Crosstalk of Metabolism and Inflammation

Publications

Environmental arginine controls multinuclear giant cell metabolism and formation

Auteurs: Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saferding, Birgit Niederreiter, Alexandra Junza, Annika Frauenstein, Carina Scholtysek, Yohei Mikami, Kristaps Klavins, Gerhard Krönke, Andreas Bergthaler, John J. O’Shea, Thomas Weichhart, Felix Meissner, Josef S. Smolen, Paul Chen
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-14285-1

The interplay of immunology and cachexia in infection and cancer

Auteurs: Hatoon Baazim, Laura Antonio-Herrera, Andreas Bergthaler
Publié dans: Nature Reviews Immunology, 2021, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-021-00624-w

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

Auteurs: Alexander Lercher, Alexandra M. Popa, Csilla Viczenczova, Lindsay Kosack, Kristaps Klavins, Benedikt Agerer, Christiane A. Opitz, Tobias V. Lanz, Michael Platten, Andreas Bergthaler
Publié dans: PLOS Pathogens, Numéro 16/10, 2020, Page(s) e1008973, ISSN 1553-7374
Éditeur: PLOS Pathogens
DOI: 10.1371/journal.ppat.1008973

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Auteurs: Enrico Girardi,Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, and Giulio Superti-Furga
Publié dans: Nature Communications, Numéro Nat Commun. 2020; 11:6145, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19871-x

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

Auteurs: Benedikt Agerer; Maximilian Koblischke; Venugopal Gudipati; Luis Fernando Montaño-Gutierrez; Mark Smyth; Alexandra Popa; Jakob-Wendelin Genger; Lukas Endler; David M. Florian; Vanessa Mühlgrabner; Marianne Graninger; Stephan W. Aberle; Anna-Maria Husa; Lisa Ellen Shaw; Alexander Lercher; Pia Gattinger; Ricard Torralba-Gombau; Doris Trapin; Thomas Penz; Daniele Barreca; Ingrid Fae; Sabine Wenda;
Publié dans: Science Immunology, Numéro 1, 2021, ISSN 2470-9468
Éditeur: Science Immunology
DOI: 10.48350/156603

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Auteurs: Jayne Louise Wilson, Thomas Nägele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschläger, Thomas Weichhart, Wolfram Weckwerth
Publié dans: Cell Reports, Numéro 30/5, 2020, Page(s) 1542-1552.e7, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.01.011

Systemic Immunometabolism: Challenges and Opportunities

Auteurs: Alexander Lercher, Hatoon Baazim, Andreas Bergthaler
Publié dans: Immunity, Numéro 53/3, 2020, Page(s) 496-509, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2020.08.012

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis

Auteurs: Lindsay Kosack, Riem Gawish, Alexander Lercher, Bojan Vilagos, Anastasiya Hladik, Karin Lakovits, Anannya Bhattacharya, Christopher Schliehe, Ildiko Mesteri, Sylvia Knapp, Andreas Bergthaler
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-10637-y

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

Auteurs: Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P.
Publié dans: Cancer Cell, Numéro 35/1, 2019, Page(s) 125-139.e9, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2018.11.018

CD8+ T cells induce cachexia during chronic viral infection

Auteurs: Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
Publié dans: Nature Immunology, Numéro 20/6, 2019, Page(s) 701-710, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-019-0397-y

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Auteurs: Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul
Publié dans: Immunity, Numéro 51/6, 2019, Page(s) 1074-1087.e9, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2019.10.014

Structural cells are key regulators of organ-specific immune responses

Auteurs: Thomas Krausgruber, Nikolaus Fortelny, Victoria Fife-Gernedl, Martin Senekowitsch, Linda C. Schuster, Alexander Lercher, Amelie Nemc, Christian Schmidl, André F. Rendeiro, Andreas Bergthaler, Christoph Bock
Publié dans: Nature, Numéro 583/7815, 2020, Page(s) 296-302, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-020-2424-4

Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells

Auteurs: Alexandra Franziska Gülich, Ramona Rica, Caroline Tizian, Csilla Viczenczova, Kseniya Khamina, Thomas Faux, Daniela Hainberger, Thomas Penz, Remy Bosselut, Christoph Bock, Asta Laiho, Laura L. Elo, Andreas Bergthaler, Wilfried Ellmeier, Shinya Sakaguchi
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.535039

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

Auteurs: Ci Zhu; Nicole Boucheron; André C. Mueller; Peter Májek; Thierry Claudel; Emina Halilbasic; Hatoon Baazim; Alexander Lercher; Csilla Viczenczova; Daniela Hainberger; Teresa Preglej; Lisa Sandner; Marlis Alteneder; Alexandra F. Guelich; Matarr Khan; Patricia Hamminger; Jelena Remetic; Anna Ohradanova-Repic; Philipp Schatzlmaier; Clemens Donner; Claudia D. Fuchs; Tatjana Stojakovic; Hubert Scharna
Publié dans: Journal of Hepatology, Numéro 1, 2021, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1101/2021.01.09.426037

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

Auteurs: Duygu Demiroz, Ekaterini Platanitis, Michael Bryant, Philipp Fischer, Michaela Prchal-Murphy, Alexander Lercher, Caroline Lassnig, Manuela Baccarini, Mathias Müller, Andreas Bergthaler, Veronika Sexl, Marlies Dolezal, Thomas Decker
Publié dans: PLOS Pathogens, Numéro 17/7, 2021, Page(s) e1009697, ISSN 1553-7374
Éditeur: PLOS Pathogens
DOI: 10.1371/journal.ppat.1009697

Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity

Auteurs: Alexander Lercher; Anannya Bhattacharya; Anannya Bhattacharya; Alexandra Popa; Michael Caldera; Moritz F. Schlapansky; Hatoon Baazim; Peter Májek; Julia S. Brunner; Lindsay Kosack; Dijana Vitko; Dijana Vitko; Theresa Pinter; Theresa Pinter; Bettina Gürtl; Daniela Reil; Ulrich Kalinke; Keiryn L. Bennett; Jörg Menche; Paul N. Cheng; Gernot Schabbauer; Michael Trauner; Kristaps Klavins; Andreas Be
Publié dans: Numéro 1, 2019
Éditeur: bioRxiv
DOI: 10.1101/762310

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