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Molecular mechanisms of cohesin-mediated sister chromatid cohesion and chromatin organization

Pubblicazioni

An experimental and computational framework to build a dynamic protein atlas for human cell division

Autori: Cai, Y., Hossain, M.J., Hériché, J.-K., Politi, A.Z., Walther, N., Koch, B., Wachsmuth, M., Nijmeijer, B., Kueblbeck, M., Martinic, M., Ladurner, L., Peters, J.-M., and Ellenberg, J.
Pubblicato in: Nature, Numero 561(7723), 2018, Pagina/e 411-415, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0518-z

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

Autori: Gordana Wutz, Rene Ladurner, Brian Glenn St Hilaire, Roman R Stocsits, Kota Nagasaka, Benoit Pignard, Adrian Sanborn, Wen Tang, Csilla Várnai, Miroslav P Ivanov, Stefan Schoenfelder, Petra van der Lelij, Xingfan Huang, Gerhard Dürnberger, Elisabeth Roitinger, Karl Mechtler, Iain Finley Davidson, Peter Fraser, Erez Lieberman-Aiden, Jan-Michael Peters
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.52091

Conformation of sister chromatids in the replicated human genome

Autori: Michael Mitter, Catherina Gasser, Zsuzsanna Takacs, Christoph C. H. Langer, Wen Tang, Gregor Jessberger, Charlie T. Beales, Eva Neuner, Stefan L. Ameres, Jan-Michael Peters, Anton Goloborodko, Ronald Micura, Daniel W. Gerlich
Pubblicato in: Nature, Numero 586/7827, 2020, Pagina/e 139-144, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2744-4

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Autori: Canela, Andres; Maman, Yaakov; Huang, Shar-yin N.; Wutz, Gordana; Tang, Wen; Zagnoli-Vieira, Guido; Callen, Elsa; Wong, Nancy; Day, Amanda; Peters, Jan-Michael; Caldecott, Keith W.; Pommier, Yves; Nussenzweig, André
Pubblicato in: Mol Cell, Numero 1, 2019, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.04.030

Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers

Autori: Michiel J. Thiecke, Gordana Wutz, Matthias Muhar, Wen Tang, Stephen Bevan, Valeriya Malysheva, Roman Stocsits, Tobias Neumann, Johannes Zuber, Peter Fraser, Stefan Schoenfelder, Jan-Michael Peters, Mikhail Spivakov
Pubblicato in: Cell Reports, Numero 32/3, 2020, Pagina/e 107929, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107929

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Autori: Louisa Hill, Anja Ebert, Markus Jaritz, Gordana Wutz, Kota Nagasaka, Hiromi Tagoh, Daniela Kostanova-Poliakova, Karina Schindler, Qiong Sun, Peter Bönelt, Maria Fischer, Jan-Michael Peters, Meinrad Busslinger
Pubblicato in: Nature, Numero 584/7819, 2020, Pagina/e 142-147, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2454-y

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes

Autori: Mariana C.C. Silva, Sean Powell, Sabrina Ladstätter, Johanna Gassler, Roman Stocsits, Antonio Tedeschi, Jan-Michael Peters, Kikuë Tachibana
Pubblicato in: Journal of Cell Biology, Numero 219/4, 2020, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201906100

Dynamics of sister chromatid resolution during cell cycle progression

Autori: Rugile Stanyte, Johannes Nuebler, Claudia Blaukopf, Rudolf Hoefler, Roman Stocsits, Jan-Michael Peters, Daniel W. Gerlich
Pubblicato in: The Journal of Cell Biology, Numero 217/6, 2018, Pagina/e 1985-2004, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201801157

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion

Autori: Miroslav P Ivanov, Rene Ladurner, Ina Poser, Rebecca Beveridge, Evelyn Rampler, Otto Hudecz, Maria Novatchkova, Jean‐Karim Hériché, Gordana Wutz, Petra van der Lelij, Emanuel Kreidl, James RA Hutchins, Heinz Axelsson‐Ekker, Jan Ellenberg, Anthony A Hyman, Karl Mechtler, Jan‐Michael Peters
Pubblicato in: The EMBO Journal, Numero 37/15, 2018, Pagina/e e97150, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201797150

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

Autori: Petra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis, Thomas Hoffmann, Matthias Hinterndorfer, Gerd Bader, Norbert Kraut, Mark A Pearson, Jan-Michael Peters, Johannes Zuber, Opher Gileadi, Mark Petronczki
Pubblicato in: Life Science Alliance, Numero 3/7, 2020, Pagina/e e202000725, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.202000725

Absolute quantification of cohesin, CTCF and their regulators in human cells.

Autori: Johann Holzmann; Antonio Z Politi; Kota Nagasaka; Merle Hantsche-Grininger; Nike Walther; Birgit Koch; Johannes Fuchs; Gerhard Dürnberger; Wen Tang; Rene Ladurner; Roman R Stocsits; Georg A Busslinger; Béla Novák; Karl Mechtler; Iain Finley Davidson; Jan Ellenberg; Jan-Michael Peters
Pubblicato in: eLife, Numero 5, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.46269

Genome folding through loop extrusion by SMC complexes

Autori: Iain F. Davidson, Jan-Michael Peters
Pubblicato in: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-021-00349-7

How DNA loop extrusion mediated by cohesin enables V(D)J recombination

Autori: Jan-Michael Peters
Pubblicato in: Current Opinion in Cell Biology, Numero 70, 2021, Pagina/e 75-83, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2020.11.007

Self-organization of parS centromeres by the ParB CTP hydrolase

Autori: Young-Min Soh, Iain Finley Davidson, Stefano Zamuner, Jérôme Basquin, Florian Patrick Bock, Michael Taschner, Jan-Willem Veening, Paolo De Los Rios, Jan-Michael Peters, Stephan Gruber
Pubblicato in: Science, Numero 366/6469, 2019, Pagina/e 1129-1133, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aay3965

Quantifying the heterogeneity of macromolecular machines by mass photometry

Autori: Adar Sonn-Segev, Katarina Belacic, Tatyana Bodrug, Gavin Young, Ryan T. VanderLinden, Brenda A. Schulman, Johannes Schimpf, Thorsten Friedrich, Phat Vinh Dip, Thomas U. Schwartz, Benedikt Bauer, Jan-Michael Peters, Weston B. Struwe, Justin L. P. Benesch, Nicholas G. Brown, David Haselbach, Philipp Kukura
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15642-w

DNA loop extrusion by human cohesin

Autori: Iain F. Davidson, Benedikt Bauer, Daniela Goetz, Wen Tang, Gordana Wutz, Jan-Michael Peters
Pubblicato in: Science, Numero 366/6471, 2019, Pagina/e 1338-1345, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aaz3418

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Autori: Benedikt W. Bauer, Iain F. Davidson, Daniel Canena, Gordana Wutz, Wen Tang, Gabriele Litos, Sabrina Horn, Peter Hinterdorfer, Jan-Michael Peters
Pubblicato in: Cell, Numero 184/21, 2021, Pagina/e 5448-5464.e22, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2021.09.016

SMC complexes can traverse physical roadblocks bigger than their ring size

Autori: Biswajit Pradhan, Roman Barth, Eugene Kim, Iain F. Davidson, Benedikt Bauer, Theo van Laar, Wayne Yang, Je-Kyung Ryu, Jaco van der Torre, Jan-Michael Peters, Cees Dekker
Pubblicato in: bioRxiv, Numero 2021.07.15.452501, 2021, ISSN 2692-8205
Editore: bioRxiv
DOI: 10.1101/2021.07.15.452501

MCM complexes are barriers that restrict cohesin-mediated loop extrusion

Autori: Bart J. H. Dequeker, Hugo B. Brandão, Matthias J. Scherr, Johanna Gassler, Sean Powell, Imre Gaspar, Ilya M. Flyamer, Wen Tang, Roman Stocsits, Iain F. Davidson, Jan-Michael Peters, Karl E. Duderstadt, Leonid A. Mirny, Kikuё Tachibana
Pubblicato in: bioRxiv, Numero 2020.10.15.340356, 2020, ISSN 2692-8205
Editore: bioRxiv
DOI: 10.1101/2020.10.15.340356

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