In terms of Innovation, SoftPro capitalizes on previous research work in engineering, validates it clinically, and assesses the economic viability and business model of components and systems for robotics-enabled aids – or in other terms, to move from bench to bedside. Thanks to the dynamical nature of the involved SMEs and the strong links between participants, the industrial pickup of at least some of these results is highly probable. Such is the case e.g. for the existing concept of soft-synergy based hand prosthesis (the SoftHand Pro), at the beginning of the project tested on a few amputees in Italian and international facilities, and which within the SoftPro duration has reached a pre-marketable state. Other SoftPro devices that will reach high TRL are shell-based exoskeletons and IMU-based posture and measurement gloves. SoftPro has integrated technologies in final demonstrators of large potential technical impact to foster, since the early phases of the project, the development of concrete industrial products, based on pre-existing technologies made available by our academic and industrial participants and ready to be picked up by our agile SMEs. In other terms, technologies that have been bench-tested (to different degrees) have participated in the SoftPro integration process, during which they have been refined according to technical specifications derived from clinical requirement analysis, reaching a TRL level that make them ready to go to bedside. In terms of Research, SoftPro has contributed importantly to applied neurosciences, to interfaces, and to assessment tools and methods. The main expected and achieved results in applied neurosciences are the clarification of the implications of the theory of sensorimotor synergies in rehabilitation and the development of novel algorithms for eliciting synergy-inspired control of robotic aids. The design and validation of novel interfaces for haptic stimulus delivery in feedback assistive devices represents an outgrowth of participants’ research in robotics and human-computer interfaces into a novel direction, substantially adding to the state of art in prosthetics and in rehabilitation. Finally, new tools for the assessment of effectiveness of robot-enabled prostheses and assistive devices include the maturation of the ReHapticKnob and the development of a re-engineered portable version (Handybot), the kinematic glove and the development and application of force/torque based, intrinsic tactile sensing techniques to measure grasping and manipulative forces with tools such as the ThimbleSense and its advanced version Exosense, including the extension to the study of the interaction with deformable surfaces. Finally, the SoftPro project pursued “red label” investigations and developments, where we have undertaken higher risks testing disruptively new hypotheses and paradigms, including an attempt to extract from nervous system signals important features for the assessment of the internal state and interoception of the users of SoftPro systems and pioneering the idea of using robotic extra limbs for providing assistance to patients with chronic motor impairments, and even venturing into the evaluation of therapeutic effects of the use of extra limbs for neuro-rehabilitation of post-stroke patients.