The chemical understanding of biomolecular recognition in epigenetics

Project Information

ChemEpigen

Grant agreement ID: 715691

DOI 10.3030/715691

Project closed

EC signature date 14 December 2016

Start date 1 April 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

SYDDANSK UNIVERSITET
Denmark

Publications

Peer reviewed articles (17)

Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1

Author(s): Miriam R. B. Porzberg, Laust Moesgaard, Catrine Johansson, Udo Oppermann, Jacob Kongsted, Jasmin Mecinović
Published in: Molecules, Issue 27, 2022, Page(s) 983, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030983

Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides

Author(s): Marijn N. Maas, Jordi C. J. Hintzen, Philipp M. G. Löffler, Jasmin Mecinović
Published in: Chemical Communications, Issue 57/26, 2021, Page(s) 3283-3286, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc08387a

Trimethyllysine: From Carnitine Biosynthesis to Epigenetics

Author(s): Marijn N. Maas, Jordi C. J. Hintzen, Miriam R. B. Porzberg, Jasmin Mecinović
Published in: International Journal of Molecular Sciences, Issue 21/24, 2020, Page(s) 9451, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249451

Effect of lysine side chain length on histone lysine acetyltransferase catalysis

Author(s): Giordano Proietti, Yali Wang, Giorgio Rainone, Jasmin Mecinović
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 13046, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69510-0

Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails

Author(s): Giordano Proietti, Giorgio Rainone, Jordi C. J. Hintzen, Jasmin Mecinović
Published in: Bioconjugate Chemistry, Issue 31/3, 2020, Page(s) 844-851, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00012

Substrate Scope for Human Histone Lysine Acetyltransferase KAT8

Author(s): Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinović
Published in: International Journal of Molecular Sciences, Issue 22/2, 2021, Page(s) 846, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020846

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins

Author(s): Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Chemical Communications, Issue 54/19, 2018, Page(s) 2409-2412, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc01009a

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Author(s): Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Published in: Chemical Communications, Issue 53/99, 2017, Page(s) 13264-13267, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc08028j

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation

Author(s): Bas J. G. E. Pieters, Jordi C. J. Hintzen, Yvonne Grobben, Abbas H. K. Al Temimi, Jos J. A. G. Kamps, Jasmin Mecinović
Published in: Bioconjugate Chemistry, Issue 30/3, 2019, Page(s) 952-958, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00065

The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis

Author(s): Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin Mecinović
Published in: Communications Chemistry, Issue 2/1, 2019, Page(s) 112, ISSN 2399-3669
Publisher: Nature Publishing Group
DOI: 10.1038/s42004-019-0210-8

γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones

Author(s): Abbas H. K. Al Temimi, Renate van der Wekken-de Bruijne, Giordano Proietti, Hong Guo, Ping Qian, Jasmin Mecinović
Published in: Bioconjugate Chemistry, Issue 30/6, 2019, Page(s) 1798-1804, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00313

Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Author(s): Abbas H. K. Al Temimi, Paul B. White, Marcus J. M. Mulders, Nicole G. A. van der Linden, Richard H. Blaauw, Anita Wegert, Floris P. J. T. Rutjes, Jasmin Mecinović
Published in: Chemical Communications, Issue 56/20, 2020, Page(s) 3039-3042, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc09098c

Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis

Author(s): Abbas H. K. Al Temimi, Vu Tran, Ruben S. Teeuwen, Arthur J. Altunc, Helene I. V. Amatdjais-Groenen, Paul B. White, Danny C. Lenstra, Giordano Proietti, Yali Wang, Anita Wegert, Richard H. Blaauw, Ping Qian, Wansheng Ren, Hong Guo, Jasmin Mecinović
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-60337-3

Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins

Author(s): Jordi C. J. Hintzen, Jordi Poater, Kiran Kumar, Abbas H. K. Al Temimi, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Molecules, Issue 25/8, 2020, Page(s) 1918, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081918

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

Author(s): Bas J. G. E. Pieters, Maud H. M. Wuts, Jordi Poater, Kiran Kumar, Paul B. White, Jos J. A. G. Kamps, Woody Sherman, Ger J. M. Pruijn, Robert S. Paton, Thijs Beuming, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Communications Chemistry, Issue 3/1, 2020, Page(s) 69, ISSN 2399-3669
Publisher: Nature Publishing Group
DOI: 10.1038/s42004-020-0313-2

Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases

Author(s): Abbas H. K. Al Temimi, Jona Merx, Christian J. van Noortwijk, Giordano Proietti, Romano Buijs, Paul B. White, Floris P. J. T. Rutjes, Thomas J. Boltje, Jasmin Mecinović
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 21574, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-78331-0

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

Author(s): Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović
Published in: Communications Chemistry, Issue 5, 2022, Page(s) 27, ISSN 2399-3669
Publisher: Nature Publishing Group
DOI: 10.1038/s42004-022-00640-4

Book chapters (1)

Biomolecular Recognition of Methylated Histones

Author(s): Miriam R. B. Porzberg, Bas J. G. E. Pieters, Jasmin Mecinović
Published in: The DNA, RNA, and Histone Methylomes, 2019, Page(s) 435-451, ISBN 978-3-030-14791-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_17