The chemical understanding of biomolecular recognition in epigenetics

Publicaciones

Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1

Autores: Miriam R. B. Porzberg, Laust Moesgaard, Catrine Johansson, Udo Oppermann, Jacob Kongsted, Jasmin Mecinović
Publicado en: Molecules, Edición 27, 2022, Página(s) 983, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030983

Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides

Autores: Marijn N. Maas, Jordi C. J. Hintzen, Philipp M. G. Löffler, Jasmin Mecinović
Publicado en: Chemical Communications, Edición 57/26, 2021, Página(s) 3283-3286, ISSN 1364-548X
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cc08387a

Trimethyllysine: From Carnitine Biosynthesis to Epigenetics

Autores: Marijn N. Maas, Jordi C. J. Hintzen, Miriam R. B. Porzberg, Jasmin Mecinović
Publicado en: International Journal of Molecular Sciences, Edición 21/24, 2020, Página(s) 9451, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249451

Effect of lysine side chain length on histone lysine acetyltransferase catalysis

Autores: Giordano Proietti, Yali Wang, Giorgio Rainone, Jasmin Mecinović
Publicado en: Scientific Reports, Edición 10/1, 2020, Página(s) 13046, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-69510-0

Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails

Autores: Giordano Proietti, Giorgio Rainone, Jordi C. J. Hintzen, Jasmin Mecinović
Publicado en: Bioconjugate Chemistry, Edición 31/3, 2020, Página(s) 844-851, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00012

Substrate Scope for Human Histone Lysine Acetyltransferase KAT8

Autores: Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinović
Publicado en: International Journal of Molecular Sciences, Edición 22/2, 2021, Página(s) 846, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020846

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins

Autores: Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Publicado en: Chemical Communications, Edición 54/19, 2018, Página(s) 2409-2412, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c8cc01009a

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Autores: Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Publicado en: Chemical Communications, Edición 53/99, 2017, Página(s) 13264-13267, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c7cc08028j

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation

Autores: Bas J. G. E. Pieters, Jordi C. J. Hintzen, Yvonne Grobben, Abbas H. K. Al Temimi, Jos J. A. G. Kamps, Jasmin Mecinović
Publicado en: Bioconjugate Chemistry, Edición 30/3, 2019, Página(s) 952-958, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00065

The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis

Autores: Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin Mecinović
Publicado en: Communications Chemistry, Edición 2/1, 2019, Página(s) 112, ISSN 2399-3669
Editor: Nature Publishing Group
DOI: 10.1038/s42004-019-0210-8

γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones

Autores: Abbas H. K. Al Temimi, Renate van der Wekken-de Bruijne, Giordano Proietti, Hong Guo, Ping Qian, Jasmin Mecinović
Publicado en: Bioconjugate Chemistry, Edición 30/6, 2019, Página(s) 1798-1804, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00313

Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Autores: Abbas H. K. Al Temimi, Paul B. White, Marcus J. M. Mulders, Nicole G. A. van der Linden, Richard H. Blaauw, Anita Wegert, Floris P. J. T. Rutjes, Jasmin Mecinović
Publicado en: Chemical Communications, Edición 56/20, 2020, Página(s) 3039-3042, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c9cc09098c

Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis

Autores: Abbas H. K. Al Temimi, Vu Tran, Ruben S. Teeuwen, Arthur J. Altunc, Helene I. V. Amatdjais-Groenen, Paul B. White, Danny C. Lenstra, Giordano Proietti, Yali Wang, Anita Wegert, Richard H. Blaauw, Ping Qian, Wansheng Ren, Hong Guo, Jasmin Mecinović
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-60337-3

Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins

Autores: Jordi C. J. Hintzen, Jordi Poater, Kiran Kumar, Abbas H. K. Al Temimi, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Publicado en: Molecules, Edición 25/8, 2020, Página(s) 1918, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081918

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

Autores: Bas J. G. E. Pieters, Maud H. M. Wuts, Jordi Poater, Kiran Kumar, Paul B. White, Jos J. A. G. Kamps, Woody Sherman, Ger J. M. Pruijn, Robert S. Paton, Thijs Beuming, F. Matthias Bickelhaupt, Jasmin Mecinović
Publicado en: Communications Chemistry, Edición 3/1, 2020, Página(s) 69, ISSN 2399-3669
Editor: Nature Publishing Group
DOI: 10.1038/s42004-020-0313-2

Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases

Autores: Abbas H. K. Al Temimi, Jona Merx, Christian J. van Noortwijk, Giordano Proietti, Romano Buijs, Paul B. White, Floris P. J. T. Rutjes, Thomas J. Boltje, Jasmin Mecinović
Publicado en: Scientific Reports, Edición 10/1, 2020, Página(s) 21574, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-78331-0

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

Autores: Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović
Publicado en: Communications Chemistry, Edición 5, 2022, Página(s) 27, ISSN 2399-3669
Editor: Nature Publishing Group
DOI: 10.1038/s42004-022-00640-4

Biomolecular Recognition of Methylated Histones

Autores: Miriam R. B. Porzberg, Bas J. G. E. Pieters, Jasmin Mecinović
Publicado en: The DNA, RNA, and Histone Methylomes, 2019, Página(s) 435-451, ISBN 978-3-030-14791-4
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_17

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