaeus/GI.1 and /GI.2

Auteurs: Alba Fresco-Taboada; Mercedes Montón; Istar Tapia; Elena Soria; Juan Bárcena; Cécile Guillou-Cloarec; Ghislaine Le Gall-Reculé; Esther Blanco; Paloma Rueda
Publié dans: Biology, Numéro 20797737, 2022, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology11030401

Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus.

Auteurs: Miaomiao Wang; Enrica Sozzi; José Alejandro Bohórquez; Mònica Alberch; Joan Pujols; Guillermo Cantero; Alessandra Gaffuri; Davide Lelli; Rosa Rosell; Albert Bensaid; Mariano Domingo; Lester J. Pérez; Ana Moreno; Llilianne Ganges
Publié dans: Viruses, Numéro 19994915, 2020, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070775

The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility

Auteurs: Morris KM, Mishra A, Raut AA, Gaunt ER, Borowska D, Kuo RI, Wang B, Vijayakumar P, Chingtham S, Dutta R, Baillie K, Digard P, Vervelde L, Burt DW and Smith J
Publié dans: Frontiers, Numéro 2, 2023, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1067993

Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards

Auteurs: Susanne Koethe; Lorenz Ulrich; Reiner Ulrich; Susanne Amler; Annika Graaf; Timm C. Harder; Christian Grund; Thomas C. Mettenleiter; Franz Josef Conraths; Martin Beer; Anja Globig
Publié dans: Emerging Microbes & Infections, Numéro 22221751, 2020, ISSN 2222-1751
Éditeur: Nature Publishing Group
DOI: 10.1080/22221751.2020.1713706

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence

Auteurs: Roger-Junior Eloiflin, Llorenç Grau-Roma, Sylvie Python, Kemal Mehinagic, Aurélie Godel, Geneviève Libeau, Artur Summerfield, Arnaud Bataille, Obdulio García-Nicolás
Publié dans: Veterinary Research, Numéro 12979716, 2022, ISSN 1297-9716
Éditeur: Elsevier
DOI: 10.1186/s13567-022-01073-6

Experimental Infection of Cattle with SARS-CoV-2

Auteurs: Ulrich L., Wernike K., Hoffmann D., Mettenleiter T.C., Beer M.
Publié dans: Emerging Infectious Diseases, Numéro 10806040, 2020, ISSN 1080-6040
Éditeur: US National Center for Infectious Diseases
DOI: 10.3201/eid2612.203799

Contemporary selection on MHC genes in a free-living ruminant population

Auteurs: Huang, W., Dicks, K.L., Hadfield, J.D., Johnston, S.E., Ballingall, K.T., Pemberton, J.M.
Publié dans: Ecology Letters, Numéro 14610248, 2021, ISSN 1461-0248
Éditeur: John Wileys & Sons
DOI: 10.1111/ele.13957

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions

Auteurs: Blanchard A.M., Staley C.E., Shaw L., Wattegedera S.R., Baumbach C.M., Michler J.K., Rutland C., Back C., Newbold N., Entrican G., Tötemeyer S.
Publié dans: Infection and Immunity, Numéro 00199567, 2021, ISSN 0019-9567
Éditeur: American Society for Microbiology
DOI: 10.1128/iai.00270-21

Comparison of three air samplers for the collection of four nebulized respiratory viruses – Collection of respiratory viruses from air

Auteurs: Jasmin S. Kutter, Dennis de Meulder, Theo M. Bestebroer, Ard Mulders, Ron A.M. Fouchier, Sander Herfst
Publié dans: International Journal of Indoor Environment and Health, Numéro 17434955, 2021, ISSN 1743-4955
Éditeur: Inderscience Enterprises
DOI: 10.1111/ina.12875

Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway

Auteurs: José M. Rojas; Alí Alejo; Verónica Martín; Noemí Sevilla
Publié dans: Cellular and Molecular Life Sciences, Numéro 14209071, 2020, ISSN 1420-9071
Éditeur: Springer
DOI: 10.1007/s00018-020-03671-z

Differential response of RTGUTGC and RTGILL-W1 rainbow trout epithelial cell lines to viral stimulation

Auteurs: Rocío Simón; Patricia Martínez; Lucía González; M. Camino Ordás; Carolina Tafalla
Publié dans: Journal of Fish Diseases, Numéro Volume46, Numéro4, 2023, Page(s) Pages 433-443, ISSN 0140-7775
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jfd.13755

Experimental Infection of Captive Red Foxes (Vulpes vulpes) with Mycobacterium bovis

Auteurs: Richomme, C., Lesellier, S., Salguero, F.J., Barrat, J.L.; Boucher, J.-M.; Reyes-Reyes, J.D.; Hénault, S.; De Cruz, K.; Tambosco, J.; Michelet, L.; Boutet, J.; Elahi, R.; Lyashchenko, K.P.; O’Halloran, C.; Balseiro, A.; Boschiroli, M.L.
Publié dans: Microorganisms, Numéro 20762607, 2022, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms10020380

Bovine endometrial MSC: mesenchymal to epithelial transition during luteolysis and tropism to implantation niche for immunomodulation.

Auteurs: Alexandra Calle; Soraya López-Martín; Marta Monguió-Tortajada; Francesc E. Borràs; María Yáñez-Mó; Miguel Ángel Ramírez
Publié dans: Stem Cell Research & Therapy, Numéro 17576512, 2019, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-018-1129-1

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Auteurs: Hartlaub J., von Arnim F., Fast C., Somova M., Mirazimi A., Groschup M.H., Keller M.
Publié dans: Microorganisms, Numéro 20762607, 2020, ISSN 2076-2607
Éditeur: Basel MDPI
DOI: 10.3390/microorganisms8121927

Identification of Differential Responses of Goat PBMCs to PPRV Virulence Using a Multi-Omics Approach

Auteurs: Eloiflin, R., Auray, G., Python, S., Rodrigues, V., Seveno, M., Urbach, S., El Koulali, K., Holzmuller, P., Totte, P., Libeau, G., Bataille, A., Summerfield, A.
Publié dans: Frontiers in Immunology, Numéro 16643224, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.745315

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Auteurs: Hartlaub J., Keller M., Groschup M.H.
Publié dans: Microorganisms, Numéro 20762607, 2021, ISSN 2076-2607
Éditeur: Basel MDPI
DOI: 10.3390/microorganisms9071493

SARS-CoV-2 is transmitted via contact and via the air between ferrets.

Auteurs: Mathilde Richard; Adinda Kok; Dennis de Meulder; Theo M. Bestebroer; Mart M. Lamers; Nisreen M.A. Okba; Martje Fentener van Vlissingen; Barry Rockx; Bart L. Haagmans; Marion Koopmans; Ron A. M. Fouchier; Sander Herfst
Publié dans: Nature Communications, Numéro 20411723, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17367-2

Egyptian Fruit Bats (Rousettus aegyptiacus) Were Resistant to Experimental Inoculation with Avian-Origin Influenza A Virus of Subtype H9N2, But Are Susceptible to Experimental Infection with Bat-Borne H9N2 Virus.

Auteurs: Nico Joel Halwe; Marco Gorka; Bernd Hoffmann; Melanie Rissmann; Angele Breithaupt; Martin Schwemmle; Martin Beer; Ahmed Kandeil; Mohamed A. Ali; Ghazi Kayali; Donata Hoffmann; Anne Balkema-Buschmann
Publié dans: Viruses, Numéro 5, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040672

Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph Nodes

Auteurs: Melzi, Eleonora; Rocchi, Mara S.; Entrican, Gary; Caporale, Marco; Palmarini, Massimo
Publié dans: Frontiers in Immunology, Numéro 16643224, 2018, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2018.02892

A Systematic Evaluation of High-Throughput Sequencing Approaches to Identify Low-Frequency Single Nucleotide Variants in Viral Populations

Auteurs: King D.J., Freimanis G., Lasecka-Dykes L., Asfor A., Ribeca P., Waters R., King D.P., Laing E.
Publié dans: Viruses, Numéro 19994915, 2020, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101187

Embryonic Trophectoderm Secretomics Reveals Chemotactic Migration and Intercellular Communication of Endometrial and Circulating MSCs in Embryonic Implantation.

Auteurs: Alexandra Calle; Víctor Toribio; María Yáñez-Mó; Miguel Ángel Ramírez
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.21203/rs.3.rs-177701/v1

High sensitivity of domestic pigs to intravenous infection with HEV

Auteurs: Lisa Dähnert; Martin Eiden; Josephine Schlosser; Christine Fast; Charlotte Schröder; Elke Lange; Albrecht Gröner; Wolfram Schäfer; Martin H. Groschup
Publié dans: BMC Veterinary Research, Numéro 17466148, 2018, ISSN 1746-6148
Éditeur: BioMed Central
DOI: 10.1186/s12917-018-1713-8

Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

Auteurs: Rojas J.M., Alejo A., Avia J.M., Rodríguez-Martín D., Sánchez C., Alcamí A., Sevilla N., Martín V.
Publié dans: Vaccines, Numéro 2076393X, 2020, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020333

Long-Term Protection and Serologic Response of European SeaBass Vaccinated with a Betanodavirus Virus-Like Particle Produced in Pichia pastoris

Auteurs: Sofie Barsøe, Anna Toffan, Francesco Pascoli, Ansgar Stratmann, Tobia Pretto, Andrea Marsella, Mériem Er-Rafik, Niccolò Vendramin, Niels J. Olesen, Dagoberto Sepúlveda, Niels Lorenzen
Publié dans: Vaccines, Numéro 2076393X, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9050447

Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs

Auteurs: Pedrera M., Macchi F., McLean R.K., Franceschi V., Thakur N., Russo L., Medfai L., Todd S., Tchilian E.Z., Audonnet J.C., Chappell K., Isaacs A., Watterson D., Young P.R., Marsh G.A., Bailey D., Graham S.P., Donofrio G.
Publié dans: Vaccines, Numéro 2076393X, 2020, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010115

In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens

Auteurs: Isabelle Lantier, Corentin Mallet, Laurent Souci, Thibaut Larcher, Andele M. Conradie, Katia Courvoisier, Sascha Trapp, David Pasdeloup, Benedikt B. Kaufer, Caroline Denesvre
Publié dans: PLOS Pathogens, Numéro 15537374, 2022, ISSN 1553-7374
Éditeur: PLOS
DOI: 10.1371/journal.ppat.1010745

Characterisation of major histocompatibility complex class IIa haplotypes in an island sheep population.

Auteurs: Kara L. Dicks; Josephine M. Pemberton; Keith T. Ballingall
Publié dans: Immunogenetics, Numéro 00937711, 2019, ISSN 0093-7711
Éditeur: Springer Verlag
DOI: 10.1007/s00251-019-01109-w

Vaccination With Recombinant Adenoviruses Expressing the Bluetongue Virus Subunits VP7 and VP2 Provides Protection Against Heterologous Virus Challenge.

Auteurs: José M. Rojas; Diego Barba-Moreno; Miguel Avia; Noemí Sevilla; Verónica Martín
Publié dans: Frontiers in Veterinary Science, Numéro 22971769, 2021, ISSN 2297-1769
Éditeur: Frontiers Media
DOI: 10.3389/fvets.2021.645561

Long term dietary vitamin D3 supplementation impacts both microbicidal and inflammatory responses to ex-vivo Mycobacterium bovis BCG challenge in dairy calves

Auteurs: Susana Flores-Villalva, Cian Reid, Aude Remot, Stephen V. Gordon, Kieran G. Meade
Publié dans: ScienceDirect, Numéro 8, 2023, ISSN 0165-2427
Éditeur: Elsevier BV
DOI: 10.1016/j.vetimm.2023.110575

Ex vivo rescue of recombinant very virulent IBDV using a RNA polymerase II driven system and primary chicken bursal cells

Auteurs: Liliana L. Cubas-Gaona, Romane Trombetta, Céline Courtillon, Kai Li, Xiaole Qi, Xiaomei Wang, Sofiane Lotmani, Alassane Keita, Michel Amelot, Nicolas Eterradossi, Sébastien Mathieu Soubies
Publié dans: Scientific Reports, Numéro 20452322, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-70095-x

Defining immune correlates during latent and active chlamydial infection in sheep

Auteurs: Sean Wattegedera; Morag Livingstone; Stephen Maley; Mara Rocchi; Susan Lee; Yvonne Pang; Nick Wheelhouse; Kevin Aitchison; Javier Palarea-Albaladejo; David Buxton; David Longbottom; Gary Entrican
Publié dans: Veterinary Research, Pp 1-18 (2020), Numéro 17466148, 2020, ISSN 1746-6148
Éditeur: BioMed Central
DOI: 10.1186/s13567-020-00798-6

Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein.

Auteurs: Haverkamp, Ann-Kathrin; Bosch, Berend J; Spitzbarth, Ingo; Lehmbecker, Annika; Te, Nigeer; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; dI&I I&I-1; LS Virologie
Publié dans: Veterinary Immunology and Immunopathology, Numéro 18732534, 2019, ISSN 1873-2534
Éditeur: Springer
DOI: 10.1016/j.vetimm.2019.109939

Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives.

Auteurs: Isabelle K. Vila; Maxence Frétaud; Dimitrios Vlachakis; Nadine Laguette; Christelle Langevin
Publié dans: Journal of Molecular Biology, Numéro 00222836, 2020, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2020.08.016

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Auteurs: Hartlaub J., Gutjahr B., Fast C., Mirazimi A., Keller M., Groschup M.H.
Publié dans: Viruses, Numéro 19994915, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

Non-Lethal Sequential Individual Monitoring of Viremia in Relation to DNA Vaccination in Fish-Example Using a Salmon Alphavirus DNA Vaccine in Atlantic Salmon Salmo salar .

Auteurs: Catherine M. Collins; Katherine Lester; Jorge Del-Pozo; Bertrand Collet; Bertrand Collet
Publié dans: Vaccines, Numéro 2076393X, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9020163

Mycobacterial Infection of Precision-Cut Lung Slices Reveals Type 1 Interferon Pathway Is Locally Induced by Mycobacterium bovis but Not M. tuberculosis in a Cattle Breed

Auteurs: Aude Remot, Florence Carreras, Anthony Coupé, Émilie Doz-Deblauwe, Maria L. Boschiroli, John A. Browne, Quentin Marquant, Delphyne Descamps, Fabienne Archer, Abraham Aseffa, Pierre Germon, Stephen V. Gordon, Nathalie Winter
Publié dans: Frontiers in Veterinary Science, Numéro 22971769, 2021, ISSN 2297-1769
Éditeur: Frontiers Media
DOI: 10.3389/fvets.2021.696525

Shuni Virus Replicates at the Maternal-Fetal Interface of the Ovine and Human Placenta

Auteurs: Judith Oymans; Lucien van Keulen; Guus M. Vermeulen; Paul J. Wichgers Schreur; Jeroen Kortekaas
Publié dans: Pathogens, Numéro 20760817, 2020, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010017

High throughput analysis of MHC-I and MHC-DR diversity of Brazilian cattle populations

Auteurs: Deepali Vasoya, Priscila Silva Oliveira, Laura Agundez Muriel, Thomas Tzelos, Christina Vrettou, W. Ivan Morrison, Isabel Kinney Ferreira de Miranda Santos, Timothy Connelley
Publié dans: HLA, Numéro 20592302, 2021, ISSN 2059-2302
Éditeur: John Wiley & Sons
DOI: 10.1111/tan.14339

Cryobanking European Mink (Mustela lutreola) Mesenchymal Stem Cells and Oocytes

Auteurs: Calle A., Ramírez M.Á.
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169319

Comparative Analysis of Different Inbred Chicken Lines Highlights How a Hereditary Inflammatory State Affects Susceptibility to Avian Influenza Virus

Auteurs: Bryson, K.J.; Sives, S.; Lee, H.-M.; Borowska, D.; Smith, J.; Digard, P.; Vervelde, L.
Publié dans: Viruses, Numéro 5, 2023, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15030591

Efficacy Assessment of Newly-designed Filtering Facemasks during the SARS-CoV-2 Pandemic

Auteurs: Bob Boogaard, Ali Tas, Joep Nijssen, Freek Broeren, John van der Dobbelsteen, Vincent Verhoeven, Jip Pluim, Sing Dekker, Eric Snijder, Martijn van Hemert, Sander Herfst
Publié dans: Aerosol Air Quality Research, Numéro 16808584, 2021, ISSN 1680-8584
Éditeur: Chinese Association for Aerosol Research in Taiwan
DOI: 10.4209/aaqr.2020.07.0424

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Auteurs: Jordi Rodon, Anna Z. Mykytyn, Guillermo Cantero, Irina C. Albulescu, Berend-Jan Bosch, Alexander Brix, Jean-Christophe Audonnet, Albert Bensaid, Júlia Vergara-Alert, Bart L. Haagmans, Joaquim Segalés
Publié dans: One Health Outlook, Numéro 25244655, 2022, ISSN 2524-4655
Éditeur: BMC part of Springer Nature
DOI: 10.1186/s42522-022-00068-9

A New Look at Vaccine Strategies Against PPRV Focused on Adenoviral Candidates

Auteurs: José M. Rojas, Noemí Sevilla, Verónica Martín
Publié dans: Frontiers in Veterinary Science, Numéro 22971769, 2021, ISSN 2297-1769
Éditeur: Frontiers Media
DOI: 10.3389/fvets.2021.729879

Reverse genetics system for shuni virus, an emerging orthobunyavirus with zoonotic potential

Auteurs: Judith Oymans; Paul J. Wichgers Schreur; Sophie van Oort; R.P.M. Vloet; Marietjie Venter; Gorben P. Pijlman; Monique M. van Oers; Jeroen Kortekaas
Publié dans: Viruses, Numéro 19994915, 2020, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12040455

High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue

Auteurs: Alf Seljenes Dalum; Aurora Kraus; Shanawaz Khan; Erna Davydova; Dimitri Rigaudeau; Håvard Bjørgen; Adrián López-Porras; Gareth Griffiths; Geert F. Wiegertjes; Erling Olaf Koppang; Irene Salinas; Pierre Boudinot; Julien Rességuier
Publié dans: Frontiers in immunology, Numéro 16643224, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.769901

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Auteurs: Hartlaub J., Daodu O.B., Sadeghi B., Keller M., Olopade J., Oluwayelu D., Groschup M.H.
Publié dans: Viruses, Numéro 19994915, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting.

Auteurs: Laura Sanz-Ortega; José M. Rojas; Domingo F. Barber
Publié dans: Pharmaceutics, Numéro 19994923, 2020, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12090812

Comparison of Biological Features of Wild European Rabbit Mesenchymal Stem Cells Derived from Different Tissues

Auteurs: Calle A., Zamora-Ceballos M., Bárcena J., Blanco E., Ramírez M.Á.
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126420

Iberian pig mesenchymal stem/stromal cells from dermal skin, abdominal and subcutaneous adipose tissues, and peripheral blood: in vitro characterization and migratory properties in inflammation

Auteurs: Alexandra Calle, Clara Barrajón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez, Miguel Ángel Ramírez
Publié dans: Stem Cell Research & Therapy, Numéro 9/1, 2018, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-018-0933-y

IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era

Auteurs: Giuseppe Maccari, James Robinson, Ronald E. Bontrop, Nel Otting, Natasja G. de Groot, Chak-Sum Ho, Keith T. Ballingall, Steven G. E. Marsh, John A. Hammond
Publié dans: Immunogenetics, Numéro 70/10, 2018, Page(s) 619-623, ISSN 0093-7711
Éditeur: Springer Verlag
DOI: 10.1007/s00251-018-1072-4

Propagation and titration of infectious bursal disease virus, including non-cell-culture-adapted strains, using ex vivo -stimulated chicken bursal cells

Auteurs: Sébastien Mathieu Soubies, Céline Courtillon, Mouna Abed, Michel Amelot, Alassane Keita, Andrew Broadbent, Sonja Härtle, Bernd Kaspers, Nicolas Eterradossi
Publié dans: Avian Pathology, Numéro 47/2, 2017, Page(s) 179-188, ISSN 0307-9457
Éditeur: Taylor & Francis
DOI: 10.1080/03079457.2017.1393044

Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein

Auteurs: Jordi Rodon, Nisreen M. A. Okba, Nigeer Te, Brenda van Dieren, Berend-Jan Bosch, Albert Bensaid, Joaquim Segalés, Bart L. Haagmans, Júlia Vergara-Alert
Publié dans: Emerging Microbes & Infections, Numéro 8/1, 2019, Page(s) 1593-1603, ISSN 2222-1751
Éditeur: Nature Publishing Group
DOI: 10.1080/22221751.2019.1685912

Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses

Auteurs: Dominika Borowska, Richard Kuo, Richard A. Bailey, Kellie A. Watson, Pete Kaiser, Lonneke Vervelde, Mark P. Stevens
Publié dans: PLOS ONE, Numéro 14/12, 2019, Page(s) e0225658, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0225658

Allelic nomenclature for the duplicated MHC class II DQ genes in sheep

Auteurs: Keith T. Ballingall, Kara Dicks, Panoraia Kyriazopoulou, Lynne Herrmann-Hoesing
Publié dans: Immunogenetics, Numéro 71/4, 2019, Page(s) 347-351, ISSN 0093-7711
Éditeur: Springer Verlag
DOI: 10.1007/s00251-018-1096-9

Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction

Auteurs: Sean R. Wattegedera, Laura E. Doull, Mariya I. Goncheva, Nicholas M. Wheelhouse, Donna M. Watson, Julian Pearce, Julio Benavides, Javier Palarea-Albaladejo, Colin J. McInnes, Keith Ballingall, Gary Entrican
Publié dans: Frontiers in Immunology, Numéro 9, 2019, ISSN 1664-3224
Éditeur: .
DOI: 10.3389/fimmu.2018.03025

Precision cut lung slices: a novel versatile tool to examine host–pathogen interaction in the chicken lung

Auteurs: Karen Jane Bryson, Damien Garrido, Marco Esposito, Gerry McLachlan, Paul Digard, Catherine Schouler, Rodrigo Guabiraba, Sascha Trapp, Lonneke Vervelde
Publié dans: Veterinary Research, Numéro 51/1, 2020, ISSN 1297-9716
Éditeur: .
DOI: 10.1186/s13567-019-0733-0

Chicken endothelial cells are highly responsive to viral innate immune stimuli and are susceptible to infections with various avian pathogens

Auteurs: Adrien Lion, Evelyne Esnault, Emmanuel Kut, Vanaïque Guillory, Laetitia Trapp-Fragnet, Sébastien M. Soubies, Nathalie Chanteloup, Alisson Niepceron, Rodrigo Guabiraba, Daniel Marc, Nicolas Eterradossi, Sascha Trapp, Pascale Quéré
Publié dans: Avian Pathology, Numéro 48/2, 2018, Page(s) 121-134, ISSN 0307-9457
Éditeur: Taylor & Francis
DOI: 10.1080/03079457.2018.1556386

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Auteurs: Hartlaub J., von Arnim F., Fast C., Mirazimi A., Keller M., Groschup M.H.
Publié dans: Viruses, Numéro 19994915, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Intramuscular DNA Vaccination of Juvenile Carp against Spring Viremia of Carp Virus Induces Full Protection and Establishes a Virus-Specific B and T Cell Response

Auteurs: Carmen W.E. Embregts; Dimitri Rigaudeau; Tomáš Veselý; Dagmar Pokorova; Niels Lorenzen; Jules Petit; Armel Houel; Malte Dauber; Heike Schütze; Pierre Boudinot; Geert F. Wiegertjes; Maria Forlenza
Publié dans: Frontiers in Immunology, Numéro 16643224, 2017, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2017.01340

Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Auteurs: Alexandra Calle; Miguel Ángel Ramírez
Publié dans: Cells, Numéro 20734409, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11121858

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Auteurs: Nigeer Te Jordi Rodon, Maria Ballester, Mónica Pérez, Lola Pailler-García, Joaquim Segalés, Júlia Vergara-Alert, Albert Bensaid
Publié dans: PLOS Pathogens, Numéro 15537366, 2021, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1009229

Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection

Auteurs: Nigeer Te; Jordi Rodon; Rhea Creve; Mónica Pérez; Joaquim Segalés; Júlia Vergara-Alert; Albert Bensaid
Publié dans: Veterinary Research, Numéro 12979716, 2022, ISSN 1297-9716
Éditeur: Springer Nature
DOI: 10.1186/s13567-022-01084-3

Immunization With Bovine Herpesvirus-4-Based Vector Delivering PPRV-H Protein Protects Sheep From PPRV Challenge

Auteurs: Daniel Rodríguez-Martín, José Manuel Rojas, Francesca Macchi, Valentina Franceschi, Luca Russo, Noemí Sevilla, Gaetano Donofrío, Verónica Martín
Publié dans: Frontiers in Immunology, Numéro 16643224, 2021, ISSN 1664-3224
Éditeur: Lausanne Frontiers Media
DOI: 10.3389/fimmu.2021.705539

SARS-CoV and SARS-CoV-2 are transmitted through the air between ferrets over more than one meter distance.

Auteurs: Jasmin S Kutter; Dennis de Meulder; Theo M. Bestebroer; Pascal Lexmond; Ard Mulders; Mathilde Richard; Ron A. M. Fouchier; Sander Herfst
Publié dans: Nature Communications, Numéro 20411723, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-21918-6

Uncovering the core principles of the gut-lung axis to enhance innate immunity in the chicken

Auteurs: Saint-Martin V., Quéré P., Trapp S., Guabiraba R.
Publié dans: Frontiers in Immunology, Numéro 16643224, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.956670

Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula

Auteurs: Nigeer Te, Jordi Rodon, Mónica Pérez, Joaquim Segalés, Júlia Vergara-Alert, Albert Bensaid
Publié dans: Emerging Microbes & Infections, Numéro 22221751, 2022, ISSN 2222-1751
Éditeur: Nature Publishing Group
DOI: 10.1080/22221751.2021.2019559

Hemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling

Auteurs: José M. Rojas, Elena Pascual, Sean R. Wattegedera, Miguel Avia, César Santiago, Verónica Martín, Gary Entrican, Noemí Sevilla
Publié dans: Virulence, Numéro 21505594, 2021, ISSN 2150-5594
Éditeur: Landes Bioscience
DOI: 10.1080/21505594.2021.1882246

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

Auteurs: Mulens-Arias V., Rojas J.M., Barber D.F.
Publié dans: Nanomaterials, Numéro 20794991, 2020, ISSN 2079-4991
Éditeur: Basel MDPI AG
DOI: 10.3390/nano10050837

Erysipelothrix rhusiopathiae-specific T-cell responses after experimental infection of chickens selectively bred for high and low serum levels of mannose-binding lectin

Auteurs: Wattrang, E., Sørensen Dalgaard, T., Brødsgaard Kjaerup, R. et al.
Publié dans: Veterinary Research, 2022, ISSN 1297-9716
Éditeur: Unknown

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing

Auteurs: Eloi R. Verrier, Christelle Langevin
Publié dans: Frontiers in Immunology, Numéro 16643224, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.637399

Genome Evolution of Two Genetically Homogeneous Infectious Bursal Disease Virus Strains During Passages in vitro and ex vivo in the Presence of a Mutagenic Nucleoside Analog

Auteurs: Liliana L. Cubas-Gaona, Alexandre Flageul, Céline Courtillon, Francois-Xavier Briand, Maud Contrant, Stephanie Bougeard, Pierrick Lucas, Hélène Quenault, Aurélie Leroux, Alassane Keita, Michel Amelot, Béatrice Grasland, Yannick Blanchard, Nicolas Eterradossi, Paul Alun Brown, Sébastien Mathieu Soubies
Publié dans: Frontiers in Microbiology, Numéro 1664302X, 2021, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2021.678563

Potential Role of Different Fish Species as Vectors of Koi Herpesvirus (CyHV-3) Infection

Auteurs: Marek Matras, Magdalena Stachnik, Ewa Borzym, Joanna Maj-Paluch, Michał Reichert
Publié dans: Journal of Veterinary Research, Numéro 24508608, 2019, ISSN 2450-8608
Éditeur: Warsaw De Gruyter Open
DOI: 10.2478/jvetres-2019-0069

Role of Rotifers in Betanodavirus Transmission to European Sea Bass Larvae

Auteurs: Vázquez-Salgado L., Pascoli F., Marsella A., Biasini L., Buratin A., Pretto T., Abbadi M., Melchiotti E., Bandín I., Toffan A.
Publié dans: Frontiers in Veterinary Science, Numéro 22971769, 2022, ISSN 2297-1769
Éditeur: Frontiers Media
DOI: 10.3389/fvets.2022.932327

Book chapters (2)

Adenovirus as Tools in Animal Health

Auteurs: José M. Rojas; Noemí Sevilla; Verónica Martín
Publié dans: Adenoviruses, 2019, ISBN 978-1-78984-991-2
Éditeur: IntechOpen Limited
DOI: 10.5772/intechopen.79132

In Vivo Tracking of Bacterial Colonization in Different Murine Models Using Bioluminescence: The Example of Salmonella

Auteurs: Michaël Koczerka, Isabelle Lantier, Anne Pinard, Marie Morillon, Justine Deperne, Ohad Gal-Mor, Olivier Grépinet, Isabelle Virlogeux-Payant
Publié dans: Bacterial Virulence, 2022, Page(s) pag. 235-248, ISBN 978-1-0716-1970-4
Éditeur: Humana
DOI: 10.1007/978-1-0716-1971-1_19