Crosstalk of Metabolism and Inflammation

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Environmental arginine controls multinuclear giant cell metabolism and formation

Autores: Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saferding, Birgit Niederreiter, Alexandra Junza, Annika Frauenstein, Carina Scholtysek, Yohei Mikami, Kristaps Klavins, Gerhard Krönke, Andreas Bergthaler, John J. O’Shea, Thomas Weichhart, Felix Meissner, Josef S. Smolen, Paul Chen
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14285-1

The interplay of immunology and cachexia in infection and cancer

Autores: Hatoon Baazim, Laura Antonio-Herrera, Andreas Bergthaler
Publicado en: Nature Reviews Immunology, 2021, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-021-00624-w

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

Autores: Alexander Lercher, Alexandra M. Popa, Csilla Viczenczova, Lindsay Kosack, Kristaps Klavins, Benedikt Agerer, Christiane A. Opitz, Tobias V. Lanz, Michael Platten, Andreas Bergthaler
Publicado en: PLOS Pathogens, Edición 16/10, 2020, Página(s) e1008973, ISSN 1553-7374
Editor: PLOS Pathogens
DOI: 10.1371/journal.ppat.1008973

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Autores: Enrico Girardi,Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, and Giulio Superti-Furga
Publicado en: Nature Communications, Edición Nat Commun. 2020; 11:6145, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19871-x

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

Autores: Benedikt Agerer; Maximilian Koblischke; Venugopal Gudipati; Luis Fernando Montaño-Gutierrez; Mark Smyth; Alexandra Popa; Jakob-Wendelin Genger; Lukas Endler; David M. Florian; Vanessa Mühlgrabner; Marianne Graninger; Stephan W. Aberle; Anna-Maria Husa; Lisa Ellen Shaw; Alexander Lercher; Pia Gattinger; Ricard Torralba-Gombau; Doris Trapin; Thomas Penz; Daniele Barreca; Ingrid Fae; Sabine Wenda;
Publicado en: Science Immunology, Edición 1, 2021, ISSN 2470-9468
Editor: Science Immunology
DOI: 10.48350/156603

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Autores: Jayne Louise Wilson, Thomas Nägele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschläger, Thomas Weichhart, Wolfram Weckwerth
Publicado en: Cell Reports, Edición 30/5, 2020, Página(s) 1542-1552.e7, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.01.011

Systemic Immunometabolism: Challenges and Opportunities

Autores: Alexander Lercher, Hatoon Baazim, Andreas Bergthaler
Publicado en: Immunity, Edición 53/3, 2020, Página(s) 496-509, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2020.08.012

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis

Autores: Lindsay Kosack, Riem Gawish, Alexander Lercher, Bojan Vilagos, Anastasiya Hladik, Karin Lakovits, Anannya Bhattacharya, Christopher Schliehe, Ildiko Mesteri, Sylvia Knapp, Andreas Bergthaler
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-10637-y

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

Autores: Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P.
Publicado en: Cancer Cell, Edición 35/1, 2019, Página(s) 125-139.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2018.11.018

CD8+ T cells induce cachexia during chronic viral infection

Autores: Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
Publicado en: Nature Immunology, Edición 20/6, 2019, Página(s) 701-710, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-019-0397-y

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Autores: Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul
Publicado en: Immunity, Edición 51/6, 2019, Página(s) 1074-1087.e9, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2019.10.014

Structural cells are key regulators of organ-specific immune responses

Autores: Thomas Krausgruber, Nikolaus Fortelny, Victoria Fife-Gernedl, Martin Senekowitsch, Linda C. Schuster, Alexander Lercher, Amelie Nemc, Christian Schmidl, André F. Rendeiro, Andreas Bergthaler, Christoph Bock
Publicado en: Nature, Edición 583/7815, 2020, Página(s) 296-302, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2424-4

Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells

Autores: Alexandra Franziska Gülich, Ramona Rica, Caroline Tizian, Csilla Viczenczova, Kseniya Khamina, Thomas Faux, Daniela Hainberger, Thomas Penz, Remy Bosselut, Christoph Bock, Asta Laiho, Laura L. Elo, Andreas Bergthaler, Wilfried Ellmeier, Shinya Sakaguchi
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.535039

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

Autores: Ci Zhu; Nicole Boucheron; André C. Mueller; Peter Májek; Thierry Claudel; Emina Halilbasic; Hatoon Baazim; Alexander Lercher; Csilla Viczenczova; Daniela Hainberger; Teresa Preglej; Lisa Sandner; Marlis Alteneder; Alexandra F. Guelich; Matarr Khan; Patricia Hamminger; Jelena Remetic; Anna Ohradanova-Repic; Philipp Schatzlmaier; Clemens Donner; Claudia D. Fuchs; Tatjana Stojakovic; Hubert Scharna
Publicado en: Journal of Hepatology, Edición 1, 2021, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1101/2021.01.09.426037

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

Autores: Duygu Demiroz, Ekaterini Platanitis, Michael Bryant, Philipp Fischer, Michaela Prchal-Murphy, Alexander Lercher, Caroline Lassnig, Manuela Baccarini, Mathias Müller, Andreas Bergthaler, Veronika Sexl, Marlies Dolezal, Thomas Decker
Publicado en: PLOS Pathogens, Edición 17/7, 2021, Página(s) e1009697, ISSN 1553-7374
Editor: PLOS Pathogens
DOI: 10.1371/journal.ppat.1009697

Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity

Autores: Alexander Lercher; Anannya Bhattacharya; Anannya Bhattacharya; Alexandra Popa; Michael Caldera; Moritz F. Schlapansky; Hatoon Baazim; Peter Májek; Julia S. Brunner; Lindsay Kosack; Dijana Vitko; Dijana Vitko; Theresa Pinter; Theresa Pinter; Bettina Gürtl; Daniela Reil; Ulrich Kalinke; Keiryn L. Bennett; Jörg Menche; Paul N. Cheng; Gernot Schabbauer; Michael Trauner; Kristaps Klavins; Andreas Be
Publicado en: Edición 1, 2019
Editor: bioRxiv
DOI: 10.1101/762310

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