Molecular mechanisms of cohesin-mediated sister chromatid cohesion and chromatin organization

Project Information

CohesinMolMech

Grant agreement ID: 693949

DOI 10.3030/693949

Project closed

EC signature date 23 September 2016

Start date 1 October 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

An experimental and computational framework to build a dynamic protein atlas for human cell division

Author(s): Cai, Y., Hossain, M.J., Hériché, J.-K., Politi, A.Z., Walther, N., Koch, B., Wachsmuth, M., Nijmeijer, B., Kueblbeck, M., Martinic, M., Ladurner, L., Peters, J.-M., and Ellenberg, J.
Published in: Nature, Issue 561(7723), 2018, Page(s) 411-415, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0518-z

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

Author(s): Gordana Wutz, Rene Ladurner, Brian Glenn St Hilaire, Roman R Stocsits, Kota Nagasaka, Benoit Pignard, Adrian Sanborn, Wen Tang, Csilla Várnai, Miroslav P Ivanov, Stefan Schoenfelder, Petra van der Lelij, Xingfan Huang, Gerhard Dürnberger, Elisabeth Roitinger, Karl Mechtler, Iain Finley Davidson, Peter Fraser, Erez Lieberman-Aiden, Jan-Michael Peters
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52091

Conformation of sister chromatids in the replicated human genome

Author(s): Michael Mitter, Catherina Gasser, Zsuzsanna Takacs, Christoph C. H. Langer, Wen Tang, Gregor Jessberger, Charlie T. Beales, Eva Neuner, Stefan L. Ameres, Jan-Michael Peters, Anton Goloborodko, Ronald Micura, Daniel W. Gerlich
Published in: Nature, Issue 586/7827, 2020, Page(s) 139-144, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2744-4

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Author(s): Canela, Andres; Maman, Yaakov; Huang, Shar-yin N.; Wutz, Gordana; Tang, Wen; Zagnoli-Vieira, Guido; Callen, Elsa; Wong, Nancy; Day, Amanda; Peters, Jan-Michael; Caldecott, Keith W.; Pommier, Yves; Nussenzweig, André
Published in: Mol Cell, Issue 1, 2019, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.04.030

Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers

Author(s): Michiel J. Thiecke, Gordana Wutz, Matthias Muhar, Wen Tang, Stephen Bevan, Valeriya Malysheva, Roman Stocsits, Tobias Neumann, Johannes Zuber, Peter Fraser, Stefan Schoenfelder, Jan-Michael Peters, Mikhail Spivakov
Published in: Cell Reports, Issue 32/3, 2020, Page(s) 107929, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107929

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Author(s): Louisa Hill, Anja Ebert, Markus Jaritz, Gordana Wutz, Kota Nagasaka, Hiromi Tagoh, Daniela Kostanova-Poliakova, Karina Schindler, Qiong Sun, Peter Bönelt, Maria Fischer, Jan-Michael Peters, Meinrad Busslinger
Published in: Nature, Issue 584/7819, 2020, Page(s) 142-147, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2454-y

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes

Author(s): Mariana C.C. Silva, Sean Powell, Sabrina Ladstätter, Johanna Gassler, Roman Stocsits, Antonio Tedeschi, Jan-Michael Peters, Kikuë Tachibana
Published in: Journal of Cell Biology, Issue 219/4, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201906100

Dynamics of sister chromatid resolution during cell cycle progression

Author(s): Rugile Stanyte, Johannes Nuebler, Claudia Blaukopf, Rudolf Hoefler, Roman Stocsits, Jan-Michael Peters, Daniel W. Gerlich
Published in: The Journal of Cell Biology, Issue 217/6, 2018, Page(s) 1985-2004, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201801157

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion

Author(s): Miroslav P Ivanov, Rene Ladurner, Ina Poser, Rebecca Beveridge, Evelyn Rampler, Otto Hudecz, Maria Novatchkova, Jean‐Karim Hériché, Gordana Wutz, Petra van der Lelij, Emanuel Kreidl, James RA Hutchins, Heinz Axelsson‐Ekker, Jan Ellenberg, Anthony A Hyman, Karl Mechtler, Jan‐Michael Peters
Published in: The EMBO Journal, Issue 37/15, 2018, Page(s) e97150, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201797150

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

Author(s): Petra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis, Thomas Hoffmann, Matthias Hinterndorfer, Gerd Bader, Norbert Kraut, Mark A Pearson, Jan-Michael Peters, Johannes Zuber, Opher Gileadi, Mark Petronczki
Published in: Life Science Alliance, Issue 3/7, 2020, Page(s) e202000725, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202000725

Absolute quantification of cohesin, CTCF and their regulators in human cells.

Author(s): Johann Holzmann; Antonio Z Politi; Kota Nagasaka; Merle Hantsche-Grininger; Nike Walther; Birgit Koch; Johannes Fuchs; Gerhard Dürnberger; Wen Tang; Rene Ladurner; Roman R Stocsits; Georg A Busslinger; Béla Novák; Karl Mechtler; Iain Finley Davidson; Jan Ellenberg; Jan-Michael Peters
Published in: eLife, Issue 5, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.46269

Genome folding through loop extrusion by SMC complexes

Author(s): Iain F. Davidson, Jan-Michael Peters
Published in: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-021-00349-7

How DNA loop extrusion mediated by cohesin enables V(D)J recombination

Author(s): Jan-Michael Peters
Published in: Current Opinion in Cell Biology, Issue 70, 2021, Page(s) 75-83, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.11.007

Self-organization of parS centromeres by the ParB CTP hydrolase

Author(s): Young-Min Soh, Iain Finley Davidson, Stefano Zamuner, Jérôme Basquin, Florian Patrick Bock, Michael Taschner, Jan-Willem Veening, Paolo De Los Rios, Jan-Michael Peters, Stephan Gruber
Published in: Science, Issue 366/6469, 2019, Page(s) 1129-1133, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay3965

Quantifying the heterogeneity of macromolecular machines by mass photometry

Author(s): Adar Sonn-Segev, Katarina Belacic, Tatyana Bodrug, Gavin Young, Ryan T. VanderLinden, Brenda A. Schulman, Johannes Schimpf, Thorsten Friedrich, Phat Vinh Dip, Thomas U. Schwartz, Benedikt Bauer, Jan-Michael Peters, Weston B. Struwe, Justin L. P. Benesch, Nicholas G. Brown, David Haselbach, Philipp Kukura
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15642-w

DNA loop extrusion by human cohesin

Author(s): Iain F. Davidson, Benedikt Bauer, Daniela Goetz, Wen Tang, Gordana Wutz, Jan-Michael Peters
Published in: Science, Issue 366/6471, 2019, Page(s) 1338-1345, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz3418

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Author(s): Benedikt W. Bauer, Iain F. Davidson, Daniel Canena, Gordana Wutz, Wen Tang, Gabriele Litos, Sabrina Horn, Peter Hinterdorfer, Jan-Michael Peters
Published in: Cell, Issue 184/21, 2021, Page(s) 5448-5464.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.09.016

Non-peer reviewed articles (2)

SMC complexes can traverse physical roadblocks bigger than their ring size

Author(s): Biswajit Pradhan, Roman Barth, Eugene Kim, Iain F. Davidson, Benedikt Bauer, Theo van Laar, Wayne Yang, Je-Kyung Ryu, Jaco van der Torre, Jan-Michael Peters, Cees Dekker
Published in: bioRxiv, Issue 2021.07.15.452501, 2021, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2021.07.15.452501

MCM complexes are barriers that restrict cohesin-mediated loop extrusion

Author(s): Bart J. H. Dequeker, Hugo B. Brandão, Matthias J. Scherr, Johanna Gassler, Sean Powell, Imre Gaspar, Ilya M. Flyamer, Wen Tang, Roman Stocsits, Iain F. Davidson, Jan-Michael Peters, Karl E. Duderstadt, Leonid A. Mirny, Kikuё Tachibana
Published in: bioRxiv, Issue 2020.10.15.340356, 2020, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2020.10.15.340356