CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENT

Informazioni relative al progetto

CLONCELLBREAST

ID dell’accordo di sovvenzione: 694620

DOI 10.3030/694620

Progetto chiuso

Data della firma CE 10 Maggio 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Giugno 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 497 660,00

Contributo UE € 2 497 660,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Pubblicazioni

Peer reviewed articles (9)

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

Autori: Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H. Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E. Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel A. J. R. Aparicio, Oscar M. Rueda, Amos Tanay, Carlos Caldas
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 5406, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25661-w

Tumor diversity and the trade-off between universal cancer tasks

Autori: Jean Hausser, Pablo Szekely, Noam Bar, Anat Zimmer, Hila Sheftel, Carlos Caldas, Uri Alon
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13195-1

Functional genomics approaches to improve pre-clinical drug screening and biomarker discovery

Autori: Long V Nguyen, Carlos Caldas
Pubblicato in: EMBO Molecular Medicine, Numero 13, 2021, Pagina/e e13189, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013189

Deciphering the signaling network of breast cancer improves drug sensitivity prediction

Autori: Marco Tognetti, Attila Gabor, Mi Yang, Valentina Cappelletti, Jonas Windhager, Oscar M. Rueda, Konstantina Charmpi, Elham Esmaeilishirazifard, Alejandra Bruna, Natalie de Souza, Carlos Caldas, Andreas Beyer, Paola Picotti, Julio Saez-Rodriguez, Bernd Bodenmiller
Pubblicato in: Cell Systems, Numero 12/5, 2021, Pagina/e 401-418.e12, ISSN 2405-4712
Editore: Cell
DOI: 10.1016/j.cels.2021.04.002

Multi-omic machine learning predictor of breast cancer therapy response

Autori: Stephen-John Sammut, Mireia Crispin-Ortuzar, Suet-Feung Chin, Elena Provenzano, Helen A. Bardwell, Wenxin Ma, Wei Cope, Ali Dariush, Sarah-Jane Dawson, Jean E. Abraham, Janet Dunn, Louise Hiller, Jeremy Thomas, David A. Cameron, John M. S. Bartlett, Larry Hayward, Paul D. Pharoah, Florian Markowetz, Oscar M. Rueda, Helena M. Earl , Carlos Caldas
Pubblicato in: Nature, Numero 601, 2022, Pagina/e 623-629, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-04278-5

Breast tumor microenvironment structures are associated with genomic features and clinical outcome

Autori: Esther Danenberg, Helen Bardwell, Vito R. T. Zanotelli, Elena Provenzano, Suet-Feung Chin, Oscar M. Rueda, Andrew Green, Emad Rakha, Samuel Aparicio, Ian O. Ellis, Bernd Bodenmiller, Carlos Caldas, H. Raza Ali
Pubblicato in: Nature Genetics, Numero 54, 2022, Pagina/e 660-669, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-022-01041-y

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Autori: Dimitra Georgopoulou, Maurizio Callari, Oscar M. Rueda, Abigail Shea, Alistair Martin, Agnese Giovannetti, Fatime Qosaj, Ali Dariush, Suet-Feung Chin, Larissa S. Carnevalli, Elena Provenzano, Wendy Greenwood, Giulia Lerda, Elham Esmaeilishirazifard, Martin O’Reilly, Violeta Serra, Dario Bressan, Gordon B. Mills, H. Raza Ali, Sabina S. Cosulich, Gregory J. Hannon, Alejandra Bruna, Carlos Caldas
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22303-z

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

Autori: Mary L. Uribe, Maik Dahlhoff, Rajbir N. Batra, Nishanth B. Nataraj, Yuya Haga, Diana Drago-Garcia, Ilaria Marrocco, Arunachalam Sekar, Soma Ghosh, Itay Vaknin, Sacha Lebon, Lior Kramarski, Yasuo Tsutsumi, Inpyo Choi, Oscar M. Rueda, Carlos Caldas, Yosef Yarden
Pubblicato in: Science Signaling, Numero 14/688, 2021, Pagina/e eabe6156, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abe6156

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Autori: Leticia De Mattos-Arruda, Stephen-John Sammut, Edith M Ross, Rachael Bashford-Rogers, Erez Greenstein, Havell Markus, Sandro Morganella, Yvonne Teng, Yosef Maruvka, Bernard Pereira, Oscar M Rueda, Suet-Feung Chin, Tania Contente-Cuomo, Regina Mayor, Alexandra Arias, H Raza Ali, Wei Cope, Daniel Tiezzi, Aliakbar Dariush, Tauanne Dias Amarante, Dan Reshef, Nikaoly Ciriaco, Elena Martinez-Saez, Vicen
Pubblicato in: Cell Reports, Numero 27, 2019, Pagina/e 2690-2708, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.04.098