Non-invasive rapid assessment of chronic liver disease using Magnetic Resonance Imaging with LiverMultiScan

Livrables

Draft of manuscript for peer-review on baseline and follow-up MRI data.

Draft of manuscript(s) for peer-review on baseline and follow-up MRI data (for participants with both datasets). In addition to evaluation of: - Patient-reported outcome measures on post COVID-19 recovery management (using Dyspnea-12, St Georges Respiratory Questionnaire and the EQ-5D-5L) - Difference in the change in these MR derived biomarkers in those with known genetic variants associated with multi-organ disease (such as PNPLA3) and those without after SARS-CoV-2 infection. - Contextualisation of results using our existing data from the UK Biobank, which includes quantitative MRI with LiverMultiScan®.

SOP for data protection

Standard Operating Procedure for the protection of medical data, in accordance with current EU (Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001, Commision Directive 2005/28/EC, 8 April 2005) and national legislation.

Report on the first 100 COVERSCAN baseline MRI scans

Report on the first 100 baseline MRI scans of participants, covering: organ volume, fat infiltration and fibro-inflammation in kidney, liver, heart, pancreas and spleen; together with biochemical, haematological and immunological measures.

Report on all 507 COVERSCAN baseline MRI scans

Report on all 507 baseline MRI scans of participants, covering: organ volume, fat infiltration and fibro-inflammation in kidney, liver, heart, pancreas and spleen; together with biochemical, haematological and immunological measures.

Report on changes in the organ-specific MRI biomarkers from cohort of participants with 6-month follow-up data

Report on changes in the organ-specific MRI biomarkers from cohort of participants with 6-month follow-up data.

Final Updated Communication Plan

Communication plan to be updated to include new sites, principal investigators and other updated information as necessary

Data management plan

Data management plan.

Communication plan and updates

Communication plan and updates devliered at: -M12 -M24 -M36

Publications

CHARACTERIZATION OF MAGNETIC RESONANCE-DERIVED BIOMARKERS OF LIVER HEALTH IN A EUROPEAN COHORT WITH METABOLIC SYNDROME AND NON-ALCOHOLIC FATTY LIVER DISEASE: INTERIM ANALYSIS OF AN ONGOING PROSPECTIVE TRIAL (RADICAL1)

Auteurs: Shumbayawonda, E., Mouchti, S., Castelo-Branco, M., Caseiro Alves, F., Coenraad, M., Lamb, H., Beer, M., Schaapman, J., Costa, T., Thomaides-Brears, H., Kelly, M., Rymell, S., French, M., Jenkins, L., Waddell, T., Herdman, L., Tonev, D., Neubauer, S., Banerjee, R., Dollinger, M.
Publié dans: Gastroenterology, Numéro 158(6), S1, 2020, Page(s) S-1292
Éditeur: Elsevier

Non-alcoholic fatty liver disease (NAFLD) associates with higher risk of developing symptomatic COVID19 infection - Initial UK Biobank Observations

Auteurs: Roca-Fernández, A., Dennis, A., Nicholls, R., McGonigle, J., Kelly, M., Banerjee, R., Sanyal, A. J.
Publié dans: Hepatology, Numéro 72/S1, 2020, Page(s) 1A-130A
Éditeur: John Wiley & Sons Inc.

Characterization of MR derived biomarkers of liver health in a European cohort with metabolic syndrome and NAFLD in comparison to healthy controls: Preliminary analysis of an ongoing prospective trial (RADIcAL1).

Auteurs: Thomaides-Brears, H.B., Shumbayawonda, E., Mouchti, S., Castelo-Branco, M., Caseiro Alves, F., Coenraad, M., Lamb, H., Beer, M., Schaapman, J., Costa, T., Kelly, M., Rymen, S., Herdman, L., Waddell, T., Neubauer, S., Banerjee, R., Dollinger, M.
Publié dans: Hepatology, Numéro 70/S1, 2019, Page(s) 188-1382, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.

The Effect of Multi-Parametric Magnetic Resonance Imaging in Standard of Care for Nonalcoholic Fatty Liver Disease: Protocol for a Randomized Control Trial

Auteurs: Dimitar Tonev, Elizabeth Shumbayawonda, Louise Ann Tetlow, Laura Herdman, Marika French, Soubera Rymell, Helena Thomaides-Brears, Filipe Caseiro-Alves, Miguel Castelo-Branco, Carlos Ferreira, Minneke Coenraad, Hildo Lamb, Meinrad Beer, Matt Kelly, Rajarshi Banerjee, Matthias Dollinger
Publié dans: JMIR Research Protocols, Numéro 9/10, 2020, Page(s) e19189, ISSN 1929-0748
Éditeur: JMIR Publications
DOI: 10.2196/19189

High Liver Fat Associates with Higher Risk of Developing Symptomatic COVID-19 Infection - Initial UK Biobank Observations

Auteurs: Roca-Fernández,A., Dennis, A., Nicholls,R., McGonigle,J., Kelly,M., Banerjee, R.
Publié dans: medRxiv, Numéro 05/06/2020, 2020
Éditeur: medRvix
DOI: 10.1101/2020.06.04.20122457

Multi-organ impairment in low-risk individuals with long COVID

Auteurs: Dennis, A., Wamil, M., Kapur, S., Alberts, J., Badley, A., Decker, G., Rizza, S., Banerjee, R., Banerjee, A.
Publié dans: medRxiv, Numéro 16/10/2020, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.10.14.20212555

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